BioPAX pathway converted from "PIP3 activates AKT signaling" in the Reactome database. PI3K/AKT Signaling PIP3 activates AKT signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT RAC1,RAC2,RHOG activate PI3K This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome RAC1:GTP,RAC2:GTP,RHOG:GTP Reactome DB_ID: 10149043 RAC1:GTP Reactome DB_ID: 10149029 plasma membrane GENE ONTOLOGY GO:0005886 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 cytosol GENE ONTOLOGY GO:0005829 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 82 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 Reactome http://www.reactome.org COMPOUND C00044 additional information MI MI:0361 1 RAC1 RAC1 A0A3Q1M7Y3 Reactome DB_ID: 10149027 UniProt:A0A3Q1M7Y3 RAC1 Bos taurus NCBI Taxonomy 9913 UniProt A0A3Q1M7Y3 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10149027 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149027 Reactome R-BTA-351141 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-351141.1 1 Reactome Database ID Release 82 10149029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149029 Reactome R-BTA-442641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-442641.1 RAC2:GTP Reactome DB_ID: 10149035 1 RAC2 Q9TU25 Reactome DB_ID: 10149033 UniProt:Q9TU25 UniProt Q9TU25 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10149033 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149033 Reactome R-BTA-195339 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-195339.1 1 Reactome Database ID Release 82 10149035 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149035 Reactome R-BTA-9014399 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9014399.1 RHOG:GTP Reactome DB_ID: 10149041 1 RHOG RHOG Q1RMI2 Reactome DB_ID: 10149039 UniProt:Q1RMI2 RHOG UniProt Q1RMI2 1 EQUAL 188 EQUAL Reactome Database ID Release 82 10149039 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149039 Reactome R-BTA-194880 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-194880.1 1 Reactome Database ID Release 82 10149041 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149041 Reactome R-BTA-9014437 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9014437.1 Reactome Database ID Release 82 10149043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149043 Reactome R-BTA-9615275 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9615275.1 PI3K alpha Reactome DB_ID: 10149051 PIK3CA PIK3CA P32871 Reactome DB_ID: 10145661 UniProt:P32871 PIK3CA UniProt P32871 1 EQUAL 1068 EQUAL Reactome Database ID Release 82 10145661 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145661 Reactome R-BTA-74787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74787.1 1 Converted from EntitySet in Reactome PI3K-regulatory subunits Reactome DB_ID: 10149049 PIK3R1 PIK3R1 P23727 Reactome DB_ID: 10145651 UniProt:P23727 PIK3R1 UniProt P23727 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10145651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145651 Reactome R-BTA-74789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74789.1 PIK3R2 PIK3R2 P23726 Reactome DB_ID: 10145655 UniProt:P23726 PIK3R2 UniProt P23726 1 EQUAL 728 EQUAL Reactome Database ID Release 82 10145655 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145655 Reactome R-BTA-74791 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74791.1 PIK3R3 PIK3R3 F1MDQ5 Reactome DB_ID: 10149047 UniProt:F1MDQ5 PIK3R3 UniProt F1MDQ5 1 EQUAL 461 EQUAL Reactome Database ID Release 82 10149047 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149047 Reactome R-BTA-205223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-205223.1 Reactome Database ID Release 82 10149049 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149049 Reactome R-BTA-391342 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-391342.1 1 Reactome Database ID Release 82 10149051 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149051 Reactome R-BTA-198379 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198379.1 RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha Reactome DB_ID: 10149053 1 1 Reactome Database ID Release 82 10149053 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149053 Reactome R-BTA-114540 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-114540.1 Reactome Database ID Release 82 10149055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149055 Reactome R-BTA-114542 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-114542.1 PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation. 8645157 Pubmed 1996 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase Bokoch, GM Vlahos, CJ Wang, Y Knaus, UG Traynor-Kaplan, AE Biochem J 315:775-9 7744773 Pubmed 1995 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation Kovacsovics, TJ Bachelot, C Toker, A Vlahos, CJ Duckworth, B Cantley, Lewis C Hartwig, JH J Biol Chem 270:11358-66 11803464 Pubmed 2002 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB Murga, C Zohar, M Teramoto, H Gutkind, JS Oncogene 21:207-16 7627555 Pubmed 1995 PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase Hawkins, PT Eguinoa, A Qiu, RG Stokoe, D Cooke, FT Walters, R Wennström, S Claesson-Welsh, Lena Evans, T Symons, M Curr Biol 5:393-403 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 2.7.1.153 PI3K phosphorylates PIP2 to PIP3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 PIP2 PI(4,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Phosphatidylinositol-4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate Reactome DB_ID: 179856 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonatooxy)cyclohexyl phosphate ChEBI CHEBI:58456 Reactome Database ID Release 82 179856 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179856 Reactome R-ALL-179856 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179856.4 COMPOUND C04637 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 PIP3 PI(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Phosphatidylinositol-3,4,5-trisphosphate Reactome DB_ID: 179838 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ChEBI CHEBI:57836 Reactome Database ID Release 82 179838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179838 Reactome R-ALL-179838 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179838.4 COMPOUND C05981 ACTIVATION Converted from EntitySet in Reactome Activator:PI3K Reactome DB_ID: 10196726 PI3K:p-KIT:sSCF dimer:p-KIT Reactome DB_ID: 10161514 p-7Y-KIT:sSCF dimer:p-7Y-KIT Reactome DB_ID: 10161479 A0A452DHX3 phospho-p-7Y-KIT Reactome DB_ID: 10161477 UniProt:A0A452DHX3 UniProt A0A452DHX3 568 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 570 EQUAL 703 EQUAL 721 EQUAL 730 EQUAL 823 EQUAL 936 EQUAL 26 EQUAL 976 EQUAL Reactome Database ID Release 82 10161477 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10161477 Reactome R-BTA-205207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-205207.1 2 sSCF dimer Reactome DB_ID: 10161456 extracellular region GENE ONTOLOGY GO:0005576 KITLG KITLG-1(26-190) Q28132 Reactome DB_ID: 10161454 UniProt:Q28132 KITLG UniProt Q28132 26 EQUAL 190 EQUAL Reactome Database ID Release 82 10161454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10161454 Reactome R-BTA-708330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-708330.1 2 Reactome Database ID Release 82 10161456 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10161456 Reactome R-BTA-1433307 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1433307.1 1 Reactome Database ID Release 82 10161479 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10161479 Reactome R-BTA-205310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-205310.1 1 1 Reactome Database ID Release 82 10161514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10161514 Reactome R-BTA-205177 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-205177.1 CD28:PI3K Reactome DB_ID: 10167928 phospho CD28:B7-1/B7-2 Reactome DB_ID: 10167833 Converted from EntitySet in Reactome FYN,LCK Reactome DB_ID: 10167831 FYN A0JNB0 Reactome DB_ID: 10149234 UniProt:A0JNB0 UniProt A0JNB0 2 EQUAL 537 EQUAL Reactome Database ID Release 82 10149234 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10149234 Reactome R-BTA-200917 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-200917.1 LCK Q3ZCM0 Reactome DB_ID: 10159966 UniProt:Q3ZCM0 UniProt Q3ZCM0 1 EQUAL 509 EQUAL Reactome Database ID Release 82 10159966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10159966 Reactome R-BTA-167609 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-167609.1 Reactome Database ID Release 82 10167831 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167831 Reactome R-BTA-2395419 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2395419.1 2 Phospho CD28 homodimer Reactome DB_ID: 10167829 A0A3Q1ND77 phospho-CD28 p-Y191-CD28 Reactome DB_ID: 10167827 UniProt:A0A3Q1ND77 CD28 UniProt A0A3Q1ND77 191 EQUAL 19 EQUAL 220 EQUAL Reactome Database ID Release 82 10167827 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167827 Reactome R-BTA-388756 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388756.1 2 Reactome Database ID Release 82 10167829 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167829 Reactome R-BTA-388778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388778.1 1 Converted from EntitySet in Reactome B7-1 homodimer/ B7-2 Reactome DB_ID: 10167808 CD80 dimer Reactome DB_ID: 10167806 CD80 CD80 A0A3S5ZP81 Reactome DB_ID: 10167804 UniProt:A0A3S5ZP81 CD80 UniProt A0A3S5ZP81 35 EQUAL 288 EQUAL Reactome Database ID Release 82 10167804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167804 Reactome R-BTA-179789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179789.1 2 Reactome Database ID Release 82 10167806 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167806 Reactome R-BTA-179787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179787.1 CD86 CD86 A0A3Q1MLL9 Reactome DB_ID: 10167796 UniProt:A0A3Q1MLL9 CD86 UniProt A0A3Q1MLL9 24 EQUAL 329 EQUAL Reactome Database ID Release 82 10167796 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167796 Reactome R-BTA-179784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179784.1 Reactome Database ID Release 82 10167808 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167808 Reactome R-BTA-388762 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388762.1 1 Reactome Database ID Release 82 10167833 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167833 Reactome R-BTA-388777 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388777.1 1 1 Reactome Database ID Release 82 10167928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167928 Reactome R-BTA-388783 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388783.1 PDGF:Phospho-PDGF receptor dimer:PI3K Reactome DB_ID: 10155520 PI3K Reactome DB_ID: 10145669 Converted from EntitySet in Reactome PI3K-regulatory subunit Reactome DB_ID: 10145657 Reactome Database ID Release 82 10145657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145657 Reactome R-BTA-74688 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74688.1 1 Converted from EntitySet in Reactome PI3K-catalytic subunit Reactome DB_ID: 10145667 PIK3CB PIK3CB F1MYM3 Reactome DB_ID: 10145665 UniProt:F1MYM3 PIK3CB UniProt F1MYM3 1 EQUAL 1070 EQUAL Reactome Database ID Release 82 10145665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145665 Reactome R-BTA-74788 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74788.1 Reactome Database ID Release 82 10145667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145667 Reactome R-BTA-74689 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74689.1 1 Reactome Database ID Release 82 10145669 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145669 Reactome R-BTA-74693 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74693.1 1 PDGF:Phospho-PDGF receptor dimer Reactome DB_ID: 10155482 Converted from EntitySet in Reactome Phospho- PDGF receptor dimer Reactome DB_ID: 10155460 Phospho-alpha receptor homodimer Reactome DB_ID: 10155438 A0A3Q1ME99 phospho-p-11Y-PDGFRA Reactome DB_ID: 10155436 UniProt:A0A3Q1ME99 UniProt A0A3Q1ME99 1018 EQUAL 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10155436 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155436 Reactome R-BTA-186806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186806.1 2 Reactome