BioPAX pathway converted from "G2/M DNA damage checkpoint" in the Reactome database. G2/M DNA damage checkpoint This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.11.1 Recruitment and activation of Chk1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CHEK1 F1S774 Reactome DB_ID: 10263192 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:F1S774 Sus scrofa NCBI Taxonomy 9823 UniProt F1S774 1 EQUAL 476 EQUAL Reactome Database ID Release 82 10263192 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263192 Reactome R-SSC-113826 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113826.1 Reactome http://www.reactome.org ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 COMPOUND C00002 additional information MI MI:0361 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 F1S774 phospho-p-S317,S345-CHEK1 Reactome DB_ID: 10250074 317 EQUAL O-phospho-L-serine MOD MOD:00046 345 EQUAL 1 EQUAL 476 EQUAL Reactome Database ID Release 82 10250074 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250074 Reactome R-SSC-113838 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113838.1 ACTIVATION activeUnit: #Protein3 ATR:ATRIP Reactome DB_ID: 10263202 ATR ATR F1SKG2 Reactome DB_ID: 10263200 UniProt:F1SKG2 ATR UniProt F1SKG2 1 EQUAL 2644 EQUAL Reactome Database ID Release 82 10263200 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263200 Reactome R-SSC-912443 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-912443.1 1 ATRIP ATRIP A0A5G2QHT7 Reactome DB_ID: 10263196 UniProt:A0A5G2QHT7 ATRIP UniProt A0A5G2QHT7 1 EQUAL 791 EQUAL Reactome Database ID Release 82 10263196 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263196 Reactome R-SSC-176231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176231.1 1 Reactome Database ID Release 82 10263202 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263202 Reactome R-SSC-176269 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176269.1 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10263203 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263203 Reactome Database ID Release 82 10263205 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263205 Reactome R-SSC-176116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176116.1 GENE ONTOLOGY GO:0006260 gene ontology term for cellular process MI MI:0359 Chk1 is a checkpoint kinase activated during genotoxic stress. Like ATR, Chk1 is essential for viability in mammals. Targeted gene disruption in mice shows that loss of Chk1 causes peri-implantation embryonic lethality. Even though ATR-ATRIP not bound to ssDNA can phosphorylate Chk1, Chk1 activation is greatly enhanced when recruited to stalled replication forks by physical interaction with a modified form of claspin and the Rad9-Hus1-Rad1 sliding clamp. Activation of Chk1 occurs following phosphorylation of two sites (serine 317 and serine 345). Mutational analysis indicates that modification of both sites is essential for maximal kinase activity, while phosphorylation of only a single site causes only weak activation of Chk1. Following phosphorylation, Chk1 can diffuse away from the complex to further amplify the checkpoint signal. ATR appears to be the primary kinase activating Chk1 as conditions that activate ATR (ultraviolet irradiation or treatment with hydroxyurea) also activate Chk1. Stresses that activate ATM, e.g., ionizing irradiation, do not cause significant Chk1 activation. While the ATR and ATM pathways are distinct, there is interplay between the two. For example, double-strand DNA breaks can be processed in an ATM-dependent manner to generate structures that can cause ATR and hence Chk1 activation. The ATR and ATM pathways also have mechanistic similarities. Analogous to the Chk1 kinase existing downstream of ATR, the Chk2 checkpoint kinase is modified and activated by ATM. Although having distinct structures, Chk1 and Chk2 also have overlapping targets with some substrate sites phosphorylatable by both kinases (e.g., serine 20 of p53). 11390642 Pubmed 2001 ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Zhao, H Piwnica-Worms, H Mol Cell Biol 21:4129-39 12781359 Pubmed 2003 Chk1 and Chk2 kinases in checkpoint control and cancer Bartek, J Lukas, J Cancer Cell 3:421-9 16431910 Pubmed 2006 Rapid activation of ATR by ionizing radiation requires ATM and Mre11 Myers, JS Cortez, D J Biol Chem 11090622 Pubmed 2000 Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts Kumagai, A Dunphy, WG Mol Cell 6:839-49 12766152 Pubmed 2003 Human claspin is required for replication checkpoint control Chini, CC Chen, J J Biol Chem 278:30057-62 15190204 Pubmed 2004 ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage Sorensen, CS Syljuasen, RG Lukas, J Bartek, J Cell Cycle 3:941-5 10859164 Pubmed 2000 Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Liu, Q Guntuku, S Cui, XS Matsuoka, S Cortez, D Tamai, K Luo, G Carattini-Rivera, S DeMayo, F Bradley, A Donehower, LA Elledge, SJ Genes Dev 14:1448-59 15272308 Pubmed 2004 Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism Uto, K Inoue, D Shimuta, K Nakajo, N Sagata, N EMBO J 23:3386-96 15279789 Pubmed 2004 Chk1 in the DNA damage response: conserved roles from yeasts to mammals Chen, Y Sanchez, Y DNA Repair (Amst) 3:1025-32 16360315 Pubmed 2006 Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response Smits, VA Reaper, PM Jackson, SP Curr Biol 16:150-9 10859163 Pubmed 2000 Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice Takai, H Tominaga, K Motoyama, N Minamishima, YA Nagahama, H Tsukiyama, T Ikeda, K Nakayama, Keiko Nakanishi, M Nakayama, Ken-ichi Genes Dev 14:1439-47 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT CHEK2 is recruited to DNA DSBs This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CHEK2 CHEK2 A0A287A7U1 Reactome DB_ID: 10250302 UniProt:A0A287A7U1 CHEK2 UniProt A0A287A7U1 1 EQUAL 543 EQUAL Reactome Database ID Release 82 10250302 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250302 Reactome R-SSC-113824 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113824.1 DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex Reactome DB_ID: 10250300 DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 Reactome DB_ID: 10250249 A0A286ZZU1 phospho-TP53BP1 p-S25,S1778-TP53BP1 Reactome DB_ID: 10250247 UniProt:A0A286ZZU1 TP53BP1 UniProt A0A286ZZU1 25 EQUAL 1778 EQUAL 1 EQUAL 1972 EQUAL Reactome Database ID Release 82 10250247 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250247 Reactome R-SSC-5683418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683418.1 1 DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 Reactome DB_ID: 10250241 PIAS4 PIAS4 A0A287ABB3 Reactome DB_ID: 10250211 UniProt:A0A287ABB3 PIAS4 UniProt A0A287ABB3 2 EQUAL 510 EQUAL Reactome Database ID Release 82 10250211 