BioPAX pathway converted from "RNA Polymerase II Pre-transcription Events" in the Reactome database.RNA Polymerase II Pre-transcription EventsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTAbortive initiation after formation of the first phosphodiester bondThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>pol II transcription complexReactome DB_ID: 10183395nucleoplasmGENE ONTOLOGYGO:0005654RNA Polymerase II (unphosphorylated):TFIIF complexReactome DB_ID: 10181207RNA Polymerase II holoenzyme complex (unphosphorylated)Reactome DB_ID: 10181205POLR2IQ1LVK2Reactome DB_ID: 10181147UniProt:Q1LVK2Danio rerioNCBI Taxonomy7955UniProtQ1LVK21EQUAL125EQUALReactome Database ID Release 7010181147Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181147ReactomeR-DRE-635251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63525.1Reactomehttp://www.reactome.org1POLR2DQ6DRG4Reactome DB_ID: 10181155UniProt:Q6DRG4UniProtQ6DRG41EQUAL142EQUALReactome Database ID Release 7010181155Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181155ReactomeR-DRE-635081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63508.11POLR2JQ4VBU5Reactome DB_ID: 10181143UniProt:Q4VBU5UniProtQ4VBU51EQUAL117EQUALReactome Database ID Release 7010181143Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181143ReactomeR-DRE-635311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63531.11POLR2HQ568H8Reactome DB_ID: 10181167UniProt:Q568H8UniProtQ568H82EQUAL150EQUALReactome Database ID Release 7010181167Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181167ReactomeR-DRE-635231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63523.11POLR2KF1RDV9Reactome DB_ID: 10181171UniProt:F1RDV9UniProtF1RDV91EQUAL58EQUALReactome Database ID Release 7010181171Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181171ReactomeR-DRE-635371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63537.11POLR2EQ6DEG5Reactome DB_ID: 10181175UniProt:Q6DEG5UniProtQ6DEG51EQUAL210EQUALReactome Database ID Release 7010181175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181175ReactomeR-DRE-837131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-83713.11POLR2AA0A0R4IMS9Reactome DB_ID: 10181203UniProt:A0A0R4IMS9UniProtA0A0R4IMS91EQUAL1970EQUALReactome Database ID Release 7010181203Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181203ReactomeR-DRE-635021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63502.11POLR2BA0A0R4IXL0Reactome DB_ID: 10181151UniProt:A0A0R4IXL0UniProtA0A0R4IXL01EQUAL1174EQUALReactome Database ID Release 7010181151Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181151ReactomeR-DRE-635041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63504.11POLR2FQ6DGS5Reactome DB_ID: 10181179UniProt:Q6DGS5UniProtQ6DGS52EQUAL127EQUALReactome Database ID Release 7010181179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181179ReactomeR-DRE-837141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-83714.11POLR2LA5D6S6Reactome DB_ID: 10181183UniProt:A5D6S6UniProtA5D6S61EQUAL67EQUALReactome Database ID Release 7010181183Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181183ReactomeR-DRE-837151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-83715.11POLR2CQ7ZV11Reactome DB_ID: 10181163UniProt:Q7ZV11UniProtQ7ZV112EQUAL275EQUALReactome Database ID Release 7010181163Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181163ReactomeR-DRE-635061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63506.11POLR2GQ7ZW41Reactome DB_ID: 10181159UniProt:Q7ZW41UniProtQ7ZW411EQUAL172EQUALReactome Database ID Release 7010181159Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181159ReactomeR-DRE-635171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-63517.11Reactome Database ID Release 7010181205Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181205ReactomeR-DRE-1134011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113401.11TFIIFReactome DB_ID: 10181195GTF2F2B8JHR3Reactome DB_ID: 10181193UniProt:B8JHR3UniProtB8JHR32EQUAL249EQUALReactome Database ID Release 7010181193Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181193ReactomeR-DRE-655671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65567.11GTF2F1Q5PNQ6Reactome DB_ID: 10181189UniProt:Q5PNQ6UniProtQ5PNQ62EQUAL517EQUALReactome Database ID Release 7010181189Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181189ReactomeR-DRE-655651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65565.11Reactome Database ID Release 7010181195Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181195ReactomeR-DRE-1096311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109631.11Reactome Database ID Release 7010181207Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181207ReactomeR-DRE-713071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-71307.11TFIIDReactome DB_ID: 10183383TAF9F1QDT4Reactome DB_ID: 10183351UniProt:F1QDT4UniProtF1QDT41EQUAL264EQUALReactome Database ID Release 7010183351Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183351ReactomeR-DRE-2124521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212452.11TAF11A8KBY5Reactome DB_ID: 10183339UniProt:A8KBY5UniProtA8KBY51EQUAL211EQUALReactome Database ID Release 7010183339Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183339ReactomeR-DRE-655531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65553.11TAF10Q1LVD6Reactome DB_ID: 10183343UniProt:Q1LVD6UniProtQ1LVD61EQUAL218EQUALReactome Database ID Release 7010183343Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183343ReactomeR-DRE-655511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65551.11TAF9BF1QDT4Reactome DB_ID: 101833611EQUAL251EQUALReactome Database ID Release 7010183361Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183361ReactomeR-DRE-2124041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212404.11Converted from EntitySet in ReactomeTAF1,TAF1LReactome DB_ID: 10183369TAF1E7F8U5Reactome DB_ID: 10183365UniProt:E7F8U5UniProtE7F8U51EQUAL1872EQUALReactome Database ID Release 