BioPAX pathway converted from "ATM phosphorylates NBN" in the Reactome database. LEFT-TO-RIGHT 2.7.11.1 ATM phosphorylates NBN This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 nucleoplasm GENE ONTOLOGY GO:0005654 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 Reactome http://www.reactome.org COMPOUND C00002 additional information MI MI:0361 DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10110457 J9JHR5 phospho-p-S1981,Ac-K3016-ATM Reactome DB_ID: 10039286 UniProt:J9JHR5 Canis familiaris NCBI Taxonomy 9615 UniProt J9JHR5 1981 EQUAL O-phospho-L-serine MOD MOD:00046 3016 EQUAL N6-acetyl-L-lysine MOD MOD:00064 1 EQUAL 3056 EQUAL Reactome Database ID Release 82 10039286 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039286 Reactome R-CFA-5693527 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693527.1 1 KAT5 A0A5F4DEP4 Reactome DB_ID: 10039263 UniProt:A0A5F4DEP4 UniProt A0A5F4DEP4 1 EQUAL 513 EQUAL Reactome Database ID Release 82 10039263 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039263 Reactome R-CFA-3321979 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3321979.1 1 DNA DSBs:MRN Reactome DB_ID: 10097373 DNA double-strand break ends Reactome DB_ID: 75165 Reactome Database ID Release 82 75165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75165 Reactome R-ALL-75165 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-75165.2 ChEBI 61120 1 MRN Reactome DB_ID: 10044116 NBN J9NSC8 Reactome DB_ID: 10044114 UniProt:J9NSC8 UniProt J9NSC8 1 EQUAL 754 EQUAL Reactome Database ID Release 82 10044114 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10044114 Reactome R-CFA-75163 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75163.1 1 MRE11A F1PUK4 Reactome DB_ID: 10039267 UniProt:F1PUK4 UniProt F1PUK4 1 EQUAL 708 EQUAL Reactome Database ID Release 82 10039267 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039267 Reactome R-CFA-59544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-59544.1 1 RAD50 J9P3S4 Reactome DB_ID: 10039271 UniProt:J9P3S4 UniProt J9P3S4 1 EQUAL 1312 EQUAL Reactome Database ID Release 82 10039271 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039271 Reactome R-CFA-75160 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75160.1 1 Reactome Database ID Release 82 10044116 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10044116 Reactome R-CFA-75164 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75164.1 1 Reactome Database ID Release 82 10097373 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10097373 Reactome R-CFA-3785763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3785763.1 1 Reactome Database ID Release 82 10110457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110457 Reactome R-CFA-5682055 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682055.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10039288 1 1 DNA DSBs:p-MRN Reactome DB_ID: 10039280 1 p-MRN Reactome DB_ID: 10039278 J9NSC8 phospho-p-S343-NBN Reactome DB_ID: 10039276 343 EQUAL 1 EQUAL 754 EQUAL Reactome Database ID Release 82 10039276 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039276 Reactome R-CFA-75237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75237.1 1 1 1 Reactome Database ID Release 82 10039278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039278 Reactome R-CFA-5682166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682166.1 1 Reactome Database ID Release 82 10039280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039280 Reactome R-CFA-5682175 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682175.1 1 Reactome Database ID Release 82 10039288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039288 Reactome R-CFA-5682162 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682162.1 ACTIVATION activeUnit: #Protein1 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10110523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110523 Reactome Database ID Release 82 10110525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110525 Reactome R-CFA-5693598 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693598.1 NSB1 (NBN) is a component of the MRN (MRE11:RAD50:NBN) complex which acts early in homologous recombination repair (HRR) during recognition and resection of double-strand breaks (DSBs). ATM-mediated phosphorylation of NBN at serine residue S343 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR (Lim et al. 2000, Gatei et al. 2000, Lee and Paull 2004). The phosphorylation of NBN by ATM may be enhanced by the presence of BRCA1 (Foray et al. 2003). 12773400 Pubmed 2003 A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray, N Marot, D Gabriel, A Randrianarison, V Perricaudet, M Ashworth, A Jeggo, P EMBO J 22:2860-71 10766245 Pubmed 2000 ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway Lim, D S Kim, S T Xu, B Maser, RS Lin, J Petrini, JH Kastan, M B Nature 404:613-7 10802669 Pubmed 2000 ATM-dependent phosphorylation of nibrin in response to radiation exposure Gatei, M Young, D Cerosaletti, K M Desai-Mehta, A Spring, K Kozlov, S Lavin, M F Gatti, R A Concannon, P Khanna, K Nat. Genet. 25:115-9 15064416 Pubmed 2004 Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex Lee, Ji-Hoon Paull, Tanya T Science 304:93-6 12861053 Pubmed 2003 Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Lee, JH Xu, B Lee, CH Ahn, JY Song, MS Lee, H Canman, CE Lee, JS Kastan, MB Lim, DS Mol Cancer Res 1:674-81 inferred from electronic annotation EVIDENCE CODE ECO:0000203