BioPAX pathway converted from "The role of GTSE1 in G2/M progression after G2 checkpoint" in the Reactome database. The role of GTSE1 in G2/M progression after G2 checkpoint This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT GTSE1 binds microtubule lattice in interphase cells This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Microtubule Reactome DB_ID: 10271313 cytosol GENE ONTOLOGY GO:0005829 Microtubule protofilament Reactome DB_ID: 10271311 Reactome Database ID Release 83 10271311 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10271311 Reactome R-SSC-8982424 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8982424.1 Reactome http://www.reactome.org 13 Reactome Database ID Release 83 10271313 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10271313 Reactome R-SSC-190599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-190599.1 GTSE1 GTSE1 F1SM83 Reactome DB_ID: 10340740 UniProt:F1SM83 GTSE1 Sus scrofa NCBI Taxonomy 9823 UniProt F1SM83 1 EQUAL 720 EQUAL Reactome Database ID Release 83 10340740 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340740 Reactome R-SSC-8852264 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852264.1 GTSE1:microtubule Reactome DB_ID: 10340742 1 1 Reactome Database ID Release 83 10340742 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340742 Reactome R-SSC-8852286 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852286.1 Reactome Database ID Release 83 10340744 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340744 Reactome R-SSC-8852280 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852280.1 In interphase cells, GTSE1 localizes to the microtubule lattice, probably due to direct binding to tubulin (Scolz et al. 2012). 23236459 Pubmed 2012 GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration Scolz, Massimilano Widlund, Per O Piazza, Silvano Bublik, Debora Rosa Reber, Simone Peche, Leticia Y Ciani, Yari Hubner, Nina Isokane, Mayumi Monte, Martin Ellenberg, Jan Hyman, Anthony A Schneider, C Bird, Alexander W PLoS ONE 7:e51259 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT GTSE1 binds MAPRE1 (EB1) at microtubule plus ends This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> MAPRE1:microtubule plus end Reactome DB_ID: 10340748 1 MAPRE1 homodimer Reactome DB_ID: 10340746 MAPRE1 MAPRE1 A0A286ZPA2 Reactome DB_ID: 10265165 UniProt:A0A286ZPA2 MAPRE1 UniProt A0A286ZPA2 2 EQUAL 268 EQUAL Reactome Database ID Release 83 10265165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10265165 Reactome R-SSC-376240 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-376240.1 2 Reactome Database ID Release 83 10340746 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340746 Reactome R-SSC-8852301 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852301.1 1 Reactome Database ID Release 83 10340748 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340748 Reactome R-SSC-8852300 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852300.1 GTSE1:MAPRE1:microtubule plus end Reactome DB_ID: 10340750 1 1 Reactome Database ID Release 83 10340750 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340750 Reactome R-SSC-8852295 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852295.1 Reactome Database ID Release 83 10340752 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340752 Reactome R-SSC-8852298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852298.1 GENE ONTOLOGY GO:0030335 gene ontology term for cellular process MI MI:0359 During interphase, GTSE1 localizes to the growing plus-end tip of microtubules by binding to the microtubule plus end protein MAPRE1 (EB1). This interaction involves two SKIP-like EB1-interaction motifs of GTSE1 and the C-terminal EB-homology (EBH) domain of MAPRE1. The interaction between GTSE1 and MAPRE1 is evolutionarily conserved. The interaction between GTSE1 and MAPRE1 at growing microtubule plus ends promotes cell migration, likely through microtubule-induced disassembly of focal adhesions. GTSE1 expression levels in G1 phase correlate with invasiveness of breast cancer cell lines (Scolz et al. 2012). LEFT-TO-RIGHT 2.7.11.1 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 83 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 additional information MI MI:0361 2 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 83 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 2 F1SM83 phospho-GTSE1 p-T513,T526-GTSE1 Reactome DB_ID: 10340756 513 EQUAL O-phospho-L-threonine MOD MOD:00047 526 EQUAL 1 EQUAL 720 EQUAL Reactome