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250211 Reactome R-SSC-2993789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2993789.1 1 RNF168 RNF168 A0A480JZ69 Reactome DB_ID: 10250215 UniProt:A0A480JZ69 RNF168 UniProt A0A480JZ69 1 EQUAL 571 EQUAL Reactome Database ID Release 82 10250215 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250215 Reactome R-SSC-4551605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-4551605.1 1 RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 Reactome DB_ID: 10250239 RNF8:Zn2+:SUMO1:p-T4827-HERC2 Reactome DB_ID: 10250227 F1RX57 phospho-HERC2 p-T4827,SUMO1-HERC2 Reactome DB_ID: 10250225 UniProt:F1RX57 HERC2 UniProt F1RX57 sumoylated lysine MOD MOD:01149 4827 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 4834 EQUAL Reactome Database ID Release 82 10250225 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250225 Reactome R-SSC-5682615 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682615.1 1 RNF8:Zn2+ Reactome DB_ID: 10250219 Ghost homologue of RNF8 Reactome DB_ID: 10250217 Reactome Database ID Release 82 10250217 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250217 Reactome R-SSC-5682539 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682539.1 2 Zn2+ Zn++ zinc(2+) Zinc ion Zn(II) Reactome DB_ID: 200493 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI CHEBI:29105 Reactome Database ID Release 82 200493 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200493 Reactome R-ALL-200493 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-200493.3 COMPOUND C00038 2 Reactome Database ID Release 82 10250219 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250219 Reactome R-SSC-5682540 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682540.1 1 Reactome Database ID Release 82 10250227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250227 Reactome R-SSC-5682608 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682608.1 1 UBE2N:UBE2V2 Reactome DB_ID: 10250237 UBE2V2 UBE2V2 A0A5G2QHC8 Reactome DB_ID: 10250235 UniProt:A0A5G2QHC8 UBE2V2 UniProt A0A5G2QHC8 2 EQUAL 145 EQUAL Reactome Database ID Release 82 10250235 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250235 Reactome R-SSC-5682543 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682543.1 1 UBE2N UBE2N A0A5G2QZC6 Reactome DB_ID: 10250231 UniProt:A0A5G2QZC6 UBE2N UniProt A0A5G2QZC6 1 EQUAL 152 EQUAL Reactome Database ID Release 82 10250231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250231 Reactome R-SSC-5682541 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682541.1 1 Reactome Database ID Release 82 10250237 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250237 Reactome R-SSC-5682542 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682542.1 1 Reactome Database ID Release 82 10250239 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250239 Reactome R-SSC-5682631 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682631.1 1 DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 Reactome DB_ID: 10250207 DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 Reactome DB_ID: 10250205 p-5T-MDC1 Reactome DB_ID: 10250118 p-5T-MDC1 phospho-MDC1 A0A5G2QQC6 Reactome DB_ID: 10250116 UniProt:A0A5G2QQC6 MDC1 UniProt A0A5G2QQC6 4 EQUAL 699 EQUAL 719 EQUAL 752 EQUAL 765 EQUAL 1 EQUAL 2089 EQUAL Reactome Database ID Release 82 10250116 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250116 Reactome R-SSC-75236 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75236.1 2 Reactome Database ID Release 82 10250118 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250118 Reactome R-SSC-5682525 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682525.1 1 DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome Reactome DB_ID: 10250203 K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome Reactome DB_ID: 10250201 F1RWC9 HIST3H3 Reactome DB_ID: 10250187 UniProt:F1RWC9 UniProt F1RWC9 2 EQUAL 136 EQUAL Reactome Database ID Release 82 10250187 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250187 Reactome R-SSC-181914 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181914.1 2 Converted from EntitySet in Reactome Histone H2B Reactome DB_ID: 10250183 H2BU1 HIST3H2BB A0A287AWZ3 Reactome DB_ID: 10250151 UniProt:A0A287AWZ3 H2BU1 UniProt A0A287AWZ3 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250151 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250151 Reactome R-SSC-181923 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181923.1 Converted from EntitySet in Reactome Homologues of HIST1H2BA Reactome DB_ID: 10250161 F1RTQ6 LOC100152135 HIST1H2BA Reactome DB_ID: 10250155 UniProt:F1RTQ6 LOC100152135 UniProt F1RTQ6 2 EQUAL 127 EQUAL Reactome Database ID Release 82 10250155 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250155 Reactome R-SSC-181916 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181916.1 F2Z580 LOC100152878 HIST1H2BA Reactome DB_ID: 10250159 UniProt:F2Z580 LOC100152878 UniProt F2Z580 2 EQUAL 127 EQUAL Reactome Database ID Release 82 10250159 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250159 Reactome R-SSC-181916-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181916-2.1 Reactome Database ID Release 82 10250161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250161 Reactome R-SSC-181916-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181916-3.1 F2Z584 HIST1H2BD HIST1H2BD Reactome DB_ID: 10250165 UniProt:F2Z584 HIST1H2BD UniProt F2Z584 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250165 Reactome R-SSC-181912 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181912.1 HIST1H2BB LOC102162202 A0A287BID4 Reactome DB_ID: 10250169 UniProt:A0A287BID4 LOC102162202 UniProt A0A287BID4 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250169 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250169 Reactome R-SSC-181903 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181903.1 I3LAJ9 HIST1H2BH Reactome DB_ID: 10250173 UniProt:I3LAJ9 UniProt I3LAJ9 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250173 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250173 Reactome R-SSC-181915 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181915.1 F1RFJ3 LOC100155267 HIST2H2BE Reactome DB_ID: 10250177 UniProt:F1RFJ3 LOC100155267 UniProt F1RFJ3 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250177 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250177 Reactome R-SSC-181908 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181908.1 H2BC11 HIST1H2BJ A0A287A7G8 Reactome DB_ID: 10250181 UniProt:A0A287A7G8 H2BC11 UniProt A0A287A7G8 2 EQUAL 126 EQUAL Reactome Database ID Release 82 10250181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250181 Reactome R-SSC-181900 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181900.1 Reactome Database ID Release 