Database ID Release 82 10155438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155438 Reactome R-BTA-186816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186816.1 Phospho-alpha-Phospho-beta receptor heterodimer Reactome DB_ID: 10155456 1 A0A3Q1N3Z8 phospho-p-12Y-PDGFRB Reactome DB_ID: 10155454 UniProt:A0A3Q1N3Z8 UniProt A0A3Q1N3Z8 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10155454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155454 Reactome R-BTA-186803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186803.1 1 Reactome Database ID Release 82 10155456 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155456 Reactome R-BTA-186769 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186769.1 Phospho-beta receptor homodimer Reactome DB_ID: 10155458 2 Reactome Database ID Release 82 10155458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155458 Reactome R-BTA-186805 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186805.1 Reactome Database ID Release 82 10155460 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155460 Reactome R-BTA-186821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186821.1 1 Converted from EntitySet in Reactome Active PDGF dimers (AA, AB, BB) Reactome DB_ID: 10155480 active PDGF-AA dimer Reactome DB_ID: 10155468 PDGFA PDGFA-1 Q2KJ15 Reactome DB_ID: 10155464 UniProt:Q2KJ15 PDGFA UniProt Q2KJ15 87 EQUAL 211 EQUAL Reactome Database ID Release 82 10155464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155464 Reactome R-BTA-184199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-184199.1 2 Reactome Database ID Release 82 10155468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155468 Reactome R-BTA-380761 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-380761.1 active PDGF-BB dimer Reactome DB_ID: 10155476 PDGFB PDGFB (82-190) B1H0W5 Reactome DB_ID: 10155472 UniProt:B1H0W5 PDGFB UniProt B1H0W5 82 EQUAL 190 EQUAL Reactome Database ID Release 82 10155472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155472 Reactome R-BTA-184201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-184201.1 2 Reactome Database ID Release 82 10155476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155476 Reactome R-BTA-184206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-184206.1 PDGF A/B heterodimer Reactome DB_ID: 10155478 PDGFA PDGFA-2 Q2KJ15 Reactome DB_ID: 10155466 87 EQUAL 196 EQUAL Reactome Database ID Release 82 10155466 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155466 Reactome R-BTA-380739 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-380739.1 1 1 Reactome Database ID Release 82 10155478 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155478 Reactome R-BTA-380759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-380759.1 Reactome Database ID Release 82 10155480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155480 Reactome R-BTA-380760 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-380760.1 1 Reactome Database ID Release 82 10155482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155482 Reactome R-BTA-186811 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186811.1 1 Reactome Database ID Release 82 10155520 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155520 Reactome R-BTA-186789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-186789.1 PI3K bound to TRAT Reactome DB_ID: 10159942 1 A0A3Q1MCW9 phospho-TRAT1 p-Y63,Y79,Y110-TRAT1 Reactome DB_ID: 10159940 UniProt:A0A3Q1MCW9 TRAT1 UniProt A0A3Q1MCW9 63 EQUAL 79 EQUAL 110 EQUAL 1 EQUAL 186 EQUAL Reactome Database ID Release 82 10159940 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10159940 Reactome R-BTA-202201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-202201.1 1 Reactome Database ID Release 82 10159942 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10159942 Reactome R-BTA-202283 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-202283.1 Phospho-IRS1/2:PI3K(p85:p110) Reactome DB_ID: 10157751 1 Converted from EntitySet in Reactome Phospho-IRS1/2 (by TRKA) Reactome DB_ID: 10157749 F1MYE0 phospho-IRS1 p-Y-IRS1 Reactome DB_ID: 10157745 UniProt:F1MYE0 IRS1 UniProt F1MYE0 1 EQUAL 1242 EQUAL Reactome Database ID Release 82 10157745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10157745 Reactome R-BTA-198366 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198366.1 F1MJE0 phospho-IRS2 p-Y-IRS2 Reactome DB_ID: 10157747 UniProt:F1MJE0 IRS2 UniProt F1MJE0 1 EQUAL 1338 EQUAL Reactome Database ID Release 82 10157747 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10157747 Reactome R-BTA-198334 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198334.1 Reactome Database ID Release 82 10157749 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10157749 Reactome R-BTA-198369 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198369.1 1 Reactome Database ID Release 82 10157751 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10157751 Reactome R-BTA-198344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198344.1 EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K Reactome DB_ID: 10184362 EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10184360 PIK3R1 PIK3R1 P23727 Reactome DB_ID: 10183563 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10183563 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183563 Reactome R-BTA-198365 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198365.1 1 EGF:p-EGFR:p-ERBB2:GRB2:GAB1 Reactome DB_ID: 10184358 Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers Reactome DB_ID: 10184356 Reactome Database ID Release 82 10184356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184356 Reactome R-BTA-1963587 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963587.1 1 GRB2:GAB1 Reactome DB_ID: 10154951 GAB1 GAB1 A6QLU3 Reactome DB_ID: 10147356 UniProt:A6QLU3 GAB1 UniProt A6QLU3 1 EQUAL 694 EQUAL Reactome Database ID Release 82 10147356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147356 Reactome R-BTA-179795 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179795.1 1 GRB2 GRB2-1 Q3T0F9 Reactome DB_ID: 10145637 UniProt:Q3T0F9 GRB2 UniProt Q3T0F9 1 EQUAL 217 EQUAL Reactome Database ID Release 82 10145637 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145637 Reactome R-BTA-74686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74686.1 1 Reactome Database ID Release 82 10154951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154951 Reactome R-BTA-179849 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179849.1 1 Reactome Database ID Release 82 10184358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184358 Reactome R-BTA-1306958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1306958.1 1 Reactome Database ID Release 82 10184360 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184360 Reactome R-BTA-1306962 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1306962.1 1 1 Reactome Database ID Release 82 10184362 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184362 Reactome R-BTA-1306961 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1306961.1 NRG1/2:p-ERBB3:p-ERBB2:PI3K Reactome DB_ID: 10183567 1 NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 Reactome DB_ID: 10183565 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB3 heterodimers Reactome DB_ID: 10183561 NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 Reactome DB_ID: 10183554 F1MCQ7 phospho-p-Y-ERBB2 Reactome DB_ID: 10183552 UniProt:F1MCQ7 UniProt F1MCQ7 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10183552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183552 Reactome R-BTA-1678589 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1678589.1 1 NRG1/2:p-10Y-ERBB3 Reactome DB_ID: 10183549 Converted from EntitySet in Reactome NRG1/2 Neuregulins NRG1 and NRG2 Reactome DB_ID: 10183485 NRG2 NRG2 G3N104 Reactome DB_ID: 10183088 UniProt:G3N104 NRG2 UniProt G3N104 112 EQUAL 404 EQUAL Reactome Database ID Release 82 10183088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183088 Reactome R-BTA-1227953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1227953.1 NRG1 NRG1 F1MPD0 Reactome DB_ID: 10183084 UniProt:F1MPD0 NRG1 UniProt F1MPD0 20 EQUAL 241 EQUAL Reactome Database ID Release 82 10183084 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183084 Reactome R-BTA-1227951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1227951.1 Reactome Database ID Release 82 10183485 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183485 Reactome R-BTA-1227956 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1227956.1 1 A6QR62 phospho-p-10Y-ERBB3-1 Reactome DB_ID: 10183547 UniProt:A6QR62 UniProt A6QR62 1328 EQUAL 1054 EQUAL 1197 EQUAL 1199 EQUAL 1222 EQUAL 1224 EQUAL 1260 EQUAL 1262 EQUAL 1276 EQUAL 1289 EQUAL 20 EQUAL 1342 EQUAL Reactome Database ID Release 82 10183547 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183547 Reactome R-BTA-1248742 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1248742.1 1 Reactome Database ID Release 82 10183549 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183549 Reactome R-BTA-1248743 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1248743.1 1 Reactome Database ID Release 82 10183554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183554 Reactome R-BTA-1963583 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963583.1 NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 Reactome DB_ID: 10183559 1 F1MCQ7 phospho-p-Y,Y877-ERBB2 Reactome DB_ID: 10183557 877 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10183557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183557 Reactome R-BTA-1810446 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1810446.1 1 Reactome Database ID Release 82 10183559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183559 Reactome R-BTA-1248749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1248749.1 Reactome Database ID Release 82 10183561 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183561 Reactome R-BTA-1963572 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963572.1 1 Reactome Database ID Release 82 10183565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183565 Reactome R-BTA-1250191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250191.1 1 Reactome Database ID Release 82 10183567 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183567 Reactome R-BTA-1250508 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250508.1 NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K Reactome DB_ID: 10183667 PIK3CA:PIK3R1 Reactome DB_ID: 10155069 1 1 Reactome Database ID Release 82 10155069 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155069 Reactome R-BTA-1806218 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806218.1 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB4cyt1 heterodimers Reactome DB_ID: 10183665 NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 Reactome DB_ID: 10183601 F1MCQ7 phospho-p-6Y-ERBB2 Reactome DB_ID: 10183583 1023 EQUAL 1139 EQUAL 1196 EQUAL 1221 EQUAL 1222 EQUAL 1248 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10183583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183583 Reactome R-BTA-1963569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963569.1 1 NRGs/EGF-like ligands:p-ERBB4cyt1 Reactome DB_ID: 10183599 Converted from EntitySet in Reactome NRGs/EGF-like ligands Neuregulins/EGF-like ligands Reactome DB_ID: 10183096 Converted from EntitySet in Reactome EGF-like ligands EGF-like growth factors Reactome DB_ID: 10183080 BTC BTC(32-111) A2VE27 Reactome DB_ID: 10154973 UniProt:A2VE27 BTC UniProt A2VE27 32 EQUAL 111 EQUAL Reactome Database ID Release 82 10154973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154973 Reactome R-BTA-1233224 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1233224.1 EREG EREG(60-108) E1BBE2 Reactome DB_ID: 10154977 UniProt:E1BBE2 EREG UniProt E1BBE2 60 EQUAL 108 EQUAL Reactome Database ID Release 82 10154977 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154977 Reactome R-BTA-1233233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1233233.1 HBEGF HBEGF(63-148) E1BIN8 Reactome DB_ID: 10154981 UniProt:E1BIN8 HBEGF UniProt E1BIN8 63 EQUAL 148 EQUAL Reactome Database ID Release 82 10154981 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154981 Reactome R-BTA-1233234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1233234.1 