7010183365Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183365ReactomeR-DRE-655391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65539.1TAF1LE7F8U5Reactome DB_ID: 101833671EQUAL1826EQUALReactome Database ID Release 7010183367Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183367ReactomeR-DRE-2124351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212435.1Reactome Database ID Release 7010183369Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183369ReactomeR-DRE-54208801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5420880.11TAF6Q66HZ5Reactome DB_ID: 10183347UniProt:Q66HZ5UniProtQ66HZ51EQUAL677EQUALReactome Database ID Release 7010183347Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183347ReactomeR-DRE-655451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65545.11Converted from EntitySet in ReactomeHomologues of TAF4Reactome DB_ID: 10183327TAF4E7FBZ0Reactome DB_ID: 10183321UniProt:E7FBZ0UniProtE7FBZ01EQUAL1085EQUALReactome Database ID Release 7010183321Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183321ReactomeR-DRE-655411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65541.1TAF4F1QMF8Reactome DB_ID: 10183325UniProt:F1QMF8UniProtF1QMF81EQUAL1085EQUALReactome Database ID Release 7010183325Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183325ReactomeR-DRE-65541-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65541-2.1Reactome Database ID Release 7010183327Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183327ReactomeR-DRE-65541-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65541-3.11Converted from EntitySet in ReactomeTAF7,TAF7LReactome DB_ID: 10183377TAF7Q8JHG4Reactome DB_ID: 10183373UniProt:Q8JHG4UniProtQ8JHG41EQUAL349EQUALReactome Database ID Release 7010183373Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183373ReactomeR-DRE-2123471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212347.1TAF7LQ8JHG4Reactome DB_ID: 101833751EQUAL462EQUALReactome Database ID Release 7010183375Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183375ReactomeR-DRE-29808741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2980874.1Reactome Database ID Release 7010183377Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183377ReactomeR-DRE-88667021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866702.11TAF4BE7FBZ0Reactome DB_ID: 101833191EQUAL862EQUALReactome Database ID Release 7010183319Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183319ReactomeR-DRE-655591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65559.11TAF13F1QBH2Reactome DB_ID: 10183331UniProt:F1QBH2UniProtF1QBH21EQUAL124EQUALReactome Database ID Release 7010183331Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183331ReactomeR-DRE-655571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65557.11TAF5B8JIQ0Reactome DB_ID: 10183315UniProt:B8JIQ0UniProtB8JIQ01EQUAL800EQUALReactome Database ID Release 7010183315Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183315ReactomeR-DRE-655431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65543.11TAF12Q6P013Reactome DB_ID: 10183335UniProt:Q6P013UniProtQ6P0131EQUAL161EQUALReactome Database ID Release 7010183335Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183335ReactomeR-DRE-655551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65555.11TAF2Q32PW3Reactome DB_ID: 10183355UniProt:Q32PW3UniProtQ32PW31EQUAL1199EQUALReactome Database ID Release 7010183355Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183355ReactomeR-DRE-2124081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212408.11TBPQ7SXL3Reactome DB_ID: 10182926UniProt:Q7SXL3UniProtQ7SXL31EQUAL339EQUALReactome Database ID Release 7010182926Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10182926ReactomeR-DRE-837181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-83718.11TAF15A1A5X7Reactome DB_ID: 10183381UniProt:A1A5X7UniProtA1A5X71EQUAL592EQUALReactome Database ID Release 7010183381Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183381ReactomeR-DRE-90206801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9020680.11TAF3Q5RH27Reactome DB_ID: 10183359UniProt:Q5RH27UniProtQ5RH271EQUAL929EQUALReactome Database ID Release 7010183359Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183359ReactomeR-DRE-2124461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-212446.11Reactome Database ID Release 7010183383Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183383ReactomeR-DRE-1096261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109626.11TFIIEReactome DB_ID: 10183393GTF2E2Q6NXA3Reactome DB_ID: 10183391UniProt:Q6NXA3UniProtQ6NXA31EQUAL291EQUALReactome Database ID Release 7010183391Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183391ReactomeR-DRE-655631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65563.11GTF2E1Q5SQE1Reactome DB_ID: 10183387UniProt:Q5SQE1UniProtQ5SQE12EQUAL439EQUALReactome Database ID Release 7010183387Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183387ReactomeR-DRE-655611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65561.11Reactome Database ID Release 7010183393Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183393ReactomeR-DRE-1096331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109633.11TFIIHReactome DB_ID: 10183093CAKReactome DB_ID: 10183063CDK7Q2V6H0Reactome DB_ID: 10183053UniProt:Q2V6H0UniProtQ2V6H01EQUAL346EQUALReactome Database ID Release 7010183053Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183053ReactomeR-DRE-692181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-69218.11MNAT1B8A5G8Reactome DB_ID: 10183061UniProt:B8A5G8UniProtB8A5G81EQUAL309EQUALReactome Database ID Release 7010183061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183061ReactomeR-DRE-590121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-59012.11CCNHA2BGI0Reactome DB_ID: 10183057UniProt:A2BGI0UniProtA2BGI01EQUAL323EQUALReactome Database ID Release 7010183057Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183057ReactomeR-DRE-692201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-69220.11Reactome Database ID Release 