BioPAX pathway converted from "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" in the Reactome database. LEFT-TO-RIGHT 2.7.11.1 Phosphorylation of MOB1A and B by p-STK3 (p-MST2) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 cytosol GENE ONTOLOGY GO:0005829 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 Reactome http://www.reactome.org COMPOUND C00002 additional information MI MI:0361 2 Converted from EntitySet in Reactome MOB1 Reactome DB_ID: 10409993 MOB1A A0A2R8Q1Z8 Reactome DB_ID: 10409989 UniProt:A0A2R8Q1Z8 Danio rerio NCBI Taxonomy 7955 UniProt A0A2R8Q1Z8 2 EQUAL 216 EQUAL Reactome Database ID Release 82 10409989 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409989 Reactome R-DRE-2028568 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028568.1 MOB1B zgc:77872 Q7ZV94 Reactome DB_ID: 10409991 UniProt:Q7ZV94 zgc:77872 UniProt Q7ZV94 2 EQUAL 216 EQUAL Reactome Database ID Release 82 10409991 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409991 Reactome R-DRE-2028569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028569.1 Reactome Database ID Release 82 10409993 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409993 Reactome R-DRE-2028544 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028544.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 2 Converted from EntitySet in Reactome p-MOB1 Reactome DB_ID: 10409905 A0A2R8Q1Z8 phospho-p-T12,T35-MOB1A Reactome DB_ID: 10409897 12 EQUAL O-phospho-L-threonine MOD MOD:00047 35 EQUAL 2 EQUAL 216 EQUAL Reactome Database ID Release 82 10409897 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409897 Reactome R-DRE-2028628 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028628.1 Q7ZV94 phospho-zgc:77872 p-T12,T35-MOB1B Reactome DB_ID: 10409903 12 EQUAL 35 EQUAL 2 EQUAL 216 EQUAL Reactome Database ID Release 82 10409903 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409903 Reactome R-DRE-2028643 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028643.1 Reactome Database ID Release 82 10409905 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409905 Reactome R-DRE-2028620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028620.1 ACTIVATION activeUnit: #Protein7 p-STK3:p-SAV1 Reactome DB_ID: 10409958 p-STK3 dimer Reactome DB_ID: 10409956 Q7ZUQ3 phospho-p-T180-STK3(1-491) Reactome DB_ID: 10409954 UniProt:Q7ZUQ3 UniProt Q7ZUQ3 180 EQUAL 1 EQUAL 491 EQUAL Reactome Database ID Release 82 10409954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409954 Reactome R-DRE-2028274 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028274.1 2 Reactome Database ID Release 82 10409956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409956 Reactome R-DRE-2028277 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028277.1 1 p-SAV1 dimer Reactome DB_ID: 10409949 Q66HX5 phospho-p-SAV1 Reactome DB_ID: 10409947 UniProt:Q66HX5 UniProt Q66HX5 phosphorylated residue MOD MOD:00696 1 EQUAL 383 EQUAL Reactome Database ID Release 82 10409947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409947 Reactome R-DRE-2028276 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028276.1 2 Reactome Database ID Release 82 10409949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409949 Reactome R-DRE-2028281 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028281.1 1 Reactome Database ID Release 82 10409958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409958 Reactome R-DRE-2028261 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028261.1 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10409959 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409959 Reactome Database ID Release 82 10409995 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409995 Reactome R-DRE-2028635 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028635.1 Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK3 (p-MST2). Phosphorylated (active) STK3 (p-MST2) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets (Praskova et al. 2008). 18328708 Pubmed 2008 MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation Praskova, M Xia, F Avruch, Joseph Curr Biol 18:311-21 inferred from electronic annotation EVIDENCE CODE ECO:0000203