BioPAX pathway converted from "SUMOylation of NR3C1 (GR) with SUMO1" in the Reactome database.LEFT-TO-RIGHTSUMOylation of NR3C1 (GR) with SUMO1SUMOylation of Glucocorticoid receptor with SUMO1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>NR3C1:(ALDO,11DCORST,CORST,CORT) dimerReactome DB_ID: 10462927nucleoplasmGENE ONTOLOGYGO:0005654NR3C1:(ALDO,11DCORST,CORST,CORT)Reactome DB_ID: 10462925NR3C1-1A0A1D5PIB1Reactome DB_ID: 10429980UniProt:A0A1D5PIB1Gallus gallusNCBI Taxonomy9031UniProtA0A1D5PIB11EQUAL777EQUALReactome Database ID Release 7010429980Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10429980ReactomeR-GGA-31961631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3196163.1Reactomehttp://www.reactome.org1Converted from EntitySet in Reactome(NR3C1 ligand)(ALDO,11DCORST,CORST,CORT)(Glucocorticoids)Reactome DB_ID: 9625949ALDOaldosteroneReactome DB_ID: 5618115aldosterone [ChEBI:27584]aldosteroneChEBICHEBI:27584Reactome Database ID Release 705618115Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5618115ReactomeR-ALL-56181153Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5618115.311DCORSTcortexone11-deoxycorticosteroneReactome DB_ID: 903533411-deoxycorticosterone [ChEBI:16973]11-deoxycorticosteroneChEBICHEBI:16973Reactome Database ID Release 709035334Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9035334ReactomeR-ALL-90353341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9035334.1CORSTcorticosteroneReactome DB_ID: 9605734corticosterone [ChEBI:16827]corticosteroneChEBICHEBI:16827Reactome Database ID Release 709605734Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9605734ReactomeR-ALL-96057341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9605734.1CORTcortisolReactome DB_ID: 5618097cortisol [ChEBI:17650]cortisolChEBICHEBI:17650Reactome Database ID Release 705618097Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5618097ReactomeR-ALL-56180973Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5618097.3Reactome Database ID Release 709625949Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9625949ReactomeR-ALL-96259491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9625949.11Reactome Database ID Release 7010462925Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462925ReactomeR-GGA-96259471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9625947.12Reactome Database ID Release 7010462927Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462927ReactomeR-GGA-8798501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-879850.1SUMO1:C93-UBE2IReactome DB_ID: 10459773P63283SUMO1-C93-UBE2IReactome DB_ID: 10459768UniProt:P63283UniProtP6328393EQUALS-(glycyl)-L-cysteine (Cys-Gly)MODMOD:002111EQUAL158EQUALReactome Database ID Release 7010459768Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10459768ReactomeR-GGA-37306171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3730617.11Q8QGH2UBE2I-G97-SUMO1Reactome DB_ID: 10459771UniProt:Q8QGH2UniProtQ8QGH297EQUAL2EQUAL97EQUALReactome Database ID Release 7010459771Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10459771ReactomeR-GGA-37306221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3730622.11Reactome Database ID Release 7010459773Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10459773ReactomeR-GGA-29937831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2993783.14UBE2IP63283Reactome DB_ID: 104597651EQUAL158EQUALReactome Database ID Release 7010459765Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10459765ReactomeR-GGA-9124811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-912481.142SUMO1:NR3C1:Glucocorticoid ligand dimerReactome DB_ID: 104629382SUMO1:NR3C1:Glucocorticoid ligandReactome DB_ID: 10462936A0A1D5PIB1SUMO1-K277,K293-NR3C1Reactome DB_ID: 10462934277EQUALsumoylated lysineMODMOD:01149293EQUAL1EQUAL777EQUALReactome Database ID Release 7010462934Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462934ReactomeR-GGA-43411061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4341106.11Q8QGH2K277-NR3C1-G97-SUMO1Reactome DB_ID: 1046293097EQUAL2EQUAL97EQUALReactome Database ID Release 7010462930Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462930ReactomeR-GGA-43410571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4341057.121Reactome Database ID Release 7010462936Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462936ReactomeR-GGA-96259701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9625970.12Reactome Database ID Release 7010462938Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462938ReactomeR-GGA-43410151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4341015.1ACTIVATIONactiveUnit: #Protein4GENE ONTOLOGYGO:0019789gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7010460436Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10460436Reactome Database ID Release 7010462940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10462940ReactomeR-GGA-43410251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4341025.1NR3C1 (Glucocorticoid receptor, GR) is SUMOylated at lysine-277 and lysine-293 with SUMO1 (Tian et al. 2002, Impens et al. 2014). SUMOylation is enhanced when NR3C1 binds ligand (dexamethasone). SUMOylation reduces transcription activation by NR3C1.12144530Pubmed2002Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptorTian, ShaPoukka, HettiPalvimo, Jorma JJänne, Olli ABiochem. J. 367:907-1125114211Pubmed2014Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuliImpens, FrancisRadoshevich, LillianaCossart, PascaleRibet, DavidProc. Natl. Acad. Sci. U.S.A. 111:12432-7inferred from electronic annotationEVIDENCE CODEECO:0000203