Database ID Release 83 10340756 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340756 Reactome R-SSC-8852308 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852308.1 ACTIVATION Converted from EntitySet in Reactome Mitotic kinase Reactome DB_ID: 10340758 Converted from EntitySet in Reactome CCNB1,CCNB2:p-T161-CDK1 Reactome DB_ID: 10268570 CCNB1:p-T161-CDK1 Reactome DB_ID: 10268528 C0SW08 phospho-p-T161-CDK1 Reactome DB_ID: 10268437 UniProt:C0SW08 UniProt C0SW08 161 EQUAL 1 EQUAL 297 EQUAL Reactome Database ID Release 83 10268437 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268437 Reactome R-SSC-157415 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-157415.1 1 CCNB1 CCNB1 D2IE28 Reactome DB_ID: 10268427 UniProt:D2IE28 CCNB1 UniProt D2IE28 1 EQUAL 433 EQUAL Reactome Database ID Release 83 10268427 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268427 Reactome R-SSC-157451 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-157451.1 1 Reactome Database ID Release 83 10268528 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268528 Reactome R-SSC-157456 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-157456.1 CCNB2:p-T161-CDK1 Reactome DB_ID: 10268568 1 CCNB2 CCNB2 A9ZPH4 Reactome DB_ID: 10268471 UniProt:A9ZPH4 CCNB2 UniProt A9ZPH4 1 EQUAL 398 EQUAL Reactome Database ID Release 83 10268471 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268471 Reactome R-SSC-68897 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68897.1 1 Reactome Database ID Release 83 10268568 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268568 Reactome R-SSC-68898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68898.1 Reactome Database ID Release 83 10268570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10268570 Reactome R-SSC-2311324 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2311324.1 Reactome Database ID Release 83 10340758 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340758 Reactome R-SSC-8853807 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8853807.1 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10340759 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340759 Reactome Database ID Release 83 10340761 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340761 Reactome R-SSC-8852306 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852306.1 GENE ONTOLOGY GO:1904527 Starting in mitotic prometaphase, GTSE1 becomes phosphorylated at threonine residues T513 and T526 (and possibly other sites), located adjacent to the two SKIP-like motifs involved in binding to MAPRE1 (EB1). Mitotic phosphorylation of GTSE1 inhibits its association with microtubule plus ends. CDK1 activity inhibits the association of recombinant human GTSE1 with microtubule plus ends in Xenopus extracts, but it is not certain whether CDK1 or another mitotic kinase phosphorylates GTSE1 (Scolz et al. 2012). LEFT-TO-RIGHT GTSE1 binds PLK1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> I3LII4 phospho-p-T210-PLK1 Reactome DB_ID: 10265542 UniProt:I3LII4 UniProt I3LII4 210 EQUAL 1 EQUAL 603 EQUAL Reactome Database ID Release 83 10265542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10265542 Reactome R-SSC-3000318 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3000318.1 GTSE1:p-T210-PLK1 Reactome DB_ID: 10340763 1 1 Reactome Database ID Release 83 10340763 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340763 Reactome R-SSC-8852323 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852323.1 Reactome Database ID Release 83 10340771 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340771 Reactome R-SSC-8852324 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852324.1 GTSE1 binds PLK1. The two proteins co-localize on centrosomes from G2 phase to prophase, but not after metaphase (Liu et al. 2010). 20577264 Pubmed 2010 Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery Liu, X Shawn Li, Hongchang Song, Bing Liu, Xiaoqi EMBO Rep. 11:626-32 LEFT-TO-RIGHT 2.7.11.1 PLK1 phosphorylates GTSE1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> F1SM83 phospho-GTSE1 p-S435-GTSE1 Reactome DB_ID: 10340766 435 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 720 EQUAL Reactome Database ID Release 83 10340766 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340766 Reactome R-SSC-8852316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852316.1 ACTIVATION activeUnit: #Protein7 Reactome Database ID Release 83 10340767 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340767 Reactome Database ID Release 