82 10250183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250183 Reactome R-SSC-181911 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-181911.1 2 A0A5G2QMX0 phospho-H2AX K63PolyUb-K14,K16,p-S140-H2AFX Reactome DB_ID: 10250199 UniProt:A0A5G2QMX0 H2AX UniProt A0A5G2QMX0 140 EQUAL 14 EQUAL ubiquitinylated lysine MOD MOD:01148 16 EQUAL 2 EQUAL 143 EQUAL Reactome Database ID Release 82 10250199 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250199 Reactome R-SSC-5682847 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682847.1 2 P62802 Me2K21-HIST1H4 Reactome DB_ID: 10250192 UniProt:P62802 UniProt P62802 21 EQUAL N6,N6-dimethyl-L-lysine MOD MOD:00084 2 EQUAL 103 EQUAL Reactome Database ID Release 82 10250192 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250192 Reactome R-SSC-5651652 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5651652.1 2 Reactome Database ID Release 82 10250201 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250201 Reactome R-SSC-5682998 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682998.1 1 DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10250147 DNA DSBs:p-MRN Reactome DB_ID: 10250139 DNA double-strand break ends Reactome DB_ID: 75165 Reactome Database ID Release 82 75165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75165 Reactome R-ALL-75165 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-75165.2 ChEBI 61120 1 p-MRN Reactome DB_ID: 10250137 RAD50 A0A287BNG5 Reactome DB_ID: 10250130 UniProt:A0A287BNG5 UniProt A0A287BNG5 1 EQUAL 1312 EQUAL Reactome Database ID Release 82 10250130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250130 Reactome R-SSC-75160 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75160.1 1 MRE11 MRE11A A0A287BGY4 Reactome DB_ID: 10250126 UniProt:A0A287BGY4 MRE11 UniProt A0A287BGY4 1 EQUAL 708 EQUAL Reactome Database ID Release 82 10250126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250126 Reactome R-SSC-59544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-59544.1 1 p-S343-NBN phospho-NBN A0A287AXZ9 Reactome DB_ID: 10250135 UniProt:A0A287AXZ9 NBN UniProt A0A287AXZ9 343 EQUAL 1 EQUAL 754 EQUAL Reactome Database ID Release 82 10250135 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250135 Reactome R-SSC-75237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75237.1 1 Reactome Database ID Release 82 10250137 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250137 Reactome R-SSC-5682166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682166.1 1 Reactome Database ID Release 82 10250139 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250139 Reactome R-SSC-5682175 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682175.1 1 KAT5 KAT5 A0A5G2R581 Reactome DB_ID: 10250122 UniProt:A0A5G2R581 KAT5 UniProt A0A5G2R581 1 EQUAL 513 EQUAL Reactome Database ID Release 82 10250122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250122 Reactome R-SSC-3321979 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3321979.1 1 F1SV20 phospho-ATM p-S1981,Ac-K3016-ATM Reactome DB_ID: 10250145 UniProt:F1SV20 ATM UniProt F1SV20 1981 EQUAL 3016 EQUAL N6-acetyl-L-lysine MOD MOD:00064 1 EQUAL 3056 EQUAL Reactome Database ID Release 82 10250145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250145 Reactome R-SSC-5693527 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5693527.1 1 Reactome Database ID Release 82 10250147 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250147 Reactome R-SSC-5682162 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682162.1 1 Reactome Database ID Release 82 10250203 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250203 Reactome R-SSC-5682995 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682995.1 1 Reactome Database ID Release 82 10250205 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250205 Reactome R-SSC-5682997 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682997.1 1 F1S8S0 phospho-NSD2 p-S102-WHSC1 Reactome DB_ID: 10250107 UniProt:F1S8S0 NSD2 UniProt F1S8S0 102 EQUAL 1 EQUAL 1365 EQUAL Reactome Database ID Release 82 10250107 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250107 Reactome R-SSC-5682984 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682984.1 1 Reactome Database ID Release 82 10250207 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250207 Reactome R-SSC-5682996 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682996.1 1 Reactome Database ID Release 82 10250241 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250241 Reactome R-SSC-5683079 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683079.1 1 Reactome Database ID Release 82 10250249 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250249 Reactome R-SSC-5683417 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683417.1 1 p-4S,2T-BRCA1-A Complex Reactome DB_ID: 10250298 BABAM1 BABAM1 A0A286ZQV9 Reactome DB_ID: 10250262 UniProt:A0A286ZQV9 BABAM1 UniProt A0A286ZQV9 1 EQUAL 329 EQUAL Reactome Database ID Release 82 10250262 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250262 Reactome R-SSC-5682582 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682582.1 1 UIMC1 UIMC1 I3LPV8 Reactome DB_ID: 10250253 UniProt:I3LPV8 UIMC1 UniProt I3LPV8 1 EQUAL 719 EQUAL Reactome Database ID Release 82 10250253 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250253 Reactome R-SSC-5682574 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682574.1 1 BRCC3 BRCC3 A0A5G2QUJ6 Reactome DB_ID: 10250266 UniProt:A0A5G2QUJ6 BRCC3 UniProt A0A5G2QUJ6 2 EQUAL 316 EQUAL Reactome Database ID Release 82 10250266 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250266 Reactome R-SSC-5682577 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682577.1 1 Converted from EntitySet in Reactome p-S1387,S1423,S1524,S1547-BRCA1:p-T714,T734-BARD1 Reactome DB_ID: 10250296 K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 Reactome DB_ID: 10250288 A0A5G2RET1 phospho-BARD1 K6PolyUb,p-T714,T734-BARD1 Reactome DB_ID: 10250286 UniProt:A0A5G2RET1 BARD1 UniProt A0A5G2RET1 714 EQUAL 734 EQUAL 1 EQUAL 777 EQUAL Reactome Database ID Release 82 10250286 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250286 Reactome R-SSC-9707286 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707286.1 1 A0A286ZS33 phospho-BRCA1 K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 Reactome DB_ID: 10250279 UniProt:A0A286ZS33 BRCA1 UniProt A0A286ZS33 1387 EQUAL 1423 EQUAL 1524 EQUAL 1547 EQUAL 1 EQUAL 1863 EQUAL Reactome Database ID Release 82 10250279 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250279 Reactome R-SSC-9707290 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707290.1 1 Reactome Database ID Release 82 10250288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250288 Reactome R-SSC-9707288 