BioPAX pathway converted from "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments" in the Reactome database.LEFT-TO-RIGHT3.2.1.35Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragmentsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+Reactome DB_ID: 10454448plasma membraneGENE ONTOLOGYGO:0005886HA:HAR:HYAL2Reactome DB_ID: 10454437HYAL2HYAL2H9KZ20Reactome DB_ID: 10454421UniProt:H9KZ20HYAL2Gallus gallusNCBI Taxonomy9031UniProtH9KZ2021EQUAL448EQUALReactome Database ID Release 7510454421Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454421ReactomeR-GGA-21609191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160919.1Reactomehttp://www.reactome.org1Converted from EntitySet in ReactomeHARsHA receptorsReactome DB_ID: 10454435CD44A0A1D5PVD2Reactome DB_ID: 10446836UniProt:A0A1D5PVD2UniProtA0A1D5PVD221EQUAL742EQUALReactome Database ID Release 7510446836Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10446836ReactomeR-GGA-10316881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1031688.1HMMRA0A1D5P2N3Reactome DB_ID: 10454425UniProt:A0A1D5P2N3UniProtA0A1D5P2N31EQUAL724EQUALReactome Database ID Release 7510454425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454425ReactomeR-GGA-21608851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160885.1LYVE1LYVE1E1C9I1Reactome DB_ID: 10454429UniProt:E1C9I1LYVE1UniProtE1C9I120EQUAL322EQUALReactome Database ID Release 7510454429Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454429ReactomeR-GGA-21609211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160921.1A0A3Q2UF11STAB2(1136-2551)Reactome DB_ID: 10454433UniProt:A0A3Q2UF11UniProtA0A3Q2UF111136EQUAL2551EQUALReactome Database ID Release 7510454433Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454433ReactomeR-GGA-21608531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160853.1Reactome Database ID Release 7510454435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454435ReactomeR-GGA-21609261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160926.11HAHA polymerHyaluronanHyaluronic acidReactome DB_ID: 2160848extracellular regionGENE ONTOLOGYGO:0005576Reactome Database ID Release 752160848Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160848ReactomeR-ALL-21608482Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2160848.2ChEBI16336additional informationMIMI:03611Reactome Database ID Release 7510454437Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454437ReactomeR-GGA-21608891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160889.11SLC9A1:p-CHP:Ca2+Reactome DB_ID: 10454446p-CHP1:Ca2+Reactome DB_ID: 10454444Ca2+Calciumcalcium(2+)Reactome DB_ID: 140648calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 75140648Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140648ReactomeR-ALL-1406484Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-140648.4COMPOUNDC000762p-CHP1phospho-CHP1Q5ZM44Reactome DB_ID: 10454442UniProt:Q5ZM44CHP1UniProtQ5ZM44phosphorylated residueMODMOD:006962EQUAL195EQUALReactome Database ID Release 7510454442Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454442ReactomeR-GGA-53337471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5333747.11Reactome Database ID Release 7510454444Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454444ReactomeR-GGA-53337521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5333752.11SLC9A1SLC9A1A0A3Q3AS64Reactome DB_ID: 10435532UniProt:A0A3Q3AS64SLC9A1UniProtA0A3Q3AS641EQUAL815EQUALReactome Database ID Release 7510435532Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435532ReactomeR-GGA-4260061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426006.11Reactome Database ID Release 7510454446Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454446ReactomeR-GGA-53336821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5333682.11Reactome Database ID Release 7510454448Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454448ReactomeR-GGA-21608911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160891.1(HA)50Hyaluronic acidHyaluronanReactome DB_ID: 2160894Reactome Database ID Release 752160894Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160894ReactomeR-ALL-21608943Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2160894.3ChEBI64024ACTIVATIONactiveUnit: #Protein1GENE ONTOLOGYGO:0004415gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510454451Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454451Reactome Database ID Release 7510454453Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454453ReactomeR-GGA-21608921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160892.1In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).16104017Pubmed2005Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysisJedrzejas, MJStern, RProteins 61:227-389712871Pubmed1998HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificityLepperdinger, GStrobl, BKreil, GJ Biol Chem 273:22466-70inferred from electronic annotationEVIDENCE CODEECO:0000203