83 10340769 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340769 Reactome R-SSC-8852317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852317.1 GENE ONTOLOGY GO:1900182 Activated PLK1 phosphorylates GTSE1 on serine residue S435, located in immediate vicinity of the GTSE1 nuclear localization signal (NLS) R431RR433 (Arg431Arg432Arg433). PLK1-mediated phosphorylation promotes GTSE1 nuclear translocation, possibly by exposing the NLS of GTSE1 to the nuclear import machinery. PLK1 can also phosphorylate human GTSE1 on serine residue S233. S233 is not evolutionarily conserved and is therefore not shown (Liu et al. 2010). LEFT-TO-RIGHT GTSE1 translocates to the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> F1SM83 phospho-GTSE1 p-S435-GTSE1 Reactome DB_ID: 10340773 nucleoplasm GENE ONTOLOGY GO:0005654 1 EQUAL 720 EQUAL Reactome Database ID Release 83 10340773 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340773 Reactome R-SSC-8852332 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852332.1 Reactome Database ID Release 83 10340775 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340775 Reactome R-SSC-8852331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852331.1 PLK1-mediated phosphorylation of GTSE1 is needed for nuclear accumulation of GTSE1, probably because it exposes the nuclear localization signal (NLS) of GTSE1 to the nuclear import machinery. Nuclear localization of GTSE1 is not needed for normal G2 phase progression, but is needed for the G2 checkpoint recovery (cell cycle re-entry after G2 checkpoint arrest) (Liu et al. 2010). LEFT-TO-RIGHT GTSE1 binds TP53 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PolyUb-TP53 Tetramer Reactome DB_ID: 10314485 Q9TUB2 PolyUb-TP53 Reactome DB_ID: 10314483 UniProt:Q9TUB2 UniProt Q9TUB2 ubiquitinylated lysine MOD MOD:01148 1 EQUAL 393 EQUAL Reactome Database ID Release 83 10314483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314483 Reactome R-SSC-6793679 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-6793679.1 4 Reactome Database ID Release 83 10314485 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314485 Reactome R-SSC-3209186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3209186.1 p-S435-GTSE1:PolyUb-TP53 Tetramer Reactome DB_ID: 10340777 1 1 Reactome Database ID Release 83 10340777 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340777 Reactome R-SSC-8852344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852344.1 Reactome Database ID Release 83 10340779 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340779 Reactome R-SSC-8852337 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852337.1 Since MDM2-mediated ubiquitination of TP53 promotes translocation of TP53 to the cytosol, and since GTSE1-facilitated translocation of TP53 to the cytosol depends on the functional MDM2 (with no reported interaction between GTSE1 and MDM2) (Monte et al. 2004), it is plausible that GTSE1 binds to TP53 polyubiquitinated by MDM2. The interaction between TP53 and GTSE1 involves the C-terminal regulatory domain of TP53 and the C-terminus of GTSE1 (Monte et al. 2003). 12750368 Pubmed 2003 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function Monte, Martin Benetti, Roberta Buscemi, Giacomo Sandy, Peter Del Sal, Giannino Schneider, C J. Biol. Chem. 278:30356-64 14707141 Pubmed 2004 hGTSE-1 expression stimulates cytoplasmic localization of p53 Monte, Martin Benetti, Roberta Collavin, Licio Marchionni, Luigi Del Sal, Giannino Schneider, C J. Biol. Chem. 279:11744-52 LEFT-TO-RIGHT GTSE1 promotes translocation of TP53 to the cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-S435-GTSE1:PolyUb-TP53 Tetramer Reactome DB_ID: 10340781 PolyUb-TP53 Tetramer Reactome DB_ID: 10332909 Q9TUB2 PolyUb-TP53 Reactome DB_ID: 10332907 1 EQUAL 393 EQUAL Reactome Database ID Release 83 10332907 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10332907 Reactome R-SSC-6793681 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-6793681.1 4 Reactome Database ID Release 83 10332909 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10332909 Reactome R-SSC-8856287 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8856287.1 1 1 Reactome Database ID Release 83 10340781 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340781 Reactome R-SSC-8852349 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852349.1 Reactome Database ID Release 83 10340783 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340783 Reactome R-SSC-8852351 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852351.1 