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707288.1 p-S1387,S1423,S1524,S1547-BRCA1:p-T714,T734-BARD1 Reactome DB_ID: 10250294 A0A286ZS33 phospho-BRCA1 p-S1387,S1423,S1524,S1547-BRCA1 Reactome DB_ID: 10250290 1 EQUAL 1863 EQUAL Reactome Database ID Release 82 10250290 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250290 Reactome R-SSC-75234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75234.1 1 A0A5G2RET1 phospho-BARD1 p-T714,T734-BARD1 Reactome DB_ID: 10250292 1 EQUAL 777 EQUAL Reactome Database ID Release 82 10250292 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250292 Reactome R-SSC-5659846 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5659846.1 1 Reactome Database ID Release 82 10250294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250294 Reactome R-SSC-5659852 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5659852.1 Reactome Database ID Release 82 10250296 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250296 Reactome R-SSC-9707287 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707287.1 1 F1RW10 phospho-ABRAXAS1 p-S406-FAM175A Reactome DB_ID: 10250258 UniProt:F1RW10 ABRAXAS1 UniProt F1RW10 406 EQUAL 1 EQUAL 409 EQUAL Reactome Database ID Release 82 10250258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250258 Reactome R-SSC-5682575 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682575.1 1 BRE BABAM2 A0A287BEJ2 Reactome DB_ID: 10250270 UniProt:A0A287BEJ2 BABAM2 UniProt A0A287BEJ2 1 EQUAL 383 EQUAL Reactome Database ID Release 82 10250270 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250270 Reactome R-SSC-5682579 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5682579.1 1 Reactome Database ID Release 82 10250298 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250298 Reactome R-SSC-5683606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683606.1 1 Reactome Database ID Release 82 10250300 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250300 Reactome R-SSC-5683605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683605.1 DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 Reactome DB_ID: 10250304 1 1 Reactome Database ID Release 82 10250304 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250304 Reactome R-SSC-5683737 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683737.1 Reactome Database ID Release 82 10320165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320165 Reactome R-SSC-5683735 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683735.1 CHEK2 (CHK2, Cds1) is recruited to DNA double-strand breaks (DSBs) mainly through its interaction with TP53BP1 (53BP1) (Wang et al. 2002), but BRCA1 also contributes to CHEK2 recruitment (Wilson and Stern 2008). 12364621 Pubmed 2002 53BP1, a mediator of the DNA damage checkpoint. Wang, B Matsuoka, S Carpenter, PB Elledge, SJ Science 298:1435-8 19001859 Pubmed 2008 NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway Wilson, Kathleen A Stern, David F Cell Cycle 7:3584-94 LEFT-TO-RIGHT 2.7.11.1 Phosphorylation and activation of CHEK2 by ATM This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> A0A287A7U1 phospho-CHEK2 p-T68-CHEK2 Reactome DB_ID: 10250306 68 EQUAL 1 EQUAL 543 EQUAL Reactome Database ID Release 82 10250306 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250306 Reactome R-SSC-113825 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113825.1 ACTIVATION activeUnit: #Protein29 Reactome Database ID Release 82 10250307 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250307 Reactome Database ID Release 82 10250309 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250309 Reactome R-SSC-69891 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69891.1 Activated ATM phosphorylates CHEK2 (CHK2, Cds1) on threonine residue T68 (Matsuoka et al. 2000, Melchionna et al. 2000). The presence of BRCA1 and TP53BP1 positively regulates ATM-mediated phosphorylation of CHEK2 (Wang et al. 2002, Foray et al. 2003). ATM-mediated phosphorylation causes formation of CHEK2 dimers and dissociation of CHEK2 from chromatin (Li and Stern 2005). 10973490 Pubmed 2000 Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Matsuoka, S Rotman, G Ogawa, A Shiloh, Y Tamai, K Elledge, SJ Proc Natl Acad Sci U S A 97:10389-94 11025670 Pubmed 2000 Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 Melchionna, R Chen, X B Blasina, A McGowan, CH Nat. Cell Biol. 2:762-5 12773400 Pubmed 2003 A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray, N Marot, D Gabriel, A Randrianarison, V Perricaudet, M Ashworth, A Jeggo, P EMBO J 22:2860-71 16150728 Pubmed 2005 DNA damage regulates Chk2 association with chromatin Li, Jia Stern, David F J. Biol. Chem. 280:37948-56 LEFT-TO-RIGHT p-T68-CHEK2 dimerizes This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 p-T68-CHEK2 dimer Reactome DB_ID: 10320167 2 Reactome Database ID Release 82 10320167 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320167 Reactome R-SSC-5683773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683773.1 Reactome Database ID Release 82 10320169 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320169 Reactome R-SSC-5683774 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683774.1 ATM-mediated phosphorylation of CHEK2 (CHK2, Cds1) on threonine residue T68 promotes formation of transitional CHEK2 homodimers primarily through intermolecular interactions of FHA domains and phospho-T68 residues of two CHEK2 protomers (Cai et al. 2009). 19782031 Pubmed 2009 Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase Cai, Zhenjian Chehab, Nabil H Pavletich, Nikola P Mol. Cell 35:818-29 LEFT-TO-RIGHT 2.7.11.1 p-T68-CHEK2 autophosphorylates This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 3 A0A287A7U1 phospho-CHEK2 p-S,3T-CHEK2 Reactome DB_ID: 10250085 379 EQUAL 383 EQUAL 387 EQUAL 1 EQUAL 543 EQUAL Reactome Database ID Release 82 10250085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250085 Reactome R-SSC-5683784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683784.1 2 3 ACTIVATION Reactome Database ID Release 82 10320170 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320170 Reactome Database ID Release 82 10320172 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320172 Reactome R-SSC-5683792 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683792.1 Upon dimerization, p-T68-CHEK2 protomers trans-autophosphorylate on serine residue S379 (Lovly et al. 2008) and threonine residues T383 and T387 (Lee et al. 2001). Autophosphorylation leads to dissociation of CHEK2 dimers into active CHEK2 monomers (Cai et al. 2009). 