BioPAX pathway converted from "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" in the Reactome database.TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTSMURF1 binds phosphorylated PARD6AThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOAReactome DB_ID: 10142721cell junctionGENE ONTOLOGYGO:0030054Tight Junction Complex:p-PARD6A:RHOAReactome DB_ID: 10142719RHOARHOAI3LVS7Reactome DB_ID: 10142704UniProt:I3LVS7RHOASus scrofaNCBI Taxonomy9823UniProtI3LVS71EQUAL190EQUALReactome Database ID Release 7510142704Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142704ReactomeR-SSC-21345031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134503.1Reactomehttp://www.reactome.org1CGNCGNF1ST04Reactome DB_ID: 10142700UniProt:F1ST04CGNUniProtF1ST041EQUAL1197EQUALReactome Database ID Release 7510142700Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142700ReactomeR-SSC-21344781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134478.11ARHGEF18A0A287A1S5Reactome DB_ID: 10142706UniProt:A0A287A1S5UniProtA0A287A1S51EQUAL1173EQUALReactome Database ID Release 7510142706Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142706ReactomeR-SSC-21344861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134486.11PARD3:p-PARD6A:PRKCZReactome DB_ID: 10142717PARD3PARD3F1RUR8Reactome DB_ID: 10142708UniProt:F1RUR8PARD3UniProtF1RUR81EQUAL1356EQUALReactome Database ID Release 7510142708Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142708ReactomeR-SSC-21344811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134481.11A0A286ZZ01phospho-PARD6Ap-S345-PARD6AReactome DB_ID: 10142715plasma membraneGENE ONTOLOGYGO:0005886UniProt:A0A286ZZ01PARD6AUniProtA0A286ZZ01345EQUALO-phospho-L-serineMODMOD:000461EQUAL346EQUALReactome Database ID Release 7510142715Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142715ReactomeR-SSC-21345331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134533.11PRKCZPRKCZA0A286ZSY3Reactome DB_ID: 10142712UniProt:A0A286ZSY3PRKCZUniProtA0A286ZSY31EQUAL592EQUALReactome Database ID Release 7510142712Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142712ReactomeR-SSC-21344831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134483.11Reactome Database ID Release 7510142717Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142717ReactomeR-SSC-21345281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134528.11F11RB2ZI35Reactome DB_ID: 10142702UniProt:B2ZI35UniProtB2ZI3528EQUAL299EQUALReactome Database ID Release 7510142702Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142702ReactomeR-SSC-21344981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134498.11Reactome Database ID Release 7510142719Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142719ReactomeR-SSC-21345291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134529.11TGFB1:TGFBR2:p-TGFBR1Reactome DB_ID: 10142696Dimeric TGFB1Reactome DB_ID: 10142682extracellular regionGENE ONTOLOGYGO:0005576Ghost homologue of TGFB1Reactome DB_ID: 10142680Reactome Database ID Release 7510142680Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142680ReactomeR-SSC-1708381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170838.12Reactome Database ID Release 7510142682Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142682ReactomeR-SSC-1708521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170852.11p-TGFBR1Reactome DB_ID: 10142694K7GSM3phospho-TGFBR1p-4S,T185,T186-TGFBR1Reactome DB_ID: 10142692UniProt:K7GSM3TGFBR1UniProtK7GSM3165EQUAL185EQUALO-phospho-L-threonineMODMOD:00047186EQUAL187EQUAL189EQUAL191EQUAL34EQUAL503EQUALReactome Database ID Release 7510142692Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142692ReactomeR-SSC-1708491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170849.12Reactome Database ID Release 7510142694Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142694ReactomeR-SSC-1708631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170863.11TGFBR2 homodimerReactome DB_ID: 10142678Ghost homologue of TGFBR2Reactome DB_ID: 10142676Reactome Database ID Release 7510142676Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142676ReactomeR-SSC-1708421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170842.12Reactome Database ID Release 7510142678Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142678ReactomeR-SSC-1708661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170866.11Reactome Database ID Release 7510142696Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142696ReactomeR-SSC-1708411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170841.11Reactome Database ID Release 7510142721Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142721ReactomeR-SSC-21345341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2134534.1SMURF1SMURF1I3LTD6Reactome