Reactome Database ID Release 82 10183080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183080 Reactome R-BTA-1233230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1233230.1 Converted from EntitySet in Reactome NRG1/2/3/4 Neuregulins Reactome DB_ID: 10183094 NRG3 NRG3 F1MS28 Reactome DB_ID: 10183092 UniProt:F1MS28 NRG3 UniProt F1MS28 1 EQUAL 359 EQUAL Reactome Database ID Release 82 10183092 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183092 Reactome R-BTA-1227943 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1227943.1 Reactome Database ID Release 82 10183094 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183094 Reactome R-BTA-1227957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1227957.1 Reactome Database ID Release 82 10183096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183096 Reactome R-BTA-1233236 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1233236.1 1 Converted from EntitySet in Reactome p-ERBB4cyt1 Reactome DB_ID: 10183597 A0A3Q1MKB4 phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform Reactome DB_ID: 10183590 UniProt:A0A3Q1MKB4 UniProt A0A3Q1MKB4 1056 EQUAL 1188 EQUAL 1242 EQUAL 26 EQUAL 1308 EQUAL Reactome Database ID Release 82 10183590 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183590 Reactome R-BTA-1250319 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250319.1 A0A3Q1MKB4 phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform Reactome DB_ID: 10183595 1046 EQUAL 1178 EQUAL 1232 EQUAL 26 EQUAL 1298 EQUAL Reactome Database ID Release 82 10183595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183595 Reactome R-BTA-1250313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250313.1 Reactome Database ID Release 82 10183597 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183597 Reactome R-BTA-1250325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250325.1 1 Reactome Database ID Release 82 10183599 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183599 Reactome R-BTA-1250305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250305.1 1 Reactome Database ID Release 82 10183601 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183601 Reactome R-BTA-1250316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250316.1 NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 Reactome DB_ID: 10183609 F1MCQ7 phospho-p-7Y-ERBB2 Reactome DB_ID: 10183607 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10183607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183607 Reactome R-BTA-1248698 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1248698.1 1 1 Reactome Database ID Release 82 10183609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183609 Reactome R-BTA-1963579 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963579.1 Reactome Database ID Release 82 10183665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183665 Reactome R-BTA-1963568 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1963568.1 1 Reactome Database ID Release 82 10183667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183667 Reactome R-BTA-1306974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1306974.1 PI3K:p-ERBB4cyt1 Reactome DB_ID: 10183678 Converted from EntitySet in Reactome p-ERBB4cyt1 homodimers Phosphorylated ERBB4cyt1 homodimers Reactome DB_ID: 10183658 p-ERBB4jmAcyt1 Reactome DB_ID: 10183652 NRGs/EGF-like ligands:P-ERBB4jmAcyt1 Reactome DB_ID: 10183650 1 1 Reactome Database ID Release 82 10183650 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183650 Reactome R-BTA-1251957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1251957.1 2 Reactome Database ID Release 82 10183652 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183652 Reactome R-BTA-1251953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1251953.1 p-ERBB4jmBcyt1 Reactome DB_ID: 10183656 NRGs/EGF-like ligands:P-ERBB4jmBcyt1 Reactome DB_ID: 10183654 1 1 Reactome Database ID Release 82 10183654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183654 Reactome R-BTA-1251958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1251958.1 2 Reactome Database ID Release 82 10183656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183656 Reactome R-BTA-1251954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1251954.1 Reactome Database ID Release 82 10183658 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183658 Reactome R-BTA-1250351 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250351.1 1 1 Reactome Database ID Release 82 10183678 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183678 Reactome R-BTA-1250373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1250373.1 EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K Reactome DB_ID: 10155071 EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 Reactome DB_ID: 10155037 EGF-like ligands:p-6Y EGFR dimer Reactome DB_ID: 10155035 Converted from EntitySet in Reactome EGF-like ligands Reactome DB_ID: 10154983 TGFA TGFA(24-98) A0A3Q1M7J4 Reactome DB_ID: 10154961 UniProt:A0A3Q1M7J4 TGFA UniProt A0A3Q1M7J4 24 EQUAL 98 EQUAL Reactome Database ID Release 82 10154961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154961 Reactome R-BTA-9624183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9624183.1 AREG AREG(101-187) F1MEV4 Reactome DB_ID: 10154965 UniProt:F1MEV4 AREG UniProt F1MEV4 101 EQUAL 187 EQUAL Reactome Database ID Release 82 10154965 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154965 Reactome R-BTA-9624190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9624190.1 EPGN EPGN(23-154) E1BDM2 Reactome DB_ID: 10154969 UniProt:E1BDM2 EPGN UniProt E1BDM2 23 EQUAL 154 EQUAL Reactome Database ID Release 82 10154969 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154969 Reactome R-BTA-9624187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9624187.1 Reactome Database ID Release 82 10154983 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10154983 Reactome R-BTA-9624194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9624194.1 2 A0A3Q1MHB0 phospho-p-6Y-EGFR Reactome DB_ID: 10155033 UniProt:A0A3Q1MHB0 UniProt A0A3Q1MHB0 992 EQUAL 1045 EQUAL 1068 EQUAL 1086 EQUAL 1148 EQUAL 1173 EQUAL 25 EQUAL 1210 EQUAL Reactome Database ID Release 82 10155033 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155033 Reactome R-BTA-179803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179803.1 2 Reactome Database ID Release 82 10155035 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155035 Reactome R-BTA-9624425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9624425.1 1 Converted from EntitySet in Reactome GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 Reactome DB_ID: 10155025 GRB2:Phospho-GAB1 Reactome DB_ID: 10155021 A6QLU3 phospho-GAB1 p-5Y-GAB1 Reactome DB_ID: 10155019 627 EQUAL 659 EQUAL 447 EQUAL 472 EQUAL 589 EQUAL 1 EQUAL 694 EQUAL Reactome Database ID Release 82 10155019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155019 Reactome R-BTA-180344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-180344.1 1 1 Reactome Database ID Release 82 10155021 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155021 Reactome R-BTA-180304 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-180304.1 GRB2:p-5Y-GAB1:PIP3 Reactome DB_ID: 10155023 1 1 Reactome Database ID Release 82 10155023 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155023 Reactome R-BTA-9038396 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9038396.1 Reactome Database ID Release 82 10155025 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155025 Reactome R-BTA-9038398 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9038398.1 1 Reactome Database ID Release 82 10155037 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155037 Reactome R-BTA-180286 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-180286.1 1 1 Reactome Database ID Release 82 10155071 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155071 Reactome R-BTA-179791 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179791.1 CD19 Signalosome Reactome DB_ID: 10193864 F1N586 phospho-CD19 p-6Y-CD19 Reactome DB_ID: 10193862 UniProt:F1N586 CD19 UniProt F1N586 348 EQUAL 378 EQUAL 409 EQUAL 439 EQUAL 500 EQUAL 531 EQUAL 20 EQUAL 556 EQUAL Reactome Database ID Release 82 10193862 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10193862 Reactome R-BTA-2076270 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2076270.1 1 VAV1 VAV1 Q08DN7 Reactome DB_ID: 10182379 UniProt:Q08DN7 VAV1 UniProt Q08DN7 1 EQUAL 845 EQUAL Reactome Database ID Release 82 10182379 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10182379 Reactome R-BTA-1045153 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1045153.1 1 GRB2 GRB2-1 Q3T0F9 Reactome DB_ID: 10181832 1 EQUAL 217 EQUAL Reactome Database ID Release 82 10181832 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181832 Reactome R-BTA-202993 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-202993.1 1 PIK3CD:PIK3R1 Reactome DB_ID: 10193552 1 PIK3CD PIK3CD E1BE66 Reactome DB_ID: 10175200 UniProt:E1BE66 PIK3CD UniProt E1BE66 1 EQUAL 1044 EQUAL Reactome Database ID Release 82 10175200 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10175200 Reactome R-BTA-392274 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-392274.1 1 Reactome Database ID Release 82 10193552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10193552 Reactome R-BTA-1045152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1045152.1 1 Reactome Database ID Release 82 10193864 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10193864 Reactome R-BTA-2076233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2076233.1 BCAP Signalosome Reactome DB_ID: 10193554 A0A3Q1M535 phospho-PIK3AP1 p-4Y-PIK3AP1 Reactome DB_ID: 10193550 UniProt:A0A3Q1M535 PIK3AP1 UniProt A0A3Q1M535 263 EQUAL 419 EQUAL 444 EQUAL 459 EQUAL 1 EQUAL 805 EQUAL Reactome Database ID Release 82 10193550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10193550 Reactome R-BTA-984814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-984814.1 1 1 Reactome Database ID Release 82 10193554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10193554 Reactome R-BTA-2045909 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2045909.1 ICOS:PI3K Reactome DB_ID: 10167919 Q58DF9 phospho-ICOS p-Y180-ICOS Reactome DB_ID: 10167917 UniProt:Q58DF9 ICOS UniProt Q58DF9 180 EQUAL 21 EQUAL 199 EQUAL Reactome Database ID Release 82 10167917 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167917 Reactome R-BTA-389927 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-389927.1 1 1 Reactome Database ID Release 82 10167919 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10167919 Reactome R-BTA-388785 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-388785.1 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10196646 1 Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196644 GRB2:GAB1:PIK3R1 Reactome DB_ID: 10155089 1 1 Reactome Database ID Release 82 10155089 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10155089 Reactome R-BTA-179864 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-179864.1 1 Activated FGFR1:p-FRS2 Reactome DB_ID: 10196642 Converted from EntitySet in Reactome Activated FGFR1 Reactome DB_ID: 10196640 Activated FGFR1b homodimer Reactome DB_ID: 10147394 Converted from EntitySet in Reactome FGFR1b-binding FGFs Reactome DB_ID: 10147378 FGF1 P03968 Reactome DB_ID: 10147360 UniProt:P03968 UniProt P03968 16 EQUAL 155 EQUAL Reactome Database ID Release 82 10147360 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147360 Reactome R-BTA-189856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189856.1 P03969 FGF2(10-155) Reactome DB_ID: 10147364 UniProt:P03969 UniProt P03969 10 EQUAL 155 EQUAL Reactome Database ID Release 82 10147364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147364 Reactome R-BTA-189898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189898.1 FGF3 FGF3 E1BGY3 Reactome DB_ID: 10147368 UniProt:E1BGY3 FGF3 UniProt E1BGY3 18 EQUAL 239 EQUAL Reactome Database ID Release 82 10147368 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147368 Reactome R-BTA-189886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189886.1 FGF10 FGF10 A0A3Q1NAV6 Reactome DB_ID: 10147372 UniProt:A0A3Q1NAV6 FGF10 UniProt A0A3Q1NAV6 38 EQUAL 