11390408 Pubmed 2001 The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation Lee, C H Chung, J H J. Biol. Chem. 276:30537-41 18644861 Pubmed 2008 Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 Lovly, Christine M Yan, Ling Ryan, Christine E Takada, Saeko Piwnica-Worms, Helen Mol. Cell. Biol. 28:5874-85 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.11.1 Phosphorylation of Cdc25C at Ser216 by CHEK2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Homologues of CDC25C Reactome DB_ID: 10254575 CDC25C CDC25C A0A2C9F3A2 Reactome DB_ID: 10254569 UniProt:A0A2C9F3A2 CDC25C UniProt A0A2C9F3A2 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254569 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254569 Reactome R-SSC-69741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69741.1 CDC25C CDC25C Q29029 Reactome DB_ID: 10254573 UniProt:Q29029 CDC25C UniProt Q29029 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254573 Reactome R-SSC-69741-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69741-2.1 Reactome Database ID Release 82 10254575 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254575 Reactome R-SSC-69741-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69741-3.1 Converted from EntitySet in Reactome Homologues of p-S216-CDC25C Reactome DB_ID: 10254583 A0A2C9F3A2 phospho-CDC25C p-S216-CDC25C Reactome DB_ID: 10254578 216 EQUAL 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254578 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254578 Reactome R-SSC-156496 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-156496.1 Q29029 phospho-CDC25C p-S216-CDC25C Reactome DB_ID: 10254581 216 EQUAL 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254581 Reactome R-SSC-156496-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-156496-2.1 Reactome Database ID Release 82 10254583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254583 Reactome R-SSC-156496-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-156496-3.1 ACTIVATION Reactome Database ID Release 82 10250086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250086 Reactome Database ID Release 82 10254949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254949 Reactome R-SSC-75809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75809.1 Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003). 12766774 Pubmed 2003 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry Bulavin, DV Higashimoto, Y Demidenko, ZN Meek, S Graves, P Phillips, C Zhao, H Moody, SA Appella, E Piwnica-Worms, H Fornace AJ, Jr Nat Cell Biol 5:545-51 10435585 Pubmed 1999 Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway Chaturvedi, P Eng, W K Zhu, Y Mattern, M R Mishra, R Hurle, M R Zhang, X Annan, R S Lu, Q Faucette, L F Scott, G F Li, X Carr, S A Johnson, R K Winkler, J D Zhou, B B Oncogene 18:4047-54 LEFT-TO-RIGHT p-S216-CDC25C translocates to the cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Homologues of p-S216-CDC25C Reactome DB_ID: 10254591 A0A2C9F3A2 phospho-CDC25C p-S216-CDC25C Reactome DB_ID: 10254587 cytosol GENE ONTOLOGY GO:0005829 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254587 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254587 Reactome R-SSC-75003 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75003.1 Q29029 phospho-CDC25C p-S216-CDC25C Reactome DB_ID: 10254589 1 EQUAL 473 EQUAL Reactome Database ID Release 82 10254589 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254589 Reactome R-SSC-75003-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75003-2.1 Reactome Database ID Release 82 10254591 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254591 Reactome R-SSC-75003-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75003-3.1 Reactome Database ID Release 82 10344569 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10344569 Reactome R-SSC-9029987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9029987.1 Phosphorylated CDC25C translocates to the cytoplasm. Phosphorylation at serine residue S216 is not a prerequisite for translocation to the cytoplasm (Dalal et al., 1999). 10330186 Pubmed 1999 Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Dalal, SN Schweitzer, CM Gan, J DeCaprio, JA Mol Cell Biol 19:4465-79 LEFT-TO-RIGHT Association of p-S216-CDC25C with 14-3-3 proteins This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome 14-3-3 dimer Reactome DB_ID: 10254623 YWHAH dimer Reactome DB_ID: 10254597 YWHAH YWHAH F2Z4Y1 Reactome DB_ID: 10254595 UniProt:F2Z4Y1 YWHAH UniProt F2Z4Y1 2 EQUAL 246 EQUAL Reactome Database ID Release 82 10254595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254595 Reactome R-SSC-1445107 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1445107.1 2 Reactome Database ID Release 82 10254597 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254597 Reactome R-SSC-2262715 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2262715.1 YWHAG dimer Reactome DB_ID: 10254603 YWHAG YWHAG F2Z4Z1 Reactome DB_ID: 10254601 UniProt:F2Z4Z1 YWHAG UniProt F2Z4Z1 1 EQUAL 247 EQUAL Reactome Database ID Release 82 10254601 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254601 Reactome R-SSC-380312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-380312.1 2 Reactome Database ID Release 82 10254603 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254603 Reactome R-SSC-2262713 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2262713.1 YWHAQ dimer Reactome DB_ID: 10254609 YWHAQ YWHAQ A0A5G2QM17 Reactome DB_ID: 10254607 UniProt:A0A5G2QM17 YWHAQ UniProt A0A5G2QM17 1 EQUAL 245 EQUAL Reactome Database ID Release 82 10254607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254607 Reactome R-SSC-1445116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1445116.1 2 Reactome Database ID Release 82 10254609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254609 Reactome R-SSC-2262714 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2262714.1 YWHAZ dimer Reactome DB_ID: 10254615 YWHAZ YWHAZ F2Z558 Reactome DB_ID: 10254613 UniProt:F2Z558 YWHAZ UniProt F2Z558 1 EQUAL 245 EQUAL Reactome Database ID Release 82 10254613 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254613 Reactome R-SSC-206099 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-206099.1 2 Reactome Database ID Release 82 10254615 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254615 Reactome R-SSC-206751 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-206751.1 YWHAB dimer Reactome DB_ID: 10254621 YWHAB YWHAB A0A287BPX7 Reactome DB_ID: 10254619 UniProt:A0A287BPX7 YWHAB UniProt A0A287BPX7 1 EQUAL 246 EQUAL Reactome Database ID Release 82 10254619 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254619 Reactome R-SSC-48888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-48888.1 2 Reactome Database ID Release 82 10254621 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254621 Reactome R-SSC-2028645 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2028645.1 Reactome Database ID Release 82 10254623 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254623 Reactome R-SSC-1445138 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1445138.1 p-S216-CDC25C:14-3-3 protein complex Reactome DB_ID: 10254625 1 1 Reactome Database ID Release 82 10254625 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254625 Reactome R-SSC-75005 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75005.1 Reactome Database ID Release 82 10254627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10254627 Reactome R-SSC-75016 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75016.1 CDC25C is phosphorylated by CHK1 at ser-216 (Blasina et al.,1999 ) resulting in both inhibition of the CDC25 phosphatase activity and creation of a 14-3-3 docking site (Peng et al., 1997). Association of 14-3-3 proteins with phosphorylated CDC25C (p-S216-CDC25C) is thought to result in retention of this complex within the cytoplasm (Dalal et al., 1999; Graves et al, 2001). 