BioPAX pathway converted from "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol" in the Reactome database.LEFT-TO-RIGHTElectrogenic Na+/Pi cotransportSLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosolThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PiOrthophosphatehydrogenphosphateinorganic phosphatephosphateReactome DB_ID: 109277extracellular regionGENE ONTOLOGYGO:0005576hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 75109277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109277ReactomeR-ALL-1092774Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109277.4Reactomehttp://www.reactome.orgCOMPOUNDC00009additional informationMIMI:0361Na+sodium ionsodium(1+)SodiumReactome DB_ID: 74113sodium(1+) [ChEBI:29101]sodium(1+)ChEBICHEBI:29101Reactome Database ID Release 7574113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113ReactomeR-ALL-741133Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74113.3COMPOUNDC013303Na+sodium ionsodium(1+)SodiumReactome DB_ID: 83910cytosolGENE ONTOLOGYGO:0005829Reactome Database ID Release 7583910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910ReactomeR-ALL-839103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83910.3COMPOUNDC013303PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 29372Reactome Database ID Release 7529372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293724Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4COMPOUNDC00009ACTIVATIONConverted from EntitySet in ReactomeSLC34A1,2Electrogenic Na+/Pi cotransportersReactome DB_ID: 10435796SLC34A1A0A1D5NWQ4Reactome DB_ID: 10435790plasma membraneGENE ONTOLOGYGO:0005886UniProt:A0A1D5NWQ4Gallus gallusNCBI Taxonomy9031UniProtA0A1D5NWQ41EQUAL639EQUALReactome Database ID Release 7510435790Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435790ReactomeR-GGA-4275901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-427590.1SLC34A2A0A3S5ZPQ9Reactome DB_ID: 10435794UniProt:A0A3S5ZPQ9UniProtA0A3S5ZPQ91EQUAL690EQUALReactome Database ID Release 7510435794Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435794ReactomeR-GGA-4275861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-427586.1Reactome Database ID Release 7510435796Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435796ReactomeR-GGA-4276401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-427640.1GENE ONTOLOGYGO:0005436gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510435797Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435797Reactome Database ID Release 7510435799Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435799ReactomeR-GGA-4276561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-427656.1SLC34A1 encodes Na+/Pi cotransporter (NaPi-IIa) which is expressed in the kidney in the renal proximal tubule (Magagnin et al. 1993). SLC34A2 encodes NaPi-IIb which is abundantly expressed in lung and to a lesser degree in tissues of epithelial origin including small intestine, pancreas, prostate, and kidney (Field et al. 1999). In the lung, SLC34A2 is expressed only in alveolar type II cells, which are responsible for surfactant production, so it is proposed that it uptakes liberated phosphate from the alveolar fluid for surfactant production. Both NaPi-IIa and NaPi-IIb cotransport inorganic phosphate (Pi) with three Na+ ions (electrogenic transport) (Forster et al. 1999, 2002).<br><br>Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1) (Prie et al. 2002). Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis, a rare disease characterised by the deposition of calcium phosphate microliths throughout the lung (Corut et al. 2006).8327470Pubmed1993Expression cloning of human and rat renal cortex Na/Pi cotransportMagagnin, SWerner, AMarkovich, DSorribas, VStange, GBiber, JMurer, HProc Natl Acad Sci U S A 90:5979-8310198426Pubmed1999Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransportersForster, I CLoo, Donald D FEskandari, SAm. J. Physiol. 276:F644-916960801Pubmed2006Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasisCorut, ASenyigit, AUgur, SAAltin, SOzcelik, UCalisir, HYildirim, ZGocmen, ATolun, AAm J Hum Genet 79:650-612324554Pubmed2002Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporterPrie, DHuart, VBakouh, NPlanelles, GDellis, OGérard, BHulin, PBenqué-Blanchet, FSilve, CGrandchamp, BFriedlander, GN Engl J Med 347:983-9110329428Pubmed1999Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestineFeild, JAZhang, LeiBrun, KABrooks, DPEdwards, RMBiochem Biophys Res Commun 258:578-8212379267Pubmed2002Forging the link between structure and function of electrogenic cotransporters: the renal type IIa Na+/Pi cotransporter as a case studyForster, Ian CKöhler, KatjaBiber, JürgMurer, HeiniProg. Biophys. Mol. Biol. 80:69-108inferred from electronic annotationEVIDENCE CODEECO:0000203