BioPAX pathway converted from "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus" in the Reactome database.LEFT-TO-RIGHT3.1.3.66PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleusThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 113518nucleoplasmGENE ONTOLOGYGO:0005654water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 75113518Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113518ReactomeR-ALL-1135183Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113518.3Reactomehttp://www.reactome.orgCOMPOUNDC00001additional informationMIMI:0361PI(4,5)P21-phosphatidyl-1D-myo-inositol 4,5-bisphosphateReactome DB_ID: 68104121-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePIP2ChEBICHEBI:18348Reactome Database ID Release 756810412Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6810412ReactomeR-ALL-68104123Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6810412.3PI5P1-phosphatidyl-1D-myo-inositol 5-phosphateReactome DB_ID: 68104081-phosphatidyl-1D-myo-inositol 5-phosphate [ChEBI:16500]1-phosphatidyl-1D-myo-inositol 5-phosphatePI5PChEBICHEBI:16500Reactome Database ID Release 756810408Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6810408ReactomeR-ALL-68104083Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6810408.3PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 113550hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 75113550Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113550ReactomeR-ALL-1135504Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113550.4COMPOUNDC00009ACTIVATIONfoxp4TMEM55BF7E9Y6Reactome DB_ID: 10395043UniProt:F7E9Y6foxp4Xenopus tropicalisNCBI Taxonomy8364UniProtF7E9Y61EQUAL277EQUALReactome Database ID Release 7510395043Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10395043ReactomeR-XTR-68104051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6810405.1GENE ONTOLOGYGO:0034597gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510395046Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10395046Reactome Database ID Release 7510395048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10395048ReactomeR-XTR-68104101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6810410.1Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010). 19846310Pubmed2010Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrumBarlow, Christy ALaishram, Rakesh SAnderson, Richard ATrends Cell Biol. 20:25-359843587Pubmed1998Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factorsBoronenkov, I VLoijens, J CUmeda, MAnderson, R AMol. Biol. Cell 9:3547-6017940011Pubmed2007Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosisZou, JMarjanovic, JasnaKisseleva, Marina VWilson, MonitaMajerus, PWProc. Natl. Acad. Sci. U.S.A. 104:16834-9inferred from electronic annotationEVIDENCE CODEECO:0000203