BioPAX pathway converted from "NSL acetylates histone H4" in the Reactome database.LEFT-TO-RIGHT2.3.1.48NSL acetylates histone H4This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Q28DR4HIST1H4Reactome DB_ID: 10310759nucleoplasmGENE ONTOLOGYGO:0005654UniProt:Q28DR4Xenopus tropicalisNCBI Taxonomy8364UniProtQ28DR42EQUAL103EQUALReactome Database ID Release 7510310759Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10310759ReactomeR-XTR-1819021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-181902.1Reactomehttp://www.reactome.org3Ac-CoAAcetyl coenzyme Aacetyl-CoAReactome DB_ID: 113560acetyl-CoA [ChEBI:15351]acetyl-CoAChEBICHEBI:15351Reactome Database ID Release 75113560Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113560ReactomeR-ALL-1135603Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113560.3COMPOUNDC00024additional informationMIMI:0361Converted from EntitySet in ReactomeAcK-HIST1H4Reactome DB_ID: 10370402Q28DR4AcK6-HIST1H4Reactome DB_ID: 103703946EQUALN6-acetyl-L-lysineMODMOD:000642EQUAL103EQUALReactome Database ID Release 7510370394Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370394ReactomeR-XTR-45687481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4568748.1Q28DR4AcK9-HIST1H4Reactome DB_ID: 103703979EQUAL2EQUAL103EQUALReactome Database ID Release 7510370397Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370397ReactomeR-XTR-45687581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4568758.1Q28DR4AcK17-HIST1H4Reactome DB_ID: 1037040017EQUAL2EQUAL103EQUALReactome Database ID Release 7510370400Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370400ReactomeR-XTR-4274691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-427469.1Reactome Database ID Release 7510370402Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370402ReactomeR-XTR-45513051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4551305.1CoACoA-SHcoenzyme AReactome DB_ID: 2485002coenzyme A [ChEBI:15346]coenzyme AChEBICHEBI:15346Reactome Database ID Release 752485002Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2485002ReactomeR-ALL-24850023Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2485002.3COMPOUNDC00010ACTIVATIONNSLReactome DB_ID: 10370432MCRS1F7E7V4Reactome DB_ID: 10370414UniProt:F7E7V4UniProtF7E7V41EQUAL462EQUALReactome Database ID Release 7510370414Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370414ReactomeR-XTR-33218491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321849.11KANSL2F7AKG4Reactome DB_ID: 10370418UniProt:F7AKG4UniProtF7AKG41EQUAL492EQUALReactome Database ID Release 7510370418Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370418ReactomeR-XTR-33217961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321796.11OGTacsbg1F6V5G4Reactome DB_ID: 10370426UniProt:F6V5G4acsbg1UniProtF6V5G42EQUAL1046EQUALReactome Database ID Release 7510370426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370426ReactomeR-XTR-33218451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321845.11phf20PHF20F6XQE6Reactome DB_ID: 10369557UniProt:F6XQE6phf20UniProtF6XQE61EQUAL1012EQUALReactome Database ID Release 7510369557Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10369557ReactomeR-XTR-32222391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3222239.11KANSL1F6X6I2Reactome DB_ID: 10370430UniProt:F6X6I2UniProtF6X6I21EQUAL1105EQUALReactome Database ID Release 7510370430Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370430ReactomeR-XTR-33218751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321875.11KAT8F6SWT5Reactome DB_ID: 10370406UniProt:F6SWT5UniProtF6SWT51EQUAL458EQUALReactome Database ID Release 7510370406Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370406ReactomeR-XTR-33218021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321802.11HCFC1znf518aF6S084Reactome DB_ID: 10357041UniProt:F6S084znf518aUniProtF6S0842EQUAL2035EQUALReactome Database ID Release 7510357041Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10357041ReactomeR-XTR-15922091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1592209.11kansl3KANSL3F7B7C8Reactome DB_ID: 10370422UniProt:F7B7C8kansl3UniProtF7B7C81EQUAL904EQUALReactome Database ID Release 7510370422Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370422ReactomeR-XTR-33218821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321882.11wdr5WDR5Q5M786Reactome DB_ID: 10370410UniProt:Q5M786wdr5UniProtQ5M7862EQUAL334EQUALReactome Database ID Release 7510370410Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370410ReactomeR-XTR-16298381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1629838.11Reactome Database ID Release 7510370432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370432ReactomeR-XTR-33218551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321855.1GENE ONTOLOGYGO:0004402gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510370433Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370433Reactome Database ID Release 7510370435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370435ReactomeR-XTR-33218051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3321805.1KAT8 (MOF, MYST1) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). KAT8 is the catalytic component of the nine-subunit non-specific lethal (NSL) complex (Mendjan et al. 2006, Cai et al. 2010).<br><br>NSL acetylates histone H4 on lysines 17 (H4K16), 6 (H4K5) and 9 (H4K8) (Cai et al. 2010).<br><br>KAT8 is also the catalytic subunit of the male-specific lethal (MSL) complex, which acetylates almost exclusively H4K16 and is responsible for a large fraction of H4K16 acetylation in human cells (Smith et al. 2005).<br><br>N.B. Coordinates of post-translational modifications described here follow UniProt standard practice whereby coordinates refer to the translated protein before any further processing. Histone literature typically refers to coordinates of the protein after the initiating methionine has been removed. Therefore the coordinates of post-translated residues in the Reactome database and described here are frequently +1 when compared with the literature. 16543150Pubmed2006Nuclear pore components are involved in the transcriptional regulation of dosage compensation in DrosophilaMendjan, SaschaTaipale, MikkoKind, JopHolz, HerbertGebhardt, PhilippSchelder, MalgorzataVermeulen, MichielBuscaino, AlessiaDuncan, KentMueller, JuergWilm, MatthiasStunnenberg, Henk GSaumweber, HaraldAkhtar, AsifaMol. Cell 21:811-2320018852Pubmed2010Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complexCai, YongJin, JingjiSwanson, Selene KCole, Michael DChoi, Seung HyukFlorens, Laurence AWashburn, Michael PConaway, Joan WConaway, Ronald CJ. Biol. Chem. 285:4268-7216227571Pubmed2005A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16Smith, Edwin RCayrou, ChristelleHuang, RongLane, William SCôté, JacquesLucchesi, John CMol. Cell. Biol. 25:9175-88inferred from electronic annotationEVIDENCE CODEECO:0000203