GENE ONTOLOGY GO:0046827 Binding of GTSE1 to TP53 (p53) in the nucleus promotes translocation of TP53 to the cytosol. This process is dependent on the nuclear export signal (NES) of GTSE1 (Monte et al. 2004). LEFT-TO-RIGHT GTSE1 facilitates proteasome-mediated degradation of TP53 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Ub ubiquitin Reactome DB_ID: 10256374 RPS27A RPS27A(1-76) A0A287AZA7 Reactome DB_ID: 10256346 UniProt:A0A287AZA7 RPS27A UniProt A0A287AZA7 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10256346 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256346 Reactome R-SSC-939205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939205.1 UBA52 UBA52(1-76) P63053 Reactome DB_ID: 10256348 UniProt:P63053 UBA52 UniProt P63053 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10256348 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256348 Reactome R-SSC-939203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939203.1 UBC UBB(1-76) P0CG68 Reactome DB_ID: 10256350 UniProt:P0CG68 UBC UniProt P0CG68 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10256350 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256350 Reactome R-SSC-939214 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-939214.1 Reactome Database ID Release 83 10256374 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256374 Reactome R-SSC-113595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-113595.1 ACTIVATION 26S proteasome Reactome DB_ID: 10256476 PSMC6 PSMC6 A0A287BG14 Reactome DB_ID: 10256426 UniProt:A0A287BG14 PSMC6 UniProt A0A287BG14 1 EQUAL 389 EQUAL Reactome Database ID Release 83 10256426 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256426 Reactome R-SSC-68783 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68783.1 1 PSMD5 PSMD5 A0A480QIP5 Reactome DB_ID: 10256444 UniProt:A0A480QIP5 PSMD5 UniProt A0A480QIP5 2 EQUAL 504 EQUAL Reactome Database ID Release 83 10256444 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256444 Reactome R-SSC-68802 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68802.1 1 Converted from EntitySet in Reactome Homologues of PSMC5 Reactome DB_ID: 10256424 PSMC5 PSMC5 A0A5G2QJH1 Reactome DB_ID: 10256420 UniProt:A0A5G2QJH1 PSMC5 UniProt A0A5G2QJH1 2 EQUAL 406 EQUAL Reactome Database ID Release 83 10256420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256420 Reactome R-SSC-68780 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780.1 PSMC5 P62197 Reactome DB_ID: 10256422 UniProt:P62197 UniProt P62197 2 EQUAL 406 EQUAL Reactome Database ID Release 83 10256422 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256422 Reactome R-SSC-68780-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780-2.1 Reactome Database ID Release 83 10256424 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256424 Reactome R-SSC-68780-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68780-3.1 1 PSMA1 PSMA1 A0A5G2QI19 Reactome DB_ID: 10256378 UniProt:A0A5G2QI19 PSMA1 UniProt A0A5G2QI19 1 EQUAL 263 EQUAL Reactome Database ID Release 83 10256378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256378 Reactome R-SSC-68724 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68724.1 1 PSMD10 PSMD10 A0A287BTN9 Reactome DB_ID: 10256430 UniProt:A0A287BTN9 PSMD10 UniProt A0A287BTN9 1 EQUAL 226 EQUAL Reactome Database ID Release 83 10256430 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256430 Reactome R-SSC-68788 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68788.1 1 PSMA2 PSMA2 A0A5G2QZH5 Reactome DB_ID: 10256380 UniProt:A0A5G2QZH5 PSMA2 UniProt A0A5G2QZH5 2 EQUAL 234 EQUAL Reactome Database ID Release 83 10256380 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256380 Reactome R-SSC-68726 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68726.1 1 PSMD6 PSMD6 F1SGF1 Reactome DB_ID: 10256446 UniProt:F1SGF1 PSMD6 UniProt F1SGF1 1 EQUAL 389 EQUAL Reactome Database ID Release 83 10256446 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256446 Reactome R-SSC-68804 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68804.1 1 PSMB5 A0A286ZS34 Reactome DB_ID: 10256402 UniProt:A0A286ZS34 UniProt A0A286ZS34 60 EQUAL 263 EQUAL Reactome Database ID Release 83 10256402 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256402 Reactome R-SSC-68753 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68753.1 1 PSMA5 PSMA5 F2Z5K2 Reactome DB_ID: 10256386 UniProt:F2Z5K2 PSMA5 UniProt F2Z5K2 1 EQUAL 241 EQUAL Reactome Database ID Release 83 10256386 