BioPAX pathway converted from "CDO binds promyogenic cadherins" in the Reactome database.LEFT-TO-RIGHTCDO binds promyogenic cadherinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Trans-cadherin homodimersReactome DB_ID: 10431257plasma membraneGENE ONTOLOGYGO:0005886Cadherin:CateninReactome DB_ID: 10431255Converted from EntitySet in Reactomealpha/beta cateninReactome DB_ID: 10431243CTNNB1A0A1D5NYE8Reactome DB_ID: 10425937cytosolGENE ONTOLOGYGO:0005829UniProt:A0A1D5NYE8Gallus gallusNCBI Taxonomy9031UniProtA0A1D5NYE81EQUAL781EQUALReactome Database ID Release 7510425937Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10425937ReactomeR-GGA-4488391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448839.1Reactomehttp://www.reactome.orgCTNNA2F1P510Reactome DB_ID: 10431237UniProt:F1P510UniProtF1P5102EQUAL953EQUALReactome Database ID Release 7510431237Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431237ReactomeR-GGA-4487981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448798.1CTNNA1CTNNA1E1C7M7Reactome DB_ID: 10431241UniProt:E1C7M7CTNNA1UniProtE1C7M72EQUAL906EQUALReactome Database ID Release 7510431241Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431241ReactomeR-GGA-1916971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-191697.1Reactome Database ID Release 7510431243Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431243ReactomeR-GGA-4488561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448856.11Converted from EntitySet in ReactomePromyogenic cadherinsReactome DB_ID: 10431253CDH15CDH15A0A1D5P5J3Reactome DB_ID: 10431247UniProt:A0A1D5P5J3CDH15UniProtA0A1D5P5J361EQUAL814EQUALReactome Database ID Release 7510431247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431247ReactomeR-GGA-3750551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375055.1CDH2CDH2P10288Reactome DB_ID: 10431251UniProt:P10288CDH2UniProtP10288160EQUAL906EQUALReactome Database ID Release 7510431251Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431251ReactomeR-GGA-1914291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-191429.1Reactome Database ID Release 7510431253Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431253ReactomeR-GGA-3750811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375081.11Reactome Database ID Release 7510431255Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431255ReactomeR-GGA-4488761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448876.12Reactome Database ID Release 7510431257Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431257ReactomeR-GGA-4488881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448888.1CDO:BOCReactome DB_ID: 10431231CDONCDONA0A1D5NW33Reactome DB_ID: 10431229UniProt:A0A1D5NW33CDONUniProtA0A1D5NW3326EQUAL1287EQUALReactome Database ID Release 7510431229Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431229ReactomeR-GGA-1978921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-197892.11BOCBOC-1E1C5M1Reactome DB_ID: 10431225UniProt:E1C5M1BOCUniProtE1C5M131EQUAL1114EQUALReactome Database ID Release 7510431225Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431225ReactomeR-GGA-1977851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-197785.11Reactome Database ID Release 7510431231Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431231ReactomeR-GGA-3750941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375094.1CDO:BOC:Trans-cadherin homodimer:cateninReactome DB_ID: 1043125911Reactome Database ID Release 7510431259Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431259ReactomeR-GGA-3750921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375092.1Reactome Database ID Release 7510431261Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431261ReactomeR-GGA-3751401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375140.1In myoblasts, CDO forms cis complexes with the cell–cell adhesion molecule N-cadherin, which is itself involved in regulation of myogenesis. These cadherin complexes contain beta- and alpha-catenins which are important for N-cadherin's effect in myoblast. When CDO binds with ligated cadherins, its intracellular region undergoes a change in conformation and/or posttranslational modi?cation that permits its stable association with Bnip-2 and JLP and, consequently, activation of p38.12634428Pubmed2003Promyogenic members of the Ig and cadherin families associate to positively regulate differentiationKang, JSFeinleib, JLKnox, SKetteringham, MAKrauss, RobertProc Natl Acad Sci U S A 100:3989-9420160094Pubmed2010N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38{alpha}/{beta} MAPK signaling in skeletal myoblastsLu, MKrauss, RobertProc Natl Acad Sci U S A15520228Pubmed2004Netrins and neogenin promote myotube formationKang, JSYi, MJZhang, WFeinleib, JLCole, FKrauss, RobertJ Cell Biol 167:493-504inferred from electronic annotationEVIDENCE CODEECO:0000203