BioPAX pathway converted from "SPOP:CUL3:RBX1 ubiquitinates GLI2,3" in the Reactome database. LEFT-TO-RIGHT SPOP:CUL3:RBX1 ubiquitinates GLI2,3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Ub Ubiquitin UBIQ_HUMAN Reactome DB_ID: 10068054 A0A3Q1LU30 RPS27A(1-76) Reactome DB_ID: 10068050 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:A0A3Q1LU30 Bos taurus NCBI Taxonomy 9913 UniProt A0A3Q1LU30 1 EQUAL 76 EQUAL Reactome Database ID Release 78 10068050 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10068050 Reactome R-BTA-939849 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-939849.1 Reactome http://www.reactome.org UBA52 UBA52(1-76) P63048 Reactome DB_ID: 10068052 UniProt:P63048 UBA52 UniProt P63048 1 EQUAL 76 EQUAL Reactome Database ID Release 78 10068052 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10068052 Reactome R-BTA-939844 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-939844.1 Reactome Database ID Release 78 10068054 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10068054 Reactome R-BTA-68524 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68524.1 2p-GLI:SPOP:CUL3:RBX1 Reactome DB_ID: 10104504 SPOP:CUL3:RBX1 Reactome DB_ID: 10104500 RBX1 LOC780968 A0A3Q1LNF8 Reactome DB_ID: 10088056 UniProt:A0A3Q1LNF8 LOC780968 UniProt A0A3Q1LNF8 2 EQUAL 108 EQUAL Reactome Database ID Release 78 10088056 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10088056 Reactome R-BTA-1234142 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1234142.1 2 Converted from EntitySet in Reactome SPOP dimer Reactome DB_ID: 10104496 SPOP dimer Reactome DB_ID: 10104488 SPOP SPOP Q0VCW1 Reactome DB_ID: 10104486 UniProt:Q0VCW1 SPOP UniProt Q0VCW1 1 EQUAL 374 EQUAL Reactome Database ID Release 78 10104486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104486 Reactome R-BTA-5635035 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635035.1 2 Reactome Database ID Release 78 10104488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104488 Reactome R-BTA-5635066 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635066.1 SPOP:SPOPL Reactome DB_ID: 10104494 1 SPOPL A0A3Q1M267 Reactome DB_ID: 10104492 UniProt:A0A3Q1M267 UniProt A0A3Q1M267 1 EQUAL 392 EQUAL Reactome Database ID Release 78 10104492 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104492 Reactome R-BTA-5635036 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635036.1 1 Reactome Database ID Release 78 10104494 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104494 Reactome R-BTA-5635068 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635068.1 Reactome Database ID Release 78 10104496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104496 Reactome R-BTA-5635065 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635065.1 1 Ghost homologue of CUL3 Reactome DB_ID: 10104498 Reactome Database ID Release 78 10104498 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104498 Reactome R-BTA-5635033 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635033.1 2 Reactome Database ID Release 78 10104500 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104500 Reactome R-BTA-5635071 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635071.1 1 F1MCY1 phospho-GLI2 2p-GLI2 Reactome DB_ID: 10104461 UniProt:F1MCY1 GLI2 UniProt F1MCY1 phosphorylated residue MOD MOD:00696 1 EQUAL 1586 EQUAL Reactome Database ID Release 78 10104461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104461 Reactome R-BTA-5635055 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635055.1 1 Reactome Database ID Release 78 10104504 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104504 Reactome R-BTA-5635087 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635087.1 ub-2p-GLI2,3:SPOP:CUL3:RBX1 Reactome DB_ID: 10104502 1 F1MCY1 phospho-GLI2 ub-2p-GLI2 Reactome DB_ID: 10104482 ubiquitinylated lysine MOD MOD:01148 1 EQUAL 1586 EQUAL Reactome Database ID Release 78 10104482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104482 Reactome R-BTA-5635059 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635059.1 1 Reactome Database ID Release 78 10104502 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104502 Reactome R-BTA-5635095 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635095.1 ACTIVATION activeUnit: #Protein4 GENE ONTOLOGY GO:0061630 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 78 10104505 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104505 Reactome Database ID Release 78 10104507 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10104507 Reactome R-BTA-5635856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5635856.1 The transcriptional activity of full-length activated Ci/GLI proteins is restricted by their rapid ubiquitin-mediated degradation after initiation of Hh signaling (Ohlmeyer et al, 1998; Humke et al, 2010; Tukachinsky et al, 2010; Wen et al, 2010). Ubiquitination of Ci, GLI2 and GLI3 is mediated by the E3 ligase complex SPOP:CUL3:RBX1, which ubiquitinates the transcription factors in a Hh-dependent manner (Zhang et al, 2006; Kent et al, 2006; Zhang et al, 2009; Chen et al, 2009). 9874371 Pubmed 1998 Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator Ohlmeyer, Johanna Talavera Kalderon, Daniel Nature 396:749-53 20956384 Pubmed 2010 A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Tukachinsky, Hanna Lopez, Lyle V Salic, Adrian J. Cell Biol. 191:415-28 16740475 Pubmed 2006 A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor Zhang, Q Zhang, Lei Wang, B Ou, CY Chien, CT Jiang, J Dev Cell 10:719-29 20360384 Pubmed 2010 The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Humke, Eric W Dorn, Karolin V Milenkovic, Ljiljana Scott, Matthew P Rohatgi, Rajat Genes Dev. 24:670-82 19684112 Pubmed 2009 Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved Chen, Miao-Hsueh Wilson, Christopher W Li, Ya-Jun Law, Kelvin King Lo Lu, Chi-Sheng Gacayan, Rhodora Zhang, Xiaoyun Hui, Chi-Chung Chuang, Pao-Tien Genes Dev. 23:1910-28 20154143 Pubmed 2010 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Wen, Xiaohui Lai, Cary K Evangelista, Marie Hongo, Jo-Anne de Sauvage, Frederic J Scales, Suzie J Mol. Cell. Biol. 30:1910-22 16651542 Pubmed 2006 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus Kent, D Bush, EW Hooper, JE Development 133:2001-10 19955409 Pubmed 2009 Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase Zhang, Qing Shi, Qing Chen, Yongbin Yue, Tao Li, Shuang Wang, Bing Jiang, Jin Proc. Natl. Acad. Sci. U.S.A. 106:21191-6 inferred from electronic annotation EVIDENCE CODE ECO:0000203