BioPAX pathway converted from "PTK2 binds activated EGFR" in the Reactome database.LEFT-TO-RIGHTPTK2 binds activated EGFRThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PTK2ptk2abA0A2R8RR02Reactome DB_ID: 10208655cytosolGENE ONTOLOGYGO:0005829UniProt:A0A2R8RR02ptk2abDanio rerioNCBI Taxonomy7955UniProtA0A2R8RR022EQUAL1052EQUALReactome Database ID Release 7510208655Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10208655ReactomeR-DRE-2016211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-201621.1Reactomehttp://www.reactome.orgEGF-like ligands:p-6Y EGFR dimerReactome DB_ID: 10203708plasma membraneGENE ONTOLOGYGO:0005886Converted from EntitySet in ReactomeEGF-like ligandsReactome DB_ID: 10203654egfEGFA0A140LGI0Reactome DB_ID: 10203620extracellular regionGENE ONTOLOGYGO:0005576UniProt:A0A140LGI0egfUniProtA0A140LGI0971EQUAL1023EQUALReactome Database ID Release 7510203620Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203620ReactomeR-DRE-1798631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-179863.1tgfaTGFA(24-98)Q7T011Reactome DB_ID: 10203624UniProt:Q7T011tgfaUniProtQ7T01124EQUAL98EQUALReactome Database ID Release 7510203624Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203624ReactomeR-DRE-96241831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624183.1Converted from EntitySet in ReactomeHomologues of AREG(101-187)Reactome DB_ID: 10203638hbegfbAREG(101-187)A0A2R8RUB3Reactome DB_ID: 10203628UniProt:A0A2R8RUB3hbegfbUniProtA0A2R8RUB3101EQUAL187EQUALReactome Database ID Release 7510203628Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203628ReactomeR-DRE-96241901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624190.1hbegfaAREG(101-187)A9JRW9Reactome DB_ID: 10203632UniProt:A9JRW9hbegfaUniProtA9JRW9101EQUAL187EQUALReactome Database ID Release 7510203632Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203632ReactomeR-DRE-9624190-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624190-2.1aregAREG(101-187)F1RB57Reactome DB_ID: 10203636UniProt:F1RB57aregUniProtF1RB57101EQUAL187EQUALReactome Database ID Release 7510203636Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203636ReactomeR-DRE-9624190-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624190-3.1Reactome Database ID Release 7510203638Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203638ReactomeR-DRE-9624190-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624190-4.1epgnEPGN(23-154)A0A0R4IWG0Reactome DB_ID: 10203642UniProt:A0A0R4IWG0epgnUniProtA0A0R4IWG023EQUAL154EQUALReactome Database ID Release 7510203642Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203642ReactomeR-DRE-96241871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624187.1btcBTC(32-111)A0A0R4INZ6Reactome DB_ID: 10203646UniProt:A0A0R4INZ6btcUniProtA0A0R4INZ632EQUAL111EQUALReactome Database ID Release 7510203646Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203646ReactomeR-DRE-12332241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1233224.1A0A2R8S013EREG(60-108)Reactome DB_ID: 10203650UniProt:A0A2R8S013UniProtA0A2R8S01360EQUAL108EQUALReactome Database ID Release 7510203650Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203650ReactomeR-DRE-12332331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1233233.1hbegfaHBEGF(63-148)A9JRW9Reactome DB_ID: 1020365263EQUAL148EQUALReactome Database ID Release 7510203652Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203652ReactomeR-DRE-12332341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1233234.1Reactome Database ID Release 7510203654Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203654ReactomeR-DRE-96241941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624194.12p-6Y-EGFRphospho-egfraA0A0R4IFV9Reactome DB_ID: 10203706UniProt:A0A0R4IFV9egfraUniProtA0A0R4IFV9992EQUALO4'-phospho-L-tyrosineMODMOD:000481045EQUAL1068EQUAL1086EQUAL1148EQUAL1173EQUAL25EQUAL1210EQUALReactome Database ID Release 7510203706Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203706ReactomeR-DRE-1798031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-179803.12Reactome Database ID Release 7510203708Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10203708ReactomeR-DRE-96244251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9624425.1EGF-like ligands:p-6Y EGFR:PTK2Reactome DB_ID: 1030142311Reactome Database ID Release 7510301423Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10301423ReactomeR-DRE-96254531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9625453.1Reactome Database ID Release 7510301425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10301425ReactomeR-DRE-96254821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9625482.1PTK2 (also known as FAK, focal adhesion kinase) binds to the activated EGFR receptor as assessed by affinity chromatography and co-immunoprecipitation (Sieg et al, 2000; Thelemann et al, 2005; Liu et al, 2010). Stimulation of the EGFR pathway increases PTK2 phosphorylation at Y397, and FAK phosphorylation contributes to cell migration and tumorigenicity (Tamura et al, 1998; Gu et al, 1999; Sieg et al, 2000; Liu et al, 2010; reviewed in Zhu et al, 2018). PTK2-stimulated cell motility depends on integrins and is transduced through phosphorylated MAPK3 and MAPK1 (also known as ERK1 and ERK2) (Sieg et al, 2000; Thelemann et al, 2000; Liu et al, 2005).10427092Pubmed1999Shc and FAK differentially regulate cell motility and directionality modulated by PTENGu, JTamura, MPankov, RDanen, E HTakino, TMatsumoto, KYamada, K MJ. Cell Biol. 146:389-40315657067Pubmed2005Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cellsThelemann, AprilPetti, FilippoGriffin, GraemeIwata, KenHunt, TonySettinari, TinaFenyo, DavidGibson, NeilHaley, John DMol. Cell Proteomics 4:356-7610806474Pubmed2000FAK integrates growth-factor and integrin signals to promote cell migrationSieg, David JHauck, Christof RIlic, DuskoKlingbeil, Candice KSchaefer, ErikDamsky, Caroline HSchlaepfer, David DNat. Cell Biol. 2:249-5629738483Pubmed2018Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and CancerZhu, XiangdongBao, YonghuaGuo, YongchenYang, WancaiCancers (Basel) 10:20650261Pubmed2010The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathwayLiu, MingzhuYang, YongWang, CanSun, LidongMei, ChuanzhongYao, WantongLiu, YongleiShi, YinghongQiu, ShuangjianFan, JiaCai, XiumeiZha, XiliangArch. Biochem. Biophys. 502:89-959616126Pubmed1998Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENTamura, MasahitoGu, JianguoMatsumoto, KazueAota, SParsons, RYamada, Kenneth MScience 280:1614-7inferred from electronic annotationEVIDENCE CODEECO:0000203