BioPAX pathway converted from "Synthesis of 5-eicosatetraenoic acids" in the Reactome database.Synthesis of 5-eicosatetraenoic acidsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHT1.13.11.34Oxidation of arachidonic acid to 5-HpETEArachidonic acid is oxidised to 5S-HpETE by ALOX5This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>O2OxygendioxygenReactome DB_ID: 29368cytosolGENE ONTOLOGYGO:0005829dioxygen [ChEBI:15379]dioxygenChEBICHEBI:15379Reactome Database ID Release 7529368Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368ReactomeR-ALL-293685Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29368.5Reactomehttp://www.reactome.orgCOMPOUNDC00007additional informationMIMI:0361AAArachidonatearachidonic acidcis-5,8,11,14-Eicosatetraenoic acidReactome DB_ID: 29768arachidonic acid [ChEBI:15843]arachidonic acidChEBICHEBI:15843Reactome Database ID Release 7529768Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29768ReactomeR-ALL-297683Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29768.3COMPOUNDC002195S-HpETE(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid5(S)-HPETEReactome DB_ID: 2660105(S)-HPETE [ChEBI:15632]5(S)-HPETEChEBICHEBI:15632Reactome Database ID Release 75266010Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010ReactomeR-ALL-2660103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266010.3COMPOUNDC05356ACTIVATIONactiveUnit: #Complex3ALOX5:ALOX5AP:LTC4SReactome DB_ID: 10211953nuclear envelopeGENE ONTOLOGYGO:0005635ALOX5AP trimerReactome DB_ID: 10211938F1QKS8alox5apALOX5APReactome DB_ID: 10211936UniProt:F1QKS8alox5apDanio rerioNCBI Taxonomy7955UniProtF1QKS81EQUAL161EQUALReactome Database ID Release 7510211936Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211936ReactomeR-DRE-23187681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2318768.13Reactome Database ID Release 7510211938Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211938ReactomeR-DRE-23187701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2318770.11p-S272-ALOX5:Ca2+:Fe2+Reactome DB_ID: 10211951Ca2+Calciumcalcium(2+)Reactome DB_ID: 2318767calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 752318767Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2318767ReactomeR-ALL-23187673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2318767.3COMPOUNDC000762A0A2R8RVT0phospho-alox5ap-S272-ALOX5Reactome DB_ID: 10211949UniProt:A0A2R8RVT0alox5aUniProtA0A2R8RVT0272EQUALO-phospho-L-serineMODMOD:000462EQUAL674EQUALReactome Database ID Release 7510211949Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211949ReactomeR-DRE-23187651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2318765.11Fe2+iron (ferrous)Fe(II)Fe++IronReactome DB_ID: 2318766iron(2+) [ChEBI:29033]iron(2+)FE (II) IONFe2+Fe(2+)iron ion(2+)Fe(II)Ferrous ionChEBICHEBI:29033Reactome Database ID Release 752318766Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2318766ReactomeR-ALL-23187664Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2318766.4COMPOUNDC000231Reactome Database ID Release 7510211951Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211951ReactomeR-DRE-23187691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2318769.11LTC4S trimerReactome DB_ID: 10211944ltc4sLTC4SE7F8E5Reactome DB_ID: 10211942UniProt:E7F8E5ltc4sUniProtE7F8E51EQUAL150EQUALReactome Database ID Release 7510211942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211942ReactomeR-DRE-2660251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-266025.13Reactome Database ID Release 7510211944Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211944ReactomeR-DRE-21427291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2142729.11Reactome Database ID Release 7510211953Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211953ReactomeR-DRE-23187641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2318764.1GENE ONTOLOGYGO:0004051gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510211954Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211954Reactome Database ID Release 7510211956Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10211956ReactomeR-DRE-2652961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-265296.1Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid in a two-step process. First, arachidonic acid AA is oxidized to form 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).3118366Pubmed1987Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenaseRouzer, CASamuelsson, BProc Natl Acad Sci U S A 84:7393-73164719Pubmed1988Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cellsRouzer, CARands, EKargman, SJones, RERegister, RBDixon, RAJ Biol Chem 263:10135-403006030Pubmed1986Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activitiesRouzer, CAMatsumoto, TSamuelsson, BProc Natl Acad Sci U S A 83:857-61inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHT3.1.1.81PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETEThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 109276extracellular regionGENE ONTOLOGYGO:0005576water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 75109276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276ReactomeR-ALL-1092764Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109276.4COMPOUNDC000015-HETEL5-hydroxy-eicosatetraenoic acid 1,5-lactonemeadowlactoneReactome DB_ID: 8932801meadowlactone [ChEBI:132873]meadowlactoneChEBICHEBI:132873Reactome Database ID Release 758932801Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8932801ReactomeR-ALL-89328013Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8932801.35-HETE5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acidReactome DB_ID: 89328045-HETE [ChEBI:60943]5-HETE(6E,8Z,11Z,14Z)-5-hydroxy-6,8,11,14-eicosatetraenoic acid5-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid(6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid5-OH 