BioPAX pathway converted from "p53-Independent G1/S DNA damage checkpoint" in the Reactome database. p53-Independent G1/S DNA damage checkpoint This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p53-Independent DNA Damage Response This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ubiquitin Mediated Degradation of Phosphorylated Cdc25A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.11.1 Phosphorylation of Cdc25A at Ser-123 by Chk2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CDC25A CDC25A A0A287B2P5 Reactome DB_ID: 10249915 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:A0A287B2P5 CDC25A Sus scrofa NCBI Taxonomy 9823 UniProt A0A287B2P5 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10249915 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249915 Reactome R-SSC-143487 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-143487.1 Reactome http://www.reactome.org ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 COMPOUND C00002 additional information MI MI:0361 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 A0A287B2P5 phospho-CDC25A p-S123-CDC25A Reactome DB_ID: 10250068 123 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10250068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250068 Reactome R-SSC-143488 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-143488.1 ACTIVATION A0A287A7U1 phospho-CHEK2 p-S,3T-CHEK2 Reactome DB_ID: 10250085 UniProt:A0A287A7U1 CHEK2 UniProt A0A287A7U1 68 EQUAL O-phospho-L-threonine MOD MOD:00047 379 EQUAL 383 EQUAL 387 EQUAL 1 EQUAL 543 EQUAL Reactome Database ID Release 82 10250085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250085 Reactome R-SSC-5683784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683784.1 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10250086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250086 Reactome Database ID Release 82 10250088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250088 Reactome R-SSC-69608 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69608.1 Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk2 (Mailand et al. 2001). 11298456 Pubmed 2001 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Mailand, N SyljuĆ„sen, RG Lukas, J Nature 410:842-7 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT Proteolytic degradation of ubiquitinated-Cdc25A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ub-p-S123-CDC25A Reactome DB_ID: 10250064 cytosol GENE ONTOLOGY GO:0005829 Converted from EntitySet in Reactome Ub ubiquitin Reactome DB_ID: 10249581 RPS27A RPS27A(1-76) A0A287AZA7 Reactome DB_ID: 10249553 UniProt:A0A287AZA7 RPS27A UniProt A0A287AZA7 1 EQUAL 76 EQUAL Reactome Database ID Release 82 10249553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249553 Reactome R-SSC-939205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939205.1 UBA52 UBA52(1-76) P63053 Reactome DB_ID: 10249555 UniProt:P63053 UBA52 UniProt P63053 1 EQUAL 76 EQUAL Reactome Database ID Release 82 10249555 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249555 Reactome R-SSC-939203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939203.1 UBC UBB(1-76) P0CG68 Reactome DB_ID: 10249557 UniProt:P0CG68 UBC UniProt P0CG68 1 EQUAL 76 EQUAL Reactome Database ID Release 82 10249557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249557 Reactome R-SSC-939214 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939214.1 Reactome Database ID Release 82 10249581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249581 Reactome R-SSC-113595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113595.1 1 A0A287B2P5 phospho-CDC25A p-S123-CDC25A Reactome DB_ID: 10250062 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10250062 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250062 Reactome R-SSC-69588 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69588.1 1 Reactome Database ID Release 82 10250064 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250064 Reactome R-SSC-69589 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69589.1 ACTIVATION 26S proteasome Reactome DB_ID: 10249683 PSMB7 PSMB7 A1XQU1 Reactome DB_ID: 10249613 UniProt:A1XQU1 PSMB7 UniProt A1XQU1 44 EQUAL 277 EQUAL Reactome Database ID Release 82 10249613 