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256386 Reactome R-SSC-68732 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68732.1 1 PSMD8 PSMD8 A0A287B5Q7 Reactome DB_ID: 10256450 UniProt:A0A287B5Q7 PSMD8 UniProt A0A287B5Q7 1 EQUAL 350 EQUAL Reactome Database ID Release 83 10256450 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256450 Reactome R-SSC-68808 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68808.1 1 PSMC3 PSMC3 A0A5G2QSU8 Reactome DB_ID: 10256416 UniProt:A0A5G2QSU8 PSMC3 UniProt A0A5G2QSU8 1 EQUAL 439 EQUAL Reactome Database ID Release 83 10256416 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256416 Reactome R-SSC-68774 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68774.1 1 PSMB1 PSMB1 A0A287BPP9 Reactome DB_ID: 10256392 UniProt:A0A287BPP9 PSMB1 UniProt A0A287BPP9 29 EQUAL 241 EQUAL Reactome Database ID Release 83 10256392 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256392 Reactome R-SSC-68738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68738.1 1 PSME1 PSME1 Q64L94 Reactome DB_ID: 10256454 UniProt:Q64L94 PSME1 UniProt Q64L94 1 EQUAL 249 EQUAL Reactome Database ID Release 83 10256454 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256454 Reactome R-SSC-68812 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68812.1 1 PSMD11 PSMD11 F1RKW8 Reactome DB_ID: 10256432 UniProt:F1RKW8 PSMD11 UniProt F1RKW8 2 EQUAL 422 EQUAL Reactome Database ID Release 83 10256432 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256432 Reactome R-SSC-68790 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68790.1 1 PSMD1 PSMD1 F1SMW9 Reactome DB_ID: 10256428 UniProt:F1SMW9 PSMD1 UniProt F1SMW9 1 EQUAL 953 EQUAL Reactome Database ID Release 83 10256428 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256428 Reactome R-SSC-68786 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68786.1 1 PSMD12 PSMD12 A0A480SMR6 Reactome DB_ID: 10256434 UniProt:A0A480SMR6 PSMD12 UniProt A0A480SMR6 2 EQUAL 456 EQUAL Reactome Database ID Release 83 10256434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256434 Reactome R-SSC-68792 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68792.1 1 PSMA4 PSMA4 A0A5G2QL81 Reactome DB_ID: 10256384 UniProt:A0A5G2QL81 PSMA4 UniProt A0A5G2QL81 1 EQUAL 261 EQUAL Reactome Database ID Release 83 10256384 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256384 Reactome R-SSC-68730 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68730.1 1 PSMC4 PSMC4 A0A287B4P8 Reactome DB_ID: 10256418 UniProt:A0A287B4P8 PSMC4 UniProt A0A287B4P8 1 EQUAL 418 EQUAL Reactome Database ID Release 83 10256418 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256418 Reactome R-SSC-68777 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68777.1 1 PSMC2 PSMC2 F1SB53 Reactome DB_ID: 10256414 UniProt:F1SB53 PSMC2 UniProt F1SB53 2 EQUAL 433 EQUAL Reactome Database ID Release 83 10256414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256414 Reactome R-SSC-68771 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68771.1 1 Ghost homologue of PSMD2 Reactome DB_ID: 10256438 Reactome Database ID Release 83 10256438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256438 Reactome R-SSC-68796 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68796.1 1 PSMB7 PSMB7 A1XQU1 Reactome DB_ID: 10256406 UniProt:A1XQU1 PSMB7 UniProt A1XQU1 44 EQUAL 277 EQUAL Reactome Database ID Release 83 10256406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256406 Reactome R-SSC-68759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68759.1 1 PSMD4 PSMD4 A0A288CG47 Reactome DB_ID: 10256442 UniProt:A0A288CG47 PSMD4 UniProt A0A288CG47 1 EQUAL 377 EQUAL Reactome Database ID Release 83 10256442 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256442 Reactome R-SSC-68800 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68800.1 1 PSMB11 PSMB11 F1S9C7 Reactome DB_ID: 10256472 UniProt:F1S9C7 PSMB11 UniProt F1S9C7 50 EQUAL 300 EQUAL Reactome Database ID Release 83 10256472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256472 Reactome R-SSC-947607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947607.1 1 PSMB10 PSMB10 A0A287BRV0 Reactome DB_ID: 10256394 UniProt:A0A287BRV0 PSMB10 UniProt A0A287BRV0 40 EQUAL 273 EQUAL Reactome Database ID Release 83 10256394 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256394 Reactome R-SSC-68741 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68741.1 1 PSMD14 PSMD14 A0A480DPN6 Reactome DB_ID: 10256376 UniProt:A0A480DPN6 PSMD14 UniProt A0A480DPN6 1 EQUAL 310 EQUAL Reactome