7010183063Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183063ReactomeR-DRE-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-69221.11ERCC2F1Q5E7Reactome DB_ID: 10183067UniProt:F1Q5E7UniProtF1Q5E71EQUAL760EQUALReactome Database ID Release 7010183067Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183067ReactomeR-DRE-674431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-67443.11GTF2H1Q66I03Reactome DB_ID: 10183087UniProt:Q66I03UniProtQ66I031EQUAL548EQUALReactome Database ID Release 7010183087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183087ReactomeR-DRE-659121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65912.11GTF2H2Q7ZVV4Reactome DB_ID: 10183079UniProt:Q7ZVV4UniProtQ7ZVV41EQUAL395EQUALReactome Database ID Release 7010183079Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183079ReactomeR-DRE-659141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65914.11GTF2H4Q1LWR3Reactome DB_ID: 10183083UniProt:Q1LWR3UniProtQ1LWR31EQUAL462EQUALReactome Database ID Release 7010183083Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183083ReactomeR-DRE-659181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65918.11GTF2H3A5WWE3Reactome DB_ID: 10183075UniProt:A5WWE3UniProtA5WWE31EQUAL308EQUALReactome Database ID Release 7010183075Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183075ReactomeR-DRE-659161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65916.11ERCC3Q7ZVV1Reactome DB_ID: 10183071UniProt:Q7ZVV1UniProtQ7ZVV11EQUAL782EQUALReactome Database ID Release 7010183071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183071ReactomeR-DRE-674391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-67439.11GTF2H5Q5SNQ6Reactome DB_ID: 10183091UniProt:Q5SNQ6UniProtQ5SNQ61EQUAL71EQUALReactome Database ID Release 7010183091Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183091ReactomeR-DRE-56884461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5688446.11Reactome Database ID Release 7010183093Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183093ReactomeR-DRE-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109634.11TFIIAReactome DB_ID: 10183307A0A0R4IDL3GTF2A1(1-274)Reactome DB_ID: 10183299UniProt:A0A0R4IDL3UniProtA0A0R4IDL31EQUAL274EQUALReactome Database ID Release 7010183299Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183299ReactomeR-DRE-1097671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109767.11GTF2A2Q503H9Reactome DB_ID: 10183305UniProt:Q503H9UniProtQ503H91EQUAL109EQUALReactome Database ID Release 7010183305Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183305ReactomeR-DRE-655331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65533.11A0A0R4IDL3GTF2A1(275-376)Reactome DB_ID: 10183301275EQUAL376EQUALReactome Database ID Release 7010183301Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183301ReactomeR-DRE-1097681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109768.11Reactome Database ID Release 7010183307Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183307ReactomeR-DRE-1096291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109629.11template DNA with first transcript dinucleotide, opened to +8 positionReactome DB_ID: 109877Reactome Database ID Release 70109877Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109877ReactomeR-ALL-1098771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109877.11GTF2BA0A0R4IRB5Reactome DB_ID: 10183311UniProt:A0A0R4IRB5UniProtA0A0R4IRB51EQUAL316EQUALReactome Database ID Release 7010183311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183311ReactomeR-DRE-658881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65888.11Reactome Database ID Release 7010183395Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183395ReactomeR-DRE-1098781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109878.1Reactome Database ID Release 7010183397Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10183397ReactomeR-DRE-739461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-73946.1At the beginning of this reaction, 1 molecule of 'pol II transcription complex' is present. At the end of this reaction, 1 molecule of 'TFIIA', 1 molecule of 'TFIIH', 1 molecule of 'TFIIE', 1 molecule of 'TFIID', 1 molecule of 'TFIIB', 1 molecule of 'RNA Polymerase II (unphosphorylated):TFIIF complex', and 1 molecule of 'template DNA with first transcript dinucleotide, opened to +8 position' are present.<br><br> This reaction takes place in the 'nucleus'.<br>1939271Pubmed1991Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.Jacob, GALuse, SWLuse, DSJ Biol Chem 266:22537-44inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTAbortive Initiation After Second TransitionThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>pol II transcription complex containing 4-9 nucleotide long transcriptReactome DB_ID: 10184693111template DNA:4-9 nucleotide transcript hybridReactome DB_ID: 75897Reactome Database ID Release 7075897Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75897ReactomeR-ALL-758972Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-75897.21Reactome Database ID Release 7010184693Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184693ReactomeR-DRE-758901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-75890.1Reactome Database ID Release 7010184695Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184695ReactomeR-DRE-758911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-75891.1At the beginning of this reaction, 1 molecule of 'pol II transcription complex containing 4-9 nucleotide long transcript' is present. At the end of this reaction, 1 molecule of 'template DNA:4-9 nucleotide transcript hybrid', 1 molecule of 'TFIIH', 1 molecule of 'TFIIE', and 1 molecule of 'RNA Polymerase II (unphosphorylated):TFIIF complex' are present.<br><br> This reaction takes place in the 'nucleus'.