BioPAX pathway converted from "Sodium/Proton exchangers" in the Reactome database.Sodium/Proton exchangersThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTNa+/H+ exchanger transport (at cell membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Na+sodium ionsodium(1+)SodiumReactome DB_ID: 74113extracellular regionGENE ONTOLOGYGO:0005576sodium(1+) [ChEBI:29101]sodium(1+)ChEBICHEBI:29101Reactome Database ID Release 7574113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113ReactomeR-ALL-741133Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74113.3Reactomehttp://www.reactome.orgCOMPOUNDC01330additional informationMIMI:0361H+protonhydronReactome DB_ID: 70106cytosolGENE ONTOLOGYGO:0005829hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 7570106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106ReactomeR-ALL-701064Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4COMPOUNDC00080Na+sodium ionsodium(1+)SodiumReactome DB_ID: 83910Reactome Database ID Release 7583910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910ReactomeR-ALL-839103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83910.3COMPOUNDC01330H+hydronReactome DB_ID: 351626Reactome Database ID Release 75351626Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626ReactomeR-ALL-3516264Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-351626.4COMPOUNDC00080ACTIVATIONConverted from EntitySet in ReactomeSLC9A1-5Na+/H+ exchanger proteinsReactome DB_ID: 10221300SLC9A1slc9a1bF1QR72Reactome DB_ID: 10221286plasma membraneGENE ONTOLOGYGO:0005886UniProt:F1QR72slc9a1bDanio rerioNCBI Taxonomy7955UniProtF1QR721EQUAL815EQUALReactome Database ID Release 7510221286Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221286ReactomeR-DRE-4260061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-426006.1slc9a2SLC9A2B0S734Reactome DB_ID: 10221290UniProt:B0S734slc9a2UniProtB0S7341EQUAL812EQUALReactome Database ID Release 7510221290Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221290ReactomeR-DRE-4259751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425975.1SLC9A3slc9a3.2A3KPJ8Reactome DB_ID: 10221294UniProt:A3KPJ8slc9a3.2UniProtA3KPJ81EQUAL834EQUALReactome Database ID Release 7510221294Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221294ReactomeR-DRE-4259921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425992.1slc9a5SLC9A5F1R610Reactome DB_ID: 10221298UniProt:F1R610slc9a5UniProtF1R6101EQUAL896EQUALReactome Database ID Release 7510221298Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221298ReactomeR-DRE-4259891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425989.1Reactome Database ID Release 7510221300Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221300ReactomeR-DRE-4259631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425963.1GENE ONTOLOGYGO:0015385gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510221301Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221301Reactome Database ID Release 7510221303Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221303ReactomeR-DRE-4259941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425994.1NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS. 10444453Pubmed1999Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Malakooti, JDahdal, RYSchmidt, LLayden, TJDudeja, PKRamaswamy, KAm J Physiol 277:G383-909933641Pubmed1999Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainBaird, NROrlowski, JSzabó, EZZaun, HCSchultheis, PJMenon, AGShull, GEJ Biol Chem 274:4377-822536298Pubmed1989Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterSardet, CFranchi, APouysségur, JacquesCell 56:271-807631746Pubmed1995Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Brant, SRYun, CHDonowitz, MTse, CMAm J Physiol 269:C198-206inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTNa+/H+ exchanger transport (at early endosome membrane)SLC9A6,7 exchange Na+ for H+ across the early endosome membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H+hydronReactome DB_ID: 425978early endosome lumenGENE ONTOLOGYGO:0031905Reactome Database ID Release 75425978Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425978ReactomeR-ALL-4259783Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425978.3COMPOUNDC00080Na+Sodium ionsodium(1+)Reactome DB_ID: 425971Reactome Database ID Release 75425971Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425971ReactomeR-ALL-4259713Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425971.3ACTIVATIONConverted from EntitySet in ReactomeSLC9A6,7Reactome DB_ID: 10221279SLC9A6slc9a6aA0A0R4IX40Reactome DB_ID: 10221273early endosome membraneGENE ONTOLOGYGO:0031901UniProt:A0A0R4IX40slc9a6aUniProtA0A0R4IX401EQUAL669EQUALReactome Database ID Release 7510221273Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221273ReactomeR-DRE-4259841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425984.1slc9a7SLC9A7F1Q610Reactome DB_ID: 10221277UniProt:F1Q610slc9a7UniProtF1Q6101EQUAL725EQUALReactome Database ID Release 7510221277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221277ReactomeR-DRE-40846751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-4084675.1Reactome Database ID Release 7510221279Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221279ReactomeR-DRE-40846781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-4084678.1Reactome Database ID Release 7510221280Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221280Reactome Database ID Release 7510221282Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221282ReactomeR-DRE-4259831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425983.1NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.11940519Pubmed2002Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondriaBrett, CLWei, YDonowitz, MRao, RAm J Physiol Cell Physiol 282:C1031-4115522866Pubmed2005Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationNakamura, NTanaka, STeko, YMitsui, KKanazawa, HJ Biol Chem 280:1561-72LEFT-TO-RIGHTNa+/H+ exchanger transport (at trans-golgi membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H+hydronReactome DB_ID: 425969Golgi lumenGENE ONTOLOGYGO:0005796Reactome Database ID Release 75425969Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425969ReactomeR-ALL-4259693Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425969.3COMPOUNDC00080Na+sodium ionsodium(1+)SodiumReactome DB_ID: 425958Reactome Database ID Release 75425958Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425958ReactomeR-ALL-4259583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425958.3COMPOUNDC01330ACTIVATIONConverted from EntitySet in ReactomeSLC9A7/8Na+/H+ exchanger proteins 7/8Reactome DB_ID: 10221311slc9a7SLC9A7F1Q610Reactome DB_ID: 10221305Golgi membraneGENE ONTOLOGYGO:00001391EQUAL725EQUALReactome Database ID Release 7510221305Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221305ReactomeR-DRE-4259601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425960.1slc9a8SLC9A8F1QHS0Reactome DB_ID: 10221309UniProt:F1QHS0slc9a8UniProtF1QHS01EQUAL581EQUALReactome Database ID Release 7510221309Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221309ReactomeR-DRE-4260031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-426003.1Reactome Database ID Release 7510221311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221311ReactomeR-DRE-4260051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-426005.1Reactome Database ID Release 7510221312Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221312Reactome Database ID Release 7510221314Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10221314ReactomeR-DRE-4260151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-426015.1NHE7 and 8 (SLC9A7,8) (Nakamura N et al, 2005) are expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the trans-golgi network.11279194Pubmed2001Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi networkNumata, MOrlowski, JJ Biol Chem 276:17387-94Reactome Database ID Release 7510304615Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10304615ReactomeR-DRE-4259861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-425986.1The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.12845533Pubmed2004Diversity of the mammalian sodium/proton exchanger SLC9 gene familyOrlowski, JGrinstein, SPflugers Arch 447:549-65