BioPAX pathway converted from "Caspase 3-mediated cleavage of PKC delta" in the Reactome database.LEFT-TO-RIGHT3.4.22Caspase 3-mediated cleavage of PKC deltaThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>prkcdPRKCDF7EG64Reactome DB_ID: 10314480cytosolGENE ONTOLOGYGO:0005829UniProt:F7EG64prkcdXenopus tropicalisNCBI Taxonomy8364UniProtF7EG641EQUAL676EQUALReactome Database ID Release 7510314480Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314480ReactomeR-XTR-582001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-58200.1Reactomehttp://www.reactome.orgprkcdPRKCD(1-329)F7EG64Reactome DB_ID: 103296971EQUAL329EQUALReactome Database ID Release 7510329697Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10329697ReactomeR-XTR-2125471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212547.1prkcdPRKCD(330-676)F7EG64Reactome DB_ID: 10329695330EQUAL676EQUALReactome Database ID Release 7510329695Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10329695ReactomeR-XTR-2125511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212551.1ACTIVATIONCaspase-3Reactome DB_ID: 10314887CASP3(29-175):CASP3(176-277)Reactome DB_ID: 10314885F6RF24casp3.2CASP3(29-175)Reactome DB_ID: 10314883UniProt:F6RF24casp3.2UniProtF6RF2429EQUAL175EQUALReactome Database ID Release 7510314883Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314883ReactomeR-XTR-1416441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-141644.11F6RF24casp3.2CASP3(176-277)Reactome DB_ID: 10314881176EQUAL277EQUALReactome Database ID Release 7510314881Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314881ReactomeR-XTR-1416461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-141646.11Reactome Database ID Release 7510314885Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314885ReactomeR-XTR-3508881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-350888.12Reactome Database ID Release 7510314887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314887ReactomeR-XTR-3508701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-350870.1GENE ONTOLOGYGO:0004197gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510327004Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10327004Reactome Database ID Release 7510329699Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10329699ReactomeR-XTR-2125521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212552.1Caspase mediated cleavage produces a constitutively active kinase that induces apoptosis (Ghayur et al.,1996).8976194Pubmed1996Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosisGhayur, THugunin, MTalanian, RVRatnofsky, SQuinlan, CEmoto, YPandey, PDatta, RHuang, YKharbanda, SAllen, HKamen, RWong, WKufe, DJ Exp Med 184:2399-404inferred from electronic annotationEVIDENCE CODEECO:0000203