BioPAX pathway converted from "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1" in the Reactome database. LEFT-TO-RIGHT YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> YWHAB dimer Reactome DB_ID: 10359098 cytosol GENE ONTOLOGY GO:0005829 YWHAB ywhabb Q7T356 Reactome DB_ID: 10359096 UniProt:Q7T356 ywhabb Danio rerio NCBI Taxonomy 7955 UniProt Q7T356 1 EQUAL 246 EQUAL Reactome Database ID Release 82 10359096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10359096 Reactome R-DRE-48888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-48888.1 Reactome http://www.reactome.org 2 Reactome Database ID Release 82 10359098 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10359098 Reactome R-DRE-2028645 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028645.1 Q1L8J7 phospho-yap1 p-S127-YAP1 Reactome DB_ID: 10409922 UniProt:Q1L8J7 yap1 UniProt Q1L8J7 127 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 504 EQUAL Reactome Database ID Release 82 10409922 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409922 Reactome R-DRE-2028553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028553.1 p-YAP1:YWHAB Reactome DB_ID: 10409997 1 1 Reactome Database ID Release 82 10409997 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409997 Reactome R-DRE-2028630 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028630.1 Reactome Database ID Release 82 10409999 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409999 Reactome R-DRE-2028644 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028644.1 YWHAB (14-3-3 beta/alpha) binds phosphorylated YAP1 proteins, sequestering them in the cytosol. Structural studies indicate that the active form of YWHAB (14-3-3 beta/alpha) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with YAP1 is unknown and has been annotated arbitrarily here to involve one YAP1 molecule and a YWHAB (14-3-3 beta/alpha) dimer. While YAP1 can be phosphorylated on several serine residues, phosphorylation of serine-127 appears to be critical for YWHAB(14-3-3 beta/alpha) binding (Zhao et al. 2007). 17974916 Pubmed 2007 Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Zhao, B Wei, X Li, W Udan, RS Yang, Q Kim, J Xie, J Ikenoue, T Yu, J Li, L Zheng, P Ye, K Chinnaiyan, A Halder, G Lai, ZC Guan, KL Genes Dev 21:2747-61 17085597 Pubmed 2006 Structural basis for protein-protein interactions in the 14-3-3 protein family Yang, X Lee, WH Sobott, F Papagrigoriou, E Robinson, CV Grossmann, JG Sundström, M Doyle, DA Elkins, JM Proc Natl Acad Sci U S A 103:17237-42 inferred from electronic annotation EVIDENCE CODE ECO:0000203