BioPAX pathway converted from "ATM binds PEX5" in the Reactome database.LEFT-TO-RIGHTATM binds PEX5This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ATMATMF1SV20Reactome DB_ID: 10186309cytosolGENE ONTOLOGYGO:0005829UniProt:F1SV20ATMSus scrofaNCBI Taxonomy9823UniProtF1SV201EQUAL3056EQUALReactome Database ID Release 7610186309Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186309ReactomeR-SSC-96651711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9665171.1Reactomehttp://www.reactome.orgPEX5PEX5 isoform LA0A287ADM4Reactome DB_ID: 10184678UniProt:A0A287ADM4PEX5UniProtA0A287ADM41EQUAL639EQUALReactome Database ID Release 7610184678Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184678ReactomeR-SSC-90331031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9033103.1ATM:PEX5Reactome DB_ID: 1018631111Reactome Database ID Release 7610186311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186311ReactomeR-SSC-96651701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9665170.1Reactome Database ID Release 7610186313Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186313ReactomeR-SSC-96648501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9664850.1The first step in pexophagy is the initiation by a signal that triggers downstream events to eventually degrade the peroxisome. Ataxia-telangiectasia mutated protein (ATM) is a serine/threonine protein kinase that is involve in DNA damage response. ATM is known to be involved in pexophagy (Katarzyna ZR et al. 2016). ATM binds with Peroxisomal targeting signal 1 receptor (PEX5) with the help of a SRL binding sequence in ATM (Zhang J et al. 2015).26344566Pubmed2015ATM functions at the peroxisome to induce pexophagy in response to ROSZhang, JiangweiTripathi, Durga NandJing, JiAlexander, AngelaKim, JinheePowell, Reid TDere, RuheeTait-Mulder, JacquelineLee, Ji-HoonPaull, Tanya TPandita, Raj KCharaka, Vijaya KPandita, Tej KKastan, Michael BWalker, Cheryl LynNat. Cell Biol. 17:1259-6927068951Pubmed2016Autophagic degradation of peroxisomes in mammalsZientara-Rytter, KatarzynaSubramani, SureshBiochem. Soc. Trans. 44:431-40inferred from electronic annotationEVIDENCE CODEECO:0000203