BioPAX pathway converted from "Orc1 is phosphorylated by cyclin A/CDK2" in the Reactome database.LEFT-TO-RIGHT2.7.11.22Orc1 is phosphorylated by cyclin A/CDK2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 29358nucleoplasmGENE ONTOLOGYGO:0005654ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 7529358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358ReactomeR-ALL-293583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3Reactomehttp://www.reactome.orgCOMPOUNDC00002additional informationMIMI:0361pre-replicative complexReactome DB_ID: 10413298MCM2-7Reactome DB_ID: 10413296MCM2MCM2F1NB20Reactome DB_ID: 10413294UniProt:F1NB20MCM2Gallus gallusNCBI Taxonomy9031UniProtF1NB202EQUAL904EQUALReactome Database ID Release 7510413294Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413294ReactomeR-GGA-685571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68557.11MCM3F1NFJ0Reactome DB_ID: 10413276UniProt:F1NFJ0UniProtF1NFJ02EQUAL808EQUALReactome Database ID Release 7510413276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413276ReactomeR-GGA-685461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68546.11MCM4MCM4E1C2U4Reactome DB_ID: 10413280UniProt:E1C2U4MCM4UniProtE1C2U42EQUAL863EQUALReactome Database ID Release 7510413280Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413280ReactomeR-GGA-685491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68549.11Ghost homologue of MCM7Reactome DB_ID: 10413290Reactome Database ID Release 7510413290Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413290ReactomeR-GGA-685551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68555.11MCM5MCM5Q5ZKL0Reactome DB_ID: 10413284UniProt:Q5ZKL0MCM5UniProtQ5ZKL01EQUAL734EQUALReactome Database ID Release 7510413284Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413284ReactomeR-GGA-685511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68551.11MCM6MCM6Q5ZKR8Reactome DB_ID: 10413288UniProt:Q5ZKR8MCM6UniProtQ5ZKR81EQUAL821EQUALReactome Database ID Release 7510413288Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413288ReactomeR-GGA-685531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68553.11Reactome Database ID Release 7510413296Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413296ReactomeR-GGA-685581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68558.11CDT1:CDC6:ORC:origin complexReactome DB_ID: 10413270CDT1CDT1E1BS75Reactome DB_ID: 10413268UniProt:E1BS75CDT1UniProtE1BS751EQUAL546EQUALReactome Database ID Release 7510413268Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413268ReactomeR-GGA-685361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68536.11CDC6:ORC:origin complexReactome DB_ID: 10413226CDC6A0A3Q2TYA4Reactome DB_ID: 10413209UniProt:A0A3Q2TYA4UniProtA0A3Q2TYA41EQUAL560EQUALReactome Database ID Release 7510413209Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413209ReactomeR-GGA-685421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68542.11ORC:origin of replicationReactome DB_ID: 10413224ORC4ORC4E1C8I5Reactome DB_ID: 10413185UniProt:E1C8I5ORC4UniProtE1C8I51EQUAL436EQUALReactome Database ID Release 7510413185Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413185ReactomeR-GGA-685191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68519.11ORC3ORC3F1P1T5Reactome DB_ID: 10413163UniProt:F1P1T5ORC3UniProtF1P1T51EQUAL711EQUALReactome Database ID Release 7510413163Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413163ReactomeR-GGA-685131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68513.11ORC1F7BXW0Reactome DB_ID: 10413193UniProt:F7BXW0UniProtF7BXW01EQUAL861EQUALReactome Database ID Release 7510413193Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413193ReactomeR-GGA-685221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68522.11ORC5ORC5A0A3Q3B266Reactome DB_ID: 10413177UniProt:A0A3Q3B266ORC5UniProtA0A3Q3B2661EQUAL435EQUALReactome Database ID Release 7510413177Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413177ReactomeR-GGA-685161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68516.11ARSorigin of replicationoriginautonomously replicating sequenceReactome DB_ID: 68419Reactome Database ID Release 7568419Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68419ReactomeR-ALL-684192Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-68419.2ChEBI611201Orc2 associated with MCM8Reactome DB_ID: 10413222ORC2ORC2F1NDM4Reactome DB_ID: 10413167UniProt:F1NDM4ORC2UniProtF1NDM41EQUAL577EQUALReactome Database ID Release 