<br>LEFT-TO-RIGHTAbortive Initiation Before Second TransitionThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Pol II Promoter Escape ComplexReactome DB_ID: 10184549111111DNA containing Pol II promoter with transcript with 2 or 3 nucleotidesReactome DB_ID: 110068Reactome Database ID Release 70110068Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110068ReactomeR-ALL-1100681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-110068.11Reactome Database ID Release 7010184549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184549ReactomeR-DRE-758591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-75859.1Reactome Database ID Release 7010184551Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184551ReactomeR-DRE-758561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-75856.1At the beginning of this reaction, 1 molecule of 'Pol II Promoter Escape Complex' is present. At the end of this reaction, 1 molecule of 'TFIIA', 1 molecule of 'TFIIH', 1 molecule of 'TFIIE', 1 molecule of 'TFIID', 1 molecule of 'TFIIB', 1 molecule of 'RNA Polymerase II (unphosphorylated):TFIIF complex', and 1 molecule of 'DNA containing Pol II promoter with transcript with 2 or 3 nucleotides' are present.<br><br> This reaction takes place in the 'nucleus'.<br>LEFT-TO-RIGHTFormation of DSIF complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Q9DDT5phospho-p-SUPT5HReactome DB_ID: 10185075UniProt:Q9DDT5UniProtQ9DDT5phosphorylated residueMODMOD:006961EQUAL1087EQUALReactome Database ID Release 7010185075Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10185075ReactomeR-DRE-30093721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3009372.1Q6DGQ0SUPT4H1Reactome DB_ID: 10186827UniProt:Q6DGQ0UniProtQ6DGQ01EQUAL117EQUALReactome Database ID Release 7010186827Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186827ReactomeR-DRE-649051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-64905.1DSIF complexReactome DB_ID: 1018682911Reactome Database ID Release 7010186829Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186829ReactomeR-DRE-1124201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112420.1Reactome Database ID Release 7010186968Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186968ReactomeR-DRE-1124341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112434.1At the beginning of this reaction, 1 molecule of 'SUPT5H protein', and 1 molecule of 'SPT4H1 protein' are present. At the end of this reaction, 1 molecule of 'DSIF complex' is present (Wada et al. 1998).<br><br> This reaction takes place in the 'nucleus'.<br>9450929Pubmed1998DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.Wada, TTakagi, TYamaguchi, YFerdous, AImai, THirose, SSugimoto, SYano, KHartzog, GAWinston, FBuratowski, StephenHanda, HiroshiGenes Dev 12:343-56LEFT-TO-RIGHTFormation of Elongin BC complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TCEB2X1WBN9Reactome DB_ID: 10186881UniProt:X1WBN9UniProtX1WBN91EQUAL118EQUALReactome Database ID Release 7010186881Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186881ReactomeR-DRE-1124231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112423.1TCEB1Q502M9Reactome DB_ID: 10186877UniProt:Q502M9UniProtQ502M91EQUAL112EQUALReactome Database ID Release 7010186877Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186877ReactomeR-DRE-1124221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112422.1Elongin B:C complexReactome DB_ID: 1018688311Reactome Database ID Release 7010186883Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186883ReactomeR-DRE-1124241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112424.1Reactome Database ID Release 7010186970Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186970ReactomeR-DRE-1124351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112435.1At the beginning of this reaction, 1 molecule of 'Elongin B protein', and 1 molecule of 'Elongin C protein' are present. At the end of this reaction, 1 molecule of 'Elongin B:C complex' is present. This reaction takes place in the 'nucleus' (Aso et al., 1995; Duan et al., 1995b; Kibel et al., 1995).7660122Pubmed1995Inhibition of transcription elongation by the VHL tumor suppressor proteinDuan, D RPause, ABurgess, W HAso, TChen, D YGarrett, K PConaway, R CConaway, J WLinehan, W MKlausner, R DScience 269:1402-67660129Pubmed1995Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase IIAso, TLane, WSConaway, J WConaway, R CScience 269:1439-437660130Pubmed1995Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and CKibel, AIliopoulos, ODeCaprio, JAKaelin, W GScience 269:1444-6LEFT-TO-RIGHTFormation of FACT complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>F6P4V6SUPT16HReactome DB_ID: 10186871UniProt:F6P4V6UniProtF6P4V62EQUAL1047EQUALReactome Database ID Release 7010186871Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186871ReactomeR-DRE-1124151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112415.1SSRP1F6NLJ7Reactome DB_ID: 10186867UniProt:F6NLJ7UniProtF6NLJ72EQUAL709EQUALReactome Database ID Release 7010186867Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186867ReactomeR-DRE-651051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65105.1FACT complexReactome DB_ID: 1018687311Reactome Database ID Release 7010186873Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186873ReactomeR-DRE-1124171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112417.1Reactome Database ID Release 7010186964Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186964ReactomeR-DRE-1124291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112429.1At the beginning of this reaction, 1 molecule of 'FACT 140 kDa subunit', and 1 molecule of 'FACT 80 kDa subunit' are present. At the end of this reaction, 1 molecule of 'FACT complex' is present.<br><br> This reaction takes place in the 'nucleus' (Kamakaka et al.1993, Orphanides et al.1998).