BioPAX pathway converted from "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" in the Reactome database.LEFT-TO-RIGHT3.1.1.4PI is hydrolyzed to 1-acyl LPI by PLA2[12]This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PIPhosphatidyl 1D-myo-inositol1-phosphatidyl-1D-myo-inositolReactome DB_ID: 426639endoplasmic reticulum membraneGENE ONTOLOGYGO:00057891-phosphatidyl-1D-myo-inositol [ChEBI:16749]1-phosphatidyl-1D-myo-inositolChEBICHEBI:16749Reactome Database ID Release 71426639Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426639ReactomeR-ALL-4266393Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-426639.3Reactomehttp://www.reactome.orgH2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7129356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293564Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.4LCFA(-)long-chain fatty acid anionReactome DB_ID: 1524021long-chain fatty acid anion [ChEBI:57560]long-chain fatty acid anionChEBICHEBI:57560Reactome Database ID Release 711524021Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524021ReactomeR-ALL-15240213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1524021.31-acyl LPI1-acyl lysophosphatidylinositol1-acyl-sn-glycero-3-phospho-D-myo-inositol1-Acylglycerophosphoinositol1-Acyl-sn-glycero-3-phosphoinositolReactome DB_ID: 14987331-acyl-sn-glycero-3-phospho-D-myo-inositol [ChEBI:28914]1-acyl-sn-glycero-3-phospho-D-myo-inositol1-Acyl-sn-glycero-3-phosphoinositolChEBICHEBI:28914Reactome Database ID Release 711498733Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498733ReactomeR-ALL-14987333Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1498733.3ACTIVATIONPLA2G2A:Ca2+Reactome DB_ID: 10353204Ca2+Calciumcalcium(2+)Reactome DB_ID: 1500625calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 711500625Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500625ReactomeR-ALL-15006253Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1500625.31F6QSN6PLA2G2AReactome DB_ID: 10353202UniProt:F6QSN6Xenopus tropicalisNCBI Taxonomy8364UniProtF6QSN621EQUAL144EQUALReactome Database ID Release 7110353202Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10353202ReactomeR-XTR-14988021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1498802.11Reactome Database ID Release 7110353204Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10353204ReactomeR-XTR-15006301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1500630.1GENE ONTOLOGYGO:0004623gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7110353205Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10353205Reactome Database ID Release 7110353315Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10353315ReactomeR-XTR-14828681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1482868.1At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A) (Singer et al. 2002) or by cytosolic phospholipase A2 gamma (PLA2G4C) (Ghomashchi et al. 2010), to form 1-acyl lysophosphatidylinositol (LPI).20705608Pubmed2010Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoformsGhomashchi, FNaika, GSBollinger, JGAloulou, AhmedLehr, MLeslie, CCGelb, Michael HJ Biol Chem 285:36100-1112359733Pubmed2002Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2Singer, AGGhomashchi, FLe Calvez, CBollinger, JBezzine, SRouault, MSadilek, MNguyen, ELazdunski, MLambeau, GGelb, Michael HJ Biol Chem 277:48535-49inferred from electronic annotationEVIDENCE CODEECO:0000203