BioPAX pathway converted from "GLI proteins bind CDC73" in the Reactome database. LEFT-TO-RIGHT GLI proteins bind CDC73 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome 2p-GLI1,2,3 Reactome DB_ID: 10189361 A0A5K1V436 phospho-2p-GLI1 Reactome DB_ID: 10189355 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:A0A5K1V436 Sus scrofa NCBI Taxonomy 9823 UniProt A0A5K1V436 phosphorylated residue MOD MOD:00696 1 EQUAL 1106 EQUAL Reactome Database ID Release 78 10189355 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189355 Reactome R-SSC-5635057 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635057.1 Reactome http://www.reactome.org F1RXX4 phospho-GLI2 2p-GLI2 Reactome DB_ID: 10189357 UniProt:F1RXX4 GLI2 UniProt F1RXX4 1 EQUAL 1586 EQUAL Reactome Database ID Release 78 10189357 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189357 Reactome R-SSC-5635055 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635055.1 F1SSD9 phospho-2p-GLI3 Reactome DB_ID: 10189359 UniProt:F1SSD9 UniProt F1SSD9 1 EQUAL 1580 EQUAL Reactome Database ID Release 78 10189359 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189359 Reactome R-SSC-5635052 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635052.1 Reactome Database ID Release 78 10189361 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189361 Reactome R-SSC-5635077 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635077.1 CDC73 CDC73 F1SAB0 Reactome DB_ID: 10134757 UniProt:F1SAB0 CDC73 UniProt F1SAB0 2 EQUAL 531 EQUAL Reactome Database ID Release 78 10134757 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10134757 Reactome R-SSC-3322360 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3322360.1 CDC73:2p-GLI Reactome DB_ID: 10189376 1 1 Reactome Database ID Release 78 10189376 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189376 Reactome R-SSC-5635076 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635076.1 Reactome Database ID Release 78 10189378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10189378 Reactome R-SSC-5635845 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5635845.1 Each of the GLI proteins can form a complex in the nucleus with CDC73, also known as Parafibromin, a component of the PAF complex (Mosimann et al, 2009). PAF1 is a conserved protein complex that affects aspects of RNA polymerase II transcription including histone modification, transcription elongation and RNA 3' end formation, among others. In humans, the PAF1 complex consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (reviewed in Tomson and Arndt, 2013). Knockdown of CDC73 in mammalian cell culture compromises GLI1- and GLI2-dependent transcriptional activation and has been shown to abrogate expression of endogenous targets in Drosophila. CDC73 interacts with the GLI proteins through the SUFU-interacting domain in region 1 of the N-terminal (Mosimann et al, 2009). Direct binding of a CDC73:GLI complex on an endogenous human target gene has not yet been demonstrated. 19368795 Pubmed 2009 The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control Mosimann, Christian Hausmann, George Basler, Konrad Mech. Dev. 126:394-405 22982193 Pubmed 2013 The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states Tomson, Brett N Arndt, KM Biochim. Biophys. Acta 1829:116-26 inferred from electronic annotation EVIDENCE CODE ECO:0000203