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249613 Reactome R-SSC-68759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68759.1 1 PSMC1 PSMC1 F2Z5J1 Reactome DB_ID: 10249619 UniProt:F2Z5J1 PSMC1 UniProt F2Z5J1 2 EQUAL 440 EQUAL Reactome Database ID Release 82 10249619 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249619 Reactome R-SSC-68768 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68768.1 1 PSMD11 PSMD11 F1RKW8 Reactome DB_ID: 10249639 UniProt:F1RKW8 PSMD11 UniProt F1RKW8 2 EQUAL 422 EQUAL Reactome Database ID Release 82 10249639 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249639 Reactome R-SSC-68790 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68790.1 1 PSME2 PSME2 F1SGM3 Reactome DB_ID: 10249663 UniProt:F1SGM3 PSME2 UniProt F1SGM3 2 EQUAL 239 EQUAL Reactome Database ID Release 82 10249663 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249663 Reactome R-SSC-68814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68814.1 1 PSMB2 PSMB2 A0A5G2R6J1 Reactome DB_ID: 10249603 UniProt:A0A5G2R6J1 PSMB2 UniProt A0A5G2R6J1 1 EQUAL 201 EQUAL Reactome Database ID Release 82 10249603 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249603 Reactome R-SSC-68744 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68744.1 1 PSMA4 PSMA4 A0A5G2QL81 Reactome DB_ID: 10249591 UniProt:A0A5G2QL81 PSMA4 UniProt A0A5G2QL81 1 EQUAL 261 EQUAL Reactome Database ID Release 82 10249591 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249591 Reactome R-SSC-68730 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68730.1 1 PSMB10 PSMB10 A0A287BRV0 Reactome DB_ID: 10249601 UniProt:A0A287BRV0 PSMB10 UniProt A0A287BRV0 40 EQUAL 273 EQUAL Reactome Database ID Release 82 10249601 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249601 Reactome R-SSC-68741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68741.1 1 PSMC6 PSMC6 A0A287BG14 Reactome DB_ID: 10249633 UniProt:A0A287BG14 PSMC6 UniProt A0A287BG14 1 EQUAL 389 EQUAL Reactome Database ID Release 82 10249633 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249633 Reactome R-SSC-68783 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68783.1 1 PSME1 PSME1 Q64L94 Reactome DB_ID: 10249661 UniProt:Q64L94 PSME1 UniProt Q64L94 1 EQUAL 249 EQUAL Reactome Database ID Release 82 10249661 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249661 Reactome R-SSC-68812 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68812.1 1 Ghost homologue of PSMB8 Reactome DB_ID: 10249615 Reactome Database ID Release 82 10249615 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249615 Reactome R-SSC-68762 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68762.1 1 PSMB11 PSMB11 F1S9C7 Reactome DB_ID: 10249679 UniProt:F1S9C7 PSMB11 UniProt F1S9C7 50 EQUAL 300 EQUAL Reactome Database ID Release 82 10249679 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249679 Reactome R-SSC-947607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947607.1 1 Converted from EntitySet in Reactome Homologues of PSMC5 Reactome DB_ID: 10249631 PSMC5 PSMC5 A0A5G2QJH1 Reactome DB_ID: 10249627 UniProt:A0A5G2QJH1 PSMC5 UniProt A0A5G2QJH1 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10249627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249627 Reactome R-SSC-68780 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780.1 PSMC5 P62197 Reactome DB_ID: 10249629 UniProt:P62197 UniProt P62197 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10249629 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249629 Reactome R-SSC-68780-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780-2.1 Reactome Database ID Release 82 10249631 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249631 Reactome R-SSC-68780-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780-3.1 1 PSMA2 PSMA2 A0A5G2QZH5 Reactome DB_ID: 10249587 UniProt:A0A5G2QZH5 PSMA2 UniProt A0A5G2QZH5 2 EQUAL 234 EQUAL Reactome Database ID Release 82 10249587 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249587 Reactome R-SSC-68726 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68726.1 1 PSMB1 PSMB1 A0A287BPP9 Reactome DB_ID: 10249599 UniProt:A0A287BPP9 PSMB1 UniProt A0A287BPP9 29 EQUAL 241 EQUAL Reactome Database ID Release 82 10249599 