9889122 Pubmed 1999 A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase Blasina, A de Weyer, IV Laus, MC Luyten, WH Parker, AE McGowan, CH Curr Biol 9:1-10 9278512 Pubmed 1997 Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Peng, CY Graves, PR Thoma, RS Wu, Z Shaw, AS Piwnica-Worms, H Science 277:1501-5 11313932 Pubmed 2001 Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Graves, PR Lovly, CM Uy, GL Piwnica-Worms, H Oncogene 20:1839-51 LEFT-TO-RIGHT 2.7.10.2 Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CCNB1:p-T14,T161-CDK1 Reactome DB_ID: 10261952 C0SW08 phospho-p-T14,T161-CDK1 Reactome DB_ID: 10261950 UniProt:C0SW08 UniProt C0SW08 14 EQUAL 161 EQUAL 1 EQUAL 297 EQUAL Reactome Database ID Release 82 10261950 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261950 Reactome R-SSC-170078 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170078.1 1 CCNB1 CCNB1 D2IE28 Reactome DB_ID: 10261911 UniProt:D2IE28 CCNB1 UniProt D2IE28 1 EQUAL 433 EQUAL Reactome Database ID Release 82 10261911 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261911 Reactome R-SSC-68901 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68901.1 1 Reactome Database ID Release 82 10261952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261952 Reactome R-SSC-170073 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170073.1 CCNB1:p-T14,Y15,T161-CDK1 Reactome DB_ID: 10261919 1 C0SW08 phospho-p-T14,Y15,T161-CDK1 Reactome DB_ID: 10261917 15 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 1 EQUAL 297 EQUAL Reactome Database ID Release 82 10261917 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261917 Reactome R-SSC-170074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170074.1 1 Reactome Database ID Release 82 10261919 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261919 Reactome R-SSC-170065 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170065.1 ACTIVATION WEE1 F1S6U8 Reactome DB_ID: 10249903 UniProt:F1S6U8 UniProt F1S6U8 1 EQUAL 646 EQUAL Reactome Database ID Release 82 10249903 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249903 Reactome R-SSC-69253 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69253.1 GENE ONTOLOGY GO:0004713 Reactome Database ID Release 82 10249904 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249904 Reactome Database ID Release 82 10261954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10261954 Reactome R-SSC-170070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-170070.1 WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991). 1836978 Pubmed 1991 Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins Galaktionov, K Beach, D Cell 67:1181-94 8428596 Pubmed 1993 Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15 McGowan, CH Russell, P EMBO J. 12:75-85 1384126 Pubmed 1992 Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase Parker, LL Piwnica-Worms, H Science 257:1955-7 Reactome Database ID Release 82 10349702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10349702 Reactome R-SSC-75035 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-75035.1 DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2 activity is regulated by a balance between the phosphorylation and dephosphorylation by the Wee1/Myt1 kinase and Cdc25 phosphatase. Inactivation of the Cyclin B:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity. LEFT-TO-RIGHT 2.7.11.1 ATR phosphorylates TP53 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> TP53 Tetramer Reactome DB_ID: 10307943 TP53 Q9TUB2 Reactome DB_ID: 10307573 UniProt:Q9TUB2 UniProt Q9TUB2 1 EQUAL 393 EQUAL Reactome Database ID Release 82 10307573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307573 Reactome R-SSC-69488 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69488.1 4 Reactome Database ID Release 82 10307943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307943 Reactome R-SSC-3209194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3209194.1 4 p-S15-TP53 Tetramer Reactome DB_ID: 10250095 Q9TUB2 phospho-p-S15-TP53 Reactome DB_ID: 10250093 15 EQUAL 1 EQUAL 393 EQUAL Reactome Database ID Release 82 10250093 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250093 Reactome R-SSC-69507 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69507.1 4 Reactome Database ID Release 82 10250095 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250095 Reactome R-SSC-349474 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-349474.1 4 ACTIVATION activeUnit: #Complex1 ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 Reactome DB_ID: 10320523 RHNO1 RHNO1 F1SKA1 Reactome DB_ID: 10320503 UniProt:F1SKA1 RHNO1 UniProt F1SKA1 1 EQUAL 238 EQUAL Reactome Database ID Release 82 10320503 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320503 Reactome R-SSC-5684880 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684880.1 1 RAD9:HUS1:RAD1 Reactome DB_ID: 10263231 HUS1 HUS1 A0A287A8S7 Reactome DB_ID: 10263225 UniProt:A0A287A8S7 HUS1 UniProt A0A287A8S7 1 EQUAL 280 EQUAL Reactome Database ID Release 82 10263225 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263225 Reactome R-SSC-176374 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176374.1 1 Converted from EntitySet in Reactome RAD9 Reactome DB_ID: 10263221 RAD9A RAD9A F1RUX7 Reactome DB_ID: 10263215 UniProt:F1RUX7 RAD9A UniProt F1RUX7 1 EQUAL 391 EQUAL Reactome Database ID Release 82 10263215 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263215 Reactome R-SSC-176372 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176372.1 RAD9B RAD9B F1RNM9 Reactome DB_ID: 10263219 UniProt:F1RNM9 RAD9B UniProt F1RNM9 1 EQUAL 426 EQUAL Reactome Database ID Release 82 10263219 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263219 Reactome R-SSC-176325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176325.1 Reactome Database ID Release 82 10263221 