<br>8370526Pubmed1993Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assemblyKamakaka, R TBulger, MKadonaga, J TGenes Dev. 7:1779-959489704Pubmed1998FACT, a factor that facilitates transcript elongation through nucleosomesOrphanides, GLeRoy, GChang, C HLuse, DSReinberg, DCell 92:105-16LEFT-TO-RIGHTFormation of NELF complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>NELFBF1RDI8Reactome DB_ID: 10186813UniProt:F1RDI8UniProtF1RDI81EQUAL580EQUALReactome Database ID Release 7010186813Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186813ReactomeR-DRE-1124271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112427.1NELFAA0A0R4IBP1Reactome DB_ID: 10186809UniProt:A0A0R4IBP1UniProtA0A0R4IBP11EQUAL528EQUALReactome Database ID Release 7010186809Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186809ReactomeR-DRE-1124261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112426.1NELFEQ1LWQ2Reactome DB_ID: 10186821UniProt:Q1LWQ2UniProtQ1LWQ21EQUAL380EQUALReactome Database ID Release 7010186821Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186821ReactomeR-DRE-629071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-62907.1NELFCDF1Q889Reactome DB_ID: 10186817UniProt:F1Q889UniProtF1Q8891EQUAL590EQUALReactome Database ID Release 7010186817Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186817ReactomeR-DRE-1124281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112428.1NELF complexReactome DB_ID: 101868231111Reactome Database ID Release 7010186823Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186823ReactomeR-DRE-1124321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112432.1Reactome Database ID Release 7010186974Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186974ReactomeR-DRE-1124371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112437.1At the beginning of this reaction, 1 molecule of 'NELF-A protein', 1 molecule of 'RD protein', 1 molecule of 'NELF-B protein', and 1 molecule of 'NELF-C/D protein' are present. At the end of this reaction, 1 molecule of 'NELF complex' is present(Yamaguchi et al.1999).<br><br> This reaction takes place in the 'nucleus'.<br>10199401Pubmed1999NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationYamaguchi, YTakagi, TWada, TYano, KFuruya, ASugimoto, SHasegawa, JHanda, HiroshiCell 97:41-51LEFT-TO-RIGHTFormation of P-TEFb complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeCCNT1,CCNT2,CCNKReactome DB_ID: 10186803CCNKQ5RGW5Reactome DB_ID: 10186793UniProt:Q5RGW5UniProtQ5RGW51EQUAL580EQUALReactome Database ID Release 7010186793Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186793ReactomeR-DRE-67966191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6796619.1CCNT1B8A521Reactome DB_ID: 10186797UniProt:B8A521UniProtB8A5211EQUAL726EQUALReactome Database ID Release 7010186797Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186797ReactomeR-DRE-516111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-51611.1CCNT2Q803Q8Reactome DB_ID: 10186801UniProt:Q803Q8UniProtQ803Q81EQUAL730EQUALReactome Database ID Release 7010186801Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186801ReactomeR-DRE-516131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-51613.1Reactome Database ID Release 7010186803Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186803ReactomeR-DRE-68074661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6807466.1CDK9A0A0R4II91Reactome DB_ID: 10186789UniProt:A0A0R4II91UniProtA0A0R4II911EQUAL372EQUALReactome Database ID Release 7010186789Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186789ReactomeR-DRE-518011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-51801.1P-TEFb complexReactome DB_ID: 1018680511Reactome Database ID Release 7010186805Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186805ReactomeR-DRE-1124311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112431.1Reactome Database ID Release 7010186966Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186966ReactomeR-DRE-1124301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112430.1At the beginning of this reaction, 1 molecule of 'Cdk 9 protein', 1 molecule of 'Cyclin T1', and 1 molecule of 'Cyclin T2' are present. At the end of this reaction, 1 molecule of 'P-TEFb complex' is present.<br><br> This reaction takes place in the 'nucleus'.<br>11884399Pubmed2002P-TEFb containing cyclin K and Cdk9 can activate transcription via RNALin, XinTaube, RanFujinaga, KohPeterlin, B MatijaJ. Biol. Chem. 277:16873-8LEFT-TO-RIGHTFormation of Elongin complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeElongin AReactome DB_ID: 10186893TCEB3A0A0R4IBY3Reactome DB_ID: 10186887UniProt:A0A0R4IBY3UniProtA0A0R4IBY31EQUAL798EQUALReactome Database ID Release 7010186887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186887ReactomeR-DRE-1124211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112421.1TCEB3BA0A0R4IBY3Reactome DB_ID: 101868891EQUAL753EQUALReactome Database ID Release 7010186889Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186889ReactomeR-DRE-88678021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8867802.1TCEB3CA0A0R4IBY3Reactome DB_ID: 101868911EQUAL546EQUALReactome Database ID Release 7010186891Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186891ReactomeR-DRE-88678061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8867806.1Reactome Database ID Release 7010186893Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186893ReactomeR-DRE-88677951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8867795.1Elongin ComplexReactome DB_ID: 1018689511Reactome Database ID Release 7010186895Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186895ReactomeR-DRE-1124251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112425.1Reactome Database ID Release 7010186972Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186972ReactomeR-DRE-1124361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112436.1At the beginning of this reaction, 1 molecule of 'Elongin A1 protein', and 1 molecule of 'Elongin B:C complex' are present. At the end of this reaction, 1 molecule of 'Elongin Complex' is present.<br><br> This reaction takes place in the 'nucleus' (Kibel et al. 1995, Aso et al. 1995, Duan et al. 1995).