7510413167Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413167ReactomeR-GGA-684051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68405.11MCM8MCM8I0IUP3Reactome DB_ID: 10413220UniProt:I0IUP3MCM8UniProtI0IUP31EQUAL840EQUALReactome Database ID Release 7510413220Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413220ReactomeR-GGA-30066461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006646.11Reactome Database ID Release 7510413222Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413222ReactomeR-GGA-1769701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-176970.11ORC6ORC6A0A1D5P9Z8Reactome DB_ID: 10413201UniProt:A0A1D5P9Z8ORC6UniProtA0A1D5P9Z81EQUAL252EQUALReactome Database ID Release 7510413201Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413201ReactomeR-GGA-685391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68539.11Reactome Database ID Release 7510413224Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413224ReactomeR-GGA-685401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68540.11Reactome Database ID Release 7510413226Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413226ReactomeR-GGA-685431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68543.11Reactome Database ID Release 7510413270Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413270ReactomeR-GGA-685441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68544.11Reactome Database ID Release 7510413298Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413298ReactomeR-GGA-685591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68559.1F7BXW0phospho-p-S,T-ORC1Reactome DB_ID: 10413414O-phospho-L-serineMODMOD:00046O-phospho-L-threonineMODMOD:000471EQUAL861EQUALReactome Database ID Release 7510413414Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413414ReactomeR-GGA-689431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68943.1pre-replicative complex (Orc1-minus)Reactome DB_ID: 10413416111111111Reactome Database ID Release 7510413416Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413416ReactomeR-GGA-1575631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-157563.1ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 113582ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 75113582Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582ReactomeR-ALL-1135823Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3COMPOUNDC00008ACTIVATIONCCNA:p-T160-CDK2Reactome DB_ID: 10413431Converted from EntitySet in ReactomeCCNACyclin AReactome DB_ID: 10413426CCNA1F1P4N0Reactome DB_ID: 10413420UniProt:F1P4N0UniProtF1P4N01EQUAL465EQUALReactome Database ID Release 7510413420Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413420ReactomeR-GGA-688911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68891.1CCNA2CCNA2F1NJI2Reactome DB_ID: 10413424UniProt:F1NJI2CCNA2UniProtF1NJI21EQUAL432EQUALReactome Database ID Release 7510413424Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413424ReactomeR-GGA-689051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68905.1Reactome Database ID Release 7510413426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413426ReactomeR-GGA-752021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-75202.11A2IAR9phospho-CDK2p-T160-CDK2Reactome DB_ID: 10413429UniProt:A2IAR9CDK2UniProtA2IAR9160EQUAL1EQUAL298EQUALReactome Database ID Release 7510413429Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413429ReactomeR-GGA-1879671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-187967.11Reactome Database ID Release 7510413431Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413431ReactomeR-GGA-1879521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-187952.1GENE ONTOLOGYGO:0004693gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510413432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413432Reactome Database ID Release 7510413434Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10413434ReactomeR-GGA-689441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-68944.1At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'pre-replicative complex' are present. At the end of this reaction, 1 molecule of 'phosphorylated Orc1', 1 molecule of 'pre-replicative complex (Orc1-minus)', and 1 molecule of 'ADP' are present.<br><br> This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'Cyclin A:Cdk2 complex'.<br>11931757Pubmed2002Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.Mendez, JZou-Yang, XHKim, SYHidaka, MTansey, WPStillman, BMol Cell 9:481-91inferred from electronic annotationEVIDENCE CODEECO:0000203