BioPAX pathway converted from "MHC class II antigen presentation" in the Reactome database. MHC class II antigen presentation This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Formation of MHC II alpha beta heterodimer This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047544 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047534 integral component of lumenal side of endoplasmic reticulum membrane GENE ONTOLOGY GO:0071556 UniProt:F1PSQ5 Canis familiaris NCBI Taxonomy 9615 UniProt F1PSQ5 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047534 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047534 Reactome R-CFA-2130709 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130709.1 Reactome http://www.reactome.org F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047536 UniProt:F1PTQ6 HLA-DQB2 UniProt F1PTQ6 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047536 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047536 Reactome R-CFA-2130611 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130611.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047542 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047538 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047538 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047538 Reactome R-CFA-2130458 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130458.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047540 UniProt:F6V690 HLA-DQB1 UniProt F6V690 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047540 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047540 Reactome R-CFA-2130458-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130458-2.1 Reactome Database ID Release 81 10047542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047542 Reactome R-CFA-2130458-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130458-3.1 Reactome Database ID Release 81 10047544 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047544 Reactome R-CFA-2130672 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130672.1 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047532 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047526 UniProt:F1PTR6 DLA-DQA1 UniProt F1PTR6 24 EQUAL 254 EQUAL Reactome Database ID Release 81 10047526 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047526 Reactome R-CFA-2130716 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130716.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047530 UniProt:A0A5F4BUG1 DLA-DRA UniProt A0A5F4BUG1 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047530 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047530 Reactome R-CFA-2130665 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130665.1 Reactome Database ID Release 81 10047532 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047532 Reactome R-CFA-2130718 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130718.1 MHC II alpha beta heterodimer Reactome DB_ID: 10047546 1 1 Reactome Database ID Release 81 10047546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047546 Reactome R-CFA-2213186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213186.1 Reactome Database ID Release 81 10048886 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048886 Reactome R-CFA-2213239 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213239.1 MHC II alpha and beta chains translocate to the ER and associate noncovalently to form an alpha beta heterodimer (Roche et al. 1991). This heterodimer then associates with a preformed invariant (Ii) chain trimer. 8415765 Pubmed 1993 The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides Freisewinkel, IM Schenck, K Koch, N Proc Natl Acad Sci U S A 90:9703-6 1956401 Pubmed 1991 Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain Roche, PA Marks, MS Cresswell, P Nature 354:392-4 9312039 Pubmed 1997 Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region Stumptner, P Benaroch, P EMBO J 16:5807-18 16242130 Pubmed 2005 Assembly of major histocompatibility complex class II subunits with invariant chain Neumann, J Koch, N FEBS Lett 579:6055-9 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT Interaction of invariant chain trimer and MHC II alpha beta dimer This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CANX CANX F1P8B4 Reactome DB_ID: 10030095 endoplasmic reticulum lumen GENE ONTOLOGY GO:0005788 UniProt:F1P8B4 CANX UniProt F1P8B4 21 EQUAL 592 EQUAL Reactome Database ID Release 81 10030095 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030095 Reactome R-CFA-195906 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-195906.1 Invariant chain trimer Reactome DB_ID: 10047524 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047522 UniProt:A0A5F4BY04 CD74 UniProt A0A5F4BY04 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047522 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047522 Reactome R-CFA-1181241 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181241.1 3 Reactome Database ID Release 81 10047524 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047524 Reactome R-CFA-2130599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130599.1 alpha beta dimer:Ii trimer:calnexin Reactome DB_ID: 10047548 1 1 1 Reactome Database ID Release 81 10047548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047548 Reactome R-CFA-2213212 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213212.1 Reactome Database ID Release 81 10047550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047550 Reactome R-CFA-2130478 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130478.1 MHC II alpha beta dimers associate with a third polypeptide, the invariant chain (Ii), required for class II molecules to reach the endocytic pathway (Roche et al. 1991). The interaction of Ii with the MHC II alpha beta dimer serves multiple functions. It plays a role in assembly, folding, egress from the ER and transport through the Golgi. Ii exists as a trimer; residues 163-183 of the Ii lumenal domain are involved in covalent cross-linking. Residues 96-104 are critical for association with class II alpha beta dimers (Bijlmakers et al. 1994, Freisewinkel et al. 1993). Residues 89-104 known as CLIP (Class II-associated invariant chain peptide) are the part of the Ii chain that binds antigen binding MHC class II groove, remaining bound until the MHC receptor is completely assembled. This CLIP domain prevents the premature binding of self-peptide fragments present in ER prior to MHC II localization within the endosomal compartment. The ER-resident chaperone protein calnexin rapidly associates with newly synthesized alpha, beta and invariant chains, and remains associated until the final nonamer assembly. The stoichiometry of calnexin in this interaction and the dynamics of association-dissociation are not known. Calnexin may stabilize the free class II chains and regulate their intracellular transport by facilitating the production of transport competent molecules out of the ER (Anderson & Cresswell 1994, Schreiber et al. 1995). 2190094 Pubmed 1990 Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding Roche, PA Cresswell, P Nature 345:615-8 8689559 Pubmed 1995 How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway Wolf, PR Ploegh, HL Annu Rev Cell Dev Biol 11:267-306 21116285 Pubmed 2011 Invariant chain increases the half-life of MHC II by delaying endosomal maturation Landsverk, OJ Barois, N Gregers, TF Bakke, O Immunol Cell Biol 89:619-29 16618111 Pubmed 2006 Invariant chain transmembrane domain trimerization: a step in MHC class II assembly Dixon, AM Stanley, BJ Matthews, EE Dawson, JP Engelman, DM Biochemistry 45:5228-34 1656276 Pubmed 1991 Sequence analysis of peptides bound to MHC class II molecules Rudensky, AYu Preston-Hurlburt, P Hong, SC Barlow, A Janeway CA, Jr Nature 353:622-7 8313912 Pubmed 1994 A role for calnexin (IP90) in the assembly of class II MHC molecules Anderson, KS Cresswell, P EMBO J 13:675-82 8148318 Pubmed 1994 Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum Schreiber, KL Bell, MP Huntoon, CJ Rajagopalan, S Brenner, MB McKean, DJ Int Immunol 6:101-11 19703008 Pubmed 2009 MHC II and the endocytic pathway: regulation by invariant chain Landsverk, OJ Bakke, O Gregers, TF Scand J Immunol 70:184-93 7519244 Pubmed 1994 Mapping functional regions in the lumenal domain of the class II-associated invariant chain Bijlmakers, MJ Benaroch, P Ploegh, HL J Exp Med 180:623-9 LEFT-TO-RIGHT Formation of nonameric complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer:calnexin Reactome DB_ID: 10048895 2 1 Reactome Database ID Release 81 10048895 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048895 Reactome R-CFA-8951502 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8951502.1 Reactome Database ID Release 81 10048897 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048897 Reactome R-CFA-2213241 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213241.1 Progressive addition of two more preformed alpha beta dimers to the invariant chain trimer and alpha beta complex ((alpha beta)1:(Ii)3) forms the complete nonameric structure ((alpha beta:Ii)3). Calnexin then disassociates on egress of the nonameric complex from the ER. LEFT-TO-RIGHT Dissociation of CANX from nonameric complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer Reactome DB_ID: 10085012 2 alpha beta dimer:Ii trimer Reactome DB_ID: 10085010 1 1 Reactome Database ID Release 81 10085010 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10085010 Reactome R-CFA-8980063 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8980063.1 1 Reactome Database ID Release 81 10085012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10085012 Reactome R-CFA-8980062 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8980062.1 Reactome Database ID Release 81 10085014 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10085014 Reactome R-CFA-8951500 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8951500.1 Calnexin disassociates on egress of the nonameric complex from the ER. LEFT-TO-RIGHT Formation of COPII vesicle This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> COPII Reactome DB_ID: 10047700 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 SAR1B:GTP:SEC23:SEC24 Reactome DB_ID: 10016328 SEC23:SEC24 Reactome DB_ID: 10016046 SEC23A SEC23A J9P1Q5 Reactome DB_ID: 10016044 UniProt:J9P1Q5 SEC23A UniProt J9P1Q5 1 EQUAL 765 EQUAL Reactome Database ID Release 81 10016044 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016044 Reactome R-CFA-203976 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203976.1 1 Converted from EntitySet in Reactome SEC24 Reactome DB_ID: 10016040 SEC24A SEC24A E2RRN0 Reactome DB_ID: 10016026 UniProt:E2RRN0 SEC24A UniProt E2RRN0 1 EQUAL 1093 EQUAL Reactome Database ID Release 81 10016026 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016026 Reactome R-CFA-203992 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203992.1 SEC24B SEC24B F1Q043 Reactome DB_ID: 10016030 UniProt:F1Q043 SEC24B UniProt F1Q043 1 EQUAL 1268 EQUAL Reactome Database ID Release 81 10016030 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016030 Reactome R-CFA-203982 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203982.1 SEC24C SEC24C E2RE90 Reactome DB_ID: 10016034 UniProt:E2RE90 SEC24C UniProt E2RE90 1 EQUAL 1094 EQUAL Reactome Database ID Release 81 10016034 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016034 Reactome R-CFA-203987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203987.1 SEC24D SEC24D E2RSG8 Reactome DB_ID: 10016038 UniProt:E2RSG8 SEC24D UniProt E2RSG8 1 EQUAL 1032 EQUAL Reactome Database ID Release 81 10016038 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016038 Reactome R-CFA-204004 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-204004.1 Reactome Database ID Release 81 10016040 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016040 Reactome R-CFA-203974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203974.1 1 Reactome Database ID Release 81 10016046 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016046 Reactome R-CFA-204007 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-204007.1 1 SAR1B:GTP Reactome DB_ID: 10016050 SAR1B SAR1B E2RRQ3 Reactome DB_ID: 10016048 UniProt:E2RRQ3 SAR1B UniProt E2RRQ3 1 EQUAL 198 EQUAL Reactome Database ID Release 81 10016048 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016048 Reactome R-CFA-203995 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203995.1 1 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 cytosol GENE ONTOLOGY GO:0005829 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 81 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 COMPOUND C00044 additional information MI MI:0361 1 Reactome Database ID Release 81 10016050 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016050 Reactome R-CFA-204003 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-204003.1 1 Reactome Database ID Release 81 10016328 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10016328 Reactome R-CFA-203997 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203997.1 1 Sec13p:Sec31p Complex Reactome DB_ID: 10035077 SEC31A SEC31A A0A5F4CH65 Reactome DB_ID: 10035073 UniProt:A0A5F4CH65 SEC31A UniProt A0A5F4CH65 1 EQUAL 1220 EQUAL Reactome Database ID Release 81 10035073 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10035073 Reactome R-CFA-204000 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-204000.1 1 SEC13 SEC13 A0A5F4CM74 Reactome DB_ID: 10035075 UniProt:A0A5F4CM74 SEC13 UniProt A0A5F4CM74 2 EQUAL 322 EQUAL Reactome Database ID Release 81 10035075 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10035075 Reactome R-CFA-203994 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203994.1 1 Reactome Database ID Release 81 10035077 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10035077 Reactome R-CFA-203993 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203993.1 1 Reactome Database ID Release 81 10047700 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047700 Reactome R-CFA-203999 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203999.1 Nonameric complex Reactome DB_ID: 10047698 3 1 Reactome Database ID Release 81 10047698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047698 Reactome R-CFA-2130477 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130477.1 Nonameric complex in COPII vesicle Reactome DB_ID: 10047730 ER to Golgi transport vesicle membrane GENE ONTOLOGY GO:0012507 1 Nonameric complex Reactome DB_ID: 10047728 MHC II alpha/beta dimer Reactome DB_ID: 10047726 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047712 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047706 24 EQUAL 255 EQUAL Reactome Database ID Release 81 10047706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047706 Reactome R-CFA-2130675 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130675.