BioPAX pathway converted from "SPAM1 Binds Hyaluronic Acid" in the Reactome database. LEFT-TO-RIGHT SPAM1 Binds Hyaluronic Acid This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> HUA hyaluronic acid Reactome DB_ID: 1297302 extracellular region GENE ONTOLOGY GO:0005576 hyaluronic acid [ChEBI:16336] hyaluronic acid ChEBI CHEBI:16336 Reactome Database ID Release 82 1297302 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1297302 Reactome R-ALL-1297302 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1297302.3 Reactome http://www.reactome.org SPAM1 SPAM1 Q8MI02 Reactome DB_ID: 10306269 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:Q8MI02 SPAM1 Sus scrofa NCBI Taxonomy 9823 UniProt Q8MI02 36 EQUAL 490 EQUAL Reactome Database ID Release 82 10306269 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306269 Reactome R-SSC-1297316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1297316.1 SPAM1:Hyaluronic acid Reactome DB_ID: 10306271 1 1 Reactome Database ID Release 82 10306271 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306271 Reactome R-SSC-1297353 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1297353.1 Reactome Database ID Release 82 10306273 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306273 Reactome R-SSC-2534346 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2534346.1 GENE ONTOLOGY GO:0035036 gene ontology term for cellular process MI MI:0359 The fertilizing spermatozoon must penetrate the surrounding cumulus mass, (or cumulus oophorus), consisting of follicular cells dispersed in a polymerized matrix composed mainly of hyaluronic acid. 8195297 Pubmed 1994 A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg Lin, Y Mahan, K Lathrop, WF Myles, DG Primakoff, P J Cell Biol 125:1157-63 inferred from electronic annotation EVIDENCE CODE ECO:0000203