BioPAX pathway converted from "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane" in the Reactome database.LEFT-TO-RIGHT3.1.3.64PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PI3P1-phosphatidyl-1D-myo-inositol 3-phosphateReactome DB_ID: 1806276plasma membraneGENE ONTOLOGYGO:00058861-phosphatidyl-1D-myo-inositol 3-phosphate [ChEBI:17283]1-phosphatidyl-1D-myo-inositol 3-phosphatePtdIns3PPtdIns-3-P1,2-Diacyl-sn-glycero-3-phospho-(1&apos;-myo-inositol-3&apos;-phosphate)Phosphatidylinositol 3-phosphateChEBICHEBI:17283Reactome Database ID Release 751806276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806276ReactomeR-ALL-18062763Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806276.3Reactomehttp://www.reactome.orgH2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001additional informationMIMI:0361PIPhosphatidyl 1D-myo-inositol1-phosphatidyl-1D-myo-inositolReactome DB_ID: 4266581-phosphatidyl-1D-myo-inositol [ChEBI:16749]1-phosphatidyl-1D-myo-inositolChEBICHEBI:16749Reactome Database ID Release 75426658Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426658ReactomeR-ALL-4266583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-426658.3COMPOUNDC01194PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 29372hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 7529372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293724Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4COMPOUNDC00009ACTIVATIONConverted from EntitySet in ReactomeSYNJ/MTM(1)MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2Reactome DB_ID: 10449005MTM1MTM1E1BRL5Reactome DB_ID: 10448871UniProt:E1BRL5MTM1Gallus gallusNCBI Taxonomy9031UniProtE1BRL51EQUAL603EQUALReactome Database ID Release 7510448871Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448871ReactomeR-GGA-16046461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604646.1MTMR1A0A1D5P2Z0Reactome DB_ID: 10448991UniProt:A0A1D5P2Z0UniProtA0A1D5P2Z01EQUAL665EQUALReactome Database ID Release 7510448991Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448991ReactomeR-GGA-16046471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604647.1MTMR3MTMR3E1C2A9Reactome DB_ID: 10448995UniProt:E1C2A9MTMR3UniProtE1C2A91EQUAL1198EQUALReactome Database ID Release 7510448995Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448995ReactomeR-GGA-16046351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604635.1MTMR6MTMR6A0A1L1S0G8Reactome DB_ID: 10448999UniProt:A0A1L1S0G8MTMR6UniProtA0A1L1S0G81EQUAL621EQUALReactome Database ID Release 7510448999Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448999ReactomeR-GGA-16046661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604666.1MTMR14F1P4J6Reactome DB_ID: 10449003UniProt:F1P4J6UniProtF1P4J61EQUAL650EQUALReactome Database ID Release 7510449003Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449003ReactomeR-GGA-16046321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604632.1SYNJ1A0A1D5NT69Reactome DB_ID: 10448915UniProt:A0A1D5NT69UniProtA0A1D5NT691EQUAL1573EQUALReactome Database ID Release 7510448915Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448915ReactomeR-GGA-16046341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1604634.1SYNJ2E1BTW4Reactome DB_ID: 10448919UniProt:E1BTW4UniProtE1BTW41EQUAL1496EQUALReactome Database ID Release 7510448919Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10448919ReactomeR-GGA-18061931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1806193.1Reactome Database ID Release 7510449005Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449005ReactomeR-GGA-18062231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1806223.1GENE ONTOLOGYGO:0004438gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510449006Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449006Reactome Database ID Release 7510449008Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449008ReactomeR-GGA-16759941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1675994.1At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002, Kim et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Kim et al. 2002, Tronchere et al. 2004), 3 (MTMR3) (Kim et al. 2002, Zhao et al. 2001, Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Kim et al. 2002, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).10224048Pubmed1999SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatasesGuo, SStolz, LELemrow, SMYork, JDJ Biol Chem 274:12990-514660569Pubmed2004Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cellsTronchère, HLaporte, JPendaries, CChaussade, CLiaubet, LPirola, LMandel, JLPayrastre, BJ Biol Chem 279:7304-1211733541Pubmed2002Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth diseaseKim, SATaylor, GSTorgersen, KMDixon, JEJ Biol Chem 277:4526-3111676921Pubmed2001Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificityWalker, DMUrbé, SDove, SKTenza, DRaposo, GClague, MJCurr Biol 11:1600-517008356Pubmed2006A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathyTosch, VRohde, HMTronchère, HZanoteli, EMonroy, NKretz, CDondaine, NPayrastre, BMandel, JLLaporte, JHum Mol Genet 15:3098-10616914545Pubmed2006Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domainChoudhury, PSrivastava, SLi, ZKo, KAlbaqumi, MNarayan, KCoetzee, WALemmon, MASkolnik, EYJ Biol Chem 281:31762-917651088Pubmed2007Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomesCao, CLaporte, JBacker, JMWandinger-Ness, AStein, MPTraffic 8:1052-6712646134Pubmed2003Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatasesSchaletzky, JDove, SKShort, BLorenzo, OClague, MJBarr, Francis ACurr Biol 13:504-912118066Pubmed2002The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane rufflesLaporte, JBlondeau, FGansmuller, ALutz, YVonesch, JLMandel, JLJ Cell Sci 115:3105-1711302699Pubmed2001FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphateZhao, RQi, YChen, JZhao, ZJExp Cell Res 265:329-3815840652Pubmed2005Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3Lorenzo, OUrbé, SClague, MJJ Cell Sci 118:2005-12inferred from electronic annotationEVIDENCE CODEECO:0000203