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047710 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047710 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047710 Reactome R-CFA-2130480 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130480.1 Reactome Database ID Release 81 10047712 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047712 Reactome R-CFA-2130353 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130353.1 1 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047724 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047714 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047714 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047714 Reactome R-CFA-2130688 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130688.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047716 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047716 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047716 Reactome R-CFA-2130317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130317.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047722 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047718 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047718 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047718 Reactome R-CFA-2130426 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130426.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047720 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047720 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047720 Reactome R-CFA-2130426-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130426-2.1 Reactome Database ID Release 81 10047722 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047722 Reactome R-CFA-2130426-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130426-3.1 Reactome Database ID Release 81 10047724 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047724 Reactome R-CFA-2130380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130380.1 1 Reactome Database ID Release 81 10047726 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047726 Reactome R-CFA-2213181 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213181.1 3 Invariant chain trimer Reactome DB_ID: 10047704 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047702 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047702 Reactome R-CFA-2130456 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130456.1 3 Reactome Database ID Release 81 10047704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047704 Reactome R-CFA-2130697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130697.1 1 Reactome Database ID Release 81 10047728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047728 Reactome R-CFA-2130379 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130379.1 1 Reactome Database ID Release 81 10047730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047730 Reactome R-CFA-2213211 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213211.1 Reactome Database ID Release 81 10047732 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047732 Reactome R-CFA-2130731 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130731.1 Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004). 2391366 Pubmed 1990 Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens Marks, MS Blum, JS Cresswell, P J Cell Biol 111:839-55 11790530 Pubmed 2002 Trafficking of MHC class II molecules in the late secretory pathway Hiltbold, EM Roche, PA Curr Opin Immunol 14:30-5 15093828 Pubmed 2004 A structural view of the COPII vesicle coat Bickford, LC Mossessova, E Goldberg, J Curr Opin Struct Biol 14:147-53 9639994 Pubmed 1998 The role of endosomes and lysosomes in MHC class II functioning Geuze, HJ Immunol Today 19:282-7 LEFT-TO-RIGHT Fusion of COPII vesicle with Golgi complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Nonameric complex Reactome DB_ID: 10047518 Golgi membrane GENE ONTOLOGY GO:0000139 Invariant chain trimer Reactome DB_ID: 10047494 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047492 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047492 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047492 Reactome R-CFA-2214388 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214388.1 3 Reactome Database ID Release 81 10047494 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047494 Reactome R-CFA-2214377 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214377.1 1 MHC II alpha/beta dimer Reactome DB_ID: 10047516 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047514 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047504 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047504 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047504 Reactome R-CFA-2214364 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214364.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047510 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047506 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047506 Reactome R-CFA-2214372 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214372.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047508 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047508 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047508 Reactome R-CFA-2214372-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214372-2.1 Reactome Database ID Release 81 10047510 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047510 Reactome R-CFA-2214372-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214372-3.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor Reactome DB_ID: 10047512 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047512 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047512 Reactome R-CFA-2214373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214373.1 Reactome Database ID Release 81 10047514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047514 Reactome R-CFA-2214376 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214376.1 1 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047502 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047496 24 EQUAL 254 EQUAL Reactome Database ID Release 81 10047496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047496 Reactome R-CFA-2214382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214382.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047500 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047500 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047500 Reactome R-CFA-2214390 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214390.1 Reactome Database ID Release 81 10047502 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047502 Reactome R-CFA-2214383 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214383.1 1 Reactome Database ID Release 81 10047516 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047516 Reactome R-CFA-2214375 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214375.1 3 Reactome Database ID Release 81 10047518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047518 Reactome R-CFA-2214394 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2214394.1 Reactome Database ID Release 81 10048899 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048899 Reactome R-CFA-2213243 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213243.1 The COPII vesicle uncoats and fuses with the cis-Golgi, releasing the MHC II:Ii complex into the Golgi. 10480952 Pubmed 1999 Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera Davidson, HW J Biol Chem 274:27315-22 LEFT-TO-RIGHT Translocation of MHC II:Ii complex to TGN Transport of MHC II:Ii complex along Golgi to TGN This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Nonameric complex Reactome DB_ID: 10047462 trans-Golgi network membrane GENE ONTOLOGY GO:0032588 Invariant chain trimer Reactome DB_ID: 10047438 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047436 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047436 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047436 Reactome R-CFA-2130493 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130493.1 3 Reactome Database ID Release 81 10047438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047438 Reactome R-CFA-2130720 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130720.1 1 MHC II alpha/beta dimer Reactome DB_ID: 10047460 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047458 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047448 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047448 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047448 Reactome R-CFA-2130397 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130397.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047450 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047450 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047450 Reactome R-CFA-2130334 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130334.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047456 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047452 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047452 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047452 Reactome R-CFA-2130622 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130622.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047454 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047454 Reactome R-CFA-2130622-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130622-2.1 Reactome Database ID Release 81 10047456 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047456 Reactome R-CFA-2130622-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130622-3.1 Reactome Database ID Release 81 10047458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047458 Reactome R-CFA-2130388 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130388.1 1 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047446 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047440 24 EQUAL 254 EQUAL Reactome Database ID Release 81 10047440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047440 Reactome R-CFA-2130568 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130568.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047444 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047444 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047444 Reactome R-CFA-2130586 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130586.1 Reactome Database ID Release 81 10047446 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047446 Reactome R-CFA-2130483 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130483.1 1 Reactome Database ID Release 81 10047460 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047460 Reactome R-CFA-2213184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213184.1 3 Reactome Database ID Release 81 10047462 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047462 Reactome R-CFA-2130491 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130491.1 Reactome Database ID Release 81 10047520 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047520 Reactome R-CFA-2130393 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130393.1 Nonameric MHC II:Ii complex move through the various cisternae to reach the trans-golgi network (TGN), a tubulo-vesicular organelle located at the trans-face of Golgi stacks. From the TGN, MHC II:Ii complexes are targeted to the endocytic pathway for peptide loading. 11529500 Pubmed 2001 Trans-Golgi network sorting Gu, F Crump, CM Thomas, G Cell Mol Life Sci 58:1067-84 LEFT-TO-RIGHT TGN-lysosomal vesicle coat assembly This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> AP-1 Complex Reactome DB_ID: 10025191 Ghost homologue of AP1G1 Reactome DB_ID: 10025175 Reactome Database ID Release 81 10025175 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025175 Reactome R-CFA-167703 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167703.1 1 AP1B1 AP1B1 E2RRJ6 Reactome DB_ID: 10025189 UniProt:E2RRJ6 AP1B1 UniProt E2RRJ6 1 EQUAL 949 EQUAL Reactome Database ID Release 81 10025189 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025189 Reactome R-CFA-167705 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167705.1 1 Converted from EntitySet in Reactome AP-1 mu Reactome DB_ID: 10025181 AP1M1 AP1M1 F1PYG5 Reactome DB_ID: 10025177 UniProt:F1PYG5 AP1M1 UniProt F1PYG5 2 EQUAL 423 EQUAL Reactome Database ID Release 81 10025177 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025177 Reactome R-CFA-167700 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167700.1 AP1M2 AP1M2 F1PFJ0 Reactome DB_ID: 10025179 UniProt:F1PFJ0 AP1M2 UniProt F1PFJ0 1 EQUAL 423 EQUAL Reactome Database ID Release 81 10025179 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025179 Reactome R-CFA-167699 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167699.1 Reactome Database ID Release 81 10025181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025181 Reactome R-CFA-167716 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167716.1 1 Converted from EntitySet in Reactome AP-1 sigma Reactome DB_ID: 10025187 AP1S1 AP1S1 E2RLN5 Reactome DB_ID: 10025183 UniProt:E2RLN5 AP1S1 UniProt E2RLN5 1 EQUAL 158 EQUAL Reactome Database ID Release 81 10025183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025183 Reactome R-CFA-167696 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167696.1 AP1S2 AP1S2 A0A5F4CQU4 Reactome DB_ID: 10025185 UniProt:A0A5F4CQU4 AP1S2 UniProt A0A5F4CQU4 1 EQUAL 157 EQUAL Reactome Database ID Release 81 10025185 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025185 Reactome R-CFA-167695 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167695.1 