BioPAX pathway converted from "ANKLE2 is deacetylated by SIRT2" in the Reactome database.LEFT-TO-RIGHTANKLE2 is deacetylated by SIRT2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ANKLE2Ac-K302-ANKLE2I3LVP6Reactome DB_ID: 10184183endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789UniProt:I3LVP6ANKLE2Sus scrofaNCBI Taxonomy9823UniProtI3LVP6302EQUALN6-acetyl-L-lysineMODMOD:000641EQUAL938EQUALReactome Database ID Release 7510184183Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184183ReactomeR-SSC-96679461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9667946.1Reactomehttp://www.reactome.orgNADNAD+NAD(+)Nicotinamide adenine dinucleotideDPNDiphosphopyridine nucleotideReactome DB_ID: 29360cytosolGENE ONTOLOGYGO:0005829NAD(1-) [ChEBI:57540]NAD(1-)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD(+)NAD anionChEBICHEBI:57540Reactome Database ID Release 7529360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360ReactomeR-ALL-293605Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29360.5COMPOUNDC00003additional informationMIMI:0361H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001ANKLE2ANKLE2I3LVP6Reactome DB_ID: 101465001EQUAL938EQUALReactome Database ID Release 7510146500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10146500ReactomeR-SSC-25290001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2529000.1NAMnicotinamideReactome DB_ID: 197277nicotinamide [ChEBI:17154]nicotinamideChEBICHEBI:17154Reactome Database ID Release 75197277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197277ReactomeR-ALL-1972773Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-197277.3COMPOUNDC001532'-O-acetyl-ADP-ribose2'-O-acetyl adenosine-5-diphosphoribose2''-O-acetyl-ADP-D-riboseReactome DB_ID: 96679562''-O-acetyl-ADP-D-ribose [ChEBI:76279]2''-O-acetyl-ADP-D-riboseChEBICHEBI:76279Reactome Database ID Release 759667956Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667956ReactomeR-ALL-96679561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667956.1ACTIVATIONSIRT2SIRT2A0A287B4T1Reactome DB_ID: 10184187UniProt:A0A287B4T1SIRT2UniProtA0A287B4T12EQUAL389EQUALReactome Database ID Release 7510184187Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184187ReactomeR-SSC-21611181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2161118.1GENE ONTOLOGYGO:0034979gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510184188Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184188Reactome Database ID Release 7510184190Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184190ReactomeR-SSC-96679521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9667952.1ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).22770216Pubmed2012Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosisAsencio, ClaudioDavidson, Iain FSantarella-Mellwig, RachelLy-Hartig, Thi Bach NgaMall, MoritzWallenfang, Matthew RMattaj, Iain WGorjánácz, MátyásCell 150:122-3527875273Pubmed2016SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylationKaufmann, TanjaKukolj, EvaBrachner, AndreasBeltzung, EtienneBruno, MelaniaKostrhon, SebastianOpravil, SusanneHudecz, OttoMechtler, KarlWarren, GrahamSlade, DeaJ. Cell. Sci. 129:4607-4621inferred from electronic annotationEVIDENCE CODEECO:0000203