208 EQUAL Reactome Database ID Release 82 10147372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147372 Reactome R-BTA-189869 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189869.1 FGF22 FGF22 A0A3Q1NNL0 Reactome DB_ID: 10147376 UniProt:A0A3Q1NNL0 FGF22 UniProt A0A3Q1NNL0 23 EQUAL 170 EQUAL Reactome Database ID Release 82 10147376 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147376 Reactome R-BTA-189877 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189877.1 Reactome Database ID Release 82 10147378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147378 Reactome R-BTA-189963 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189963.1 2 HS Heparan Sulphate heparan sulfate Reactome DB_ID: 190915 heparan sulfate [ChEBI:28815] heparan sulfate N-Acetylheparan sulfate Heparin monosulfate Heparatan sulfate Heparitin monosulfate Heparan sulphate Heparan N-sulfate Heparitin sulfate Heparin sulfate ChEBI CHEBI:28815 Reactome Database ID Release 82 190915 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190915 Reactome R-ALL-190915 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-190915.3 1 p-8Y-FGFR1b dimer Reactome DB_ID: 10147392 A0A3Q1LUE0 phospho-p-8Y-FGFR1b Reactome DB_ID: 10147390 UniProt:A0A3Q1LUE0 UniProt A0A3Q1LUE0 463 EQUAL 583 EQUAL 585 EQUAL 653 EQUAL 654 EQUAL 730 EQUAL 766 EQUAL 776 EQUAL 2 EQUAL 822 EQUAL Reactome Database ID Release 82 10147390 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147390 Reactome R-BTA-5656338 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5656338.1 2 Reactome Database ID Release 82 10147392 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147392 Reactome R-BTA-5656340 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5656340.1 1 Reactome Database ID Release 82 10147394 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147394 Reactome R-BTA-190430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190430.1 Activated FGFR1c homodimer Reactome DB_ID: 10147433 A0A3Q1LUE0 phospho-p-8Y-FGFR1c Reactome DB_ID: 10147431 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10147431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147431 Reactome R-BTA-190434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190434.1 2 Converted from EntitySet in Reactome FGFR1c-binding FGFs Reactome DB_ID: 10147429 Fgf4 FGF4 G3XGD3 Reactome DB_ID: 10147398 UniProt:G3XGD3 Fgf4 UniProt G3XGD3 31 EQUAL 206 EQUAL Reactome Database ID Release 82 10147398 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147398 Reactome R-BTA-189907 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189907.1 FGF5 FGF5-1 A0MTF4 Reactome DB_ID: 10147402 UniProt:A0MTF4 FGF5 UniProt A0MTF4 18 EQUAL 268 EQUAL Reactome Database ID Release 82 10147402 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147402 Reactome R-BTA-189903 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189903.1 FGF6 FGF6 E1BHC1 Reactome DB_ID: 10147406 UniProt:E1BHC1 FGF6 UniProt E1BHC1 38 EQUAL 208 EQUAL Reactome Database ID Release 82 10147406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147406 Reactome R-BTA-189881 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189881.1 FGF8 FGF8-1 F1N6G8 Reactome DB_ID: 10147410 UniProt:F1N6G8 FGF8 UniProt F1N6G8 23 EQUAL 233 EQUAL Reactome Database ID Release 82 10147410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147410 Reactome R-BTA-189892 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189892.1 FGF9 FGF9 D8KXU9 Reactome DB_ID: 10147414 UniProt:D8KXU9 FGF9 UniProt D8KXU9 4 EQUAL 208 EQUAL Reactome Database ID Release 82 10147414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147414 Reactome R-BTA-189870 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189870.1 FGF17 FGF17-1 G3MXR4 Reactome DB_ID: 10147418 UniProt:G3MXR4 FGF17 UniProt G3MXR4 23 EQUAL 216 EQUAL Reactome Database ID Release 82 10147418 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147418 Reactome R-BTA-189914 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189914.1 FGF20 FGF20 E1BP37 Reactome DB_ID: 10147422 UniProt:E1BP37 FGF20 UniProt E1BP37 1 EQUAL 211 EQUAL Reactome Database ID Release 82 10147422 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147422 Reactome R-BTA-189862 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189862.1 FGF23 GalNAc-T178-FGF23(25-251) E1BJU2 Reactome DB_ID: 10147427 UniProt:E1BJU2 FGF23 UniProt E1BJU2 178 EQUAL O-(N-acetylamino)galactosyl-L-threonine MOD MOD:00164 25 EQUAL 251 EQUAL Reactome Database ID Release 82 10147427 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147427 Reactome R-BTA-8851633 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8851633.1 Reactome Database ID Release 82 10147429 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147429 Reactome R-BTA-189953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189953.1 2 1 Reactome Database ID Release 82 10147433 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147433 Reactome R-BTA-190425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190425.1 Activated FGFR1c bound to FGF23:Klotho Reactome DB_ID: 10147453 2 1 Klotho bound to FGF23 Reactome DB_ID: 10147451 FGF23 FGF23(25-251) E1BJU2 Reactome DB_ID: 10147435 25 EQUAL 251 EQUAL Reactome Database ID Release 82 10147435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147435 Reactome R-BTA-189891 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189891.1 1 Klotho homodimer Reactome DB_ID: 10147449 Converted from EntitySet in Reactome Klotho Reactome DB_ID: 10147447 Membrane-bound Klotho homodimer Reactome DB_ID: 10147441 KL KL-1 E1BAI2 Reactome DB_ID: 10147439 UniProt:E1BAI2 KL UniProt E1BAI2 34 EQUAL 1012 EQUAL Reactome Database ID Release 82 10147439 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147439 Reactome R-BTA-190198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190198.1 2 Reactome Database ID Release 82 10147441 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147441 Reactome R-BTA-190204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190204.1 Secreted Klotho homodimer Reactome DB_ID: 10147445 KL KL-2 E1BAI2 Reactome DB_ID: 10147443 34 EQUAL 549 EQUAL Reactome Database ID Release 82 10147443 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147443 Reactome R-BTA-190201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190201.1 2 Reactome Database ID Release 82 10147445 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147445 Reactome R-BTA-190203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190203.1 Reactome Database ID Release 82 10147447 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147447 Reactome R-BTA-190207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190207.1 2 Reactome Database ID Release 82 10147449 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147449 Reactome R-BTA-190309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190309.1 1 Reactome Database ID Release 82 10147451 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147451 Reactome R-BTA-190208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190208.1 2 Reactome Database ID Release 82 10147453 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147453 Reactome R-BTA-500333 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-500333.1 Reactome Database ID Release 82 10196640 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196640 Reactome R-BTA-5654170 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654170.1 1 E1B7I9 phospho-FRS2 p-6Y-FRS2 Reactome DB_ID: 10147578 UniProt:E1B7I9 FRS2 UniProt E1B7I9 436 EQUAL 196 EQUAL 306 EQUAL 349 EQUAL 392 EQUAL 471 EQUAL 1 EQUAL 508 EQUAL Reactome Database ID Release 82 10147578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147578 Reactome R-BTA-170959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-170959.1 1 Reactome Database ID Release 82 10196642 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196642 Reactome R-BTA-5654200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654200.1 1 Reactome Database ID Release 82 10196644 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196644 Reactome R-BTA-5654186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654186.1 1 Reactome Database ID Release 82 10196646 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196646 Reactome R-BTA-5654205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654205.1 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10196654 Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196652 1 Activated FGFR2:p-FRS2 Reactome DB_ID: 10196650 Converted from EntitySet in Reactome Activated FGFR2 Reactome DB_ID: 10196648 Converted from EntitySet in Reactome Activated FGFR2b homodimer bound to FGF Reactome DB_ID: 10147486 Activated FGFR2b long homodimer Reactome DB_ID: 10147473 Converted from EntitySet in Reactome FGFR2b-binding FGFs Reactome DB_ID: 10147459 FGF7 FGF7 A0A3Q1M3Q3 Reactome DB_ID: 10147457 UniProt:A0A3Q1M3Q3 FGF7 UniProt A0A3Q1M3Q3 32 EQUAL 194 EQUAL Reactome Database ID Release 82 10147457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147457 Reactome R-BTA-189884 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189884.1 Reactome Database ID Release 82 10147459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147459 Reactome R-BTA-189967 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189967.1 2 A0A3Q1LRU7 phospho-p-8Y-FGFR2-3 Reactome DB_ID: 10147471 UniProt:A0A3Q1LRU7 UniProt A0A3Q1LRU7 467 EQUAL 587 EQUAL 589 EQUAL 657 EQUAL 658 EQUAL 734 EQUAL 770 EQUAL 780 EQUAL 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10147471 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147471 Reactome R-BTA-190412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190412.1 2 1 Reactome Database ID Release 82 10147473 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147473 Reactome R-BTA-190411 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190411.1 Activated FGFR2b short homodimer bound to FGF Reactome DB_ID: 10147484 2 A0A3Q1LRU7 phospho-Phosphorylated Fibroblast growth factor receptor 2b short Reactome DB_ID: 10147482 465 EQUAL 585 EQUAL 655 EQUAL 656 EQUAL 732 EQUAL 768 EQUAL 778 EQUAL 22 EQUAL 820 EQUAL Reactome Database ID Release 82 10147482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147482 Reactome R-BTA-192603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192603.1 2 1 Reactome Database ID Release 82 10147484 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147484 Reactome R-BTA-192597 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192597.1 Reactome Database ID Release 82 10147486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147486 Reactome R-BTA-192606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192606.1 Converted from EntitySet in Reactome Activated FGFR2c homodimer bound to FGF Reactome DB_ID: 10147517 Activated FGFR2c long homodimer Reactome DB_ID: 10147506 Converted from EntitySet in Reactome FGFR2c-binding FGFs Reactome DB_ID: 10147496 FGF16 FGF16 F1MHC6 Reactome DB_ID: 10147490 UniProt:F1MHC6 FGF16 UniProt F1MHC6 1 EQUAL 207 EQUAL Reactome Database ID Release 82 10147490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147490 Reactome R-BTA-189918 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189918.1 FGF18 FGF18 F2Z4J0 Reactome DB_ID: 10147494 UniProt:F2Z4J0 FGF18 UniProt F2Z4J0 28 EQUAL 207 EQUAL Reactome Database ID Release 82 10147494 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147494 Reactome R-BTA-189905 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189905.1 Reactome Database ID Release 82 10147496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147496 Reactome R-BTA-189957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189957.1 2 1 A0A3Q1LRU7 phospho-p-8Y-FGFR2c long Reactome DB_ID: 10147504 466 EQUAL 586 EQUAL 588 EQUAL 733 EQUAL 769 EQUAL 779 EQUAL 22 EQUAL 821 EQUAL Reactome Database ID Release 82 10147504 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147504 Reactome R-BTA-190416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190416.1 2 Reactome Database ID Release 82 10147506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147506 Reactome R-BTA-190418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190418.1 Activated FGFR2c short homodimer bound to FGF Reactome DB_ID: 10147515 2 1 A0A3Q1LRU7 phospho-p-8Y-FGFR2-5 Reactome DB_ID: 10147513 464 EQUAL 584 EQUAL 