Reactome Database ID Release 81 10025187 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025187 Reactome R-CFA-167713 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167713.1 1 Reactome Database ID Release 81 10025191 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025191 Reactome R-CFA-167717 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167717.1 Clathrin Triskelion Reactome DB_ID: 10025161 CLTC CLTC-1 F1PHQ0 Reactome DB_ID: 10025157 UniProt:F1PHQ0 CLTC UniProt F1PHQ0 2 EQUAL 1675 EQUAL Reactome Database ID Release 81 10025157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025157 Reactome R-CFA-350824 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-350824.1 3 CLTA Clathrin light chain A0A5F4D392 Reactome DB_ID: 10025159 UniProt:A0A5F4D392 CLTA UniProt A0A5F4D392 1 EQUAL 248 EQUAL Reactome Database ID Release 81 10025159 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025159 Reactome R-CFA-350828 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-350828.1 3 Reactome Database ID Release 81 10025161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025161 Reactome R-CFA-350827 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-350827.1 Arf1-GTP Reactome DB_ID: 10018637 1 ARF1 ARF1 E2RNQ7 Reactome DB_ID: 10018635 UniProt:E2RNQ7 ARF1 UniProt E2RNQ7 2 EQUAL 181 EQUAL Reactome Database ID Release 81 10018635 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10018635 Reactome R-CFA-199971 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-199971.1 1 Reactome Database ID Release 81 10018637 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10018637 Reactome R-CFA-199981 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-199981.1 Converted from EntitySet in Reactome Dynamin Reactome DB_ID: 10047653 DNM2 DNM2 E2RNC3 Reactome DB_ID: 10025163 UniProt:E2RNC3 DNM2 UniProt E2RNC3 1 EQUAL 870 EQUAL Reactome Database ID Release 81 10025163 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10025163 Reactome R-CFA-2213180 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213180.1 DNM1 DNM1 F1PAK1 Reactome DB_ID: 10047649 UniProt:F1PAK1 DNM1 UniProt F1PAK1 1 EQUAL 864 EQUAL Reactome Database ID Release 81 10047649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047649 Reactome R-CFA-2213182 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213182.1 DNM3 DNM3 F1PFB8 Reactome DB_ID: 10047651 UniProt:F1PFB8 DNM3 UniProt F1PFB8 1 EQUAL 869 EQUAL Reactome Database ID Release 81 10047651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047651 Reactome R-CFA-2213188 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213188.1 Reactome Database ID Release 81 10047653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047653 Reactome R-CFA-2213185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213185.1 AP-1 Complex:Arf1-GTP:Clathrin Triskelion:Nonameric complex Reactome DB_ID: 10047655 1 1 1 1 1 Reactome Database ID Release 81 10047655 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047655 Reactome R-CFA-8951497 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8951497.1 Reactome Database ID Release 81 10047657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047657 Reactome R-CFA-2130619 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130619.1 The trans-Golgi network (TGN) is the sorting and package centre for trafficking cargo to the endoplasmic reticulum, plasma membrane and endosomes. Signal peptides determine the sorting and trafficking of proteins to the endosomal-lysosomal pathway or to the cell surface. The main signals that mediate targeting of MHC-II molecules to the endocytic pathway are two dileucine-based motifs, Leu23-Ile24 and Pro31-Leu33 present in the short cytoplasmic tail of Ii (Odorizzi et al. 1994). These motifs bind both the adaptor proteins AP-1 and AP-2, which are components of clathrin coats associated with the TGN/endosomes and the plasma membrane, respectively (McCormick et al. 2005). The precise pathway of class II:Ii complex trafficking from TGN to endocytic pathway is not well understood. In one view MHC II:Ii complexes directly traffic from the TGN to lysosomes, possibly using AP-1 dependent endocytic vesicles (Peters et al. 1991, Amigorena et al. 1994). Alternatively trafficking occurs via transient expression on the cell surface followed by rapid internalization and delivery to endocytic compartments. Early immunoelectron microscopy data has shown the presence of MHC class II:Ii complex molecules primarily in TGN and lysosomes (Peters et al. 1991, Hiltbold & Roche 2002). This theory was further supported by a study examining the trafficking of sulphate-tagged class II molecules, which concluded that the rapid appearance of these molecules in lysosomes was consistent with their direct transport from the TGN to lysosomes (Hiltbold & Roche 2002, Davidson 1999). The transport of cargo MHC II:Ii complexes from the TGN to lysosomes may be mediated by small TGN vesicles coated with AP-1 and clathrin. The di-leucine-based sorting signal in the Ii cytoplasmic chain recruits AP-1 and clathrin from cytosol to TGN to form AP-1 clathrin-coated TGN-derived vesicles. This process is regulated by the small GTPase ARF-1 (Salamero et al. 1996). 15911768 Pubmed 2005 Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments McCormick, PJ Martina, JA Bonifacino, JS Proc Natl Acad Sci U S A 102:7910-5 7650016 Pubmed 1995 A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway Pond, L Kuhn, LA Teyton, L Schutze, MP Tainer, JA Jackson, MR Peterson, PA J Biol Chem 270:19989-97 7592972 Pubmed 1995 Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain Motta, A Bremnes, B Morelli, MA Frank, RW Saviano, G Bakke, O J Biol Chem 270:27165-71 8034737 Pubmed 1994 Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment Odorizzi, CG Trowbridge, IS Xue, L Hopkins, Colin R Davis, CD Collawn, JF J Cell Biol 126:317-30 10593899 Pubmed 1999 The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains Hofmann, MW Höning, S Rodionov, D Dobberstein, B von Figura, K Bakke, O J Biol Chem 274:36153-8 9497313 Pubmed 1998 Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain Rodionov, DG Bakke, O J Biol Chem 273:6005-8 11520080 Pubmed 2001 Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice Sevilla, LM Richter, SS Miller, J Cell Immunol 210:143-53 8177316 Pubmed 1994 Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes Amigorena, S Drake, JR Webster, P Mellman, I Nature 369:113-20 14731593 Pubmed 1994 Targeting of membrane proteins to endosomes and lysosomes Sandoval, IV Bakke, O Trends Cell Biol 4:292-7 2121367 Pubmed 1990 MHC class II-associated invariant chain contains a sorting signal for endosomal compartments Bakke, O Dobberstein, B Cell 63:707-16 8939989 Pubmed 1996 Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes Salamero, J Le Borgne, R Saudrais, C Goud, B Hoflack, B J Biol Chem 271:30318-21 LEFT-TO-RIGHT Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 29372 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate [PO3(OH)](2-) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE ION HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 81 29372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372 Reactome R-ALL-29372 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4 COMPOUND C00009 AP-1 Clathrin coated nonameric complex Reactome DB_ID: 10047687 1 AP-1 Complex Reactome DB_ID: 10047679 Ghost homologue of AP1G1 Reactome DB_ID: 10047663 Reactome Database ID Release 81 10047663 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047663 Reactome R-CFA-2130340 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130340.1 1 Converted from EntitySet in Reactome AP1M1,2 Reactome DB_ID: 10047669 AP1M1 AP1M1 F1PYG5 Reactome DB_ID: 10047665 2 EQUAL 423 EQUAL Reactome Database ID Release 81 10047665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047665 Reactome R-CFA-2130512 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130512.1 AP1M2 AP1M2 F1PFJ0 Reactome DB_ID: 10047667 1 EQUAL 423 EQUAL Reactome Database ID Release 81 10047667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047667 Reactome R-CFA-2130404 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130404.1 Reactome Database ID Release 81 10047669 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047669 Reactome R-CFA-2130503 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130503.1 1 Converted from EntitySet in Reactome AP1S1,2,3 Reactome DB_ID: 10047675 AP1S1 AP1S1 E2RLN5 Reactome DB_ID: 10047671 1 EQUAL 158 EQUAL Reactome Database ID Release 81 10047671 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047671 Reactome R-CFA-2130566 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130566.1 AP1S2 AP1S2 A0A5F4CQU4 Reactome DB_ID: 10047673 1 EQUAL 157 EQUAL Reactome Database ID Release 81 10047673 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047673 Reactome R-CFA-2130394 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130394.1 Reactome Database ID Release 81 10047675 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047675 Reactome R-CFA-2130555 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130555.1 1 AP1B1 AP1B1 E2RRJ6 Reactome DB_ID: 10047677 1 EQUAL 949 EQUAL Reactome Database ID Release 81 10047677 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047677 Reactome R-CFA-2130596 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130596.1 1 Reactome Database ID Release 81 10047679 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047679 Reactome R-CFA-2130687 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130687.1 1 Clathrin Reactome DB_ID: 10047685 CLTC CLTC-1 F1PHQ0 Reactome DB_ID: 10047681 2 EQUAL 1675 EQUAL Reactome Database ID Release 81 10047681 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047681 Reactome R-CFA-2130474 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130474.1 3 CLTA Clathrin light chain A0A5F4D392 Reactome DB_ID: 10047683 1 EQUAL 248 EQUAL Reactome Database ID Release 81 10047683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047683 Reactome R-CFA-2130302 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130302.1 3 Reactome Database ID Release 81 10047685 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047685 Reactome R-CFA-2130469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130469.1 1 1 Reactome Database ID Release 81 10047687 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047687 Reactome R-CFA-2130552 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130552.1 Arf1-GDP Reactome DB_ID: 10018633 ARF1 ARF1 E2RNQ7 Reactome DB_ID: 10018631 2 EQUAL 181 EQUAL Reactome Database ID Release 81 10018631 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10018631 Reactome R-CFA-200826 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-200826.1 1 GDP Guanosine 5'-diphosphate Guanosine diphosphate GDP(3-) Reactome DB_ID: 29420 GDP(3-) [ChEBI:58189] GDP(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate(3-) GDP guanosine 5'-diphosphate trianion guanosine 5'-diphosphate GDP trianion ChEBI CHEBI:58189 Reactome Database ID Release 81 29420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420 Reactome R-ALL-29420 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.3 COMPOUND C00035 1 Reactome Database ID Release 81 10018633 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10018633 Reactome R-CFA-201340 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201340.1 Reactome Database ID Release 81 10085006 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10085006 Reactome R-CFA-8951498 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8951498.1 The trans-Golgi network (TGN) is the sorting and package centre for trafficking cargo to the endoplasmic reticulum, plasma membrane and endosomes. Signal peptides determine the sorting and trafficking of proteins to the endosomal-lysosomal pathway or to the cell surface. The main signals that mediate targeting of MHC-II molecules to the endocytic pathway are two dileucine-based motifs, Leu23-Ile24 and Pro31-Leu33 present in the short cytoplasmic tail of Ii (Odorizzi et al. 1994). These motifs bind both the adaptor proteins AP-1 and AP-2, which are components of clathrin coats associated with the TGN/endosomes and the plasma membrane, respectively (McCormick et al. 2005). The precise pathway of class II:Ii complex trafficking from TGN to endocytic pathway is not well understood. In one view MHC II:Ii complexes directly traffic from the TGN to lysosomes, possibly using AP-1 dependent endocytic vesicles (Peters et al. 1991, Amigorena et al. 1994). Alternatively trafficking occurs via transient expression on the cell surface followed by rapid internalization and delivery to endocytic compartments. Early immunoelectron microscopy data has shown the presence of MHC class II:Ii complex molecules primarily in TGN and lysosomes (Peters et al. 1991, Hiltbold & Roche 2002). This theory was further supported by a study examining the trafficking of sulphate-tagged class II molecules, which concluded that the rapid appearance of these molecules in lysosomes was consistent with their direct transport from the TGN to lysosomes (Hiltbold & Roche 2002, Davidson 1999). The transport of cargo MHC II:Ii complexes from the TGN to lysosomes may be mediated by small TGN vesicles coated with AP-1 and clathrin. The di-leucine-based sorting signal in the Ii cytoplasmic chain recruits AP-1 and clathrin from cytosol to TGN to form AP-1 clathrin-coated TGN-derived vesicles. This process is regulated by the small GTPase ARF-1 (Salamero et al. 1996). LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 Translocation of TGN-lysosome vesicle to lysosome This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> TGN-lysosome vesicle with nonameric complex Reactome DB_ID: 10047689 1 1 1 Reactome Database ID Release 81 10047689 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047689 Reactome R-CFA-2213234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213234.1 ACTIVATION GENE ONTOLOGY GO:0003924 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 81 10047690 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047690 Reactome Database ID Release 81 10047692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047692 Reactome R-CFA-2130641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130641.1 Budding vesicles loaded with the nonameric complex bud off from the TGN to reach the late-endosome/lysosome membrane. LEFT-TO-RIGHT TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Nonameric complex Reactome DB_ID: 10047372 lysosomal membrane GENE ONTOLOGY GO:0005765 Invariant chain trimer Reactome DB_ID: 10047348 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047346 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047346 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047346 Reactome R-CFA-2130320 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130320.1 3 Reactome Database ID Release 81 10047348 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047348 Reactome R-CFA-2130584 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130584.1 1 MHC II alpha/beta dimer Reactome DB_ID: 10047370 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047356 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047350 24 EQUAL 255 EQUAL Reactome Database ID Release 81 10047350 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047350 Reactome R-CFA-2130434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130434.