BioPAX pathway converted from "GLI translocates to the nucleus" in the Reactome database. LEFT-TO-RIGHT GLI translocates to the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome p-GLI1,2,3 Reactome DB_ID: 10399036 A0A6I8RCT3 phospho-p-GLI2 Reactome DB_ID: 10399030 ciliary tip GENE ONTOLOGY GO:0097542 UniProt:A0A6I8RCT3 Xenopus tropicalis NCBI Taxonomy 8364 UniProt A0A6I8RCT3 phosphorylated residue MOD MOD:00696 1 EQUAL 1586 EQUAL Reactome Database ID Release 78 10399030 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399030 Reactome R-XTR-5635044 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635044.1 Reactome http://www.reactome.org p-GLI1 phospho-gli1 A0A6I8QGB6 Reactome DB_ID: 10399032 UniProt:A0A6I8QGB6 gli1 UniProt A0A6I8QGB6 1 EQUAL 1106 EQUAL Reactome Database ID Release 78 10399032 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399032 Reactome R-XTR-5635040 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635040.1 p-GLI3 phospho-gli3 F6XFR9 Reactome DB_ID: 10399034 UniProt:F6XFR9 gli3 UniProt F6XFR9 1 EQUAL 1580 EQUAL Reactome Database ID Release 78 10399034 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399034 Reactome R-XTR-5635048 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635048.1 Reactome Database ID Release 78 10399036 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399036 Reactome R-XTR-5635089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635089.1 Converted from EntitySet in Reactome p-GLI1,2,3 Reactome DB_ID: 10399020 p-GLI1 phospho-gli1 A0A6I8QGB6 Reactome DB_ID: 10399012 nucleoplasm GENE ONTOLOGY GO:0005654 1 EQUAL 1106 EQUAL Reactome Database ID Release 78 10399012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399012 Reactome R-XTR-5635042 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635042.1 A0A6I8RCT3 phospho-p-GLI2 Reactome DB_ID: 10399015 1 EQUAL 1586 EQUAL Reactome Database ID Release 78 10399015 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399015 Reactome R-XTR-5635047 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635047.1 p-GLI3 phospho-gli3 F6XFR9 Reactome DB_ID: 10399018 1 EQUAL 1580 EQUAL Reactome Database ID Release 78 10399018 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399018 Reactome R-XTR-5635051 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635051.1 Reactome Database ID Release 78 10399020 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399020 Reactome R-XTR-5635090 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635090.1 Reactome Database ID Release 78 10399041 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399041 Reactome R-XTR-5635843 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5635843.1 Activation of SMO downstream of Hh ligand binding results in the dissociation of the SUFU:GLI complex and the translocation of the full-length GLI proteins to the nucleus where it is converted to a short-lived transcriptionally active form (Pan et al, 2006; Kim et al, 2009; Wen et al, 2010; Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Briscoe and Therond, 2013). 16611981 Pubmed 2006 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Yong Bai, Chunyang Brian Joyner, Alexandra L Wang, Baolin Mol. Cell. Biol. 26:3365-77 20956384 Pubmed 2010 A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Tukachinsky, Hanna Lopez, Lyle V Salic, Adrian J. Cell Biol. 191:415-28 20360384 Pubmed 2010 The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Humke, Eric W Dorn, Karolin V Milenkovic, Ljiljana Scott, Matthew P Rohatgi, Rajat Genes Dev. 24:670-82 19996169 Pubmed 2009 Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus Kim, Jynho Kato, Masaki Beachy, Philip A Proc. Natl. Acad. Sci. U.S.A. 106:21666-71 20154143 Pubmed 2010 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Wen, Xiaohui Lai, Cary K Evangelista, Marie Hongo, Jo-Anne de Sauvage, Frederic J Scales, Suzie J Mol. Cell. Biol. 30:1910-22 23719536 Pubmed 2013 The mechanisms of Hedgehog signalling and its roles in development and disease Briscoe, James Thérond, Pascal P Nat. Rev. Mol. Cell Biol. 14:416-29 inferred from electronic annotation EVIDENCE CODE ECO:0000203