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263221 Reactome R-SSC-176222 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176222.1 1 RAD1 RAD1 F1SND5 Reactome DB_ID: 10263229 UniProt:F1SND5 RAD1 UniProt F1SND5 1 EQUAL 282 EQUAL Reactome Database ID Release 82 10263229 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263229 Reactome R-SSC-176382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176382.1 1 Reactome Database ID Release 82 10263231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263231 Reactome R-SSC-176312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176312.1 1 ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 Reactome DB_ID: 10320483 RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 Reactome DB_ID: 10320481 RPA heterotrimer Reactome DB_ID: 10249846 RPA3 RPA3 I3LFZ2 Reactome DB_ID: 10249400 UniProt:I3LFZ2 RPA3 UniProt I3LFZ2 1 EQUAL 121 EQUAL Reactome Database ID Release 82 10249400 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249400 Reactome R-SSC-68459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68459.1 1 RPA2 RPA2 A0A5G2RE33 Reactome DB_ID: 10249406 UniProt:A0A5G2RE33 RPA2 UniProt A0A5G2RE33 1 EQUAL 270 EQUAL Reactome Database ID Release 82 10249406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249406 Reactome R-SSC-68457 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68457.1 1 RPA1 RPA1 A0A480KQ60 Reactome DB_ID: 10249396 UniProt:A0A480KQ60 RPA1 UniProt A0A480KQ60 2 EQUAL 616 EQUAL Reactome Database ID Release 82 10249396 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249396 Reactome R-SSC-68461 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68461.1 1 Reactome Database ID Release 82 10249846 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249846 Reactome R-SSC-68462 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68462.1 1 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 Reactome DB_ID: 10320479 A0A287AQ29 phospho-BRIP1 p-S990,Ac-K1249-BRIP1 Reactome DB_ID: 10320477 UniProt:A0A287AQ29 BRIP1 UniProt A0A287AQ29 990 EQUAL 1249 EQUAL 1 EQUAL 1249 EQUAL Reactome Database ID Release 82 10320477 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320477 Reactome R-SSC-5687710 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5687710.1 1 BRCA1-C complex Reactome DB_ID: 10320335 p-S327,T847,T859-RBBP8 homotetramer Reactome DB_ID: 10320331 A0A286ZL06 phospho-RBBP8 p-S327,T847,T859-RBBP8 Reactome DB_ID: 10320329 UniProt:A0A286ZL06 RBBP8 UniProt A0A286ZL06 327 EQUAL 847 EQUAL 859 EQUAL 1 EQUAL 897 EQUAL Reactome Database ID Release 82 10320329 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320329 Reactome R-SSC-5684138 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684138.1 4 Reactome Database ID Release 82 10320331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320331 Reactome R-SSC-5684137 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684137.1 1 Converted from EntitySet in Reactome p-5S-BRCA1:p-2T-BARD1 Reactome DB_ID: 10320183 p-5S-BRCA1:p-2T-BARD1 Reactome DB_ID: 10320177 A0A286ZS33 phospho-BRCA1 p-S988,S1387,S1423,S1524,S1547-BRCA1 Reactome DB_ID: 10320175 988 EQUAL 1 EQUAL 1863 EQUAL Reactome Database ID Release 82 10320175 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320175 Reactome R-SSC-5683800 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683800.1 1 1 Reactome Database ID Release 82 10320177 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320177 Reactome R-SSC-5683809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5683809.1 K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 Reactome DB_ID: 10320181 1 A0A286ZS33 phospho-BRCA1 K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 Reactome DB_ID: 10320179 1 EQUAL 1863 EQUAL Reactome Database ID Release 82 10320179 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320179 Reactome R-SSC-9707298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707298.1 1 Reactome Database ID Release 82 10320181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320181 Reactome R-SSC-9707296 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707296.1 Reactome Database ID Release 82 10320183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320183 Reactome R-SSC-9707299 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-9707299.1 1 Reactome Database ID Release 82 10320335 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320335 Reactome R-SSC-5685656 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685656.1 1 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10320447 3' overhanging ssDNA-DSBs:p-MRN Reactome DB_ID: 10320445 3' overhanging DNA at resected DSB ends Reactome DB_ID: 75156 Reactome Database ID Release 82 75156 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75156 Reactome R-ALL-75156 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-75156.2 ChEBI 61120 1 1 Reactome Database ID Release 82 10320445 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320445 Reactome R-SSC-5684116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684116.1 1 1 1 Reactome Database ID Release 82 10320447 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320447 Reactome R-SSC-5684122 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684122.1 1 Converted from EntitySet in Reactome EXO1,DNA2:BLM,WRN Reactome DB_ID: 10320471 DNA2:BLM:TOP3A:RMI1:RMI2 Reactome DB_ID: 10320463 BLM:TOP3A:RMI1:RMI2 Reactome DB_ID: 10320461 RMI1 RMI1 F1S4G5 Reactome DB_ID: 10320455 UniProt:F1S4G5 RMI1 UniProt F1S4G5 1 EQUAL 625 EQUAL Reactome Database ID Release 82 10320455 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320455 Reactome R-SSC-5685949 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685949.1 1 BLM BLM F1RMJ2 Reactome DB_ID: 10262859 UniProt:F1RMJ2 BLM UniProt F1RMJ2 1 EQUAL 1417 EQUAL Reactome Database ID Release 82 10262859 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10262859 Reactome R-SSC-174881 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-174881.1 1 TOP3A TOP3A A0A287BF93 Reactome DB_ID: 10320451 UniProt:A0A287BF93 TOP3A UniProt A0A287BF93 1 EQUAL 1001 EQUAL Reactome Database ID Release 82 10320451 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320451 Reactome R-SSC-912452 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-912452.1 1 RMI2 RMI2 F1RL13 Reactome DB_ID: 10320459 UniProt:F1RL13 RMI2 UniProt F1RL13 2 EQUAL 147 EQUAL Reactome Database ID Release 82 10320459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320459 Reactome R-SSC-5685951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685951.1 1 Reactome Database ID Release 82 10320461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320461 Reactome R-SSC-5685972 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685972.1 1 DNA2 DNA2 A0A287ATY4 Reactome DB_ID: 10249854 UniProt:A0A287ATY4 DNA2 UniProt