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047354 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047354 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047354 Reactome R-CFA-2130677 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130677.1 Reactome Database ID Release 81 10047356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047356 Reactome R-CFA-2130598 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130598.1 1 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047368 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047358 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047358 Reactome R-CFA-2130601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130601.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047360 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047360 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047360 Reactome R-CFA-2130681 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130681.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047366 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047362 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047362 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047362 Reactome R-CFA-2130385 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130385.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047364 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047364 Reactome R-CFA-2130385-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130385-2.1 Reactome Database ID Release 81 10047366 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047366 Reactome R-CFA-2130385-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130385-3.1 Reactome Database ID Release 81 10047368 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047368 Reactome R-CFA-2130392 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130392.1 1 Reactome Database ID Release 81 10047370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047370 Reactome R-CFA-2213179 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213179.1 3 Reactome Database ID Release 81 10047372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047372 Reactome R-CFA-2130532 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130532.1 Reactome Database ID Release 81 10048884 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048884 Reactome R-CFA-2213236 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213236.1 On reaching the late endosomes/lysosomes the TGN-lysosome vesicle uncoats and fuses with the lysosome to releases the MHC II nonameric complex. LEFT-TO-RIGHT Transport of MHC II:Ii complex to plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC class II alpha/beta/Ii nonamer Reactome DB_ID: 10047488 transport vesicle membrane GENE ONTOLOGY GO:0030658 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047482 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047472 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047472 Reactome R-CFA-2130533 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130533.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047474 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047474 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047474 Reactome R-CFA-2130658 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130658.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047480 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047476 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047476 Reactome R-CFA-2130471 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130471.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047478 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047478 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047478 Reactome R-CFA-2130471-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130471-2.1 Reactome Database ID Release 81 10047480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047480 Reactome R-CFA-2130471-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130471-3.1 Reactome Database ID Release 81 10047482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047482 Reactome R-CFA-2130321 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130321.1 3 Invariant chain trimer Reactome DB_ID: 10047486 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047484 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047484 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047484 Reactome R-CFA-2130624 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130624.1 3 Reactome Database ID Release 81 10047486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047486 Reactome R-CFA-2130656 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130656.1 1 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047470 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047464 24 EQUAL 255 EQUAL Reactome Database ID Release 81 10047464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047464 Reactome R-CFA-2130581 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130581.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047468 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047468 Reactome R-CFA-2130530 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130530.1 Reactome Database ID Release 81 10047470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047470 Reactome R-CFA-2130565 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130565.1 3 Reactome Database ID Release 81 10047488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047488 Reactome R-CFA-2130431 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130431.1 Reactome Database ID Release 81 10047490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047490 Reactome R-CFA-2130378 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130378.1 The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane. 16824007 Pubmed 2006 The formation of TGN-to-plasma-membrane transport carriers Bard, F Malhotra, V Annu Rev Cell Dev Biol 22:439-55 10540230 Pubmed 1999 Cell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell lines Ong, GL Goldenberg, DM Hansen, HJ Mattes, MJ Immunology 98:296-302 8397411 Pubmed 1993 Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization Roche, PA Teletski, CL Stang, E Bakke, O Long, EO Proc Natl Acad Sci U S A 90:8581-5 LEFT-TO-RIGHT Insertion of MHC II:Ii complex in to the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC class II alpha/beta/Ii nonamer Reactome DB_ID: 10047640 plasma membrane GENE ONTOLOGY GO:0005886 MHC class II alpha/beta dimer Reactome DB_ID: 10015161 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10015141 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10015133 24 EQUAL 255 EQUAL Reactome Database ID Release 81 10015133 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015133 Reactome R-CFA-197576 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197576.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10015139 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10015139 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015139 Reactome R-CFA-197588 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197588.1 Reactome Database ID Release 81 10015141 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015141 Reactome R-CFA-2130597 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130597.1 1 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10015159 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10015145 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10015145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015145 Reactome R-CFA-197648 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197648.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10015149 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10015149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015149 Reactome R-CFA-197578 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197578.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10015157 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10015151 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10015151 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015151 Reactome R-CFA-197649 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197649.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10015155 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10015155 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015155 Reactome R-CFA-197649-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197649-2.1 Reactome Database ID Release 81 10015157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015157 Reactome R-CFA-197649-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197649-3.1 Reactome Database ID Release 81 10015159 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015159 Reactome R-CFA-2130476 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130476.1 1 Reactome Database ID Release 81 10015161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015161 Reactome R-CFA-2213189 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213189.1 3 CD74 trimer Reactome DB_ID: 10047638 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047636 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047636 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047636 Reactome R-CFA-2130666 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130666.1 3 Reactome Database ID Release 81 10047638 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047638 Reactome R-CFA-2130505 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130505.1 1 Reactome Database ID Release 81 10047640 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047640 Reactome R-CFA-2130467 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130467.1 Reactome Database ID Release 81 10047642 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047642 Reactome R-CFA-2130500 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130500.1 On reaching the cell surface, transport carrier vesicles insert the cargo MHC II:Ii complex into the plasma membrane. LEFT-TO-RIGHT Recruitment of clathrin coated vesicle by Ii This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Clathrin:AP-2 complex Reactome DB_ID: 10010586 AP-2 complex Reactome DB_ID: 10010574 Converted from EntitySet in Reactome Adaptor protein complex 2 (AP-2) large adaptins Reactome DB_ID: 10010572 AP2A1 AP2A1 A0A5F4BU88 Reactome DB_ID: 10010566 UniProt:A0A5F4BU88 AP2A1 UniProt A0A5F4BU88 1 EQUAL 977 EQUAL Reactome Database ID Release 81 10010566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010566 Reactome R-CFA-177494 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177494.1 AP2A2 AP2A2(1-939) A0A5F4BTD6 Reactome DB_ID: 10010570 UniProt:A0A5F4BTD6 AP2A2 UniProt A0A5F4BTD6 1 EQUAL 939 EQUAL Reactome Database ID Release 81 10010570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010570 Reactome R-CFA-177502 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177502.1 Reactome Database ID Release 81 10010572 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010572 Reactome R-CFA-444999 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-444999.1 1 AP2B1 AP2B1 A0A5F4CPQ9 Reactome DB_ID: 10010554 UniProt:A0A5F4CPQ9 AP2B1 UniProt A0A5F4CPQ9 1 EQUAL 937 EQUAL Reactome Database ID Release 81 10010554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010554 Reactome R-CFA-167690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167690.1 1 AP2M1 AP2M1 A0A5F4BQ86 Reactome DB_ID: 10010558 UniProt:A0A5F4BQ86 AP2M1 UniProt A0A5F4BQ86 1 EQUAL 435 EQUAL Reactome Database ID Release 81 10010558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010558 Reactome R-CFA-167585 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167585.1 1 AP2S1 AP2S1 A0A5F4CSI6 Reactome DB_ID: 10010562 UniProt:A0A5F4CSI6 AP2S1 UniProt A0A5F4CSI6 1 EQUAL 142 EQUAL Reactome Database ID Release 81 10010562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010562 Reactome R-CFA-389382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-389382.1 1 Reactome Database ID Release 81 10010574 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010574 Reactome R-CFA-177480 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177480.1 1 Clathrin Reactome DB_ID: 10010584 CLTC CLTC F1PHQ0 Reactome DB_ID: 10010582 2 EQUAL 1675 EQUAL Reactome Database ID Release 81 10010582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010582 Reactome R-CFA-2980668 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2980668.1 3 CLTA CLTA A0A5F4D392 Reactome DB_ID: 10010578 1 EQUAL 248 EQUAL Reactome Database ID Release 81 10010578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010578 Reactome R-CFA-2980611 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2980611.1 3 Reactome Database ID Release 81 10010584 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010584 Reactome R-CFA-177482 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177482.1 1 Reactome Database ID Release 81 10010586 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010586 Reactome R-CFA-177505 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177505.1 Clathrin coated MHC class II alpha/beta/Ii nonamer Reactome DB_ID: 10047659 1 1 Reactome Database ID Release 81 10047659 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047659 Reactome R-CFA-2130309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130309.1 Reactome Database ID Release 81 10047661 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047661 Reactome R-CFA-2130640 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130640.1 Plasma membrane-associated nonameric complexes (MHC II alpha/beta/Ii complex) are rapidly internalized and delivered to late endosomes (LEs) and lysosomes. The dileucine-based signal present in the cytoplasmic tail of Ii is required for sorting of the nonameric MHC II-Ii complex from the plasma membrane to peptide loading compartments. These signals promote rapid internalization by recognising and binding to clathrin adaptor AP-2, a scaffolding-protein complex that brings together components of the vesicle-formation machinery. AP-2 is an essential component of an endocytic clathrin coat and participates in initiation of coat assembly. The critical role of AP2 in delivering MHC II:Ii complex to antigen processing compartments came from RNA interference studies targeting clathrin and AP2. The knockout of AP2 profoundly inhibited MHC II:Ii complex internalization and resulted in the accumulation of Ii at the surface (Dugast et al. 2005, McCormick et al. 2005). 