BioPAX pathway converted from "Alternative endo-mannosidase I route" in the Reactome database.LEFT-TO-RIGHT3.2.1.130Alternative endo-mannosidase I routeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>(Glc)3 (GlcNAc)2 (Man)9 (Asn)1N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueReactome DB_ID: 964754Golgi lumenGENE ONTOLOGYGO:0005796N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59084]N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueChEBICHEBI:59084Reactome Database ID Release 75964754Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964754ReactomeR-ALL-9647543Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-964754.3Reactomehttp://www.reactome.org(GlcNAc)2 (Man)8 (Asn)1N-{alpha-Man-(1->4)-alpha-Man-(1->4)-alpha-Man-(1->3)-[alpha-Man-(1->3)-[alpha-Man-(1->4)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueReactome DB_ID: 964744N-{alpha-Man-(1->4)-alpha-Man-(1->4)-alpha-Man-(1->3)-[alpha-Man-(1->3)-[alpha-Man-(1->4)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59089]N-{alpha-Man-(1->4)-alpha-Man-(1->4)-alpha-Man-(1->3)-[alpha-Man-(1->3)-[alpha-Man-(1->4)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residueChEBICHEBI:59089Reactome Database ID Release 75964744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964744ReactomeR-ALL-9647443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-964744.3Glcalpha-D-glucoseReactome DB_ID: 964746alpha-D-glucose [ChEBI:17925]alpha-D-glucoseChEBICHEBI:17925Reactome Database ID Release 75964746Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964746ReactomeR-ALL-9647463Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-964746.3COMPOUNDC00267additional informationMIMI:03613ACTIVATIONConverted from EntitySet in ReactomeHomologues of MANEAReactome DB_ID: 10229681maneaMANEAE7EYY9Reactome DB_ID: 10229675Golgi membraneGENE ONTOLOGYGO:0000139UniProt:E7EYY9maneaDanio rerioNCBI Taxonomy7955UniProtE7EYY91EQUAL462EQUALReactome Database ID Release 7510229675Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229675ReactomeR-DRE-9647291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-964729.1MANEAmanealQ1L8D2Reactome DB_ID: 10229679UniProt:Q1L8D2manealUniProtQ1L8D21EQUAL462EQUALReactome Database ID Release 7510229679Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229679ReactomeR-DRE-964729-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-964729-2.1Reactome Database ID Release 7510229681Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229681ReactomeR-DRE-964729-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-964729-3.1GENE ONTOLOGYGO:0004569gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510229682Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229682Reactome Database ID Release 7510229684Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229684ReactomeR-DRE-9647591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-964759.1Cells exposed to castanospermine or 1-deoxynojirimycin (inhibitors of the glucosidase enzymes GCS1 and GANAB), are still able to carry out glycosylation and produce complex glycans. This is due to the existence of an alternative route catalyzed by the enzyme endomannosidase (Moore and Spiro, 1990).<br>Glycoproteins that pass through this route probably skip or have a reduced interaction with the Calnexin/Calreticulin cycle, and are transported to the cis-golgi through a route that has not been described yet (probably through the general ER to Golgi flow). Here, the Endomannosidase enzyme, which resides on the Golgi membrane (Hardt et al 2005; Hamilton et al 2005) is able to remove the tri-, di-, or mono-glucose substituted mannose on branch A, leading to a deglucosylated N-glycan structure (Lubas and Spiro, 1988).15760709Pubmed2005Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane proteinHardt, BVölker, CMundt, SSalska-Navarro, MHauptmann, MBause, EBiochimie 87:169-7915677381Pubmed2005Intact {alpha}-1,2-endomannosidase is a typical type II membrane proteinHamilton, SRLi, HWischnewski, HPrasad, AKerley-Hamilton, JSMitchell, TWalling, AJDavidson, RCWildt, SGerngross, TUGlycobiology 15:615-242165493Pubmed1990Demonstration that Golgi endo-alpha-D-mannosidase provides a glucosidase-independent pathway for the formation of complex N-linked oligosaccharides of glycoproteinsMoore, SESpiro, RGJ Biol Chem 265:13104-123346233Pubmed1988Evaluation of the role of rat liver Golgi endo-alpha-D-mannosidase in processing N-linked oligosaccharidesLubas, WASpiro, RGJ Biol Chem 263:3990-8inferred from electronic annotationEVIDENCE CODEECO:0000203