BioPAX pathway converted from "Fibrillin-1 binds integrins" in the Reactome database.LEFT-TO-RIGHTFibrillin-1 binds integrinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeFibrilin-binding integrinsReactome DB_ID: 10255107Integrin alphaVbeta3Reactome DB_ID: 10210639plasma membraneGENE ONTOLOGYGO:0005886ITGB3itgb3bB3DIP9Reactome DB_ID: 10197260UniProt:B3DIP9itgb3bDanio rerioNCBI Taxonomy7955UniProtB3DIP927EQUAL788EQUALReactome Database ID Release 7510197260Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10197260ReactomeR-DRE-576001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-57600.1Reactomehttp://www.reactome.org1itgavITGAV(31-1048)B8JLK8Reactome DB_ID: 10210637UniProt:B8JLK8itgavUniProtB8JLK831EQUAL1048EQUALReactome Database ID Release 7510210637Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10210637ReactomeR-DRE-2100131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-210013.11Reactome Database ID Release 7510210639Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10210639ReactomeR-DRE-2102161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-210216.1Integrin alphaVbeta6Reactome DB_ID: 10211659itgb6ITGB6F1QGX0Reactome DB_ID: 10211657UniProt:F1QGX0itgb6UniProtF1QGX022EQUAL788EQUALReactome Database ID Release 7510211657Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211657ReactomeR-DRE-2159511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-215951.111Reactome Database ID Release 7510211659Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211659ReactomeR-DRE-2160241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-216024.1Integrin alpha5beta1Reactome DB_ID: 10209360itga5ITGA5(42-894)Q5I2A9Reactome DB_ID: 10209358UniProt:Q5I2A9itga5UniProtQ5I2A942EQUAL894EQUALReactome Database ID Release 7510209358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10209358ReactomeR-DRE-2027351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-202735.11ITGB1itgb1aA0A286Y9W0Reactome DB_ID: 10207040UniProt:A0A286Y9W0itgb1aUniProtA0A286Y9W021EQUAL798EQUALReactome Database ID Release 7510207040Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10207040ReactomeR-DRE-575961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-57596.11Reactome Database ID Release 7510209360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10209360ReactomeR-DRE-2027301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-202730.1Reactome Database ID Release 7510255107Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10255107ReactomeR-DRE-23963521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2396352.1Fibrillin-1Reactome DB_ID: 10243218extracellular regionGENE ONTOLOGYGO:0005576Reactome Database ID Release 7510243218Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10243218ReactomeR-DRE-21598741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2159874.1Fibrilin-1:Fibrilin-binding integrinsReactome DB_ID: 1025510911Reactome Database ID Release 7510255109Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10255109ReactomeR-DRE-23962001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2396200.1Reactome Database ID Release 7510255111Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10255111ReactomeR-DRE-23280371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2328037.1Fibrillin-1 splice variants that include the RGD sequence located in the fourth 8-cysteine domain mediate cell adhesion, binding integrin alphaVbeta3 (Pfaff et al. 1996), alpha5beta1 (Bax et al. 2003) and alphaVbeta6 (Jovanovic et al. 2008). AlphaVbeta3 has the highest affinity for fibrillin-1. Integrin alphaVbeta3 is a high-affinity fibrillin-1 receptor (K(d) approximately 40 nM), whereas integrins alphaVbeta6 and alpha5beta1 show moderate-affinity (K(d) approximately 450 nM) and low-affinity (K(d) >1 microM) binding respectively (Jovanovic et al. 2008). 12807887Pubmed2003Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrinsBax, DVBernard, SELomas, AMorgan, AHumphries, JShuttleworth, CAHumphries, MartinKielty, CMJ Biol Chem 278:34605-168617364Pubmed1996Cell adhesion and integrin binding to recombinant human fibrillin-1Pfaff, MReinhardt, D PSakai, L YTimpl, RFEBS Lett. 384:247-5018363569Pubmed2008Fibrillin-integrin interactions in health and diseaseJovanovic, JIqbal, SJensen, SMardon, HHandford, Penny ABiochem Soc Trans 36:257-62inferred from electronic annotationEVIDENCE CODEECO:0000203