15749704 Pubmed 2005 AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes Dugast, M Toussaint, H Dousset, C Benaroch, P J Biol Chem 280:19656-64 LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 Internalization of MHC II:Ii clathrin coated vesicle This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 81 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 SH3GL2 SH3GL2 F1PDT4 Reactome DB_ID: 10010590 UniProt:F1PDT4 SH3GL2 UniProt F1PDT4 1 EQUAL 352 EQUAL Reactome Database ID Release 81 10010590 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10010590 Reactome R-CFA-177495 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177495.1 Clathrin coated MHC class II alpha/beta/Ii nonamer Reactome DB_ID: 10047604 clathrin-coated endocytic vesicle membrane GENE ONTOLOGY GO:0030669 Clathrin:AP2 complex Reactome DB_ID: 10047602 Clathrin Reactome DB_ID: 10047600 CLTC CLTC F1PHQ0 Reactome DB_ID: 10047596 endolysosome membrane GENE ONTOLOGY GO:0036020 2 EQUAL 1675 EQUAL Reactome Database ID Release 81 10047596 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047596 Reactome R-CFA-8870827 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8870827.1 3 CLTA CLTA A0A5F4D392 Reactome DB_ID: 10047598 1 EQUAL 248 EQUAL Reactome Database ID Release 81 10047598 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047598 Reactome R-CFA-8870825 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8870825.1 3 Reactome Database ID Release 81 10047600 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047600 Reactome R-CFA-2130407 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130407.1 1 Adaptor protein 2 complex Reactome DB_ID: 10047594 Converted from EntitySet in Reactome Adaptor protein complex 2 (AP-2) large adaptins Reactome DB_ID: 10047592 AP2A1 AP2A1 A0A5F4BU88 Reactome DB_ID: 10047588 1 EQUAL 977 EQUAL Reactome Database ID Release 81 10047588 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047588 Reactome R-CFA-6784829 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784829.1 AP2A2 AP2A2(1-939) A0A5F4BTD6 Reactome DB_ID: 10047590 1 EQUAL 939 EQUAL Reactome Database ID Release 81 10047590 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047590 Reactome R-CFA-6784819 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784819.1 Reactome Database ID Release 81 10047592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047592 Reactome R-CFA-6784826 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784826.1 1 AP2M1 AP2M1 A0A5F4BQ86 Reactome DB_ID: 10047584 1 EQUAL 435 EQUAL Reactome Database ID Release 81 10047584 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047584 Reactome R-CFA-6784828 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784828.1 1 AP2S1 AP2S1 A0A5F4CSI6 Reactome DB_ID: 10047586 1 EQUAL 142 EQUAL Reactome Database ID Release 81 10047586 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047586 Reactome R-CFA-6784821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784821.1 1 AP2B1 AP2B1 A0A5F4CPQ9 Reactome DB_ID: 10047582 1 EQUAL 937 EQUAL Reactome Database ID Release 81 10047582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047582 Reactome R-CFA-6784827 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6784827.1 1 Reactome Database ID Release 81 10047594 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047594 Reactome R-CFA-2130637 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130637.1 1 Reactome Database ID Release 81 10047602 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047602 Reactome R-CFA-2130671 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130671.1 1 SH3GL2 SH3GL2 F1PDT4 Reactome DB_ID: 10047580 1 EQUAL 352 EQUAL Reactome Database ID Release 81 10047580 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047580 Reactome R-CFA-2130629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130629.1 1 MHC class II alpha/beta/Ii nonamer Reactome DB_ID: 10047578 MHC class II alpha/beta dimer Reactome DB_ID: 10047576 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047562 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047556 24 EQUAL 254 EQUAL Reactome Database ID Release 81 10047556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047556 Reactome R-CFA-2130595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130595.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047560 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047560 Reactome R-CFA-2130442 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130442.1 Reactome Database ID Release 81 10047562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047562 Reactome R-CFA-2130470 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130470.1 1 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047574 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047564 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047564 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047564 Reactome R-CFA-2130390 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130390.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047566 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047566 Reactome R-CFA-2130525 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130525.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047572 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047568 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047568 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047568 Reactome R-CFA-2130472 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130472.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047570 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047570 Reactome R-CFA-2130472-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130472-2.1 Reactome Database ID Release 81 10047572 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047572 Reactome R-CFA-2130472-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130472-3.1 Reactome Database ID Release 81 10047574 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047574 Reactome R-CFA-2130690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130690.1 1 Reactome Database ID Release 81 10047576 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047576 Reactome R-CFA-2213178 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213178.1 3 Invariant chain trimer Reactome DB_ID: 10047554 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047552 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047552 Reactome R-CFA-2130522 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130522.1 3 Reactome Database ID Release 81 10047554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047554 Reactome R-CFA-2130372 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130372.1 1 Reactome Database ID Release 81 10047578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047578 Reactome R-CFA-2130425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130425.1 1 Reactome Database ID Release 81 10047604 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047604 Reactome R-CFA-2130331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130331.1 ACTIVATION Converted from EntitySet in Reactome Dynamin-1/2/3 Reactome DB_ID: 10030207 DNM1 DNM1 F1PAK1 Reactome DB_ID: 10011752 1 EQUAL 864 EQUAL Reactome Database ID Release 81 10011752 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10011752 Reactome R-CFA-177488 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177488.1 DNM3 DNM3 F1PFB8 Reactome DB_ID: 10030205 1 EQUAL 869 EQUAL Reactome Database ID Release 81 10030205 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030205 Reactome R-CFA-443610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-443610.1 DNM2 DNM2 E2RNC3 Reactome DB_ID: 10011756 1 EQUAL 870 EQUAL Reactome Database ID Release 81 10011756 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10011756 Reactome R-CFA-2984201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2984201.1 Reactome Database ID Release 81 10030207 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030207 Reactome R-CFA-446847 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-446847.1 Reactome Database ID Release 81 10030208 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030208 Reactome Database ID Release 81 10047696 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047696 Reactome R-CFA-2130725 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130725.1 MHC II:Ii complexes are internalized in to the endocytic clathrin coated-pit. Dynamin, the GTPase involved in the scission of clathrin-coated vesicles from plasma membrane is observed to be involved in the effective endocytosis of MHC II:Ii complexes. Wang et al, demonstrated that overexpression of a dominant-negative mutant of the GTPase dynamin resulted in the cell surface accumulation of MHC II:Ii complex, supporting that endocytosis is required for delivery to antigen processing compartments (Wang et al, 1997). However, another study using the same dynamin mutant generated opposite conclusions (Davidson, 1999). This discrepancy may be caused by differences in experimental set-up and in the levels of expression of the dynamin mutant and MHC II chains (Dugast et al, 2005). 9202021 Pubmed 1997 Decreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cells Wang, K Peterson, PA Karlsson, L J Biol Chem 272:17055-60 LEFT-TO-RIGHT Uncoating of clathrin-coated vesicles and fusion with endosomes This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Nonameric complex Reactome DB_ID: 10047632 endocytic vesicle membrane GENE ONTOLOGY GO:0030666 MHC class II alpha/beta dimer Reactome DB_ID: 10047630 Converted from EntitySet in Reactome HLA II alpha chain Reactome DB_ID: 10047616 F1PTR6 DLA-DQA1 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047610 24 EQUAL 255 EQUAL Reactome Database ID Release 81 10047610 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047610 Reactome R-CFA-2130563 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130563.1 DLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor A0A5F4BUG1 Reactome DB_ID: 10047614 26 EQUAL 254 EQUAL Reactome Database ID Release 81 10047614 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047614 Reactome R-CFA-2130463 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130463.1 Reactome Database ID Release 81 10047616 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047616 Reactome R-CFA-2130459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130459.1 1 Converted from EntitySet in Reactome HLA II beta chain Reactome DB_ID: 10047628 F1PSQ5 HLA class II histocompatibility antigen, DP Reactome DB_ID: 10047618 30 EQUAL 258 EQUAL Reactome Database ID Release 81 10047618 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047618 Reactome R-CFA-2130419 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130419.1 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ Reactome DB_ID: 10047620 33 EQUAL 261 EQUAL Reactome Database ID Release 81 10047620 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047620 Reactome R-CFA-2130646 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130646.1 Converted from EntitySet in Reactome Homologues of HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047626 F1PTQ6 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047622 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047622 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047622 Reactome R-CFA-2130440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130440.1 F6V690 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 2 chain Reactome DB_ID: 10047624 33 EQUAL 268 EQUAL Reactome Database ID Release 81 10047624 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047624 Reactome R-CFA-2130440-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130440-2.1 Reactome Database ID Release 81 10047626 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047626 Reactome R-CFA-2130440-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130440-3.1 Reactome Database ID Release 81 10047628 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047628 Reactome R-CFA-2130696 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130696.1 1 Reactome Database ID Release 81 10047630 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047630 Reactome R-CFA-2213187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213187.1 3 Invariant chain trimer Reactome DB_ID: 10047608 CD74 CD74 A0A5F4BY04 Reactome DB_ID: 10047606 1 EQUAL 296 EQUAL Reactome Database ID Release 81 10047606 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047606 Reactome R-CFA-2130460 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130460.1 3 Reactome Database ID Release 81 10047608 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047608 Reactome R-CFA-2130371 