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249599 Reactome R-SSC-68738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68738.1 1 PSMD4 PSMD4 A0A288CG47 Reactome DB_ID: 10249649 UniProt:A0A288CG47 PSMD4 UniProt A0A288CG47 1 EQUAL 377 EQUAL Reactome Database ID Release 82 10249649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249649 Reactome R-SSC-68800 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68800.1 1 PSMB3 PSMB3 A0A286ZN52 Reactome DB_ID: 10249605 UniProt:A0A286ZN52 PSMB3 UniProt A0A286ZN52 2 EQUAL 205 EQUAL Reactome Database ID Release 82 10249605 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249605 Reactome R-SSC-68747 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68747.1 1 PSMB6 PSMB6 A0A5G2R4Y9 Reactome DB_ID: 10249611 UniProt:A0A5G2R4Y9 PSMB6 UniProt A0A5G2R4Y9 35 EQUAL 239 EQUAL Reactome Database ID Release 82 10249611 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249611 Reactome R-SSC-68756 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68756.1 1 Ghost homologue of PSMD2 Reactome DB_ID: 10249645 Reactome Database ID Release 82 10249645 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249645 Reactome R-SSC-68796 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68796.1 1 PSMA8 PSMA8 F1SBA5 Reactome DB_ID: 10249675 UniProt:F1SBA5 PSMA8 UniProt F1SBA5 1 EQUAL 256 EQUAL Reactome Database ID Release 82 10249675 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249675 Reactome R-SSC-947610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947610.1 1 PSME4 PSME4 A0A287APQ3 Reactome DB_ID: 10249671 UniProt:A0A287APQ3 PSME4 UniProt A0A287APQ3 1 EQUAL 1843 EQUAL Reactome Database ID Release 82 10249671 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249671 Reactome R-SSC-947606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947606.1 1 PSMD12 PSMD12 A0A480SMR6 Reactome DB_ID: 10249641 UniProt:A0A480SMR6 PSMD12 UniProt A0A480SMR6 2 EQUAL 456 EQUAL Reactome Database ID Release 82 10249641 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249641 Reactome R-SSC-68792 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68792.1 1 PSMA1 PSMA1 A0A5G2QI19 Reactome DB_ID: 10249585 UniProt:A0A5G2QI19 PSMA1 UniProt A0A5G2QI19 1 EQUAL 263 EQUAL Reactome Database ID Release 82 10249585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249585 Reactome R-SSC-68724 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68724.1 1 PSMA7 PSMA7 A0A287BRR7 Reactome DB_ID: 10249597 UniProt:A0A287BRR7 PSMA7 UniProt A0A287BRR7 1 EQUAL 248 EQUAL Reactome Database ID Release 82 10249597 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249597 Reactome R-SSC-68736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68736.1 1 PSMB9 PSMB9 Q2PYM7 Reactome DB_ID: 10249617 UniProt:Q2PYM7 PSMB9 UniProt Q2PYM7 21 EQUAL 219 EQUAL Reactome Database ID Release 82 10249617 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249617 Reactome R-SSC-68765 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68765.1 1 PSMC2 PSMC2 F1SB53 Reactome DB_ID: 10249621 UniProt:F1SB53 PSMC2 UniProt F1SB53 2 EQUAL 433 EQUAL Reactome Database ID Release 82 10249621 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249621 Reactome R-SSC-68771 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68771.1 1 PSMD9 PSMD9 A0A286ZLP7 Reactome DB_ID: 10249659 UniProt:A0A286ZLP7 PSMD9 UniProt A0A286ZLP7 1 EQUAL 223 EQUAL Reactome Database ID Release 82 10249659 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249659 Reactome R-SSC-68810 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68810.1 1 PSMD6 PSMD6 F1SGF1 Reactome DB_ID: 10249653 UniProt:F1SGF1 PSMD6 UniProt F1SGF1 1 EQUAL 389 EQUAL Reactome Database ID Release 82 10249653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249653 Reactome R-SSC-68804 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68804.1 1 Ghost homologue of PSMA6 Reactome DB_ID: 10249595 Reactome Database ID Release 82 10249595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249595 Reactome R-SSC-68734 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68734.1 1 PSME3 PSME3 P61291 Reactome DB_ID: 10249665 UniProt:P61291 PSME3 UniProt P61291 2 EQUAL 254 EQUAL Reactome Database ID Release 82 