BioPAX pathway converted from "USP43 deISGylates ISG:K164,ISG:K168-PCNA" in the Reactome database. LEFT-TO-RIGHT USP43 deISGylates ISG:K164,ISG:K168-PCNA This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10112945 nucleoplasm GENE ONTOLOGY GO:0005654 USP43 USP43 E1BKF4 Reactome DB_ID: 10112939 UniProt:E1BKF4 USP43 Bos taurus NCBI Taxonomy 9913 UniProt E1BKF4 1 EQUAL 1123 EQUAL Reactome Database ID Release 79 10112939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112939 Reactome R-BTA-5653784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653784.1 Reactome http://www.reactome.org 1 ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10112943 RPA heterotrimer Reactome DB_ID: 10076341 RPA3 RPA3 Q3SZ11 Reactome DB_ID: 10072893 UniProt:Q3SZ11 RPA3 UniProt Q3SZ11 1 EQUAL 121 EQUAL Reactome Database ID Release 79 10072893 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072893 Reactome R-BTA-68459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68459.1 1 RPA2 RPA2 Q2KI86 Reactome DB_ID: 10072909 UniProt:Q2KI86 RPA2 UniProt Q2KI86 1 EQUAL 270 EQUAL Reactome Database ID Release 79 10072909 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072909 Reactome R-BTA-68457 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68457.1 1 Ghost homologue of RPA1 Reactome DB_ID: 10072889 Reactome Database ID Release 79 10072889 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072889 Reactome R-BTA-68461 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68461.1 1 Reactome Database ID Release 79 10076341 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10076341 Reactome R-BTA-68462 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68462.1 1 ISG:K164,ISG:K168-PCNA homotrimer Reactome DB_ID: 10112941 PCNA PCNA Q3ZBW4 Reactome DB_ID: 10076350 UniProt:Q3ZBW4 PCNA UniProt Q3ZBW4 1 EQUAL 261 EQUAL Reactome Database ID Release 79 10076350 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10076350 Reactome R-BTA-68439 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68439.1 2 ISG:K164,ISG:K168-PCNA Reactome DB_ID: 10112929 PCNA ISG-K164,ISG-K168-PCNA Q3ZBW4 Reactome DB_ID: 10112927 164 EQUAL N6-glycyl-L-lysine MOD MOD:00134 168 EQUAL 1 EQUAL 261 EQUAL Reactome Database ID Release 79 10112927 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112927 Reactome R-BTA-5653768 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653768.1 1 ISG15 K164-PCNA-G157-ISG15 O02741 Reactome DB_ID: 10112923 UniProt:O02741 ISG15 UniProt O02741 157 EQUAL 2 EQUAL 157 EQUAL Reactome Database ID Release 79 10112923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112923 Reactome R-BTA-5653745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653745.1 2 Reactome Database ID Release 79 10112929 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112929 Reactome R-BTA-5653767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653767.1 1 Reactome Database ID Release 79 10112941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112941 Reactome R-BTA-5653771 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653771.1 1 RFC Heteropentamer Reactome DB_ID: 10072976 RFC1 RFC1 A0A3Q1N5S1 Reactome DB_ID: 10072974 UniProt:A0A3Q1N5S1 RFC1 UniProt A0A3Q1N5S1 1 EQUAL 1148 EQUAL Reactome Database ID Release 79 10072974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072974 Reactome R-BTA-68435 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68435.1 1 RFC4 RFC4 A0A3Q1M1J3 Reactome DB_ID: 10072964 UniProt:A0A3Q1M1J3 RFC4 UniProt A0A3Q1M1J3 1 EQUAL 363 EQUAL Reactome Database ID Release 79 10072964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072964 Reactome R-BTA-68429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68429.1 1 RFC5 RFC5 A0A3Q1LY33 Reactome DB_ID: 10072960 UniProt:A0A3Q1LY33 RFC5 UniProt A0A3Q1LY33 1 EQUAL 340 EQUAL Reactome Database ID Release 79 10072960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072960 Reactome R-BTA-68427 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68427.1 1 Ghost homologue of RFC2 Reactome DB_ID: 10072970 Reactome Database ID Release 79 10072970 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072970 Reactome R-BTA-68433 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68433.1 1 RFC3 RFC3 Q2TBV1 Reactome DB_ID: 10072968 UniProt:Q2TBV1 RFC3 UniProt Q2TBV1 1 EQUAL 356 EQUAL Reactome Database ID Release 79 10072968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072968 Reactome R-BTA-68431 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68431.1 1 Reactome Database ID Release 79 10072976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072976 Reactome R-BTA-68436 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68436.1 1 Ghost homologue of TLS-DNA Template Reactome DB_ID: 10112898 Reactome Database ID Release 79 10112898 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112898 Reactome R-BTA-5653662 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653662.1 1 Reactome Database ID Release 79 10112943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112943 Reactome R-BTA-5653772 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653772.1 1 Reactome Database ID Release 79 10112945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112945 Reactome R-BTA-5653781 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653781.1 H2O water Reactome DB_ID: 113518 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 79 113518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113518 Reactome R-ALL-113518 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113518.3 COMPOUND C00001 additional information MI MI:0361 2 PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10112949 1 PCNA homotrimer Reactome DB_ID: 10079364 3 Reactome Database ID Release 79 10079364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10079364 Reactome R-BTA-68440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68440.1 1 1 1 Reactome Database ID Release 79 10112949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112949 Reactome R-BTA-5653782 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653782.1 ISG15 ISG15 O02741 Reactome DB_ID: 10112951 2 EQUAL 157 EQUAL Reactome Database ID Release 79 10112951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112951 Reactome R-BTA-5653665 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653665.1 2 ACTIVATION activeUnit: #Protein1 GENE ONTOLOGY GO:0019785 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 79 10112952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112952 Reactome Database ID Release 79 10112954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112954 Reactome R-BTA-5653786 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653786.1 USP43 acts as an ISG15 protease to cleave ISG15 from lysines K164 and K168 of PCNA, thus deISGylating PCNA (Park et al. 2014). 24768535 Pubmed 2014 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Park, Jung Mi Yang, Seung Wook Yu, Kyung Ryun Ka, Seung Hyun Lee, Seong Won Seol, Jae Hong Jeon, Young Joo Chung, Chin Ha Mol. Cell 54:626-38 inferred from electronic annotation EVIDENCE CODE ECO:0000203