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130371.1 1 Reactome Database ID Release 81 10047632 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047632 Reactome R-CFA-2130531 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130531.1 Reactome Database ID Release 81 10047634 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047634 Reactome R-CFA-2130486 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130486.1 MHC II:Ii complexes bound to clathrin-coated vesicles rapidly fuse with endosomes. LEFT-TO-RIGHT Trafficking of nonameric complex in the endocytic pathway This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 81 10048882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048882 Reactome R-CFA-2213235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213235.1 The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009). LEFT-TO-RIGHT 3.4.22.41 3.4.22.40 3.4.22.34 3.4.22.8 3.4.22.28 3.4.22.16 3.4.22.27 3.4.22.38 3.4.22.1 3.4.22.15 3.4.22.14 Initial proteolyis of Ii by aspartic proteases to lip22 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC II:lip22 nonamer Reactome DB_ID: 10047378 3 lip22 trimer Reactome DB_ID: 10047376 CD74 CD74(1-176) A0A5F4BY04 Reactome DB_ID: 10047374 1 EQUAL 176 EQUAL Reactome Database ID Release 81 10047374 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047374 Reactome R-CFA-2130602 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130602.1 3 Reactome Database ID Release 81 10047376 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047376 Reactome R-CFA-2213190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213190.1 1 Reactome Database ID Release 81 10047378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047378 Reactome R-CFA-2130680 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130680.1 ACTIVATION LGMN LGMN E2QXF2 Reactome DB_ID: 10047380 lysosomal lumen GENE ONTOLOGY GO:0043202 UniProt:E2QXF2 LGMN UniProt E2QXF2 18 EQUAL 323 EQUAL Reactome Database ID Release 81 10047380 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047380 Reactome R-CFA-350135 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-350135.1 GENE ONTOLOGY GO:0004197 Reactome Database ID Release 81 10047381 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047381 Reactome Database ID Release 81 10047383 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047383 Reactome R-CFA-2130336 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130336.1 Within acidic endocytic compartments Ii is proteolytically cleaved, ultimately freeing the class II peptide-binding groove for loading of antigenic peptides. Ii is degraded in a stepwise manner by a combination of aspartyl and cysteine proteases, following a well defined path with intermediates lip22, lip10 and finally CLIP. The initial Ii cleavage has been ascribed to leupeptin-insensitive cysteine or aspartic proteases, which include aspartyl protease and asparagine endopeptidase (AEP) (Maric et al. 1994, Manoury et al. 2003, Costantino et al. 2008). These proteases generate 22 kDa fragments of Ii (lip22). The trimerization domain of human Ii (residues 134-208) has three possible AEP cleavage sites, Asn148, 165 and 171. Asn171, located at the C-terminal end of helix B, is the demonstrated cleavage site for AEP (Manoury et al. 2003, Jasanoff et al. 1998). This cleavage eliminates the C-terminal trimerization domain of Ii, which causes disassociation of the (MHC II:Ii)3 nonamer and exposes new cleavage sites in the MHC II:lip22 trimers (Villadangos et al. 1999, Guillaume et al. 2008). The residue numbering of Ii given above is based on Uniprot isoform 1. 9843486 Pubmed 1998 Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii Jasanoff, A Wagner, G Wiley, DC EMBO J 17:6812-8 18582577 Pubmed 2008 Endosomal sorting of MHC class II determines antigen presentation by dendritic cells van Niel, G Wubbolts, R Stoorvogel, W Curr Opin Cell Biol 20:437-44 18292509 Pubmed 2008 Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation Costantino, CM Hang, HC Kent, SC Hafler, DA Ploegh, HL J Immunol 180:2876-85 8134367 Pubmed 1994 Endosomal aspartic proteinases are required for invariant-chain processing Mari?, MA Taylor, MD Blum, JS Proc Natl Acad Sci U S A 91:2171-5 10631941 Pubmed 1999 Proteases involved in MHC class II antigen presentation Villadangos, JA Bryant, RA Deussing, J Driessen, C Lennon-Duménil, AM Riese, RJ Roth, W Saftig, P Shi, GP Chapman, HA Peters, C Ploegh, HL Immunol Rev 172:109-20 LEFT-TO-RIGHT 3.4.22.41 3.4.22.40 3.4.22.34 3.4.22.8 3.4.22.28 3.4.22.16 3.4.22.27 3.4.22.38 3.4.22.1 3.4.22.15 3.4.22.14 Cleavage of lip22 to lip10 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC II:lip10 nonamer Reactome DB_ID: 10047389 lip10 trimer Reactome DB_ID: 10047387 CD74 CD74(1-117) A0A5F4BY04 Reactome DB_ID: 10047385 1 EQUAL 117 EQUAL Reactome Database ID Release 81 10047385 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047385 Reactome R-CFA-2130632 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130632.1 3 Reactome Database ID Release 81 10047387 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047387 Reactome R-CFA-2213183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213183.1 1 3 Reactome Database ID Release 81 10047389 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047389 Reactome R-CFA-2130723 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130723.1 ACTIVATION Converted from EntitySet in Reactome Cathepsin Reactome DB_ID: 10047644 CTSS CTSS F1PAK0 Reactome DB_ID: 10047401 UniProt:F1PAK0 CTSS UniProt F1PAK0 115 EQUAL 331 EQUAL Reactome Database ID Release 81 10047401 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047401 Reactome R-CFA-1181234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181234.1 CTSA CTSA(29-480) F1P9I9 Reactome DB_ID: 10047407 UniProt:F1P9I9 CTSA UniProt F1P9I9 29 EQUAL 480 EQUAL Reactome Database ID Release 81 10047407 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047407 Reactome R-CFA-1181230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181230.1 CTSB CTSB(80-333) A0A5F4CYW8 Reactome DB_ID: 10047409 UniProt:A0A5F4CYW8 CTSB UniProt A0A5F4CYW8 80 EQUAL 333 EQUAL Reactome Database ID Release 81 10047409 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047409 Reactome R-CFA-1181222 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181222.1 CTSC CTSC(25-134) F1PSK8 Reactome DB_ID: 10047411 UniProt:F1PSK8 CTSC UniProt F1PSK8 25 EQUAL 134 EQUAL Reactome Database ID Release 81 10047411 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047411 Reactome R-CFA-1181233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181233.1 CTSD CTSD(65-412) Q4LAL9 Reactome DB_ID: 10047395 UniProt:Q4LAL9 CTSD UniProt Q4LAL9 65 EQUAL 412 EQUAL Reactome Database ID Release 81 10047395 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047395 Reactome R-CFA-1181223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181223.1 CTSE CTSE(54-401) E2RJN2 Reactome DB_ID: 10047415 UniProt:E2RJN2 CTSE UniProt E2RJN2 54 EQUAL 401 EQUAL Reactome Database ID Release 81 10047415 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047415 Reactome R-CFA-1181228 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181228.1 CTSF CTSF E2RR02 Reactome DB_ID: 10047405 UniProt:E2RR02 CTSF UniProt E2RR02 271 EQUAL 484 EQUAL Reactome Database ID Release 81 10047405 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047405 Reactome R-CFA-1181231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181231.1 CTSH CTSH(116-335) F6X9C1 Reactome DB_ID: 10047419 UniProt:F6X9C1 CTSH UniProt F6X9C1 116 EQUAL 335 EQUAL Reactome Database ID Release 81 10047419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047419 Reactome R-CFA-1181224 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181224.1 Converted from EntitySet in Reactome Homologues of CTSK Reactome DB_ID: 10047425 CTSK CTSK G1K2A7 Reactome DB_ID: 10047421 UniProt:G1K2A7 CTSK UniProt G1K2A7 115 EQUAL 329 EQUAL Reactome Database ID Release 81 10047421 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047421 Reactome R-CFA-1181226 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181226.1 CTSK CTSK Q3ZKN1 Reactome DB_ID: 10047423 UniProt:Q3ZKN1 CTSK UniProt Q3ZKN1 115 EQUAL 329 EQUAL Reactome Database ID Release 81 10047423 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047423 Reactome R-CFA-1181226-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181226-2.1 Reactome Database ID Release 81 10047425 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047425 Reactome R-CFA-1181226-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181226-3.1 CTSL3 CTSL1(114-288) F1PMM9 Reactome DB_ID: 10047397 UniProt:F1PMM9 CTSL3 UniProt F1PMM9 114 EQUAL 288 EQUAL Reactome Database ID Release 81 10047397 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047397 Reactome R-CFA-1181225 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181225.1 CTSL CTSL2 Q9GL24 Reactome DB_ID: 10047399 UniProt:Q9GL24 CTSL UniProt Q9GL24 114 EQUAL 334 EQUAL Reactome Database ID Release 81 10047399 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047399 Reactome R-CFA-1181232 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181232.1 CTSO CTSO F1PGK4 Reactome DB_ID: 10047429 UniProt:F1PGK4 CTSO UniProt F1PGK4 108 EQUAL 321 EQUAL Reactome Database ID Release 81 10047429 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047429 Reactome R-CFA-1181227 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1181227.1 Reactome Database ID Release 81 10047644 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047644 Reactome R-CFA-2130544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130544.1 Reactome Database ID Release 81 10047645 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047645 Reactome Database ID Release 81 10047647 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047647 Reactome R-CFA-2130504 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130504.1 The cleavage of lip22 occurs in residues 115-125, closer to the C-terminus than CLIP (residues 81-105). The resulting lip10 fragment is approximately 100 residues long and extends just through the C-terminus of the Ii CLIP. The proteases responsible for generating lip10 in vivo are not determined. Cysteine proteases like cathepsin S (CatS) are capable of degrading lip22 to lip10 (Bania et al. 2003) but in the presence of LHVS, an inhibitor of CatS, lip22 degradation is still observed, suggesting that other proteases are involved (Villadangos et al. 1997), possibly aspartic proteinases such as cathepsins D and E (Kageyama et al. 1996). The degradation of lip22 may depend on cell type (Bania et al. 2003). The lip22 and lip10 intermediate forms are still maintained as a nonameric complex due to the existence of the last trimerisation domain in the transmembrane region. 11684289 Pubmed 2001 Presentation of antigens by MHC class II molecules: getting the most out of them Villadangos, JA Mol Immunol 38:329-46 12078484 Pubmed 2002 Proteolysis and antigen presentation by MHC class II molecules Bryant, PW Lennon-Duménil, AM Fiebiger, E Lagaudrière-Gesbert, C Ploegh, HL Adv Immunol 80:71-114 12748383 Pubmed 2003 Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs Bania, J Gatti, E Lelouard, H David, A Cappello, F Weber, E Camosseto, V Pierre, P Proc Natl Acad Sci U S A 100:6664-9 8687433 Pubmed 1996 Potential sites for processing of the human invariant chain by cathepsins D and E Kageyama, T Yonezawa, S Ichinose, M Miki, K Moriyama, A Biochem Biophys Res Commun 223:549-53 9254653 Pubmed 1997 Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism Villadangos, JA Riese, RJ Peters, C Chapman, HA Ploegh, HL J Exp Med 186:549-60 LEFT-TO-RIGHT 3.4.22.41 3.4.22.40 3.4.22.34 3.4.22.8 3.4.22.28 3.4.22.16 3.4.22.27 3.4.22.38 3.4.22.1 3.4.22.15 3.4.22.14 Generation of CLIP from lip10 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC II:CLIP Reactome DB_ID: 10047393 1 CD74 CD74(81-104) A0A5F4BY04 Reactome DB_ID: 10047391 81 EQUAL 104 EQUAL Reactome Database ID Release 81 10047391 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047391 Reactome R-CFA-2130446 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130446.1 1 Reactome Database ID Release 81 10047393 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047393 Reactome R-CFA-2130574 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130574.1 3 ACTIVATION Converted from EntitySet in Reactome Cathepsin Reactome DB_ID: 10047431 Reactome Database ID Release 81 10047431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047431 Reactome R-CFA-2130682 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130682.1 Reactome Database ID Release 81 10047432 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047432 Reactome Database ID Release 81 10047434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047434 Reactome R-CFA-2130349 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130349.1 The lip10 fragments bound in the nonameric complex are processed leaving only the CLIP fragment (81-105) bound to the MHC II peptide binding groove. Three cysteine proteases have been shown to be capable of digesting lip10, each with a different expression pattern among different APC. Cathepsin (Cat) S digests Ii in B cells and dendritic cells, thymic epithelial cells use Cat L and Cat L, while Cat S and F are active in macrophages (Villadangos, 2001; Bryant et al, 2002). Cat S appears to be the major enzyme involved as demonstrated by the use of specific inhibitors and of knockout experiments (Stumptner-Cuvelette et al. 2002). Following lip10 digestion, the MHC-like molecule HLA-DM induces the exchange of CLIP fragment for a highly diverse array of antigens (Denzin & Cresswell. 1995). 