Database ID Release 83 10256376 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256376 Reactome R-SSC-68722 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68722.1 1 PSMD7 PSMD7 A0A287AEH0 Reactome DB_ID: 10256448 UniProt:A0A287AEH0 PSMD7 UniProt A0A287AEH0 1 EQUAL 324 EQUAL Reactome Database ID Release 83 10256448 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256448 Reactome R-SSC-68806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68806.1 1 PSMD9 PSMD9 A0A286ZLP7 Reactome DB_ID: 10256452 UniProt:A0A286ZLP7 PSMD9 UniProt A0A286ZLP7 1 EQUAL 223 EQUAL Reactome Database ID Release 83 10256452 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256452 Reactome R-SSC-68810 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68810.1 1 PSMB3 PSMB3 A0A286ZN52 Reactome DB_ID: 10256398 UniProt:A0A286ZN52 PSMB3 UniProt A0A286ZN52 2 EQUAL 205 EQUAL Reactome Database ID Release 83 10256398 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256398 Reactome R-SSC-68747 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68747.1 1 PSMF1 PSMF1 F1S870 Reactome DB_ID: 10256460 UniProt:F1S870 PSMF1 UniProt F1S870 1 EQUAL 271 EQUAL Reactome Database ID Release 83 10256460 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256460 Reactome R-SSC-68818 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68818.1 1 PSME4 PSME4 A0A287APQ3 Reactome DB_ID: 10256464 UniProt:A0A287APQ3 PSME4 UniProt A0A287APQ3 1 EQUAL 1843 EQUAL Reactome Database ID Release 83 10256464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256464 Reactome R-SSC-947606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947606.1 1 PSMA8 PSMA8 F1SBA5 Reactome DB_ID: 10256468 UniProt:F1SBA5 PSMA8 UniProt F1SBA5 1 EQUAL 256 EQUAL Reactome Database ID Release 83 10256468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256468 Reactome R-SSC-947610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-947610.1 1 Ghost homologue of SEM1 Reactome DB_ID: 10256474 Reactome Database ID Release 83 10256474 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256474 Reactome R-SSC-8866674 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8866674.1 1 PSMC1 PSMC1 F2Z5J1 Reactome DB_ID: 10256412 UniProt:F2Z5J1 PSMC1 UniProt F2Z5J1 2 EQUAL 440 EQUAL Reactome Database ID Release 83 10256412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256412 Reactome R-SSC-68768 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68768.1 1 PSMB2 PSMB2 A0A5G2R6J1 Reactome DB_ID: 10256396 UniProt:A0A5G2R6J1 PSMB2 UniProt A0A5G2R6J1 1 EQUAL 201 EQUAL Reactome Database ID Release 83 10256396 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256396 Reactome R-SSC-68744 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68744.1 1 PSMD13 PSMD13 A0A5G2R6X9 Reactome DB_ID: 10256436 UniProt:A0A5G2R6X9 PSMD13 UniProt A0A5G2R6X9 1 EQUAL 376 EQUAL Reactome Database ID Release 83 10256436 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256436 Reactome R-SSC-68794 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68794.1 1 PSME3 PSME3 P61291 Reactome DB_ID: 10256458 UniProt:P61291 PSME3 UniProt P61291 2 EQUAL 254 EQUAL Reactome Database ID Release 83 10256458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256458 Reactome R-SSC-68816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68816.1 1 PSMB9 PSMB9 Q2PYM7 Reactome DB_ID: 10256410 UniProt:Q2PYM7 PSMB9 UniProt Q2PYM7 21 EQUAL 219 EQUAL Reactome Database ID Release 83 10256410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256410 Reactome R-SSC-68765 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68765.1 1 PSMD3 PSMD3 F1RXA7 Reactome DB_ID: 10256440 UniProt:F1RXA7 PSMD3 UniProt F1RXA7 1 EQUAL 534 EQUAL Reactome Database ID Release 83 10256440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256440 Reactome R-SSC-68798 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68798.1 1 PSMA3 PSMA3 A0A5G2QWE9 Reactome DB_ID: 10256382 UniProt:A0A5G2QWE9 PSMA3 UniProt A0A5G2QWE9 2 EQUAL 255 EQUAL Reactome Database ID Release 83 10256382 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256382 Reactome R-SSC-68728 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68728.1 1 PSMA7 PSMA7 A0A287BRR7 Reactome DB_ID: 10256390 UniProt:A0A287BRR7 PSMA7 UniProt A0A287BRR7 1 EQUAL 248 EQUAL Reactome Database ID Release 83 10256390 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256390 Reactome R-SSC-68736 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68736.1 1 Ghost homologue of PSMA6 Reactome DB_ID: 10256388 Reactome Database ID Release 83 