10249665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249665 Reactome R-SSC-68816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68816.1 1 Ghost homologue of PSMB4 Reactome DB_ID: 10249607 Reactome Database ID Release 82 10249607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249607 Reactome R-SSC-68750 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68750.1 1 PSMB5 A0A286ZS34 Reactome DB_ID: 10249609 UniProt:A0A286ZS34 UniProt A0A286ZS34 60 EQUAL 263 EQUAL Reactome Database ID Release 82 10249609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249609 Reactome R-SSC-68753 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68753.1 1 PSMD8 PSMD8 A0A287B5Q7 Reactome DB_ID: 10249657 UniProt:A0A287B5Q7 PSMD8 UniProt A0A287B5Q7 1 EQUAL 350 EQUAL Reactome Database ID Release 82 10249657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249657 Reactome R-SSC-68808 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68808.1 1 PSMA5 PSMA5 F2Z5K2 Reactome DB_ID: 10249593 UniProt:F2Z5K2 PSMA5 UniProt F2Z5K2 1 EQUAL 241 EQUAL Reactome Database ID Release 82 10249593 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249593 Reactome R-SSC-68732 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68732.1 1 PSMF1 PSMF1 F1S870 Reactome DB_ID: 10249667 UniProt:F1S870 PSMF1 UniProt F1S870 1 EQUAL 271 EQUAL Reactome Database ID Release 82 10249667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249667 Reactome R-SSC-68818 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68818.1 1 PSMC3 PSMC3 A0A5G2QSU8 Reactome DB_ID: 10249623 UniProt:A0A5G2QSU8 PSMC3 UniProt A0A5G2QSU8 1 EQUAL 439 EQUAL Reactome Database ID Release 82 10249623 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249623 Reactome R-SSC-68774 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68774.1 1 Ghost homologue of SEM1 Reactome DB_ID: 10249681 Reactome Database ID Release 82 10249681 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249681 Reactome R-SSC-8866674 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8866674.1 1 PSMA3 PSMA3 A0A5G2QWE9 Reactome DB_ID: 10249589 UniProt:A0A5G2QWE9 PSMA3 UniProt A0A5G2QWE9 2 EQUAL 255 EQUAL Reactome Database ID Release 82 10249589 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249589 Reactome R-SSC-68728 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68728.1 1 PSMD10 PSMD10 A0A287BTN9 Reactome DB_ID: 10249637 UniProt:A0A287BTN9 PSMD10 UniProt A0A287BTN9 1 EQUAL 226 EQUAL Reactome Database ID Release 82 10249637 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249637 Reactome R-SSC-68788 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68788.1 1 PSMD5 PSMD5 A0A480QIP5 Reactome DB_ID: 10249651 UniProt:A0A480QIP5 PSMD5 UniProt A0A480QIP5 2 EQUAL 504 EQUAL Reactome Database ID Release 82 10249651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249651 Reactome R-SSC-68802 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68802.1 1 PSMC4 PSMC4 A0A287B4P8 Reactome DB_ID: 10249625 UniProt:A0A287B4P8 PSMC4 UniProt A0A287B4P8 1 EQUAL 418 EQUAL Reactome Database ID Release 82 10249625 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249625 Reactome R-SSC-68777 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68777.1 1 PSMD13 PSMD13 A0A5G2R6X9 Reactome DB_ID: 10249643 UniProt:A0A5G2R6X9 PSMD13 UniProt A0A5G2R6X9 1 EQUAL 376 EQUAL Reactome Database ID Release 82 10249643 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249643 Reactome R-SSC-68794 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68794.1 1 PSMD14 PSMD14 A0A480DPN6 Reactome DB_ID: 10249583 UniProt:A0A480DPN6 PSMD14 UniProt A0A480DPN6 1 EQUAL 310 EQUAL Reactome Database ID Release 82 10249583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249583 Reactome R-SSC-68722 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68722.1 1 PSMD3 PSMD3 F1RXA7 Reactome DB_ID: 10249647 UniProt:F1RXA7 PSMD3 UniProt F1RXA7 1 EQUAL 534 EQUAL Reactome Database ID Release 82 10249647 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249647 Reactome R-SSC-68798 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68798.1 1 PSMD7 PSMD7 A0A287AEH0 Reactome DB_ID: 10249655 UniProt:A0A287AEH0 PSMD7 UniProt A0A287AEH0 1 EQUAL 324 EQUAL Reactome Database ID Release 82 10249655 