654 EQUAL 731 EQUAL 767 EQUAL 22 EQUAL 819 EQUAL Reactome Database ID Release 82 10147513 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147513 Reactome R-BTA-192600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192600.1 2 Reactome Database ID Release 82 10147515 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147515 Reactome R-BTA-192592 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192592.1 Reactome Database ID Release 82 10147517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147517 Reactome R-BTA-192616 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-192616.1 Reactome Database ID Release 82 10196648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196648 Reactome R-BTA-5654152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654152.1 1 1 Reactome Database ID Release 82 10196650 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196650 Reactome R-BTA-5654201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654201.1 1 Reactome Database ID Release 82 10196652 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196652 Reactome R-BTA-5654189 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654189.1 1 1 Reactome Database ID Release 82 10196654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196654 Reactome R-BTA-5654190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654190.1 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10196662 Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196660 1 Activated FGFR3:p-FRS2 Reactome DB_ID: 10196658 Converted from EntitySet in Reactome Activated FGFR3 Reactome DB_ID: 10196656 Activated FGFR3b homodimer Reactome DB_ID: 10147531 A0A3Q1MPT9 phospho-p-6Y-FGFR3b Reactome DB_ID: 10147529 UniProt:A0A3Q1MPT9 UniProt A0A3Q1MPT9 579 EQUAL 649 EQUAL 650 EQUAL 726 EQUAL 762 EQUAL 772 EQUAL 23 EQUAL 806 EQUAL Reactome Database ID Release 82 10147529 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147529 Reactome R-BTA-190384 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190384.1 2 1 Converted from EntitySet in Reactome FGFR3b-binding FGFs Reactome DB_ID: 10147519 Reactome Database ID Release 82 10147519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147519 Reactome R-BTA-189964 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189964.1 2 Reactome Database ID Release 82 10147531 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147531 Reactome R-BTA-190380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190380.1 Activated FGFR3c homodimer Reactome DB_ID: 10147543 1 A0A3Q1MPT9 phospho-p-6Y-FGFR3c Reactome DB_ID: 10147541 577 EQUAL 647 EQUAL 648 EQUAL 724 EQUAL 760 EQUAL 770 EQUAL 23 EQUAL 808 EQUAL Reactome Database ID Release 82 10147541 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147541 Reactome R-BTA-190382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190382.1 2 Converted from EntitySet in Reactome FGFR3c-binding FGFs Reactome DB_ID: 10147533 Reactome Database ID Release 82 10147533 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147533 Reactome R-BTA-189955 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189955.1 2 Reactome Database ID Release 82 10147543 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147543 Reactome R-BTA-190389 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190389.1 Reactome Database ID Release 82 10196656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196656 Reactome R-BTA-5654146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654146.1 1 1 Reactome Database ID Release 82 10196658 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196658 Reactome R-BTA-5654196 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654196.1 1 Reactome Database ID Release 82 10196660 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196660 Reactome R-BTA-5654203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654203.1 1 1 Reactome Database ID Release 82 10196662 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196662 Reactome R-BTA-5654195 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654195.1 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10196670 Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196668 Activated FGFR4:p-FRS2 Reactome DB_ID: 10196666 Converted from EntitySet in Reactome Activated FGFR4 Reactome DB_ID: 10196664 Activated FGFR4 homodimer Reactome DB_ID: 10147560 F1MN51 phospho-p-5Y-FGFR4 Reactome DB_ID: 10147552 UniProt:F1MN51 UniProt F1MN51 643 EQUAL 642 EQUAL 719 EQUAL 754 EQUAL 764 EQUAL 22 EQUAL 802 EQUAL Reactome Database ID Release 82 10147552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147552 Reactome R-BTA-190330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190330.1 2 1 Converted from EntitySet in Reactome FGFR4-binding FGFs Reactome DB_ID: 10147558 FGF19 FGF19 E1BFP8 Reactome DB_ID: 10147556 UniProt:E1BFP8 FGF19 UniProt E1BFP8 25 EQUAL 216 EQUAL Reactome Database ID Release 82 10147556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147556 Reactome R-BTA-189888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189888.1 Reactome Database ID Release 82 10147558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147558 Reactome R-BTA-189959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-189959.1 2 Reactome Database ID Release 82 10147560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147560 Reactome R-BTA-190328 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-190328.1 Activated FGFR4 bound to FGF19:BetaKlotho Reactome DB_ID: 10147566 2 KLB KLB F1N4S9 Reactome DB_ID: 10147564 UniProt:F1N4S9 KLB UniProt F1N4S9 1 EQUAL 1044 EQUAL Reactome Database ID Release 82 10147564 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147564 Reactome R-BTA-1307932 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1307932.1 2 2 Reactome Database ID Release 82 10147566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147566 Reactome R-BTA-1307958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1307958.1 Reactome Database ID Release 82 10196664 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196664 Reactome R-BTA-5654158 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654158.1 1 1 Reactome Database ID Release 82 10196666 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196666 Reactome R-BTA-5654193 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654193.1 1 1 Reactome Database ID Release 82 10196668 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196668 Reactome R-BTA-5654191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654191.1 1 1 Reactome Database ID Release 82 10196670 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196670 Reactome R-BTA-5654187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654187.1 Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10196676 Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196674 1 Activated FGFR1:p-FRS2:p-PTPN11 Reactome DB_ID: 10196672 F1N339 phospho-p-Y546,Y584-PTPN11 Reactome DB_ID: 10147586 UniProt:F1N339 UniProt F1N339 546 EQUAL 584 EQUAL 1 EQUAL 597 EQUAL Reactome Database ID Release 82 10147586 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147586 Reactome R-BTA-162573 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-162573.1 1 1 Reactome Database ID Release 82 10196672 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196672 Reactome R-BTA-5654204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654204.1 1 Reactome Database ID Release 82 10196674 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196674 Reactome R-BTA-5654185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654185.1 1 1 Reactome Database ID Release 82 10196676 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196676 Reactome R-BTA-5654188 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654188.1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10196682 1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196680 Activated FGFR2:p-FRS2:p-PTPN11 Reactome DB_ID: 10196678 1 1 Reactome Database ID Release 82 10196678 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196678 Reactome R-BTA-5654184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654184.1 1 1 Reactome Database ID Release 82 10196680 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196680 Reactome R-BTA-5654194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654194.1 1 Reactome Database ID Release 82 10196682 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196682 Reactome R-BTA-5654192 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654192.1 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10196688 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10196686 1 Activated FGFR3:p-FRS2:p-PTPN11 Reactome DB_ID: 10196684 1 1 Reactome Database ID Release 82 10196684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196684 Reactome R-BTA-5654198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654198.1 1 Reactome Database ID Release 82 10196686 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196686 Reactome R-BTA-5654199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654199.1 1 1 Reactome Database ID Release 82 10196688 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196688 Reactome R-BTA-5654197 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5654197.1 HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K Reactome DB_ID: 10196706 Converted from EntitySet in Reactome HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 Reactome DB_ID: 10196704 HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 Reactome DB_ID: 10196700 1 1 HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer Reactome DB_ID: 10196698 HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET Reactome DB_ID: 10196696 HGF dimer Reactome DB_ID: 10174656 HGF HGF(495-728) F1MZD6 Reactome DB_ID: 10174652 UniProt:F1MZD6 HGF UniProt F1MZD6 495 EQUAL 728 EQUAL Reactome Database ID Release 82 10174652 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10174652 Reactome R-BTA-141767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-141767.1 1 HGF HGF(32-494) F1MZD6 Reactome DB_ID: 10174654 32 EQUAL 494 EQUAL Reactome Database ID Release 82 10174654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10174654 Reactome R-BTA-56497 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-56497.1 1 Reactome Database ID Release 82 10174656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10174656 Reactome R-BTA-141763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-141763.1 1 Z4YHD9 phospho-p-Y1234,Y1235,Y1349,Y1356-MET Reactome DB_ID: 10196694 UniProt:Z4YHD9 UniProt Z4YHD9 1234 EQUAL 1235 EQUAL 1349 EQUAL 1356 EQUAL 25 EQUAL 1390 EQUAL Reactome Database ID Release 82 10196694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196694 Reactome R-BTA-6806973 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6806973.1 1 Reactome Database ID Release 82 10196696 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196696 Reactome R-BTA-6806975 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6806975.1 2 Reactome Database ID Release 82 10196698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196698 Reactome R-BTA-6806977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6806977.1 1 Reactome Database ID Release 82 10196700 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196700 Reactome R-BTA-8851942 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8851942.1 HGF:p-4Y-MET dimer:p-5Y-GAB1 Reactome DB_ID: 10196702 1 1 Reactome Database ID Release 82 10196702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196702 Reactome R-BTA-8851941 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8851941.1 Reactome Database ID Release 82 10196704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196704 Reactome R-BTA-8851943 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8851943.1 1 1 Reactome Database ID Release 82 10196706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196706 Reactome R-BTA-8851953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8851953.1 ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha Reactome DB_ID: 10196722 ESRs:STRN:ESTG:MyrG-pY419-SRC Reactome DB_ID: 10196720 E1BIM8 phospho-MyrG-p-Y419-SRC Reactome DB_ID: 10163742 UniProt:E1BIM8 UniProt E1BIM8 2 EQUAL N-myristoylglycine MOD MOD:00068 419 EQUAL 2 EQUAL 536 EQUAL Reactome Database ID Release 82 10163742 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10163742 