BioPAX pathway converted from "PTK6 phosphorylates STAP2" in the Reactome database. LEFT-TO-RIGHT 2.7.10.2 BRK phosphorylates STAP2 PTK6 phosphorylates STAP2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-Y342-PTK6:STAP2 Reactome DB_ID: 10404998 cytosol GENE ONTOLOGY GO:0005829 Converted from EntitySet in Reactome Homologues of p-Y342-PTK6 Reactome DB_ID: 10404989 F1Q7D7 phospho-ptk6a p-Y342-PTK6 Reactome DB_ID: 10404984 UniProt:F1Q7D7 ptk6a Danio rerio NCBI Taxonomy 7955 UniProt F1Q7D7 342 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 1 EQUAL 451 EQUAL Reactome Database ID Release 81 10404984 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404984 Reactome R-DRE-8848007 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848007.1 Reactome http://www.reactome.org Q08BY6 phospho-ptk6b p-Y342-PTK6 Reactome DB_ID: 10404987 UniProt:Q08BY6 ptk6b UniProt Q08BY6 342 EQUAL 1 EQUAL 451 EQUAL Reactome Database ID Release 81 10404987 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404987 Reactome R-DRE-8848007-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848007-2.1 Reactome Database ID Release 81 10404989 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404989 Reactome R-DRE-8848007-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848007-3.1 1 STAP2 stap2a Q7T2F4 Reactome DB_ID: 10404996 UniProt:Q7T2F4 stap2a UniProt Q7T2F4 1 EQUAL 403 EQUAL Reactome Database ID Release 81 10404996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404996 Reactome R-DRE-8848028 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848028.1 1 Reactome Database ID Release 81 10404998 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404998 Reactome R-DRE-8848029 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848029.1 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 81 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 additional information MI MI:0361 p-Y342-PTK6:p-Y250-STAP2 Reactome DB_ID: 10405010 Q7T2F4 phospho-stap2a p-Y250-STAP2 Reactome DB_ID: 10405008 plasma membrane GENE ONTOLOGY GO:0005886 250 EQUAL 1 EQUAL 403 EQUAL Reactome Database ID Release 81 10405008 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405008 Reactome R-DRE-8848079 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848079.1 1 1 Reactome Database ID Release 81 10405010 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405010 Reactome R-DRE-8848073 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848073.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 81 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 ACTIVATION activeUnit: #Protein1 GENE ONTOLOGY GO:0004713 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 81 10405011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405011 Reactome Database ID Release 81 10405013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405013 Reactome R-DRE-8848077 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8848077.1 Activated PTK6 (BRK) phosphorylates STAP2 at tyrosine residue Y250 (Ikeda et al. 2009). 19393627 Pubmed 2009 STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation Ikeda, Osamu Miyasaka, Yuto Sekine, Yuichi Mizushima, Akihiro Muromoto, Ryuta Nanbo, Asuka Yoshimura, A Matsuda, Tadashi Biochem. Biophys. Res. Commun. 384:71-5 inferred from electronic annotation EVIDENCE CODE ECO:0000203