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249655 Reactome R-SSC-68806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68806.1 1 PSMD1 PSMD1 F1SMW9 Reactome DB_ID: 10249635 UniProt:F1SMW9 PSMD1 UniProt F1SMW9 1 EQUAL 953 EQUAL Reactome Database ID Release 82 10249635 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249635 Reactome R-SSC-68786 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68786.1 1 Reactome Database ID Release 82 10249683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249683 Reactome R-SSC-68819 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68819.1 GENE ONTOLOGY GO:0004175 Reactome Database ID Release 82 10249684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249684 Reactome Database ID Release 82 10250066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250066 Reactome R-SSC-69600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69600.1 At the beginning of this reaction, 1 molecule of 'Ubiquitinated Phospho-Cdc25A' is present. At the end of this reaction, 1 molecule of 'Amino Acid' is present.<br><br> This reaction takes place in the 'cytosol' and is mediated by the 'endopeptidase activity' of '26S proteasome' (Bernardi et al. 2000).<br> 10828887 Pubmed 2000 Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation Bernardi, R Liebermann, DA Hoffman, B Oncogene 19:2447-54 LEFT-TO-RIGHT 2.7.11.1 Phosphorylation of Cdc25A at Ser-123 by Chk1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ACTIVATION F1S774 phospho-p-S317,S345-CHEK1 Reactome DB_ID: 10250074 UniProt:F1S774 UniProt F1S774 317 EQUAL 345 EQUAL 1 EQUAL 476 EQUAL Reactome Database ID Release 82 10250074 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250074 Reactome R-SSC-113838 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113838.1 Reactome Database ID Release 82 10250075 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250075 Reactome Database ID Release 82 10250077 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250077 Reactome R-SSC-69604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69604.1 Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk1, inhibiting Cdc25A. 12399544 Pubmed 2002 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Zhao, H Watkins, JL Piwnica-Worms, H Proc Natl Acad Sci U S A 99:14795-800 Reactome Database ID Release 82 10349438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10349438 Reactome R-SSC-69601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69601.1 cdc25A protein is degraded by the ubiquitin-proteasome machinery in both terminally differentiating and cycling cells (Bernardi et al. 2000). Reactome Database ID Release 82 10349440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10349440 Reactome R-SSC-69610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69610.1 In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. The phosphorylation of Cdc25A at ser-123, in response to DNA damage from ionizing radiation is a signal for ubiquitination and subsequent degradation of Cdc25A. The destruction of Cdc25A prevents the normal G1/S transition. Cdc25A is required for the activation of the Cyclin E:Cdk2 complexes via dephosphorylation.<p>Chk1 is activated in response to DNA damage due to uv light. However, the phosphorylation occurs at a different site. Reactome Database ID Release 82 10349442 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10349442 Reactome R-SSC-69613 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69613.1 The G1 arrest induced by DNA damage has been ascribed to the transcription factor and tumor suppressor protein p53. To be effective within minutes after DNA damage, induction of the G1 block should exploit transcription and protein synthesis independent mechanisms.<p>Upon exposure to ultraviolet light (UV) or ionizing radiation (IR), the abundance and activity of a protein, Cdc25A, rapidly decreases; this DNA damage response is not dependent on p53. The rapid destruction of Cdc25A phosphatase prevents entry of a cell into S-phase, by maintaining the CyclinE:Cdk2 complexes in their T14Y15 phosphorylated form. 10827953 Pubmed 2000 Rapid destruction of human Cdc25A in response to DNA damage. Mailand, N Lukas, C SyljuĆ¢sen, RG Welcker, M Lukas, J Science 288:1425-9