6t,8c,11c,14c-20:45-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acidC20H32O35-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acidKGIJOOYOSFUGPC-XTDASVJISA-NCCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O(6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid5-hydroxy,6E,8Z,11Z,14Z-eicosatetraenoic acidInChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+ChEBICHEBI:60943Reactome Database ID Release 758932804Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8932804ReactomeR-ALL-89328042Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8932804.2ACTIVATIONConverted from EntitySet in ReactomePON1,2,3:2xCa2+ dimersReactome DB_ID: 10293902PON1:2xCa2+ dimerReactome DB_ID: 10293886Ca2+Calciumcalcium(2+)Reactome DB_ID: 74112Reactome Database ID Release 7574112Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74112ReactomeR-ALL-741124Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74112.4COMPOUNDC000764Converted from EntitySet in ReactomeHomologues of PON1Reactome DB_ID: 10293884PON1pon3.2E7FFZ8Reactome DB_ID: 10293874UniProt:E7FFZ8pon3.2UniProtE7FFZ82EQUAL355EQUALReactome Database ID Release 7510293874Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293874ReactomeR-DRE-52160771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5216077.1pon1PON1Q66JN5Reactome DB_ID: 10293878UniProt:Q66JN5pon1UniProtQ66JN52EQUAL355EQUALReactome Database ID Release 7510293878Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293878ReactomeR-DRE-5216077-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5216077-2.1pon2PON1Q6NXA5Reactome DB_ID: 10293882UniProt:Q6NXA5pon2UniProtQ6NXA52EQUAL355EQUALReactome Database ID Release 7510293882Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293882ReactomeR-DRE-5216077-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5216077-3.1Reactome Database ID Release 7510293884Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293884ReactomeR-DRE-5216077-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5216077-4.12Reactome Database ID Release 7510293886Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293886ReactomeR-DRE-89326441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932644.1PON2:2xCa2+ dimerReactome DB_ID: 10293890PON2pon3.2E7FFZ8Reactome DB_ID: 102938881EQUAL354EQUALReactome Database ID Release 7510293888Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293888ReactomeR-DRE-89326361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932636.124Reactome Database ID Release 7510293890Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293890ReactomeR-DRE-89326321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932632.1PON3:2xCa2+ dimerReactome DB_ID: 10293900Converted from EntitySet in ReactomeHomologues of PON3Reactome DB_ID: 10293898PON3pon3.2E7FFZ8Reactome DB_ID: 102938922EQUAL354EQUALReactome Database ID Release 7510293892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293892ReactomeR-DRE-89326471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932647.1pon1PON3Q66JN5Reactome DB_ID: 102938942EQUAL354EQUALReactome Database ID Release 7510293894Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293894ReactomeR-DRE-8932647-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932647-2.1pon2PON3Q6NXA5Reactome DB_ID: 102938962EQUAL354EQUALReactome Database ID Release 7510293896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293896ReactomeR-DRE-8932647-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932647-3.1Reactome Database ID Release 7510293898Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293898ReactomeR-DRE-8932647-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932647-4.124Reactome Database ID Release 7510293900Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293900ReactomeR-DRE-89326391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932639.1Reactome Database ID Release 7510293902Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293902ReactomeR-DRE-89326451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932645.1GENE ONTOLOGYGO:0102007Reactome Database ID Release 7510293903Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293903Reactome Database ID Release 7510293905Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293905ReactomeR-DRE-89326331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8932633.1Serum paraoxonase/arylesterases 1, 2 and 3 (PON1,2 and 3) are extracellular lactonases/lactonysing enzymes with overlapping, but also distinct substrate specificity. PONs are homodimeric proteins which bind 2 Ca2+ ions per subunit, necessary for enzyme stability and enzymatic activity. All three PONs can efficiently metabolise 5-hydroxy-eicosatetraenoic acid 1,5-lactone (5-HETEL), a product of both enzymatic and nonenzymatic oxidation of arachidonic acid and may represent one of the PONs' endogenous substrates (Draganov et al. 2005).15772423Pubmed2005Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificitiesDraganov, Dragomir ITeiber, John FSpeelman, AudreyOsawa, YoichiSunahara, RogerLa Du, Bert NJ. Lipid Res. 46:1239-4719082953Pubmed2008Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseasesAviram, MichaelRosenblat, MiraMethods Mol. Biol. 477:259-76Reactome Database ID Release 7510304293Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10304293ReactomeR-DRE-21426881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2142688.1GENE ONTOLOGYGO:0019372gene ontology term for cellular processMIMI:03595-hydroperoxy-eicosatetraenoic acid (5-HpETE), 5-hydroxyeicosatetraenoic acid (5S-HETE) and 5-oxo-eicosatetraenoic acid (5-oxoETE) are formed after the initial step of arachidonic acid oxidation by arachidonate 5-lipoxygenase (ALOX5) (Buczynski et al. 2009, Vance & Vance 2008).19244215Pubmed2009Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biologyBuczynski, MWDumlao, DSDennis, EAJ Lipid Res 50:1015-38978-0-444-53219-0ISBN2008The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathwaysSmith, William LMurphy, RCBiochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 331-362