10256388 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256388 Reactome R-SSC-68734 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68734.1 1 PSME2 PSME2 F1SGM3 Reactome DB_ID: 10256456 UniProt:F1SGM3 PSME2 UniProt F1SGM3 2 EQUAL 239 EQUAL Reactome Database ID Release 83 10256456 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256456 Reactome R-SSC-68814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68814.1 1 Ghost homologue of PSMB4 Reactome DB_ID: 10256400 Reactome Database ID Release 83 10256400 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256400 Reactome R-SSC-68750 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68750.1 1 PSMB6 PSMB6 A0A5G2R4Y9 Reactome DB_ID: 10256404 UniProt:A0A5G2R4Y9 PSMB6 UniProt A0A5G2R4Y9 35 EQUAL 239 EQUAL Reactome Database ID Release 83 10256404 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256404 Reactome R-SSC-68756 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68756.1 1 Ghost homologue of PSMB8 Reactome DB_ID: 10256408 Reactome Database ID Release 83 10256408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256408 Reactome R-SSC-68762 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68762.1 1 Reactome Database ID Release 83 10256476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256476 Reactome R-SSC-68819 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-68819.1 GENE ONTOLOGY GO:0004175 Reactome Database ID Release 83 10256477 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10256477 Reactome Database ID Release 83 10340785 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340785 Reactome R-SSC-8852354 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852354.1 GENE ONTOLOGY GO:0043161 GTSE1 promotes down-regulation of TP53 in a proteasome-dependent way. Nuclear export of TP53 facilitated by GTSE1 and MDM2likely makes ubiquitinated TP53 available to the proteasome machinery. GTSE1-mediated decrease of TP53 levels is needed for the G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest) and rescues cells from DNA damage induced apoptosis during S/G2 phase (Monte et al. 2003, Monte et al. 2004). LEFT-TO-RIGHT GTSE1 binds CDKN1A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome HSP90:HSP90 HSP90 dimer Reactome DB_ID: 10316042 HSP90 Reactome DB_ID: 10304476 Converted from EntitySet in Reactome Homologues of HSP90AA1 Reactome DB_ID: 10274463 HSP90AA1 HSP90AA1 A0A287AQK7 Reactome DB_ID: 10274457 UniProt:A0A287AQK7 HSP90AA1 UniProt A0A287AQK7 2 EQUAL 732 EQUAL Reactome Database ID Release 83 10274457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10274457 Reactome R-SSC-192864 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-192864.1 O02705 HSP90AA1 Reactome DB_ID: 10274461 UniProt:O02705 UniProt O02705 2 EQUAL 732 EQUAL Reactome Database ID Release 83 10274461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10274461 Reactome R-SSC-192864-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-192864-2.1 Reactome Database ID Release 83 10274463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10274463 Reactome R-SSC-192864-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-192864-3.1 2 Reactome Database ID Release 83 10304476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10304476 Reactome R-SSC-1221657 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1221657.1 HSP90-beta dimer Reactome DB_ID: 10316040 HSP90AB1 HSP90AB1 A0A286ZKC5 Reactome DB_ID: 10284512 UniProt:A0A286ZKC5 HSP90AB1 UniProt A0A286ZKC5 2 EQUAL 724 EQUAL Reactome Database ID Release 83 10284512 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10284512 Reactome R-SSC-419617 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-419617.1 2 Reactome Database ID Release 83 10316040 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10316040 Reactome R-SSC-3371509 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3371509.1 Reactome Database ID Release 83 10316042 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10316042 Reactome R-SSC-3371429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-3371429.1 CDKN1A CDKN1A F1RVT3 Reactome DB_ID: 10270776 UniProt:F1RVT3 CDKN1A UniProt F1RVT3 2 EQUAL 164 EQUAL Reactome Database ID Release 83 10270776 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10270776 Reactome R-SSC-182512 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-182512.1 FKBPL FKBPL A5A8W3 Reactome DB_ID: 10340789 UniProt:A5A8W3 FKBPL UniProt A5A8W3 1 EQUAL 349 EQUAL Reactome Database ID Release 83 10340789 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340789 