10748235 Pubmed 2000 Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages Shi, GP Bryant, RA Riese, R Verhelst, S Driessen, C Li, Z Bromme, D Ploegh, HL Chapman, HA J Exp Med 191:1177-86 11853874 Pubmed 2002 Multiple roles of the invariant chain in MHC class II function Stumptner-Cuvelette, P Benaroch, P Biochim Biophys Acta 1542:1-13 7606781 Pubmed 1995 HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading Denzin, LK Cresswell, P Cell 82:155-65 10072072 Pubmed 1999 Cathepsin S required for normal MHC class II peptide loading and germinal center development Shi, GP Villadangos, JA Dranoff, G Small, C Gu, L Haley, KJ Riese, R Ploegh, HL Chapman, HA Immunity 10:197-206 9545226 Pubmed 1998 Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus Nakagawa, T Roth, W Wong, P Nelson, A Farr, A Deussing, J Villadangos, JA Ploegh, H Peters, C Rudensky, AY Science 280:450-3 LEFT-TO-RIGHT 1.8 Reduction of disulphide bonds in MHC II antigens This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Antigen Reactome DB_ID: 2213221 Reactome Database ID Release 81 2213221 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2213221 Reactome R-ALL-2213221 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2213221.2 ChEBI 36080 unfolded antigen Reactome DB_ID: 2213225 Reactome Database ID Release 81 2213225 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2213225 Reactome R-ALL-2213225 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2213225.2 ChEBI 23367 ACTIVATION IFI30 IFI30 F1PK63 Reactome DB_ID: 10048890 UniProt:F1PK63 IFI30 UniProt F1PK63 58 EQUAL 232 EQUAL Reactome Database ID Release 81 10048890 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048890 Reactome R-CFA-1031704 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1031704.1 GENE ONTOLOGY GO:0016667 Reactome Database ID Release 81 10048891 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048891 Reactome Database ID Release 81 10048893 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048893 Reactome R-CFA-2213240 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213240.1 MHC class II epitopes require protein denaturation and removal of intra- and inter-chain disulphide bonds prior to proteolysis. The lysosomal thiol reductase gamma-IFN-inducible lysosomal thiol reductase (GILT) has been shown to facilitate MHC class II-restricted antigen (Ag) processing by breaking disulphide bonds. GILT is constitutively expressed in APCs. The reduction of disulphide bonds by mature GILT is optimal at acidic pH (Hastings et al. 2006, Arunachalam et al. 2000). 10639150 Pubmed 2000 Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT) Arunachalam, B Phan, UT Geuze, HJ Cresswell, P Proc Natl Acad Sci U S A 97:745-50 17142755 Pubmed 2006 Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing Hastings, KT Lackman, RL Cresswell, P J Immunol 177:8569-77 LEFT-TO-RIGHT 3.4.22.41 3.4.22.40 3.4.22.34 3.4.22.8 3.4.22.28 3.4.22.16 3.4.22.27 3.4.22.38 3.4.22.1 3.4.22.15 3.4.22.14 MHC class II antigen processing This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MHC class II epitopes Reactome DB_ID: 2213226 Reactome Database ID Release 81 2213226 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2213226 Reactome R-ALL-2213226 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2213226.2 ChEBI 15841 3 ACTIVATION Reactome Database ID Release 81 10047694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10047694 Reactome R-CFA-2130706 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2130706.1 Antigen processing and loading on to MHC class II molecules occurs in late endocytic/lysosomal vesicles, where epitopes which require extensive proteolytic processing are generated (Bryant & Ploegh 2003). These late endosome/lysosomal-like compartments are enriched in MHC II and are referred to as MIICs (MHC class II compartments) (Peters et al. 1991). A variety of lysosomal proteases like cathepsins S, D, B etc. and Asparaginyl endopeptidase (AEP) are suggested to be involved in the processing of antigens to generate CD4+ T cell epitopes (Deusing et al. 1998, Shi et al. 1999, Pluger et al. 2002, Watts et al. 2005). An initial cleavage by endopeptidases (AEP) would be necessary to unlock the antigen and allow further trimming of the ends by exopeptidases (Cathepsins). In the acidic environment of the lysosome, cathepsins are generally activated by autocatalytic cleavage of a propeptide which otherwise blocks the active site. 16181339 Pubmed 2005 Asparaginyl endopeptidase: case history of a class II MHC compartment protease Watts, C Matthews, SP Mazzeo, D Manoury, B Moss, CX Immunol Rev 207:218-28 11813165 Pubmed 2002 Specific role for cathepsin S in the generation of antigenic peptides in vivo Plüger, EB Boes, M Alfonso, C Schröter, CJ Kalbacher, H Ploegh, HL Driessen, C Eur J Immunol 32:467-76 14734116 Pubmed 2004 Class II MHC peptide loading by the professionals Bryant, P Ploegh, H Curr Opin Immunol 16:96-102 10809954 Pubmed 2000 Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice Zhang, T Maekawa, Y Hanba, J Dainichi, T Nashed, BF Hisaeda, H Sakai, T Asao, T Himeno, K Good, RA Katunuma, Nobuhiko Immunology 100:13-20 1847504 Pubmed 1991 Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments Peters, PJ Neefjes, JJ Oorschot, V Ploegh, HL Geuze, HJ Nature 349:669-76 12742663 Pubmed 2003 Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies Wiendl, H Lautwein, A Mitsdörffer, M Krause, S Erfurth, S Wienhold, W Morgalla, M Weber, E Overkleeft, HS Lochmüller, H Melms, A Tolosa, E Driessen, C J Neuroimmunol 138:132-43 9539769 Pubmed 1998 Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Deussing, J Roth, W Saftig, P Peters, C Ploegh, HL Villadangos, JA Proc Natl Acad Sci U S A 95:4516-21 LEFT-TO-RIGHT Transport of antigen loaded MHC II molecules to surface This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> peptide loaded MHC class II Reactome DB_ID: 10048901 1 1 Reactome Database ID Release 81 10048901 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048901 Reactome R-CFA-2213223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213223.1 Dynein:Dynactin:microtubule Reactome DB_ID: 10048975 Microtubule Reactome DB_ID: 10027577 Microtubule protofilament Reactome DB_ID: 10027575 Reactome Database ID Release 81 10027575 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10027575 Reactome R-CFA-8982424 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982424.1 13 Reactome Database ID Release 81 10027577 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10027577 Reactome R-CFA-190599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-190599.1 1 Dynein complex Reactome DB_ID: 10005955 DHC dimer Reactome DB_ID: 10005927 F1PGY9 DYNC1H1 DYNC1H1 Reactome DB_ID: 10005925 UniProt:F1PGY9 DYNC1H1 UniProt F1PGY9 1 EQUAL 4646 EQUAL Reactome Database ID Release 81 10005925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005925 Reactome R-CFA-380285 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380285.1 2 Reactome Database ID Release 81 10005927 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005927 Reactome R-CFA-2029144 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029144.1 1 Converted from EntitySet in Reactome DICs Dynein intermediate chains Reactome DB_ID: 10005937 F1PSE8 DYNC1I1 DYNC1I1 Reactome DB_ID: 10005931 UniProt:F1PSE8 DYNC1I1 UniProt F1PSE8 1 EQUAL 645 EQUAL Reactome Database ID Release 81 10005931 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005931 Reactome R-CFA-201578 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201578.1 DYNC1I2 DYNC1I2 A0A5F4CZW1 Reactome DB_ID: 10005935 UniProt:A0A5F4CZW1 DYNC1I2 UniProt A0A5F4CZW1 1 EQUAL 638 EQUAL Reactome Database ID Release 81 10005935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005935 Reactome R-CFA-201607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201607.1 Reactome Database ID Release 81 10005937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005937 Reactome R-CFA-2029119 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029119.1 2 Converted from EntitySet in Reactome DLIs Dynein-1 light intermediate chain Reactome DB_ID: 10005953 F1P6V8 DYNC1LI2 DYNC1LI2 Reactome DB_ID: 10005947 UniProt:F1P6V8 DYNC1LI2 UniProt F1P6V8 1 EQUAL 492 EQUAL Reactome Database ID Release 81 10005947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005947 Reactome R-CFA-2029025 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029025.1 DYNC1LI1 DYNC1LI1 A0A5F4D394 Reactome DB_ID: 10005951 UniProt:A0A5F4D394 DYNC1LI1 UniProt A0A5F4D394 1 EQUAL 523 EQUAL Reactome Database ID Release 81 10005951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005951 Reactome R-CFA-8943213 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8943213.1 Reactome Database ID Release 81 10005953 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005953 Reactome R-CFA-2029122 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029122.1 2 Converted from EntitySet in Reactome DLCs Dynein light chain Reactome DB_ID: 10005943 DYNLL1 DYNLL1 A0A5F4CQ75 Reactome DB_ID: 10005939 UniProt:A0A5F4CQ75 DYNLL1 UniProt A0A5F4CQ75 1 EQUAL 89 EQUAL Reactome Database ID Release 81 10005939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005939 Reactome R-CFA-387105 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-387105.1 DYNLL2 DYNLL2 E2RFR5 Reactome DB_ID: 10005941 UniProt:E2RFR5 DYNLL2 UniProt E2RFR5 1 EQUAL 89 EQUAL Reactome Database ID Release 81 10005941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005941 Reactome R-CFA-2029024 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029024.1 Reactome Database ID Release 81 10005943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005943 Reactome R-CFA-2029105 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029105.1 2 Reactome Database ID Release 81 10005955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005955 Reactome R-CFA-2029145 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029145.1 1 Dynactin Reactome DB_ID: 10048973 Dynactin arm Reactome DB_ID: 10048971 Dynactin shoulder Reactome DB_ID: 10048969 DCTN3 dimer Reactome DB_ID: 10048965 DCTN3 DCTN3 E2RBC1 Reactome DB_ID: 10021928 UniProt:E2RBC1 DCTN3 UniProt E2RBC1 1 EQUAL 186 EQUAL Reactome Database ID Release 81 10021928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10021928 Reactome R-CFA-380264 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380264.1 2 Reactome Database ID Release 81 10048965 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048965 Reactome R-CFA-8982337 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982337.1 1 Dynamitin tetramer Reactome DB_ID: 10048967 DCTN2 DCTN2 A0A5F4C6E4 Reactome DB_ID: 10021936 UniProt:A0A5F4C6E4 DCTN2 UniProt A0A5F4C6E4 2 EQUAL 401 EQUAL Reactome Database ID Release 81 10021936 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10021936 Reactome R-CFA-380302 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380302.1 4 Reactome Database ID Release 81 10048967 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048967 Reactome R-CFA-8982328 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982328.1 1 Reactome Database ID Release 81 10048969 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048969 Reactome R-CFA-8982344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982344.1 1 DCTN1 dimer Reactome DB_ID: 10048963 DCTN1 DCTN1-2 F6UMF1 Reactome DB_ID: 10021912 UniProt:F6UMF1 DCTN1 UniProt F6UMF1 1 EQUAL 1278 EQUAL Reactome Database ID Release 81 10021912 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10021912 Reactome R-CFA-380301 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380301.1 2 Reactome Database ID Release 81 10048963 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048963 Reactome R-CFA-8982336 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982336.1 1 Reactome Database ID Release 81 10048971 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048971 Reactome R-CFA-8982311 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982311.1 1 Dynactin rod Reactome DB_ID: 10048961 Arp1 octameric polymer Reactome DB_ID: 10048927 ACTR1A ACTR1A P61162 Reactome DB_ID: 10021932 UniProt:P61162 ACTR1A UniProt P61162 1 EQUAL 376 EQUAL Reactome Database ID Release 81 10021932 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10021932 Reactome R-CFA-380258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380258.1 8 Reactome Database ID Release 81 10048927 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048927 Reactome R-CFA-8982309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982309.1 1 ACTR10:DCTN4:DCTN5:DCTN6 Reactome DB_ID: 10048959 ACTR10 ACTR10 E2RLP1 Reactome DB_ID: 10048943 UniProt:E2RLP1 ACTR10 UniProt E2RLP1 1 EQUAL 417 EQUAL Reactome Database ID Release 81 10048943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048943 Reactome R-CFA-6801556 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6801556.1 1 Pointed end complex Reactome DB_ID: 10048957 DCTN6 DCTN6 F1PXZ8 Reactome DB_ID: 10048955 UniProt:F1PXZ8 DCTN6 UniProt F1PXZ8 1 EQUAL 190 EQUAL Reactome Database ID Release 81 10048955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048955 Reactome R-CFA-2029035 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029035.1 1 DCTN4 DCTN4 E2RG82 Reactome DB_ID: 10048947 UniProt:E2RG82 DCTN4 UniProt E2RG82 2 EQUAL 460 EQUAL Reactome Database ID Release 81 10048947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048947 Reactome R-CFA-2029070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029070.1 1 DCTN5 DCTN5 E2RNC1 Reactome DB_ID: 10048951 UniProt:E2RNC1 DCTN5 UniProt E2RNC1 1 EQUAL 182 EQUAL Reactome Database ID Release 81 10048951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048951 Reactome R-CFA-2029012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029012.1 1 Reactome Database ID Release 81 10048957 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048957 Reactome R-CFA-8982345 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982345.1 1 Reactome Database ID Release 81 10048959 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048959 Reactome R-CFA-8982321 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982321.1 1 Converted from EntitySet in Reactome CAPZ Reactome DB_ID: 10048939 CAPZA1:CAPZB Reactome DB_ID: 10048929 CAPZB CAPZB A0A5F4DFI6 Reactome DB_ID: 10030906 UniProt:A0A5F4DFI6 CAPZB UniProt A0A5F4DFI6 2 EQUAL 277 EQUAL Reactome Database ID Release 81 10030906 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030906 Reactome R-CFA-879409 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-879409.1 1 CAPZA1 CAPZA1 F1P7P3 Reactome DB_ID: 10030898 UniProt:F1P7P3 CAPZA1 UniProt F1P7P3 2 EQUAL 286 EQUAL Reactome Database ID Release 81 10030898 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030898 Reactome R-CFA-879363 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-879363.1 