BioPAX pathway converted from "DVL2 binds phosphorylated WWTR1 (TAZ)" in the Reactome database. LEFT-TO-RIGHT DVL2 binds phosphorylated WWTR1 (TAZ) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Q307I6 phospho-p-S89-WWTR1 Reactome DB_ID: 10410004 cytosol GENE ONTOLOGY GO:0005829 UniProt:Q307I6 Danio rerio NCBI Taxonomy 7955 UniProt Q307I6 89 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 400 EQUAL Reactome Database ID Release 82 10410004 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410004 Reactome R-DRE-2028665 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028665.1 Reactome http://www.reactome.org DVL2 F1QM97 Reactome DB_ID: 10373294 UniProt:F1QM97 UniProt F1QM97 1 EQUAL 736 EQUAL Reactome Database ID Release 82 10373294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10373294 Reactome R-DRE-201694 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-201694.1 p-WWTR1:DVL2 Reactome DB_ID: 10410602 1 1 Reactome Database ID Release 82 10410602 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410602 Reactome R-DRE-2066300 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2066300.1 Reactome Database ID Release 82 10410604 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410604 Reactome R-DRE-2066299 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2066299.1 Phosphorylated WWTR1 (TAZ) and DVL interact to form a complex in the cytosol. Thus sequestered, DVL2 is unable to undergo phosphorylation by casein kinase, inhibiting its role in WNT signaling. WWTR1 - DLV interaction thus appears to link the Hippo and WNT signaling processes (Varelas et al. 2010). The stoichiometry of the WWTR1:DVL complex is unknown. 20412773 Pubmed 2010 The Hippo pathway regulates Wnt/beta-catenin signaling Varelas, X Miller, BW Sopko, R Song, S Gregorieff, A Fellouse, FA Sakuma, R Pawson, T Hunziker, W McNeill, H Wrana, JL Attisano, L Dev Cell 18:579-91 inferred from electronic annotation EVIDENCE CODE ECO:0000203