<br>LEFT-TO-RIGHTResumption of elongation after recovery from pausingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Paused processive elongation complexReactome DB_ID: 10186950MLLT1E9QEN8Reactome DB_ID: 10186857UniProt:E9QEN8UniProtE9QEN81EQUAL559EQUALReactome Database ID Release 7010186857Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186857ReactomeR-DRE-89329181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932918.1111CTDP1E7FFL3Reactome DB_ID: 10186833UniProt:E7FFL3UniProtE7FFL31EQUAL961EQUALReactome Database ID Release 7010186833Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186833ReactomeR-DRE-1134161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113416.111Elongating transcript in processive Pol II mediated elongationReactome DB_ID: 113717Reactome Database ID Release 70113717Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113717ReactomeR-ALL-1137171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113717.11ELLQ6PEG4Reactome DB_ID: 10186853UniProt:Q6PEG4UniProtQ6PEG41EQUAL621EQUALReactome Database ID Release 7010186853Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186853ReactomeR-DRE-542571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-54257.11IWS1F1QJ31Reactome DB_ID: 10186925UniProt:F1QJ31UniProtF1QJ311EQUAL819EQUALReactome Database ID Release 7010186925Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186925ReactomeR-DRE-89329111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932911.11SUPT6HQ8UVK2Reactome DB_ID: 10186929UniProt:Q8UVK2UniProtQ8UVK22EQUAL1726EQUALReactome Database ID Release 7010186929Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186929ReactomeR-DRE-89329081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932908.1111EAF2Q6IQU8Reactome DB_ID: 10186845UniProt:Q6IQU8UniProtQ6IQU81EQUAL260EQUALReactome Database ID Release 7010186845Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186845ReactomeR-DRE-89327901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932790.11EAF1Q6IQD2Reactome DB_ID: 10186841UniProt:Q6IQD2UniProtQ6IQD21EQUAL268EQUALReactome Database ID Release 7010186841Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186841ReactomeR-DRE-89327871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932787.11PAF1CReactome DB_ID: 10186921LEO1Q6NYV9Reactome DB_ID: 10186907UniProt:Q6NYV9UniProtQ6NYV92EQUAL666EQUALReactome Database ID Release 7010186907Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186907ReactomeR-DRE-33223611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3322361.11RTF1G1K2X4Reactome DB_ID: 10186915UniProt:G1K2X4UniProtG1K2X41EQUAL710EQUALReactome Database ID Release 7010186915Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186915ReactomeR-DRE-88666931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866693.11WDR61Q6P5M2Reactome DB_ID: 10186919UniProt:Q6P5M2UniProtQ6P5M21EQUAL305EQUALReactome Database ID Release 7010186919Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186919ReactomeR-DRE-88666961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866696.11CDC73X1WHN7Reactome DB_ID: 10186899UniProt:X1WHN7UniProtX1WHN72EQUAL531EQUALReactome Database ID Release 7010186899Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186899ReactomeR-DRE-33223601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3322360.11CTR9A3KDM3Reactome DB_ID: 10186903UniProt:A3KDM3UniProtA3KDM31EQUAL1173EQUALReactome Database ID Release 7010186903Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186903ReactomeR-DRE-88666941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866694.11PAF1Q4U0S5Reactome DB_ID: 10186911UniProt:Q4U0S5UniProtQ4U0S51EQUAL531EQUALReactome Database ID Release 7010186911Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186911ReactomeR-DRE-88666891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866689.11Reactome Database ID Release 7010186921Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186921ReactomeR-DRE-88666901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8866690.11MLLT3F1QFU7Reactome DB_ID: 10186849UniProt:F1QFU7UniProtF1QFU71EQUAL568EQUALReactome Database ID Release 7010186849Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186849ReactomeR-DRE-89327891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932789.11TCEA1Q7T3C1Reactome DB_ID: 10186863UniProt:Q7T3C1UniProtQ7T3C11EQUAL301EQUALReactome Database ID Release 7010186863Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186863ReactomeR-DRE-657481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-65748.11RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complexReactome DB_ID: 101867851RNA Polymerase II holoenzyme complex (hyperphosphorylated)Reactome DB_ID: 101867831111A0A0R4IMS9phospho-p-S2,S5-POLR2AReactome DB_ID: 101867815EQUALO-phospho-L-serineMODMOD:000462EQUAL1EQUAL1970EQUALReactome Database ID Release 7010186781Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186781ReactomeR-DRE-1134201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113420.111111111Reactome Database ID Release 7010186783Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186783ReactomeR-DRE-1099091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109909.11Reactome Database ID Release 7010186785Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186785ReactomeR-DRE-1134251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113425.11AFF4I3ISK1Reactome DB_ID: 10186837UniProt:I3ISK1UniProtI3ISK11EQUAL1163EQUALReactome Database ID Release 7010186837Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186837ReactomeR-DRE-89327881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932788.11Reactome Database ID Release 7010186950Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186950ReactomeR-DRE-1137201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113720.1Processive elongation complexReactome DB_ID: 10186946111Converted from EntitySet in ReactomeNTPReactome DB_ID: 30595ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 29358ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 7029358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358ReactomeR-ALL-293583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3CTPcytidine 5'-triphosphateCytidine triphosphateReactome DB_ID: 29470CTP [ChEBI:17677]CTPcytidine 5'-triphosphateCytidine triphosphateChEBICHEBI:17677Reactome Database ID Release 