A0A287ATY4 1 EQUAL 1060 EQUAL Reactome Database ID Release 82 10249854 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249854 Reactome R-SSC-68465 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68465.1 1 Reactome Database ID Release 82 10320463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320463 Reactome R-SSC-5685974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685974.1 EXO1:BLM,WRN Reactome DB_ID: 10320467 EXO1 EXO1 A0A5G2R616 Reactome DB_ID: 10314143 UniProt:A0A5G2R616 EXO1 UniProt A0A5G2R616 1 EQUAL 846 EQUAL Reactome Database ID Release 82 10314143 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314143 Reactome R-SSC-5357514 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5357514.1 1 Converted from EntitySet in Reactome BLM,WRN Reactome DB_ID: 10320465 WRN WRN F1RX70 Reactome DB_ID: 10262863 UniProt:F1RX70 WRN UniProt F1RX70 1 EQUAL 1432 EQUAL Reactome Database ID Release 82 10262863 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10262863 Reactome R-SSC-67387 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-67387.1 Reactome Database ID Release 82 10320465 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320465 Reactome R-SSC-5685968 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685968.1 1 Reactome Database ID Release 82 10320467 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320467 Reactome R-SSC-5685976 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685976.1 DNA2:WRN Reactome DB_ID: 10320469 1 1 Reactome Database ID Release 82 10320469 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320469 Reactome R-SSC-5685969 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685969.1 Reactome Database ID Release 82 10320471 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320471 Reactome R-SSC-5685980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685980.1 1 Reactome Database ID Release 82 10320479 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320479 Reactome R-SSC-5684128 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684128.1 1 Reactome Database ID Release 82 10320481 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320481 Reactome R-SSC-5693552 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5693552.1 1 1 Reactome Database ID Release 82 10320483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320483 Reactome R-SSC-5684874 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684874.1 1 TOPBP1 TOPBP1 A0A287BSI9 Reactome DB_ID: 10320499 UniProt:A0A287BSI9 TOPBP1 UniProt A0A287BSI9 1 EQUAL 1522 EQUAL Reactome Database ID Release 82 10320499 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320499 Reactome R-SSC-5684878 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5684878.1 1 RAD17:RFC Reactome DB_ID: 10263184 RFC5 RFC5 A0A287A6L4 Reactome DB_ID: 10249777 UniProt:A0A287A6L4 RFC5 UniProt A0A287A6L4 1 EQUAL 340 EQUAL Reactome Database ID Release 82 10249777 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249777 Reactome R-SSC-68427 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68427.1 1 RFC2 RFC2 A0A287BRT6 Reactome DB_ID: 10249789 UniProt:A0A287BRT6 RFC2 UniProt A0A287BRT6 1 EQUAL 354 EQUAL Reactome Database ID Release 82 10249789 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249789 Reactome R-SSC-68433 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68433.1 1 RFC4 RFC4 F1SFI3 Reactome DB_ID: 10249781 UniProt:F1SFI3 RFC4 UniProt F1SFI3 1 EQUAL 363 EQUAL Reactome Database ID Release 82 10249781 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249781 Reactome R-SSC-68429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68429.1 1 RAD17 RAD17 A0A287BR55 Reactome DB_ID: 10263182 UniProt:A0A287BR55 RAD17 UniProt A0A287BR55 1 EQUAL 681 EQUAL Reactome Database ID Release 82 10263182 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263182 Reactome R-SSC-3008665 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3008665.1 1 RFC3 RFC3 A0A480UUW0 Reactome DB_ID: 10249785 UniProt:A0A480UUW0 RFC3 UniProt A0A480UUW0 1 EQUAL 356 EQUAL Reactome Database ID Release 82 10249785 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10249785 Reactome R-SSC-68431 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68431.1 1 Reactome Database ID Release 82 10263184 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10263184 Reactome R-SSC-176353 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-176353.1 1 Reactome Database ID Release 82 10320523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320523 Reactome R-SSC-5685039 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-5685039.1 Reactome Database ID Release 82 10320526 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10320526 Reactome Database ID Release 82 10328728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10328728 Reactome R-SSC-6799332 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-6799332.1 ATR, bound to DNA damage sites, phosphorylates TP53 (p53) at serine residue S15. S15 phosphorylation stabilizes TP53 by inhibiting the binding of TP53 to the ubiquitin ligase MDM2 (Tibbetts et al. 1999, Lakin et al. 1999). 9925639 Pubmed 1999 A role for ATR in the DNA damage-induced phosphorylation of p53 Tibbetts, R S Brumbaugh, K M Williams, J M Sarkaria, J N Cliby, W A Shieh, SY Taya, Y Prives, C Abraham, Robert T Genes Dev. 13:152-7 10435622 Pubmed 1999 The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53 Lakin, N D Hann, B C Jackson, SP Oncogene 18:3989-95 LEFT-TO-RIGHT 2.7.11.1 CHEK1 phosphorylates TP53 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 4 p-S15,S20-TP53 Tetramer Reactome DB_ID: 10250100 Q9TUB2 phospho-p-S15,S20-TP53 Reactome DB_ID: 10250098 20 EQUAL 1 EQUAL 393 EQUAL Reactome Database ID Release 82 10250098 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250098 Reactome R-SSC-69683 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69683.1 4 Reactome Database ID Release 82 10250100 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250100 Reactome R-SSC-3222171 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3222171.1 4 ACTIVATION Reactome Database ID Release 82 10250075 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10250075 Reactome Database ID Release 82 10328726 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10328726 Reactome R-SSC-6799246 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-6799246.1 CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000). 10673501 Pubmed 2000 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Shieh, SY Ahn, J Tamai, K Taya, Y Prives, C Genes Dev 14:289-300 Reactome Database ID Release 82 10349454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10349454 Reactome R-SSC-69473 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-69473.1 Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes.