BioPAX pathway converted from "RUNX3 regulates CDKN1A transcription" in the Reactome database.RUNX3 regulates CDKN1A transcriptionThis event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTRUNX3 binds ZFHX3This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ZFHX3ZFHX3F1S397Reactome DB_ID: 10177346nucleoplasmGENE ONTOLOGYGO:0005654UniProt:F1S397ZFHX3Sus scrofaNCBI Taxonomy9823UniProtF1S3971EQUAL3703EQUALReactome Database ID Release 7510177346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10177346ReactomeR-SSC-88780841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8878084.1Reactomehttp://www.reactome.orgRUNX3RUNX3A0A287B209Reactome DB_ID: 10175122UniProt:A0A287B209RUNX3UniProtA0A287B2091EQUAL415EQUALReactome Database ID Release 7510175122Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10175122ReactomeR-SSC-88653931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8865393.1RUNX3:ZFHX3Reactome DB_ID: 1017734811Reactome Database ID Release 7510177348Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10177348ReactomeR-SSC-88781201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8878120.1Reactome Database ID Release 7510177350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10177350ReactomeR-SSC-88781171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8878117.1In response to TGF-beta (TGFB1) signaling, RUNX3 binds to the homeobox transcription factor and tumor suppressor ZFHX3 (ATBF1). The exact mechanism and regulation of RUNX3 and ATBF1 binding is not known (Mabuchi et al. 2010).20599712Pubmed2010Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transductionMabuchi, MotoshiKataoka, HiromiMiura, YutakaKim, Tae-SunKawaguchi, MakotoEbi, MasahideTanaka, MamoruMori, YoshinoriKubota, EijiMizushima, TakashiShimura, TakayaMizoshita, TsutomuTanida, SatoshiKamiya, TakeshiAsai, KJoh, TakashiBiochem. Biophys. Res. Commun. 398:321-5inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTRUNX3 binds TP53This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TP53 TetramerReactome DB_ID: 10147194TP53TP53Q9TUB2Reactome DB_ID: 10146546UniProt:Q9TUB2TP53UniProtQ9TUB21EQUAL393EQUALReactome Database ID Release 7510146546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10146546ReactomeR-SSC-694881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69488.14Reactome Database ID Release 7510147194Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147194ReactomeR-SSC-32091941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3209194.1RUNX3:TP53 tetramerReactome DB_ID: 1017981311Reactome Database ID Release 7510179813Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10179813ReactomeR-SSC-89521231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8952123.1Reactome Database ID Release 7510179815Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10179815ReactomeR-SSC-89521281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8952128.1RUNX3 can bind to TP53 (p53). The interaction involves the C-termini of both RUNX3 and TP53. RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21). RUNX3 may also interact with phosphorylated ATM kinase in response to DNA damage and facilitate ATM-mediated phosphorylation and stabilization of TP53 (Yamada et al. 2010).20353948Pubmed2010RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53Yamada, ChizuOzaki, ToshinoriAndo, KSuenaga, YusukeInoue, Ken-ichiIto, YoshiakiOkoshi, RintaroKageyama, HajimeKimura, HidekiMiyazaki, MasaruNakagawara, AkiraJ. Biol. Chem. 285:16693-703Reactome Database ID Release 7510187543Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10187543ReactomeR-SSC-89418551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8941855.1RUNX3 contributes to the upregulation of the CDKN1A (p21) gene transcription in response to TGF-beta (TGFB1) signaling. RUNX3 binds to SMAD3 and SMAD4, and cooperates with the activated SMAD3:SMAD4 complex in transactivation of CDKN1A. Runx3 knockout mice exhibit decreased sensitivity to TGF-beta and develop gastric epithelial hyperplasia (Chi et al. 2005). In response to TGF-beta signaling, the CBFB:RUNX3 complex binds to the tumor suppressor ZFHX3 (ATBF1) and, through an unknown mechanism, this complex positively regulates the CDKN1A transcription (Mabuchi et al. 2010). In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010).16135801Pubmed2005RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMADChi, Xin-ZiYang, Jeung-OokLee, Kwang-YoulIto, KoseiSakakura, ChoheiLi, Qing-LinKim, Hye-RyunCha, Eun-JeungLee, Yong-HeeKaneda, AtsushiUshijima, ToshikazuKim, Wun-JaeIto, YoshiakiBae, Suk-ChulMol. Cell. Biol. 25:8097-107