BioPAX pathway converted from "BH2 binding can lead to eNOS uncoupling" in the Reactome database.LEFT-TO-RIGHTBH2 binding can lead to eNOS uncouplingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>BH2dihydrobiopterinD-erythro-7,8-dihydrobiopterin7,8-dihydrobiopterinReactome DB_ID: 1497857cytosolGENE ONTOLOGYGO:0005829D-erythro-7,8-dihydrobiopterin [ChEBI:15375]D-erythro-7,8-dihydrobiopterinChEBICHEBI:15375Reactome Database ID Release 751497857Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1497857ReactomeR-ALL-14978573Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1497857.3Reactomehttp://www.reactome.orgp-S1177-eNOS:CaM:HSP90:p-AKT1:BH4Reactome DB_ID: 10427730plasma membraneGENE ONTOLOGYGO:0005886BH4Tetrahydrobiopterin5,6,7,8-tetrahydrobiopterin2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinoneReactome DB_ID: 298705,6,7,8-tetrahydrobiopterin [ChEBI:15372]5,6,7,8-tetrahydrobiopterinChEBICHEBI:15372Reactome Database ID Release 7529870Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29870ReactomeR-ALL-298703Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29870.3COMPOUNDC00272additional informationMIMI:03611p-S1177-eNOS:CaM:HSP90:p-AKT1Reactome DB_ID: 10427726HSP90AA1HSP90AA1A0A1L1RND0Reactome DB_ID: 10427719UniProt:A0A1L1RND0HSP90AA1Gallus gallusNCBI Taxonomy9031UniProtA0A1L1RND02EQUAL732EQUALReactome Database ID Release 7510427719Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10427719ReactomeR-GGA-1928641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-192864.11A0A3Q2U4X3phospho-p-T308,S473-AKT1Reactome DB_ID: 10426175UniProt:A0A3Q2U4X3UniProtA0A3Q2U4X3308EQUALO-phospho-L-threonineMODMOD:00047473EQUALO-phospho-L-serineMODMOD:000461EQUAL480EQUALReactome Database ID Release 7510426175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10426175ReactomeR-GGA-1983561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-198356.11p-S1177-eNOS dimerReactome DB_ID: 104277242FADFlavin adenine dinucleotideReactome DB_ID: 29386FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBICHEBI:16238Reactome Database ID Release 7529386Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386ReactomeR-ALL-293862Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29386.2COMPOUNDC000162hemehemeferroheme bheme (ferrous)Reactome DB_ID: 71185ferroheme b [ChEBI:17627]ferroheme bChEBICHEBI:17627Reactome Database ID Release 7571185Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185ReactomeR-ALL-711853Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-71185.3COMPOUNDC000322Zn2+Zn++zinc(2+)Zinc ionZn(II)Reactome DB_ID: 29426zinc(2+) [ChEBI:29105]zinc(2+)ChEBICHEBI:29105Reactome Database ID Release 7529426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426ReactomeR-ALL-294263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29426.3COMPOUNDC000381FMNFlavin mononucleotideRiboflavin-5-phosphateReactome DB_ID: 73524FMN [ChEBI:17621]FMNRiboflavin-5-phosphateFlavin mononucleotideChEBICHEBI:17621Reactome Database ID Release 7573524Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524ReactomeR-ALL-735242Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-73524.2COMPOUNDC000612A0A3Q2UNW2phospho-LOC1070571702xPalmC-MyrG-p-S1177-NOS3Reactome DB_ID: 10427722UniProt:A0A3Q2UNW2LOC107057170UniProtA0A3Q2UNW21177EQUAL15EQUALS-palmitoyl-L-cysteineMODMOD:0011526EQUAL2EQUALN-myristoylglycineMODMOD:000682EQUAL1203EQUALReactome Database ID Release 7510427722Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10427722ReactomeR-GGA-2021391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-202139.12Reactome Database ID Release 7510427724Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10427724ReactomeR-GGA-2035641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-203564.11CALM1:4xCa2+Reactome DB_ID: 10419016Ca2+Calciumcalcium(2+)Reactome DB_ID: 74016calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 7574016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74016ReactomeR-ALL-740163Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74016.3COMPOUNDC000764CALM1F1P596Reactome DB_ID: 10419014UniProt:F1P596UniProtF1P5962EQUAL149EQUALReactome Database ID Release 7510419014Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10419014ReactomeR-GGA-90167071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9016707.11Reactome Database ID Release 7510419016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10419016ReactomeR-GGA-742941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-74294.11Reactome Database ID Release 7510427726Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10427726ReactomeR-GGA-2021211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-202121.11Reactome Database ID Release 7510427730Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10427730ReactomeR-GGA-14978301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1497830.1p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2Reactome DB_ID: 1044780311111Reactome Database ID Release 7510447803Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10447803ReactomeR-GGA-14978891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1497889.1Reactome Database ID Release 7510447805Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10447805ReactomeR-GGA-14977961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1497796.1The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).11879202Pubmed2002The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping studyVásquez-Vivar, JMartasek, PWhitsett, JJoseph, JacobKalyanaraman, BBiochem J 362:733-9inferred from electronic annotationEVIDENCE CODEECO:0000203