Reactome R-BTA-1810408 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1810408.1 1 ESRs:STRN:ESTG Reactome DB_ID: 10196718 STRN STRN A0A3Q1MGW7 Reactome DB_ID: 10196716 UniProt:A0A3Q1MGW7 STRN UniProt A0A3Q1MGW7 1 EQUAL 780 EQUAL Reactome Database ID Release 82 10196716 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196716 Reactome R-BTA-9037081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9037081.1 2 ESTG estrogen Reactome DB_ID: 9027649 estrogen [ChEBI:50114] estrogen ChEBI CHEBI:50114 Reactome Database ID Release 82 9027649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9027649 Reactome R-ALL-9027649 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9027649.3 2 Converted from EntitySet in Reactome ESRs Reactome DB_ID: 10196712 ESR1 ESR1 P49884 Reactome DB_ID: 10196708 UniProt:P49884 ESR1 UniProt P49884 1 EQUAL 595 EQUAL Reactome Database ID Release 82 10196708 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196708 Reactome R-BTA-9020968 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9020968.1 ESR2 ESR2 Q9XSB5 Reactome DB_ID: 10196710 UniProt:Q9XSB5 ESR2 UniProt Q9XSB5 1 EQUAL 530 EQUAL Reactome Database ID Release 82 10196710 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196710 Reactome R-BTA-9020970 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9020970.1 Reactome Database ID Release 82 10196712 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196712 Reactome R-BTA-9021045 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9021045.1 2 Reactome Database ID Release 82 10196718 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196718 Reactome R-BTA-9027648 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9027648.1 1 Reactome Database ID Release 82 10196720 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196720 Reactome R-BTA-9021593 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9021593.1 1 1 Reactome Database ID Release 82 10196722 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196722 Reactome R-BTA-9021654 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9021654.1 Active FLT3:GRB2:p-Y GAB2:PI3K Reactome DB_ID: 10196724 Active FLT3:GRB2:p-Y-GAB2:PIK3R1 Reactome DB_ID: 10147621 Active FLT3:GRB2:p-Y-GAB2 Reactome DB_ID: 10147619 p-Y-GAB2 phospho-GAB2 A0A3Q1M864 Reactome DB_ID: 10147617 UniProt:A0A3Q1M864 GAB2 UniProt A0A3Q1M864 1 EQUAL 676 EQUAL Reactome Database ID Release 82 10147617 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147617 Reactome R-BTA-912529 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-912529.1 1 Active FLT3: GRB2 Reactome DB_ID: 10147612 Active FLT3 Reactome DB_ID: 10147610 F1MRU0 phospho-Autophosphorylated FLT3 Reactome DB_ID: 10147608 UniProt:F1MRU0 UniProt F1MRU0 589 EQUAL 591 EQUAL 599 EQUAL 768 EQUAL 955 EQUAL 969 EQUAL 27 EQUAL 993 EQUAL Reactome Database ID Release 82 10147608 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147608 Reactome R-BTA-9604780 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9604780.1 2 FLT3LG dimer Reactome DB_ID: 10147598 FLT3LG FLT3LG A2VE24 Reactome DB_ID: 10147596 UniProt:A2VE24 FLT3LG UniProt A2VE24 27 EQUAL 235 EQUAL Reactome Database ID Release 82 10147596 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147596 Reactome R-BTA-6786793 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6786793.1 2 Reactome Database ID Release 82 10147598 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147598 Reactome R-BTA-8854740 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8854740.1 1 Reactome Database ID Release 82 10147610 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147610 Reactome R-BTA-9604751 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9604751.1 1 1 Reactome Database ID Release 82 10147612 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147612 Reactome R-BTA-9604756 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9604756.1 1 Reactome Database ID Release 82 10147619 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147619 Reactome R-BTA-9606627 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9606627.1 1 1 Reactome Database ID Release 82 10147621 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147621 Reactome R-BTA-9607223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9607223.1 1 1 Reactome Database ID Release 82 10196724 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196724 Reactome R-BTA-9698169 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9698169.1 Reactome Database ID Release 82 10196726 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196726 Reactome R-BTA-2316432 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2316432.1 GENE ONTOLOGY GO:0046934 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10196727 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196727 Reactome Database ID Release 82 10196733 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196733 Reactome R-BTA-2316434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2316434.1 GENE ONTOLOGY GO:0051897 gene ontology term for cellular process MI MI:0359 A number of different extracellular signals converge on PI3K activation. PI3K can be activated downstream of receptor tyrosine kinases (RTKs) such as FGFR (Ong et al. 2001, Eswarakumar et al. 2005), KIT (Chian et al. 2001, Ronnstrand 2004, Reber et al. 2006), PDGF (Coughlin et al. 1989, Fantl et al. 1992, Heldin et al. 1998), insulin receptor IGF1R (Hadari et al. 1992, Kooijman et al. 1995), and EGFR and its family members (Rodrigues et al. 2000, Jackson et al. 2004, Kainulainen et al. 2000, Junttila et al. 2009). Other proteins, such as CD28 (Pages et al. 1996, Koyasu 2003, Kane and Weiss, 2003) and TRAT1 (Bruyns et al. 1998, Koyasu 2003, Kolsch et al. 2006), can also trigger PI3K activity.<br><br>In unstimulated cells, PI3K class IA exists as an inactive heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). Binding of the iSH2 domain of the p85 regulatory subunit to the ABD and C2 domains of the p110 catalytic subunit both stabilizes p110 and inhibits its catalytic activity. This inhibition is relieved when the SH2 domains of p85 bind phosphorylated tyrosines on activated RTKs or their adaptor proteins. Binding to membrane-associated receptors brings activated PI3K in proximity to its membrane-localized substrate, PIP2 (Mandelker et al. 2009, Burke et al. 2011). 16612002 Pubmed 2006 Normal T-cell development and immune functions in TRIM-deficient mice Kolsch, U Arndt, B Reinhold, D Lindquist, JA Juling, N Kliche, S Pfeffer, K Bruyns, E Schraven, B Simeoni, L Mol Cell Biol 26:3639-48 10722704 Pubmed 2000 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis Kainulainen, V Sundvall, M Määttä, JA Santiestevan, E Klagsbrun, Michael Elenius, K J Biol Chem 275:8641-9 21827948 Pubmed 2011 Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110? Burke, John E Vadas, Oscar Berndt, Alex Finegan, Tara Perisic, O Williams, RL Structure 19:1127-37 11353842 Pubmed 2001 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH Hadari, YR Gotoh, N Guy, GR Schlessinger, J Lax, I Proc Natl Acad Sci U S A 98:6074-9 2466336 Pubmed 1989 Role of phosphatidylinositol kinase in PDGF receptor signal transduction Coughlin, SR Escobedo, JA Williams, LT Science 243:1191-4 16483568 Pubmed 2006 Stem cell factor and its receptor c-Kit as targets for inflammatory diseases Reber, L Da Silva, CA Frossard, N Eur J Pharmacol 533:327-40 10648629 Pubmed 2000 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA Falasca, M Zhang, Z Ong, SH Schlessinger, J Mol Cell Biol 20:1448-59 15526160 Pubmed 2004 Signal transduction via the stem cell factor receptor/c-Kit Rönnstrand, Lars Cell Mol Life Sci 61:2535-48 15059917 Pubmed 2004 Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects Jackson, JG St Clair, P Sliwkowski, MX Brattain, Michael G Cancer Res 64:2601-9 12660731 Pubmed 2003 The role of PI3K in immune cells Koyasu, S Nat Immunol 4:313-9 15863030 Pubmed 2005 Cellular signaling by fibroblast growth factor receptors Eswarakumar, VP Lax, I Schlessinger, J Cytokine Growth Factor Rev 16:139-49 8621607 Pubmed 1996 Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association Pagès, F Ragueneau, M Klasen, S Battifora, M Couez, D Sweet, R Truneh, A Ward, SG Olive, D J Biol Chem 271:9403-9 19411071 Pubmed 2009 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 Junttila, TT Akita, Robert W Parsons, K Fields, C Lewis Phillips, GD Friedman, LS Sampath, D Sliwkowski, MX Cancer Cell 15:429-40 1381348 Pubmed 1992 Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers Hadari, Yaron Tzahar, E Nadiv, Orna Rothenberg, Paul Roberts, Charles LeRoith, Derek Yarden, Y Zick, Yehiel J. Biol. Chem. 267:17483-6 11520784 Pubmed 2001 Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant Chian, R Young, S Danilkovitch-Miagkova, A Rönnstrand, Lars Leonard, E Ferrao, P Ashman, L Linnekin, D Blood 98:1365-73 9687533 Pubmed 1998 T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane Bruyns, E Marie-Cardine, A Kirchgessner, H Sagolla, K Shevchenko, A Mann, M Autschbach, F Bensussan, A Meuer, S Schraven, B J Exp Med 188:561-75 9739761 Pubmed 1998 Signal transduction via platelet-derived growth factor receptors Heldin, Carl-Henrik Ostman, A Rönnstrand, Lars Biochim Biophys Acta 1378:F79-113 19805105 Pubmed 2009 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane Mandelker, Diana Gabelli, Sandra B Schmidt-Kittler, Oleg Zhu, Jiuxiang Cheong, Ian Huang, Chuan-Hsiang Kinzler, KW Vogelstein, B Amzel, L Mario Proc. Natl. Acad. Sci. U.S.A. 106:16996-7001 7543144 Pubmed 1995 Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes Kooijman, Ron Lauf, Jeroen Kappers, Astrid Rijkers, Ger J. Exp. Med. 182:593-7 1374684 Pubmed 1992 Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Fantl, WJ Escobedo, JA Martin, GA Turck, CW del Rosario, M McCormick, F Williams, LT Cell 69:413-23 12670391 Pubmed 2003 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 Kane, LP Weiss, A Immunol Rev 192:7-20 ACTIVATION Reactome Database ID Release 82 10196734 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196734 IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 Reactome DB_ID: 10196731 IL33:IL1RL1:IL1RAP-1:MYD88 dimer Reactome DB_ID: 10196729 IL33:IL1RL1:IL1RAP-1 Reactome DB_ID: 10173322 IL1RL1:IL33 Reactome DB_ID: 10173320 IL1RL1 IL1RL1 F1MRU1 Reactome DB_ID: 10173314 UniProt:F1MRU1 IL1RL1 UniProt F1MRU1 19 EQUAL 556 EQUAL Reactome Database ID Release 82 10173314 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173314 Reactome R-BTA-197594 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-197594.1 1 IL33 IL33 Q08DU3 Reactome DB_ID: 10173318 UniProt:Q08DU3 IL33 UniProt Q08DU3 1 EQUAL 270 EQUAL Reactome Database ID Release 82 10173318 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173318 Reactome R-BTA-448567 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-448567.1 1 Reactome Database ID Release 82 10173320 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173320 Reactome R-BTA-448601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-448601.1 1 IL1RAP IL1RAP-1 E1BFL8 Reactome DB_ID: 10172907 UniProt:E1BFL8 IL1RAP UniProt E1BFL8 21 EQUAL 570 EQUAL Reactome Database ID Release 82 10172907 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10172907 Reactome R-BTA-445745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-445745.1 1 Reactome Database ID Release 82 10173322 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173322 Reactome R-BTA-448571 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-448571.1 1 MYD88 dimer Reactome DB_ID: 10156977 MYD88 MYD88 A0A452DHW6 Reactome DB_ID: 10156975 UniProt:A0A452DHW6 MYD88 UniProt A0A452DHW6 1 EQUAL 296 EQUAL Reactome Database ID Release 82 10156975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10156975 Reactome R-BTA-166059 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-166059.1 2 Reactome Database ID Release 82 10156977 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10156977 Reactome R-BTA-193932 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-193932.1 1 Reactome Database ID Release 82 10196729 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196729 Reactome R-BTA-8981947 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8981947.1 1 IRAK4 Q1RMT8 Reactome DB_ID: 10173136 UniProt:Q1RMT8 UniProt Q1RMT8 1 EQUAL 460 