7029470Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29470ReactomeR-ALL-294702Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29470.2GTPGuanosine 5'-triphosphateReactome DB_ID: 113571GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 70113571Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113571ReactomeR-ALL-1135712Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113571.2UTPuridine 5'-triphosphateUridine triphosphateReactome DB_ID: 113562UTP [ChEBI:15713]UTPuridine 5'-triphosphateUridine triphosphateChEBICHEBI:15713Reactome Database ID Release 70113562Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113562ReactomeR-ALL-1135622Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113562.2Reactome Database ID Release 7030595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30595ReactomeR-ALL-305951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30595.11111111111111111Reactome Database ID Release 7010186946Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186946ReactomeR-DRE-1137191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113719.1Reactome Database ID Release 7010186952Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186952ReactomeR-DRE-1123921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112392.1Recovery from pausing occurs spontaneously after a variable length of time as the enzyme spontaneously slides forward again. This renders the transcript's 3'-OH terminus realigned with the catalytic Mg2+ site of the enzyme. TFIIS is capable of excising the nascent transcript at 2 or 3 nucleotides upstream of the transcript's 3'-end to reinitiate processive elongation (reviewed by Shilatifard et al., 2003).12676794Pubmed2003The RNA polymerase II elongation complex.Shilatifard, AConaway, Ron CConaway, Joan WAnnu Rev Biochem 72:693-715LEFT-TO-RIGHT2-4 nt.backtracking of Pol II complex on the template leading to elongation pausingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome Database ID Release 7010186982Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186982ReactomeR-DRE-1134111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113411.1Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).LEFT-TO-RIGHT7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrestThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome Database ID Release 7010186988Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186988ReactomeR-DRE-1134141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113414.1RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. It is suggested that, arrest leads to extrusion of displaced transcripts 3'-end through the small pore near the Mg2+ ion. Pol II arrest may lead to abortive termination of elongation due to irreversible trapping of the 3'-end of the displaced transcript in the pore (reviewed by Shilatifard et al., 2003).LEFT-TO-RIGHTTFIIS-mediated recovery of elongation from arrestThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome Database ID Release 7010186986Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186986ReactomeR-DRE-1134131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113413.1TFIIS reactivates arrested RNA Pol II directly interacting with the enzyme resulting in endonucleolytic excision of nascent transcript ~7-14 nucleotides upstream of the 3' end. This reaction is catalyzed by the catalytic site and results in the generation of a new 3'-OH terminus that could be used for re-extension from the correctly base paired site (reviewed by Shilatifard et al., 2003).LEFT-TO-RIGHTAbortive termination of early transcription elongation by DSIF:NELFThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>DSIF:NELF:early elongation complexReactome DB_ID: 10186941RNA Pol II (hypophosphorylated) complex bound to DSIF proteinReactome DB_ID: 10186939RNA Pol II (hypophosphorylated):capped pre-mRNA complexReactome DB_ID: 10186937capped pre-mRNAReactome DB_ID: 72085Reactome Database ID Release 7072085Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72085ReactomeR-ALL-720851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-72085.11Cap Binding Complex (CBC)Reactome DB_ID: 10181134Ghost homologue of NCBP1Reactome DB_ID: 10181132Reactome Database ID Release 7010181132Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181132ReactomeR-DRE-514691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-51469.11NCBP2Q8JGR6Reactome DB_ID: 10181130UniProt:Q8JGR6UniProtQ8JGR61EQUAL156EQUALReactome Database ID Release 7010181130Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181130ReactomeR-DRE-514631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-51463.11Reactome Database ID Release 7010181134Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181134ReactomeR-DRE-770881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-77088.111RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complexReactome DB_ID: 1018693511111A0A0R4IMS9phospho-p-S5-POLR2AReactome DB_ID: 101811391EQUAL1970EQUALReactome Database ID Release 7010181139Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10181139ReactomeR-DRE-771001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-77100.111111111Reactome Database ID Release 7010186935Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186935ReactomeR-DRE-1134271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113427.11Reactome Database ID Release 7010186937Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186937ReactomeR-DRE-1137151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113715.111Reactome Database ID Release 7010186939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186939ReactomeR-DRE-1134061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113406.111Reactome Database ID Release 7010186941Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186941ReactomeR-DRE-1134081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113408.1Reactome Database ID Release 7010186980Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186980ReactomeR-DRE-1134091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113409.1In the early elongation phase, shorter transcripts typically of ~30 nt in length