BioPAX pathway converted from "Activated FMNL3 binds G-actin" in the Reactome database. LEFT-TO-RIGHT Activated FMNL3 binds G-actin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> RHOC:GTP:FMNL3 Reactome DB_ID: 10106025 plasma membrane GENE ONTOLOGY GO:0005886 RHOC:GTP Reactome DB_ID: 10106009 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 cytosol GENE ONTOLOGY GO:0005829 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 82 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 Reactome http://www.reactome.org COMPOUND C00044 additional information MI MI:0361 1 RHOC A0A5F4D0R1 Reactome DB_ID: 10066420 UniProt:A0A5F4D0R1 Canis familiaris NCBI Taxonomy 9615 UniProt A0A5F4D0R1 1 EQUAL 190 EQUAL Reactome Database ID Release 82 10066420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10066420 Reactome R-CFA-194870 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-194870.1 1 Reactome Database ID Release 82 10106009 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106009 Reactome R-CFA-5665750 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665750.1 1 FMNL3 Reactome DB_ID: 10106023 FMNL3 A0A5F4C0K7 Reactome DB_ID: 10106021 UniProt:A0A5F4C0K7 UniProt A0A5F4C0K7 2 EQUAL 1028 EQUAL Reactome Database ID Release 82 10106021 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106021 Reactome R-CFA-5665760 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665760.1 2 Reactome Database ID Release 82 10106023 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106023 Reactome R-CFA-5665954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665954.1 1 Reactome Database ID Release 82 10106025 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106025 Reactome R-CFA-5665759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665759.1 Profilin:G-actin Reactome DB_ID: 10057904 Converted from EntitySet in Reactome PFN Profilin (PFN1,PFN2) Reactome DB_ID: 10057902 Converted from EntitySet in Reactome Homologues of PFN1 Reactome DB_ID: 10057900 PFN1 A0A5F4D7S4 Reactome DB_ID: 10057894 UniProt:A0A5F4D7S4 UniProt A0A5F4D7S4 2 EQUAL 140 EQUAL Reactome Database ID Release 82 10057894 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057894 Reactome R-CFA-203081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203081.1 PFN1 F1Q3Y0 Reactome DB_ID: 10057898 UniProt:F1Q3Y0 UniProt F1Q3Y0 2 EQUAL 140 EQUAL Reactome Database ID Release 82 10057898 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057898 Reactome R-CFA-203081-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203081-2.1 Reactome Database ID Release 82 10057900 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057900 Reactome R-CFA-203081-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203081-3.1 Reactome Database ID Release 82 10057902 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057902 Reactome R-CFA-203077 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203077.1 1 G-actin Reactome DB_ID: 10057890 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 1 Converted from EntitySet in Reactome actin Reactome DB_ID: 10057888 ACTB ACTB(1-375) O18840 Reactome DB_ID: 10057884 UniProt:O18840 ACTB UniProt O18840 1 EQUAL 375 EQUAL Reactome Database ID Release 82 10057884 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057884 Reactome R-CFA-201861 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201861.1 ACTG1 J9NXE2 Reactome DB_ID: 10057886 UniProt:J9NXE2 UniProt J9NXE2 1 EQUAL 375 EQUAL Reactome Database ID Release 82 10057886 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057886 Reactome R-CFA-201858 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201858.1 Reactome Database ID Release 82 10057888 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057888 Reactome R-CFA-201859 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201859.1 1 Reactome Database ID Release 82 10057890 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057890 Reactome R-CFA-201857 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201857.1 1 Reactome Database ID Release 82 10057904 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057904 Reactome R-CFA-203080 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203080.1 2 RHOC:GTP:FMNL3:G-actin Reactome DB_ID: 10106029 1 2 Reactome Database ID Release 82 10106029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106029 Reactome R-CFA-5665773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665773.1 Reactome Database ID Release 82 10106031 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106031 Reactome R-CFA-5665767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665767.1 Activated FMNL3 (presumably associated with RHOC:GTP) has the ability to directly bind G-actin through knob and coiled-coil subdomains of the FMNL3 FH2 domain. The proline-rich FH1 domain which precedes the FH2 domain presumably interacts with profilins bound to G-actin (Romero et al. 2004, Kovar et al. 2006, Kuhn and Geyer 2014). FMNL3 contributes to the elongation of actin filaments (Heimsath and Higgs 2012, Thompson et al. 2013). Activated FMNL3 may also trigger microtubule alignment during angiogenesis (Hetheridge et al. 2012). 23222643 Pubmed 2013 FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation Thompson, Morgan E Heimsath, Ernest G Gauvin, Timothy J Higgs, Henry N Kull, F Jon Nat. Struct. Mol. Biol. 20:111-8 15507212 Pubmed 2004 Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis Romero, Stéphane Le Clainche, Christophe Didry, Dominique Egile, Coumaran Pantaloni, Dominique Carlier, Marie-France Cell 119:419-29 16439214 Pubmed 2006 Control of the assembly of ATP- and ADP-actin by formins and profilin Kovar, David R Harris, Elizabeth S Mahaffy, Rachel Higgs, Henry N Pollard, Thomas D Cell 124:423-35 22094460 Pubmed 2012 The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends Heimsath, Ernest G Higgs, Henry N J. Biol. Chem. 287:3087-98 21576392 Pubmed 2011 RhoA and RhoC have distinct roles in migration and invasion by acting through different targets Vega, Francisco M Fruhwirth, Gilbert Ng, Tony Ridley, Anne J J. Cell Biol. 193:655-65 24914801 Pubmed 2014 Formins as effector proteins of Rho GTPases Kühn, Sonja Geyer, Matthias Small GTPases 5:e29513 22275430 Pubmed 2012 The formin FMNL3 is a cytoskeletal regulator of angiogenesis Hetheridge, Clare Scott, Alice N Swain, Rajeeb K Copeland, John W Higgs, Henry N Bicknell, R Mellor, Harry J. Cell. Sci. 125:1420-8 inferred from electronic annotation EVIDENCE CODE ECO:0000203