DB_ID: 10108782cytosolGENE ONTOLOGYGO:0005829UniProt:I3LTD6SMURF1UniProtI3LTD61EQUAL757EQUALReactome Database ID Release 7510108782Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10108782ReactomeR-SSC-9759721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-975972.1Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1Reactome DB_ID: 1014272311Reactome Database ID Release 7510142723Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142723ReactomeR-SSC-21609291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2160929.1Reactome Database ID Release 7510142729Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142729ReactomeR-SSC-21609321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2160932.1SMURF1 ubiquitin ligase is recruited to tight junctions by binding to phosphorylated PARD6A (Ozdamar et al. 2005).15761148Pubmed2005Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticityOzdamar, BBose, RBarrios-Rodiles, MWang, HRZhang, YWrana, JLScience 307:1603-9inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTSMURF1 ubiquitinates RHOAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeUbubiquitinReactome DB_ID: 10091209RPS27ARPS27A(1-76)A0A287AZA7Reactome DB_ID: 10091195UniProt:A0A287AZA7RPS27AUniProtA0A287AZA71EQUAL76EQUALReactome Database ID Release 7510091195Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10091195ReactomeR-SSC-9392051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939205.1P63053UBA52(1-76)Reactome DB_ID: 10091199UniProt:P63053UniProtP630531EQUAL76EQUALReactome Database ID Release 7510091199Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10091199ReactomeR-SSC-9392031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939203.1UBBUBB(1-76)A7U5U2Reactome DB_ID: 10091203UniProt:A7U5U2UBBUniProtA7U5U21EQUAL76EQUALReactome Database ID Release 7510091203Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10091203ReactomeR-SSC-9392141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939214.1Reactome Database ID Release 7510091209Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10091209ReactomeR-SSC-1135951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113595.1Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1Reactome DB_ID: 1014272511Reactome Database ID Release 7510142725Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142725ReactomeR-SSC-21609341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2160934.1Reactome Database ID Release 7510142731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142731ReactomeR-SSC-21609351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2160935.1SMURF1, recruited to tight junctions through association with phosphorylated PARD6A, ubiquitinates RHOA, leading to RHOA degradation and disassembly of tight junctions (Ozdamar et al. 2005). Disassembly of tight junctions is an important step in epithelial to mesenchymal transition. SMURF1, but not SMURF2, decreases RHOA level, and this effect is proteasome dependent (Wang et al. 2003). 14657501Pubmed2003Regulation of cell polarity and protrusion formation by targeting RhoA for degradationWang, HRZhang, YOzdamar, BOgunjimi, AAAlexandrova, EThomsen, GHWrana, JLScience 302:1775-9LEFT-TO-RIGHTDisassembly of tight junctionsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome Database ID Release 7510142727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10142727ReactomeR-SSC-21609311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2160931.1Ubiquitination of RHOA by SMURF1 leads to disassembly of tight junctions, an important step in epithelial to mesenchymal transition.Reactome Database ID Release 7510186891Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186891ReactomeR-SSC-21737911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2173791.1GENE ONTOLOGYGO:0007179gene ontology term for cellular processMIMI:0359In normal cells and in the early stages of cancer development, signaling by TGF-beta plays a tumor suppressive role, as SMAD2/3:SMAD4-mediated transcription inhibits cell division by downregulating MYC oncogene transcription and stimulating transcription of CDKN2B tumor suppressor gene. In advanced cancers however, TGF-beta signaling promotes metastasis by stimulating epithelial to mesenchymal transition (EMT). <br>TGFBR1 is recruited to tight junctions by binding PARD6A, a component of tight junctions. After TGF-beta stimulation, activated TGFBR2 binds TGFBR1 at tight junctions, and phosphorylates both TGFBR1 and PARD6A. Phosphorylated PARD6A recruits SMURF1 to tight junctions. SMURF1 is able to ubiquitinate RHOA, a component of tight junctions needed for tight junction maintenance, leading to disassembly of tight junctions, an important step in EMT (Wang et al. 2003, Ozdamar et al. 2005).