are generated due to random termination of elongating nascent transcripts. This abortive cessation of elongation has been observed mainly in the presence of DSIF-NELF bound to Pol II complex. (Reviewed in Conaway et al.,2000; Shilatifard et al., 2003 ).10916156Pubmed2000Control of elongation by RNA polymerase II.Conaway, Joan WShilatifard, ADvir, AConaway, Ron CTrends Biochem Sci 25:375-80LEFT-TO-RIGHTAbortive termination of elongation after arrestThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Aborted elongation complex after arrestReactome DB_ID: 101869541111111111111111111Reactome Database ID Release 7010186954Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186954ReactomeR-DRE-1137221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113722.1Reactome Database ID Release 7010186956Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186956ReactomeR-DRE-1123951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-112395.1At the beginning of this reaction, 1 molecule of 'Arrested processive elongation complex' is present. At the end of this reaction, 1 molecule of 'Aborted elongation complex after arrest' is present.<br><br> This reaction takes place in the 'nucleus'.<br>LEFT-TO-RIGHTElongating transcript encounters a lesion in the templateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>damaged DNA substrate:nascent mRNA hybridReactome DB_ID: 110291Reactome Database ID Release 70110291Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110291ReactomeR-ALL-1102911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-110291.1Reactome Database ID Release 7010186990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10186990ReactomeR-DRE-1134291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113429.1At the beginning of this reaction, 1 molecule of 'Processive elongation complex' is present. At the end of this reaction, 1 molecule of 'DSIF complex', 1 molecule of 'FACT complex', 1 molecule of 'RNA Polymerase II holoenzyme complex (hyperphosphorylated)', 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid', 1 molecule of 'Elongin Complex', 1 molecule of 'FCP1P protein', 1 molecule of 'P-TEFb complex', 1 molecule of 'NELF complex', 1 molecule of 'RNA polymerase II elongation factor ELL', 1 molecule of 'NTP', 1 molecule of 'TFIIS protein', and 1 molecule of 'TFIIF' are present.<br><br> This reaction takes place in the 'nucleus' (Woudstra et al. 2002).<br>15489290Pubmed2004Elongation by RNA polymerase II: the short and long of itSims, Robert JBelotserkovskaya, RimmaReinberg, DannyGenes Dev. 18:2437-6811859374Pubmed2002A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damageWoudstra, Elies CGilbert, ChrisFellows, JaneJansen, LarsBrouwer, JaapErdjument-Bromage, HTempst, PaulSvejstrup, JQNature 415:929-33LEFT-TO-RIGHTFall Back to Closed Pre-initiation ComplexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>pol II open pre-initiation complexReactome DB_ID: 10184553Open DNA -10 to +2 containing RNA Polymerase II promoterReactome DB_ID: 109875Reactome Database ID Release 70109875Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109875ReactomeR-ALL-1098751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109875.11111111Reactome Database ID Release 7010184553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184553ReactomeR-DRE-1098761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109876.1pol II closed pre-initiation complexReactome DB_ID: 1018456111pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complexReactome DB_ID: 101841911pol II promoter:TFIID:TFIIA:TFIIB complexReactome DB_ID: 1018418911pol II promoter:TFIID complexReactome DB_ID: 101841871DNA containing RNA Polymerase II promoterReactome DB_ID: 109627Reactome Database ID Release 70109627Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109627ReactomeR-ALL-1096271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109627.11Reactome Database ID Release 7010184187Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184187ReactomeR-DRE-1096281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109628.11Reactome Database ID Release 7010184189Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184189ReactomeR-DRE-1096301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109630.11Reactome Database ID Release 7010184191Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184191ReactomeR-DRE-1096321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109632.11Reactome Database ID Release 7010184561Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184561ReactomeR-DRE-1096351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109635.1Reactome Database ID Release 7010184563Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10184563ReactomeR-DRE-758621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-75862.1At the beginning of this reaction, 1 molecule of 'pol II open pre-initiation complex' is present. At the end of this reaction, 1 molecule of 'pol II closed pre-initiation complex' is present.<br><br> This reaction takes place in the 'nucleus'.<br>2449431Pubmed1988ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.Conaway, Ron CConaway, Joan WJ Biol Chem 263:2962-8Reactome Database ID Release 7010290277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10290277ReactomeR-DRE-6746951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-674695.1For initiation, Pol II assembles with the general transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH, which are collectively known as the general transcription factors, at promoter DNA to form the pre-initiation complex (PIC). Until the nascent transcript is about 15 nucleotides long, the early transcribing complex is functionally unstable. In the beginning, short RNAs are frequently released and Pol II has to restart transcription (abortive cycling). There is a decline in the level of abortive transcription when the RNA reaches a length of about four nucleotides, and this transition is termed escape commitment14969722Pubmed2004Structure and function of RNA polymerase IICramer, PAdv. Protein Chem. 67:1-42