BioPAX pathway converted from "Translocation of YAP1 to the nucleus" in the Reactome database. LEFT-TO-RIGHT Translocation of YAP1 to the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> yap1 YAP1 Q1L8J7 Reactome DB_ID: 10399972 cytosol GENE ONTOLOGY GO:0005829 UniProt:Q1L8J7 yap1 Danio rerio NCBI Taxonomy 7955 UniProt Q1L8J7 1 EQUAL 504 EQUAL Reactome Database ID Release 82 10399972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399972 Reactome R-DRE-1253345 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1253345.1 Reactome http://www.reactome.org yap1 YAP1 Q1L8J7 Reactome DB_ID: 10399976 nucleoplasm GENE ONTOLOGY GO:0005654 1 EQUAL 504 EQUAL Reactome Database ID Release 82 10399976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10399976 Reactome R-DRE-1253322 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1253322.1 Reactome Database ID Release 82 10410266 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410266 Reactome R-DRE-2032770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2032770.1 In its unphosphorylated state, the YAP1 transcriptional coactivator moves freely into the nucleus. Phosphorylated YAP1, in contrast, is sequestered in the cytosol (Hao et al. 2008). 18158288 Pubmed 2008 Tumor suppressor LATS1 is a negative regulator of oncogene YAP Hao, Y Chun, A Cheung, K Rashidi, B Yang, X J Biol Chem 283:5496-509 inferred from electronic annotation EVIDENCE CODE ECO:0000203