EQUAL Reactome Database ID Release 82 10173136 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173136 Reactome R-BTA-166081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-166081.1 1 TRAF6 TRAF6 Q3ZCC3 Reactome DB_ID: 10152838 UniProt:Q3ZCC3 TRAF6 UniProt Q3ZCC3 1 EQUAL 522 EQUAL Reactome Database ID Release 82 10152838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10152838 Reactome R-BTA-166366 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-166366.1 1 IRAK1 Q2LGB3 Reactome DB_ID: 10173168 UniProt:Q2LGB3 UniProt Q2LGB3 1 EQUAL 712 EQUAL Reactome Database ID Release 82 10173168 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10173168 Reactome R-BTA-446639 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-446639.1 1 Reactome Database ID Release 82 10196731 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196731 Reactome R-BTA-8981951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8981951.1 LEFT-TO-RIGHT PIP3 recruits PDPK1 to the membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PDPK1 F1MQJ7 Reactome DB_ID: 10159797 UniProt:F1MQJ7 UniProt F1MQJ7 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10159797 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10159797 Reactome R-BTA-202210 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-202210.1 PDPK1:PIP3 Reactome DB_ID: 10147652 1 PDPK1 F1MQJ7 Reactome DB_ID: 10147650 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10147650 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147650 Reactome R-BTA-61459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-61459.1 1 Reactome Database ID Release 82 10147652 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147652 Reactome R-BTA-109697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109697.1 Reactome Database ID Release 82 10196638 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10196638 Reactome R-BTA-2316429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2316429.1 PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999). 9895304 Pubmed 1999 Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Currie, RA Walker, KS Gray, A Deak, M Casamayor, A Downes, CP Cohen, P Alessi, DR Lucocq, J Biochem J 337:575-83 Negative regulation of the PI3K/AKT network This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 3.1.3.67 PTEN dephosphorylates PIP3 PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 82 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 29372 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate [PO3(OH)](2-) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE ION HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 82 29372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372 Reactome R-ALL-29372 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4 COMPOUND C00009 ACTIVATION PTEN PTEN F1MDX9 Reactome DB_ID: 10158688 UniProt:F1MDX9 PTEN UniProt F1MDX9 2 EQUAL 403 EQUAL Reactome Database ID Release 82 10158688 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10158688 Reactome R-BTA-199420 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-199420.1 GENE ONTOLOGY GO:0016314 Reactome Database ID Release 82 10158689 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10158689 Reactome Database ID Release 82 10158691 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10158691 Reactome R-BTA-199456 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-199456.1 GENE ONTOLOGY GO:0051898 At the plasma membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) (Maehama & Dixon 1998, Myers et al. 1998, Das et al. 2003). The PI3K network is negatively regulated by phospholipid phosphatases that dephosphorylate PIP3, thus hampering AKT activation (Myers et al. 1998). The tumour suppressor PTEN is the primary phospholipid phosphatase.<br>Early studies indicated that magnesium ion, Mg2+, was needed for the catalytic activity of PTEN isolated from bovine thymus (Kabuyama et al. 1996). Subsequent studies have shown that PTEN was catalytically active in buffers free of magnesium and magnesium was not detected as part of the PTEN crystal (Lee et al. 1999). 12808147 Pubmed 2003 Membrane-binding and activation mechanism of PTEN Das, S Dixon, JE Cho, W Proc Natl Acad Sci U S A 100:7491-6 9811831 Pubmed 1998 The lipid phosphatase activity of PTEN is critical for its tumor supressor function Myers, MP Pass, I Batty, IH van der Kaay, J Stolarov, JP Hemmings, BA Downes, CP Tonks, NK Wigler, Michael H Proc Natl Acad Sci U S A 95:13513-8 10555148 Pubmed 1999 Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Lee, Jie-Oh Yang, Haijuan Georgescu, Maria-Magdalena Di Cristofano, Antonio Maehama, Tomohiko Shi, Y Dixon, Jack Pandolfi, Pier Pavletich, Nikola Cell 99:323-34 8681945 Pubmed 1996 Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus Kabuyama, Y Nakatsu, N Homma, Y Fukui, Y Eur. J. Biochem. 238:350-6 9593664 Pubmed 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate Maehama, T Dixon, JE J Biol Chem 273:13375-8 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.1.68 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI4P Phosphatidylinositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphates Reactome DB_ID: 392417 1-phosphatidyl-1D-myo-inositol 4-phosphate [ChEBI:17526] 1-phosphatidyl-1D-myo-inositol 4-phosphate ChEBI CHEBI:17526 Reactome Database ID Release 82 392417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392417 Reactome R-ALL-392417 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-392417.3 COMPOUND C01277 PubChem Substance 4496 ACTIVATION Converted from EntitySet in Reactome PIP5K1A-C Reactome DB_ID: 10188525 A6QLC5 PIP5K1A PIP5K1A Reactome DB_ID: 10188519 UniProt:A6QLC5 PIP5K1A UniProt A6QLC5 1 EQUAL 562 EQUAL Reactome Database ID Release 82 10188519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188519 Reactome R-BTA-1806260 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806260.1 F1N7M1 PIP5K1B PIP5K1B Reactome DB_ID: 10188523 UniProt:F1N7M1 PIP5K1B UniProt F1N7M1 1 EQUAL 540 EQUAL Reactome Database ID Release 82 10188523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188523 Reactome R-BTA-1806216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806216.1 PIP5K1C PIP5K1C A0A3Q1MBL1 Reactome DB_ID: 10168917 UniProt:A0A3Q1MBL1 PIP5K1C UniProt A0A3Q1MBL1 1 EQUAL 668 EQUAL Reactome Database ID Release 82 10168917 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10168917 Reactome R-BTA-392427 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-392427.1 Reactome Database ID Release 82 10188525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188525 Reactome R-BTA-1806157 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806157.1 GENE ONTOLOGY GO:0016308 Reactome Database ID Release 82 10188774 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188774 Reactome Database ID Release 82 10188776 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188776 Reactome R-BTA-1676082 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1676082.1 At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).<br><br>This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007). 17245604 Pubmed 2007 Phospholipase D signaling: orchestration by PIP2 and small GTPases Oude Weernink, PA López de Jesús, M Schmidt, M Naunyn Schmiedebergs Arch Pharmacol 374:399-411 9211928 Pubmed 1997 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Zhang, Xiaoxuan Loijens, JC Boronenkov, IV Parker, GJ Norris, FA Chen, J Thum, O Prestwich, GD Majerus, PW Anderson, RA J Biol Chem 272:17756-61 16979564 Pubmed 2006 A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis Halstead, JR van Rheenen, J Snel, MH Meeuws, S Mohammed, S D'Santos, CS Heck, AJ Jalink, K Divecha, Nullin Curr Biol 16:1850-6 12422219 Pubmed 2002 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Di Paolo, G Pellegrini, L Letinic, K Cestra, G Zoncu, R Voronov, S Chang, S Guo, J Wenk, MR De Camilli, Pietro Nature 420:85-9 15464023 Pubmed 2004 Regulation and cellular roles of phosphoinositide 5-kinases Oude Weernink, PA Schmidt, M Jakobs, KH Eur J Pharmacol 500:87-99 LEFT-TO-RIGHT 2.7.1.149 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI5P 1-phosphatidyl-1D-myo-inositol 5-phosphate Reactome DB_ID: 1806240 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [ChEBI:57795] 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) 1-phosphatidyl-1D-myo-inositol 5-phosphate trianions a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3R,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonatooxy)cyclohexyl phosphate 1-phosphatidyl-1D-myo-inositol 5-phosphate trianion ChEBI CHEBI:57795 Reactome Database ID Release 82 1806240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240 Reactome R-ALL-1806240 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806240.4 ACTIVATION Converted from EntitySet in Reactome PIP4K2 dimers Reactome DB_ID: 10188554 PIP4K2A:PIP4K2A Reactome DB_ID: 10188534 F1MHR4 PIP4K2A PIP4K2A Reactome DB_ID: 10188532 UniProt:F1MHR4 PIP4K2A UniProt F1MHR4 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10188532 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188532 Reactome R-BTA-1604641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1604641.1 2 Reactome Database ID Release 82 10188534 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188534 Reactome R-BTA-1806252 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806252.1 PIP4K2A:PIP4K2B Reactome DB_ID: 10188540 1 F1MHT2 PIP4K2B PIP4K2B Reactome DB_ID: 10188538 UniProt:F1MHT2 PIP4K2B UniProt F1MHT2 1 EQUAL 416 EQUAL Reactome Database ID Release 82 10188538 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188538 Reactome R-BTA-1806208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806208.1 1 Reactome Database ID Release 82 10188540 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188540 Reactome R-BTA-1806183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806183.1 PIP4K2B:PIP4K2B Reactome DB_ID: 10188542 2 Reactome Database ID Release 82 10188542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188542 Reactome R-BTA-1806168 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806168.1 PIP4K2A:PIP4K2C Reactome DB_ID: 10188548 1 Q0P5F7 PIP4K2C PIP4K2C Reactome DB_ID: 10188546 UniProt:Q0P5F7 PIP4K2C UniProt Q0P5F7 2 EQUAL 421 EQUAL Reactome Database ID Release 82 10188546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188546 Reactome R-BTA-1604638 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1604638.1 1 Reactome Database ID Release 82 10188548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188548 Reactome R-BTA-6808605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6808605.1 PIP4K2C:PIP4K2C Reactome DB_ID: 10188550 2 Reactome Database ID Release 82 10188550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188550 Reactome R-BTA-6808604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6808604.1 PIP4K2B:PIP4K2C Reactome DB_ID: 10188552 1 1 Reactome Database ID Release 82 10188552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188552 Reactome R-BTA-6808599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6808599.1 Reactome Database ID Release 82 10188554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188554 Reactome R-BTA-1806229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1806229.1 GENE ONTOLOGY GO:0016309 Reactome Database ID Release 82 10188555 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188555 Reactome Database ID Release 82 10188557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10188557 Reactome R-BTA-1675776 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1675776.1 At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015). 