BioPAX pathway converted from "PNPLA4 hydrolyzes TAG" in the Reactome database.LEFT-TO-RIGHT3.1.1.3PNPLA4 hydrolyzes TAGThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5Reactomehttp://www.reactome.orgCOMPOUNDC00001additional informationMIMI:0361TAGtriacylglyceroltriglycerideReactome DB_ID: 549167triglyceride [ChEBI:17855]triglycerideChEBICHEBI:17855Reactome Database ID Release 75549167Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=549167ReactomeR-ALL-5491673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-549167.3DAG1,2-diacylglycerol1,2-diacyl-sn-glycerolReactome DB_ID: 761031,2-diacyl-sn-glycerol [ChEBI:17815]1,2-diacyl-sn-glycerolChEBICHEBI:17815Reactome Database ID Release 7576103Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76103ReactomeR-ALL-761033Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76103.3COMPOUNDC00165LCFA(-)long-chain fatty acid anionReactome DB_ID: 8876730long-chain fatty acid anion [ChEBI:57560]long-chain fatty acid anionChEBICHEBI:57560Reactome Database ID Release 758876730Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8876730ReactomeR-ALL-88767303Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8876730.3COMPOUNDC00060ACTIVATIONpnpla4PNPLA4A8E596Reactome DB_ID: 10288061UniProt:A8E596pnpla4Danio rerioNCBI Taxonomy7955UniProtA8E5961EQUAL253EQUALReactome Database ID Release 7510288061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10288061ReactomeR-DRE-88483561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848356.1GENE ONTOLOGYGO:0004806gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510288062Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10288062Reactome Database ID Release 7510288064Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10288064ReactomeR-DRE-88483381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848338.1PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).15364929Pubmed2004Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activitiesJenkins, CMMancuso, DJYan, WSims, HFGibson, BGross, RWJ Biol Chem 279:48968-7517603008Pubmed2007A comparative study of human GS2, its paralogues, and its rat orthologueGao, Jay GSimon, MarciaBiochem. Biophys. Res. Commun. 360:501-6inferred from electronic annotationEVIDENCE CODEECO:0000203