Reactome R-SSC-8852374 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852374.1 GTSE1:CDKN1A:FKBPL:HSP90 Reactome DB_ID: 10340791 1 1 1 1 Reactome Database ID Release 83 10340791 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340791 Reactome R-SSC-8852380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852380.1 Reactome Database ID Release 83 10340793 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10340793 Reactome R-SSC-8852362 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852362.1 GENE ONTOLOGY GO:0050821 Stabilization of the newly synthesized protein product of the CDKN1A (p21) gene, a CDK inhibitor and a TP53 (p53) transcriptional target, requires binding of CDKN1A to FKBPL (WISp39). FKBPL simultaneously interacts with CDKN1A and a chaperone protein HSP90, forming a ternary complex (Jascur et al. 2005). GTSE1 was identified as another component of the complex of CDKN1A, FKBPL and HSP90. GTSE1 directly interacts with CDKN1A and FKBPL and contributes to CDKN1A stabilization (Bublik et al. 2010). Increased CDKN1A levels delay G2/M onset and rescue cells from G2 checkpoint-induced apoptosis, thus causing resistance to taxol induced cytotoxicity (Yu et al. 1998, Bublik et al. 2010). 9844631 Pubmed 1998 Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase Yu, D Jing, T Liu, B Yao, J Tan, M McDonnell, T J Hung, M C Mol. Cell 2:581-91 15664193 Pubmed 2005 Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein Jascur, Thomas Brickner, Howard Salles-Passador, Isabelle Barbier, Valerie El Khissiin, Abdelhamid Smith, Brian Fotedar, Rati Fotedar, Arun Mol. Cell 17:237-49 20018861 Pubmed 2010 Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment Bublik, Debora Rosa Scolz, Massimiliano Triolo, Gianluca Monte, Martin Schneider, C J. Biol. Chem. 285:5274-81 Reactome Database ID Release 83 10359526 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10359526 Reactome R-SSC-8852276 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-8852276.1 GENE ONTOLOGY GO:1902749 GTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggered expression under direct control of TP53 (p53) (Utrera et al. 1998, Collavin et al. 2000). Human GTSE1, similar to the mouse counterpart, binds to microtubules, shows cell cycle regulated expression with a peak in G2 and plays a role in G2 checkpoint recovery after DNA damage but is not transcriptionally regulated by TP53 (Monte et al. 2003, Monte et al. 2004, Scolz et al. 2012).<p>In G1 cells, GTSE1 is found at the microtubule lattice, likely due to direct binding to tubulin. An evolutionarily conserved interaction between GTSE1 and MAPRE1 (EB1), a microtubule plus end protein, promotes GTSE1 localization to the growing tip of the microtubules, which contributes to cell migration and is likely involved in cancer cell invasiveness. Highly invasive breast cancer cell lines exhibit high GTSE1 levels in G1, while GTSE1 levels in G1 are normally low. At the beginning of mitotic prometaphase, GTSE1 is phosphorylated by mitotic kinase(s), possibly CDK1, in proximity to the MAPRE1-binding region, causing GTSE1 dissociation from the plus end microtubule ends (Scolz et al. 2012).<p>During G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest), GTSE1 relocates to the nucleus where it binds TP53 and, in an MDM2-dependent manner, promotes TP53 cytoplasmic translocation and proteasome mediated degradation (Monte et al. 2003, Monte et al. 2004). Relocation of GTSE1 to the nucleus in G2 phase depends on PLK1-mediated phosphorylation of GTSE1 (Liu et al. 2010).<p>GTSE1-facilitated down-regulation of TP53 in G2 allows cells to avoid TP53 mediated apoptosis upon DNA damage and to re-enter cell cycle (Monte et al. 2003). While TP53 down-regulation mediated by GTSE1 in G2 correlates with decreased expression of TP53 target genes involved in apoptosis and cell cycle arrest, GTSE1 can also increase the half-life of the TP53 target p21 (CDKN1A). GTSE1-mediated stabilization of CDKN1A involves interaction of GTSE1 with CDKN1A and its chaperone complex, consisting of HSP90 and FKBPL (WISp39), and may be involved in resistance to paclitaxel treatment (Bublik et al. 2010). 9724637 Pubmed 1998 A novel p53-inducible gene coding for a microtubule-localized protein with G2-phase-specific expression Utrera, R Collavin, L Lazarević, D Delia, D Schneider, C EMBO J. 17:5015-25 10984615 Pubmed 2000 Cell-cycle regulation of the p53-inducible gene B99 Collavin, L Monte, M Verardo, R Pfleger, C Schneider, C FEBS Lett. 481:57-62