18753295 Pubmed 2008 Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Clarke, JH Emson, PC Irvine, RF Am J Physiol Renal Physiol 295:F1422-30 19896968 Pubmed 2010 Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Clarke, JH Wang, M Irvine, RF Adv Enzyme Regul 50:12-8 23758345 Pubmed 2013 Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Clarke, Jonathan H Irvine, Robin F Biochem. J. 454:49-57 9367159 Pubmed 1997 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Rameh, Lucia Tolias, KF Duckworth, BC Cantley, Lewis C Nature 390:192-6 25495341 Pubmed 2015 The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site Clarke, Jonathan H Giudici, Maria-Luisa Burke, John E Williams, RL Maloney, David J Marugan, Juan Irvine, Robin F Biochem. J. 466:359-67 LEFT-TO-RIGHT 2.7.10.2 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PP2A Reactome DB_ID: 10150118 Converted from EntitySet in Reactome PP2A regulatory subunit B56 Reactome DB_ID: 10150104 A2VDZ0 PPP2R5A PPP2R5A Reactome DB_ID: 10150086 UniProt:A2VDZ0 PPP2R5A UniProt A2VDZ0 1 EQUAL 486 EQUAL Reactome Database ID Release 82 10150086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150086 Reactome R-BTA-196235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-196235.1 Q08DP7 PPP2R5B PPP2R5B Reactome DB_ID: 10150090 UniProt:Q08DP7 PPP2R5B UniProt Q08DP7 1 EQUAL 497 EQUAL Reactome Database ID Release 82 10150090 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150090 Reactome R-BTA-535469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-535469.1 F1N1S8 PPP2R5D PPP2R5D Reactome DB_ID: 10150094 UniProt:F1N1S8 PPP2R5D UniProt F1N1S8 1 EQUAL 602 EQUAL Reactome Database ID Release 82 10150094 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150094 Reactome R-BTA-3008950 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-3008950.1 PPP2R5C PPP2R5C A0A3Q1MM63 Reactome DB_ID: 10150098 UniProt:A0A3Q1MM63 PPP2R5C UniProt A0A3Q1MM63 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10150098 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150098 Reactome R-BTA-3008954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-3008954.1 A4FV68 PPP2R5E PPP2R5E Reactome DB_ID: 10150102 UniProt:A4FV68 PPP2R5E UniProt A4FV68 1 EQUAL 467 EQUAL Reactome Database ID Release 82 10150102 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150102 Reactome R-BTA-1638770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1638770.1 Reactome Database ID Release 82 10150104 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150104 Reactome R-BTA-196216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-196216.1 1 Converted from EntitySet in Reactome PP2A-catalytic subunit C Reactome DB_ID: 10150116 PPP2CA P67774 Reactome DB_ID: 10150112 UniProt:P67774 UniProt P67774 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10150112 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150112 Reactome R-BTA-165971 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165971.1 PPP2CB Q0P594 Reactome DB_ID: 10150114 UniProt:Q0P594 UniProt Q0P594 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10150114 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150114 Reactome R-BTA-165987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165987.1 Reactome Database ID Release 82 10150116 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150116 Reactome R-BTA-165977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165977.1 1 Converted from EntitySet in Reactome PP2A-subunit A Reactome DB_ID: 10150110 A5D973 PPP2R1A PPP2R1A Reactome DB_ID: 10150106 UniProt:A5D973 PPP2R1A UniProt A5D973 2 EQUAL 589 EQUAL Reactome Database ID Release 82 10150106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150106 Reactome R-BTA-165982 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165982.1 F1MQN0 PPP2R1B PPP2R1B Reactome DB_ID: 10150108 UniProt:F1MQN0 PPP2R1B UniProt F1MQN0 1 EQUAL 601 EQUAL Reactome Database ID Release 82 10150108 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150108 Reactome R-BTA-165980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165980.1 Reactome Database ID Release 82 10150110 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150110 Reactome R-BTA-165990 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-165990.1 1 Reactome Database ID Release 82 10150118 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10150118 Reactome R-BTA-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-196206.1 p-Y307-PP2A Reactome DB_ID: 10229956 1 1 Converted from EntitySet in Reactome p-Y307-PP2A-catalytic subunit C Reactome DB_ID: 10229954 P67774 phospho-p-Y307-PPP2CA Reactome DB_ID: 10229949 307 EQUAL 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10229949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229949 Reactome R-BTA-8857939 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857939.1 Q0P594 phospho-p-Y307-PPP2CB Reactome DB_ID: 10229952 307 EQUAL 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10229952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229952 Reactome R-BTA-8857935 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857935.1 Reactome Database ID Release 82 10229954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229954 Reactome R-BTA-8857933 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857933.1 1 Reactome Database ID Release 82 10229956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229956 Reactome R-BTA-8857938 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857938.1 ACTIVATION Converted from EntitySet in Reactome Activated SRC,LCK,EGFR,INSR Reactome DB_ID: 10229962 E1BIM8 phospho-p-Y419-SRC-1 Reactome DB_ID: 10229958 2 EQUAL 536 EQUAL Reactome Database ID Release 82 10229958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229958 Reactome R-BTA-112331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-112331.1 Insulin:p-6Y-Insulin receptor Reactome DB_ID: 10145416 p-6Y-insulin receptor Reactome DB_ID: 10145401 F1MV64 phospho-p-6Y-INSR(763-1382) Reactome DB_ID: 10145399 UniProt:F1MV64 UniProt F1MV64 999 EQUAL 1185 EQUAL 1189 EQUAL 1190 EQUAL 1355 EQUAL 1361 EQUAL 763 EQUAL 1382 EQUAL Reactome Database ID Release 82 10145399 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145399 Reactome R-BTA-74670 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74670.1 2 F1MV64 INSR(28-758) Reactome DB_ID: 10145391 28 EQUAL 758 EQUAL Reactome Database ID Release 82 10145391 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145391 Reactome R-BTA-74668 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74668.1 2 Reactome Database ID Release 82 10145401 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145401 Reactome R-BTA-74671 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74671.1 1 Insulin Reactome DB_ID: 10145414 INS 2xHC-INS(25-54) A5PJB2 Reactome DB_ID: 10145412 UniProt:A5PJB2 INS UniProt A5PJB2 31 EQUAL L-cystine (cross-link) MOD MOD:00034 43 EQUAL 25 EQUAL 54 EQUAL Reactome Database ID Release 82 10145412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145412 Reactome R-BTA-74673 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74673.1 1 INS 4xHC-INS(90-110) A5PJB2 Reactome DB_ID: 10145408 95 EQUAL 109 EQUAL 96 EQUAL 90 EQUAL 110 EQUAL Reactome Database ID Release 82 10145408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145408 Reactome R-BTA-74672 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74672.1 1 Reactome Database ID Release 82 10145414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145414 Reactome R-BTA-74674 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74674.1 1 Reactome Database ID Release 82 10145416 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10145416 Reactome R-BTA-74678 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-74678.1 Q3ZCM0 phospho-p-Y394-LCK Reactome DB_ID: 10229960 394 EQUAL 1 EQUAL 509 EQUAL Reactome Database ID Release 82 10229960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229960 Reactome R-BTA-8857940 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857940.1 Reactome Database ID Release 82 10229962 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229962 Reactome R-BTA-8857936 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857936.1 GENE ONTOLOGY GO:0004713 Reactome Database ID Release 82 10229963 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229963 Reactome Database ID Release 82 10229965 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229965 Reactome R-BTA-8857925 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8857925.1 SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307. 19576174 Pubmed 2009 PtdIns5P protects Akt from dephosphorylation through PP2A inhibition Ramel, Damien Lagarrigue, Frédéric Dupuis-Coronas, Sophie Chicanne, Gaëtan Leslie, Nicholas Gaits-Iacovoni, Frédérique Payrastre, Bernard Tronchère, Hélène Biochem. Biophys. Res. Commun. 387:127-31 1325671 Pubmed 1992 Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Chen, J Martin, B L Brautigan, D L Science 257:1261-4 ACTIVATION Reactome Database ID Release 82 9909778 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9909778 LEFT-TO-RIGHT IEX1 recruits ERKs to PP2A IER3 recruits MAPKs to PP2A-B56-beta,gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome p-ERK dimer p-T,Y MAPK dimers Reactome DB_ID: 10153763 p-T202, Y204 MAPK3 dimer Reactome DB_ID: 10153759 E1B8P9 phospho-p-T202,Y204-MAPK3 Reactome DB_ID: 10147772 UniProt:E1B8P9 UniProt E1B8P9 202 EQUAL O-phospho-L-threonine MOD MOD:00047 204 EQUAL 2 EQUAL 379 EQUAL Reactome Database ID Release 82 10147772 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147772 Reactome R-BTA-109842 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109842.1 2 Reactome Database ID Release 82 10153759 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10153759 Reactome R-BTA-109844 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109844.1 p-T185,Y187 MAPK1 dimer Reactome DB_ID: 10153761 P46196 phospho-p-T185,Y187-MAPK1 Reactome DB_ID: 10147790 UniProt:P46196 UniProt P46196 185 EQUAL 187 EQUAL 2 EQUAL 360 EQUAL Reactome Database ID Release 82 10147790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10147790 Reactome R-BTA-109853 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109853.1 2 Reactome Database ID Release 82 10153761 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10153761 Reactome R-BTA-109855 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109855.1 Reactome Database ID Release 82 10153763 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10153763 Reactome R-BTA-1268261 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1268261.1 PP2A-B56-beta,gamma Reactome DB_ID: 10227068 1 1 Converted from EntitySet in Reactome PPP2R5B,PPP2R5C B56beta,B56gamma Reactome DB_ID: 10227066 Reactome Database ID Release 82 10227066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227066 Reactome R-BTA-6811516 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811516.1 1 Reactome Database ID Release 82 10227068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227068 Reactome R-BTA-6811526 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811526.1 IER3 IER3 Q0P5G7 Reactome DB_ID: 10227064 UniProt:Q0P5G7 IER3 UniProt Q0P5G7 1 EQUAL 156 EQUAL Reactome Database ID Release 82 10227064 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227064 Reactome R-BTA-6811515 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811515.1 PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers Reactome DB_ID: 10227070 1 1 1 Reactome Database ID Release 82 10227070 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227070 Reactome R-BTA-6811477 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811477.1 Reactome Database ID Release 82 10227085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227085 Reactome R-BTA-6811472 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811472.1 IER3 (IEX-1) recruits both an activated MAPK (MAPK1 (ERK2) or MAPK3 (ERK1)) and the protein phosphatase 2A (PP2A) complex containing regulatory subunits B56-beta (PPP2R5B) or B56-gamma (PPP2R5C), through an interaction with the B56 subunit, forming a tripartite complex (Letourneux et al. 2006, Rocher et al. 2007). 16456541 Pubmed 2006 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK Letourneux, C Rocher, G Porteu, F EMBO J 25:727-38 17200115 Pubmed 2007 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, Géraldine Letourneux, Claire Lenormand, Philippe Porteu, Françoise J. Biol. Chem. 282:5468-77 LEFT-TO-RIGHT 2.7.11.1 MAPKs phosphorylate PP2A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome p-S-B56-beta,gamma p-S368-PPP2R5B,p-S337-PPP2R5C Reactome DB_ID: 10227078 A0A3Q1MM63 phospho-PPP2R5C p-S337-PPP2R5C Reactome DB_ID: 10227073 337 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10227073 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10227073 Reactome R-BTA-6811447 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-6811447.1 Q08DP7 phospho-PPP2R5B p-S368-PPP2R5B Reactome DB_ID: 10227076 368 EQUAL 1 EQUAL