BioPAX pathway converted from "ceramide + H2O => stearate + sphingosine [Golgi]" in the Reactome database.LEFT-TO-RIGHT3.5.1.23ceramide + H2O => stearate + sphingosine [Golgi]This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>CERAceramideReactome DB_ID: 428270Golgi membraneGENE ONTOLOGYGO:0000139ceramide [ChEBI:17761]ceramideChEBICHEBI:17761Reactome Database ID Release 75428270Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428270ReactomeR-ALL-4282703Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-428270.3Reactomehttp://www.reactome.orgH2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001additional informationMIMI:0361STEAstearic acidmagnesium distearateReactome DB_ID: 8934421magnesium distearate [ChEBI:9254]magnesium distearateChEBICHEBI:9254Reactome Database ID Release 758934421Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8934421ReactomeR-ALL-89344213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8934421.3SPGsphingosineReactome DB_ID: 428248sphingosine [ChEBI:16393]sphingosineChEBICHEBI:16393Reactome Database ID Release 75428248Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428248ReactomeR-ALL-4282483Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-428248.3ACTIVATIONACER2A0A287A341Reactome DB_ID: 10121151UniProt:A0A287A341Sus scrofaNCBI Taxonomy9823UniProtA0A287A3411EQUAL275EQUALReactome Database ID Release 7510121151Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10121151ReactomeR-SSC-4282391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-428239.1GENE ONTOLOGYGO:0017040gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510121152Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10121152Reactome Database ID Release 7510121154Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10121154ReactomeR-SSC-4282051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-428205.1ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid (annotated here as stearate) and sphingosine. ACER2 mRNA is widely expressed in the body, although only at low levels except in placenta (Xu et al. 2006).16940153Pubmed2006Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1PXu, RJin, JHu, WSun, WBielawski, JSzulc, ZMTaha, TObeid, LMMao, CFASEB J 20:1813-25inferred from electronic annotationEVIDENCE CODEECO:0000203