1 Reactome Database ID Release 81 10048929 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048929 Reactome R-CFA-8982308 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982308.1 CAPZA2:CAPZB Reactome DB_ID: 10048931 1 CAPZA2 CAPZA2 A0A5S6CBX9 Reactome DB_ID: 10030900 UniProt:A0A5S6CBX9 CAPZA2 UniProt A0A5S6CBX9 2 EQUAL 286 EQUAL Reactome Database ID Release 81 10030900 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030900 Reactome R-CFA-879448 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-879448.1 1 Reactome Database ID Release 81 10048931 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048931 Reactome R-CFA-8982304 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982304.1 CAPZA3:CAPZB Reactome DB_ID: 10048937 1 CAPZA3 CAPZA3 F1PV43 Reactome DB_ID: 10048935 UniProt:F1PV43 CAPZA3 UniProt F1PV43 1 EQUAL 299 EQUAL Reactome Database ID Release 81 10048935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048935 Reactome R-CFA-8982306 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982306.1 1 Reactome Database ID Release 81 10048937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048937 Reactome R-CFA-8982305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982305.1 Reactome Database ID Release 81 10048939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048939 Reactome R-CFA-8982310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982310.1 1 Reactome Database ID Release 81 10048961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048961 Reactome R-CFA-8982312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8982312.1 1 Reactome Database ID Release 81 10048973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048973 Reactome R-CFA-2029120 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029120.1 1 Reactome Database ID Release 81 10048975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048975 Reactome R-CFA-2029135 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2029135.1 SPTBN2 SPTBN2 E2RSI4 Reactome DB_ID: 10023571 UniProt:E2RSI4 SPTBN2 UniProt E2RSI4 2 EQUAL 2390 EQUAL Reactome Database ID Release 81 10023571 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10023571 Reactome R-CFA-420049 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-420049.1 Converted from EntitySet in Reactome ARP-1 Reactome DB_ID: 10048985 ACTR1B ACTR1B A0A5F4BXQ1 Reactome DB_ID: 10048983 UniProt:A0A5F4BXQ1 ACTR1B UniProt A0A5F4BXQ1 1 EQUAL 376 EQUAL Reactome Database ID Release 81 10048983 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048983 Reactome R-CFA-2228745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2228745.1 Reactome Database ID Release 81 10048985 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048985 Reactome R-CFA-2228747 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2228747.1 RAB7:RILP:ORP1L complex Reactome DB_ID: 10048925 RAB7A:GTP Reactome DB_ID: 10048919 GTP Guanosine 5'-triphosphate Reactome DB_ID: 2213216 GTP [ChEBI:15996] GTP Guanosine 5'-triphosphate ChEBI CHEBI:15996 Reactome Database ID Release 81 2213216 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2213216 Reactome R-ALL-2213216 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2213216.2 COMPOUND C00044 1 Converted from EntitySet in Reactome Homologues of RAB7A Reactome DB_ID: 10048917 RAB7A RAB7A A0A5F4BPT0 Reactome DB_ID: 10048911 UniProt:A0A5F4BPT0 RAB7A UniProt A0A5F4BPT0 1 EQUAL 207 EQUAL Reactome Database ID Release 81 10048911 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048911 Reactome R-CFA-2213231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213231.1 RAB7A RAB7A P18067 Reactome DB_ID: 10048915 UniProt:P18067 RAB7A UniProt P18067 1 EQUAL 207 EQUAL Reactome Database ID Release 81 10048915 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048915 Reactome R-CFA-2213231-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213231-2.1 Reactome Database ID Release 81 10048917 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048917 Reactome R-CFA-2213231-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213231-3.1 1 Reactome Database ID Release 81 10048919 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048919 Reactome R-CFA-2213222 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213222.1 2 RILP dimer Reactome DB_ID: 10048907 RILP RILP E2R525 Reactome DB_ID: 10048905 UniProt:E2R525 RILP UniProt E2R525 1 EQUAL 401 EQUAL Reactome Database ID Release 81 10048905 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048905 Reactome R-CFA-2213229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213229.1 2 Reactome Database ID Release 81 10048907 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048907 Reactome R-CFA-2213233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213233.1 1 E2RMD4 OSBPL1A OSBPL1A Reactome DB_ID: 10048923 UniProt:E2RMD4 OSBPL1A UniProt E2RMD4 1 EQUAL 950 EQUAL Reactome Database ID Release 81 10048923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048923 Reactome R-CFA-2213214 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213214.1 2 Reactome Database ID Release 81 10048925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10048925 Reactome R-CFA-2213215 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2213215.1 Kinesins:Dynactin:microtubule Reactome DB_ID: 10048979 1 1 Converted from EntitySet in Reactome Kinesins Reactome DB_ID: 10048977 Kinesin-1 Reactome DB_ID: 10034808 Converted from EntitySet in Reactome KLC1,KLC2,KLC3,KLC4 Kinesin-1 light chains Reactome DB_ID: 10034796 KLC1 KLC1 A0A5F4D080 Reactome DB_ID: 10034782 UniProt:A0A5F4D080 KLC1 UniProt A0A5F4D080 1 EQUAL 573 EQUAL Reactome Database ID Release 81 10034782 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034782 Reactome R-CFA-983284 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983284.1 KLC2 KLC2 E2RGH8 Reactome DB_ID: 10034786 UniProt:E2RGH8 KLC2 UniProt E2RGH8 1 EQUAL 622 EQUAL Reactome Database ID Release 81 10034786 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034786 Reactome R-CFA-983191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983191.1 KLC3 KLC3 A0A5F4CT63 Reactome DB_ID: 10034790 UniProt:A0A5F4CT63 KLC3 UniProt A0A5F4CT63 1 EQUAL 504 EQUAL Reactome Database ID Release 81 10034790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034790 Reactome R-CFA-983232 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983232.1 KLC4 KLC4 A0A5F4D704 Reactome DB_ID: 10034794 UniProt:A0A5F4D704 KLC4 UniProt A0A5F4D704 1 EQUAL 619 EQUAL Reactome Database ID Release 81 10034794 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034794 Reactome R-CFA-983244 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983244.1 Reactome Database ID Release 81 10034796 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034796 Reactome R-CFA-983226 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983226.1 2 Converted from EntitySet in Reactome Kinesin-1 heavy chain Reactome DB_ID: 10034806 KIF5A KIF5A J9P5I9 Reactome DB_ID: 10034800 UniProt:J9P5I9 KIF5A UniProt J9P5I9 2 EQUAL 1032 EQUAL Reactome Database ID Release 81 10034800 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034800 Reactome R-CFA-983190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983190.1 KIF5B KIF5B E2QTN0 Reactome DB_ID: 10034804 UniProt:E2QTN0 KIF5B UniProt E2QTN0 2 EQUAL 963 EQUAL Reactome Database ID Release 81 10034804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034804 Reactome R-CFA-265181 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-265181.1 Reactome Database ID Release 81 10034806 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034806 Reactome R-CFA-983211 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983211.1 2 Reactome Database ID Release 81 10034808 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034808 Reactome R-CFA-983227 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983227.1 Kinesin-2 Reactome DB_ID: 10034838 KIFAP3 KIFAP3 E2RMU6 Reactome DB_ID: 10034836 UniProt:E2RMU6 KIFAP3 UniProt E2RMU6 1 EQUAL 792 EQUAL Reactome Database ID Release 81 10034836 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034836 Reactome R-CFA-984736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984736.1 1 KIF3A KIF3A F1PSQ4 Reactome DB_ID: 10034828 UniProt:F1PSQ4 KIF3A UniProt F1PSQ4 1 EQUAL 699 EQUAL Reactome Database ID Release 81 10034828 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034828 Reactome R-CFA-984767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984767.1 1 KIF3C KIF3C E2RR39 Reactome DB_ID: 10034832 UniProt:E2RR39 KIF3C UniProt E2RR39 1 EQUAL 793 EQUAL Reactome Database ID Release 81 10034832 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034832 Reactome R-CFA-984660 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984660.1 1 Reactome Database ID Release 81 10034838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034838 Reactome R-CFA-984619 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984619.1 KIF3A dimer Reactome DB_ID: 10034840 2 Reactome Database ID Release 81 10034840 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034840 Reactome R-CFA-984646 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984646.1 Converted from EntitySet in Reactome Chromokinesin dimers Reactome DB_ID: 10034852 Kinesin-10 Reactome DB_ID: 10034846 KIF22 KIF22 E2RRZ0 Reactome DB_ID: 10034844 UniProt:E2RRZ0 KIF22 UniProt E2RRZ0 1 EQUAL 665 EQUAL Reactome Database ID Release 81 10034844 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034844 Reactome R-CFA-984764 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984764.1 2 Reactome Database ID Release 81 10034846 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034846 Reactome R-CFA-984651 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984651.1 Converted from EntitySet in Reactome Kinesin-4 homodimers Reactome DB_ID: 10034850 KIF4 dimer Reactome DB_ID: 10027585 KIF4A KIF4A A0A5F4BZE0 Reactome DB_ID: 10027581 UniProt:A0A5F4BZE0 KIF4A UniProt A0A5F4BZE0 1 EQUAL 1232 EQUAL Reactome Database ID Release 81 10027581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10027581 Reactome R-CFA-443853 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-443853.1 2 Reactome Database ID Release 81 10027585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10027585 Reactome R-CFA-445013 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-445013.1 KIF4B homodimer Reactome DB_ID: 10034848 KIF4A KIF4B A0A5F4BZE0 Reactome DB_ID: 10027583 1 EQUAL 1234 EQUAL Reactome Database ID Release 81 10027583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10027583 Reactome R-CFA-443855 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-443855.1 2 Reactome Database ID Release 81 10034848 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034848 Reactome R-CFA-984621 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984621.1 Reactome Database ID Release 81 10034850 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034850 Reactome R-CFA-984704 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984704.1 Reactome Database ID Release 81 10034852 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034852 Reactome R-CFA-984722 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984722.1 Kinesin-5 homotetramer Reactome DB_ID: 10034858 KIF11 KIF11 E2QXT6 Reactome DB_ID: 10034856 UniProt:E2QXT6 KIF11 UniProt E2QXT6 1 EQUAL 1056 EQUAL Reactome Database ID Release 81 10034856 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034856 Reactome R-CFA-984686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984686.1 4 Reactome Database ID Release 81 10034858 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034858 Reactome R-CFA-984691 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984691.1 Centralspindlin Reactome DB_ID: 10034870 Converted from EntitySet in Reactome Kinesin-6 Reactome DB_ID: 10034864 KIF23 KIF23 F1PML0 Reactome DB_ID: 10034860 UniProt:F1PML0 KIF23 UniProt F1PML0 1 EQUAL 960 EQUAL Reactome Database ID Release 81 10034860 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034860 Reactome R-CFA-1015863 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1015863.1 KIF20A KIF20A E2RHG7 Reactome DB_ID: 10034862 UniProt:E2RHG7 KIF20A UniProt E2RHG7 2 EQUAL 890 EQUAL Reactome Database ID Release 81 10034862 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034862 Reactome R-CFA-1015868 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1015868.1 Reactome Database ID Release 81 10034864 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034864 Reactome R-CFA-984628 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984628.1 2 J9NSX3 RACGAP1 RACGAP1 Reactome DB_ID: 10034868 UniProt:J9NSX3 RACGAP1 UniProt J9NSX3 1 EQUAL 632 EQUAL Reactome Database ID Release 81 10034868 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034868 Reactome R-CFA-195122 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-195122.1 2 Reactome Database ID Release 81 10034870 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034870 Reactome R-CFA-984587 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984587.1 KIF18A dimer Reactome DB_ID: 10034872 KIF18A KIF18A E2RAH7 Reactome DB_ID: 10005651 UniProt:E2RAH7 KIF18A UniProt E2RAH7 1 EQUAL 898 EQUAL Reactome Database ID Release 81 10005651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005651 Reactome R-CFA-376239 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376239.1 2 Reactome Database ID Release 81 10034872 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034872 Reactome R-CFA-984631 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984631.1 CENP-E dimer Reactome DB_ID: 10034874 CENPE CENPE E2R200 Reactome DB_ID: 10005627 UniProt:E2R200 CENPE UniProt E2R200 1 EQUAL 2698 EQUAL Reactome Database ID Release 81 10005627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005627 Reactome R-CFA-376245 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376245.1 2 Reactome Database ID Release 81 10034874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034874 Reactome R-CFA-984773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-984773.1 KIF26A KIF26A F1PU35 Reactome DB_ID: 10034878 UniProt:F1PU35 KIF26A UniProt F1PU35 1 EQUAL 1882 EQUAL Reactome Database ID Release 81 10034878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10034878