BioPAX pathway converted from "APBB1 and MAPK8 bind diphosphorylated H2AFX" in the Reactome database. LEFT-TO-RIGHT APBB1 and MAPK8 bind diphosphorylated H2AFX This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> A0A5F4C144 phospho-p-T,Y-MAPK8 Reactome DB_ID: 10050711 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:A0A5F4C144 Canis familiaris NCBI Taxonomy 9615 UniProt A0A5F4C144 O-phospho-L-threonine MOD MOD:00047 O4'-phospho-L-tyrosine MOD MOD:00048 1 EQUAL 427 EQUAL Reactome Database ID Release 82 10050711 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10050711 Reactome R-CFA-216349 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-216349.1 Reactome http://www.reactome.org DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome Reactome DB_ID: 10107839 p-S139,Y142-H2AFX-Nucleosome Reactome DB_ID: 10107837 H4C9 HIST1H4 F2Z4N2 Reactome DB_ID: 10042656 UniProt:F2Z4N2 H4C9 UniProt F2Z4N2 2 EQUAL 103 EQUAL Reactome Database ID Release 82 10042656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10042656 Reactome R-CFA-181902 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181902.1 2 Converted from EntitySet in Reactome Histone H2B Reactome DB_ID: 10039330 HIST1H2BK A0A5F4BWK7 Reactome DB_ID: 10039292 UniProt:A0A5F4BWK7 UniProt A0A5F4BWK7 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039292 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039292 Reactome R-CFA-181898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181898.1 L7N0L5 HIST3H2BB Reactome DB_ID: 10039296 UniProt:L7N0L5 UniProt L7N0L5 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039296 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039296 Reactome R-CFA-181923 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181923.1 L7N0C3 HIST1H2BA Reactome DB_ID: 10039300 UniProt:L7N0C3 UniProt L7N0C3 2 EQUAL 127 EQUAL Reactome Database ID Release 82 10039300 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039300 Reactome R-CFA-181916 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181916.1 J9P0B2 HIST1H2BC Reactome DB_ID: 10039304 UniProt:J9P0B2 UniProt J9P0B2 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039304 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039304 Reactome R-CFA-181906 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181906.1 H9GWB1 LOC119867718 HIST1H2BD Reactome DB_ID: 10039308 UniProt:H9GWB1 LOC119867718 UniProt H9GWB1 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039308 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039308 Reactome R-CFA-181912 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181912.1 J9P2Y4 HIST1H2BN Reactome DB_ID: 10039312 UniProt:J9P2Y4 UniProt J9P2Y4 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039312 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039312 Reactome R-CFA-181907 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181907.1 HIST1H2BB A0A5F4BU46 Reactome DB_ID: 10039316 UniProt:A0A5F4BU46 UniProt A0A5F4BU46 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039316 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039316 Reactome R-CFA-181903 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181903.1 H2BC15 HIST1H2BH J9P6S8 Reactome DB_ID: 10039320 UniProt:J9P6S8 H2BC15 UniProt J9P6S8 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039320 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039320 Reactome R-CFA-181915 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181915.1 J9P086 HIST2H2BE Reactome DB_ID: 10039324 UniProt:J9P086 UniProt J9P086 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039324 Reactome R-CFA-181908 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181908.1 HIST1H2BJ A0A5F4CAF8 Reactome DB_ID: 10039328 UniProt:A0A5F4CAF8 UniProt A0A5F4CAF8 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10039328 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039328 Reactome R-CFA-181900 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181900.1 Reactome Database ID Release 82 10039330 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039330 Reactome R-CFA-181911 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181911.1 2 E2RNB0 phospho-p-S140,Y143-H2AFX Reactome DB_ID: 10107835 UniProt:E2RNB0 UniProt E2RNB0 140 EQUAL O-phospho-L-serine MOD MOD:00046 143 EQUAL 2 EQUAL 143 EQUAL Reactome Database ID Release 82 10107835 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107835 Reactome R-CFA-5683953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683953.1 2 Ghost homologue of HIST3H3 Reactome DB_ID: 10039332 Reactome Database ID Release 82 10039332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039332 Reactome R-CFA-181914 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-181914.1 2 Reactome Database ID Release 82 10107837 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107837 Reactome R-CFA-5683972 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683972.1 1 DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10039288 J9JHR5 phospho-p-S1981,Ac-K3016-ATM Reactome DB_ID: 10039286 UniProt:J9JHR5 UniProt J9JHR5 1981 EQUAL 3016 EQUAL N6-acetyl-L-lysine MOD MOD:00064 1 EQUAL 3056 EQUAL Reactome Database ID Release 82 10039286 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039286 Reactome R-CFA-5693527 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693527.1 1 KAT5 A0A5F4DEP4 Reactome DB_ID: 10039263 UniProt:A0A5F4DEP4 UniProt A0A5F4DEP4 1 EQUAL 513 EQUAL Reactome Database ID Release 82 10039263 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039263 Reactome R-CFA-3321979 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3321979.1 1 DNA DSBs:p-MRN Reactome DB_ID: 10039280 DNA double-strand break ends Reactome DB_ID: 75165 Reactome Database ID Release 82 75165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75165 Reactome R-ALL-75165 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-75165.2 ChEBI 61120 additional information MI MI:0361 1 p-MRN Reactome DB_ID: 10039278 J9NSC8 phospho-p-S343-NBN Reactome DB_ID: 10039276 UniProt:J9NSC8 UniProt J9NSC8 343 EQUAL 1 EQUAL 754 EQUAL Reactome Database ID Release 82 10039276 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039276 Reactome R-CFA-75237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75237.1 1 MRE11A F1PUK4 Reactome DB_ID: 10039267 UniProt:F1PUK4 UniProt F1PUK4 1 EQUAL 708 EQUAL Reactome Database ID Release 82 10039267 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039267 Reactome R-CFA-59544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-59544.1 1 RAD50 J9P3S4 Reactome DB_ID: 10039271 UniProt:J9P3S4 UniProt J9P3S4 1 EQUAL 1312 EQUAL Reactome Database ID Release 82 10039271 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039271 Reactome R-CFA-75160 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75160.1 1 Reactome Database ID Release 82 10039278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039278 Reactome R-CFA-5682166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682166.1 1 Reactome Database ID Release 82 10039280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039280 Reactome R-CFA-5682175 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682175.1 1 Reactome Database ID Release 82 10039288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039288 Reactome R-CFA-5682162 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682162.1 1 Reactome Database ID Release 82 10107839 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107839 Reactome R-CFA-5683952 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683952.1 APBB1 E2QWV4 Reactome DB_ID: 10107849 UniProt:E2QWV4 UniProt E2QWV4 1 EQUAL 710 EQUAL Reactome Database ID Release 82 10107849 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107849 Reactome R-CFA-5683987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683987.1 DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 Reactome DB_ID: 10107851 1 1 1 Reactome Database ID Release 82 10107851 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107851 Reactome R-CFA-5683988 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683988.1 Reactome Database ID Release 82 10107853 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10107853 Reactome R-CFA-5683986 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5683986.1 In the absence of sufficient EYA1-4 activity, APBB1 (FE65) binds diphosphorylated H2AFX and recruits MAPK8 (JNK1) to H2AFX. This triggers pro-apoptotic signaling and targets the affected cell for apoptosis instead of DNA repair (Cook et al. 2009). 19234442 Pubmed 2009 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions Cook, Peter J Ju, Bong Gun Telese, Francesca Wang, Xiangting Glass, Christopher K Rosenfeld, Michael G Nature 458:591-6 inferred from electronic annotation EVIDENCE CODE ECO:0000203