BioPAX pathway converted from "Parkin binds Ub:UBE2N:UBE2V1" in the Reactome database. LEFT-TO-RIGHT Parkin binds Ub:UBE2N:UBE2V1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ub:UBE2N:UBE2V1 Reactome DB_ID: 10470713 cytosol GENE ONTOLOGY GO:0005829 Converted from EntitySet in Reactome Ub ubiquitin Reactome DB_ID: 10361089 B0R189 RPS27A(1-76) Reactome DB_ID: 10361057 UniProt:B0R189 Danio rerio NCBI Taxonomy 7955 UniProt B0R189 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10361057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361057 Reactome R-DRE-939205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939205.1 Reactome http://www.reactome.org Converted from EntitySet in Reactome Homologues of UBA52(1-76) Reactome DB_ID: 10361063 F1QHN6 UBA52(1-76) Reactome DB_ID: 10361059 UniProt:F1QHN6 UniProt F1QHN6 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10361059 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361059 Reactome R-DRE-939203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939203.1 Q7SXA3 zgc:66168 UBA52(1-76) Reactome DB_ID: 10361061 UniProt:Q7SXA3 zgc:66168 UniProt Q7SXA3 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10361061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361061 Reactome R-DRE-939203-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939203-2.1 Reactome Database ID Release 83 10361063 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361063 Reactome R-DRE-939203-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939203-3.1 UBB(1-76) A0A2R8RR55 Reactome DB_ID: 10361065 UniProt:A0A2R8RR55 UniProt A0A2R8RR55 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10361065 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361065 Reactome R-DRE-939214 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939214.1 A0A2R8RR55 UBB(77-152) Reactome DB_ID: 10361067 77 EQUAL 152 EQUAL Reactome Database ID Release 83 10361067 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361067 Reactome R-DRE-939213 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939213.1 A0A2R8RR55 UBB(153-228) Reactome DB_ID: 10361069 153 EQUAL 228 EQUAL Reactome Database ID Release 83 10361069 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361069 Reactome R-DRE-939230 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939230.1 UBC(1-76) A0A0N4SUD2 Reactome DB_ID: 10361071 UniProt:A0A0N4SUD2 UniProt A0A0N4SUD2 1 EQUAL 76 EQUAL Reactome Database ID Release 83 10361071 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361071 Reactome R-DRE-939188 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939188.1 A0A0N4SUD2 UBC(77-152) Reactome DB_ID: 10361073 77 EQUAL 152 EQUAL Reactome Database ID Release 83 10361073 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361073 Reactome R-DRE-939164 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939164.1 A0A0N4SUD2 UBC(153-228) Reactome DB_ID: 10361075 153 EQUAL 228 EQUAL Reactome Database ID Release 83 10361075 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361075 Reactome R-DRE-939258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939258.1 A0A0N4SUD2 UBC(229-304) Reactome DB_ID: 10361077 229 EQUAL 304 EQUAL Reactome Database ID Release 83 10361077 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361077 Reactome R-DRE-939192 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939192.1 A0A0N4SUD2 UBC(305-380) Reactome DB_ID: 10361079 305 EQUAL 380 EQUAL Reactome Database ID Release 83 10361079 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361079 Reactome R-DRE-939232 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939232.1 A0A0N4SUD2 UBC(381-456) Reactome DB_ID: 10361081 381 EQUAL 456 EQUAL Reactome Database ID Release 83 10361081 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361081 Reactome R-DRE-939191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939191.1 A0A0N4SUD2 UBC(457-532) Reactome DB_ID: 10361083 457 EQUAL 532 EQUAL Reactome Database ID Release 83 10361083 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361083 Reactome R-DRE-939184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939184.1 A0A0N4SUD2 UBC(533-608) Reactome DB_ID: 10361085 533 EQUAL 608 EQUAL Reactome Database ID Release 83 10361085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361085 Reactome R-DRE-939239 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939239.1 A0A0N4SUD2 UBC(609-684) Reactome DB_ID: 10361087 609 EQUAL 684 EQUAL Reactome Database ID Release 83 10361087 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361087 Reactome R-DRE-939165 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-939165.1 Reactome Database ID Release 83 10361089 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10361089 Reactome R-DRE-113595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-113595.1 1 UBE2N:UBE2V1 Reactome DB_ID: 10380540 UBE2V1 F1R1E9 Reactome DB_ID: 10380538 UniProt:F1R1E9 UniProt F1R1E9 2 EQUAL 147 EQUAL Reactome Database ID Release 83 10380538 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380538 Reactome R-DRE-205753 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-205753.1 1 Converted from EntitySet in Reactome Homologues of UBE2N Reactome DB_ID: 10380534 UBE2N A0A2R8QIN6 Reactome DB_ID: 10380528 UniProt:A0A2R8QIN6 UniProt A0A2R8QIN6 1 EQUAL 152 EQUAL Reactome Database ID Release 83 10380528 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380528 Reactome R-DRE-206072 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-206072.1 UBE2N ube2nl Q7T3F3 Reactome DB_ID: 10380530 UniProt:Q7T3F3 ube2nl UniProt Q7T3F3 1 EQUAL 152 EQUAL Reactome Database ID Release 83 10380530 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380530 Reactome R-DRE-206072-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-206072-2.1 ube2n UBE2N Q803J2 Reactome DB_ID: 10380532 UniProt:Q803J2 ube2n UniProt Q803J2 1 EQUAL 152 EQUAL Reactome Database ID Release 83 10380532 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380532 Reactome R-DRE-206072-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-206072-3.1 Reactome Database ID Release 83 10380534 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380534 Reactome R-DRE-206072-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-206072-4.1 1 Reactome Database ID Release 83 10380540 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380540 Reactome R-DRE-202463 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-202463.1 1 Reactome Database ID Release 83 10470713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470713 Reactome R-DRE-9640491 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9640491.1 PRKN park2 A0A0H2UKX4 Reactome DB_ID: 10403002 UniProt:A0A0H2UKX4 park2 UniProt A0A0H2UKX4 1 EQUAL 465 EQUAL Reactome Database ID Release 83 10403002 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10403002 Reactome R-DRE-201579 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-201579.1 Ub:UBE2N:UBE2V1:PRKN Reactome DB_ID: 10470715 1 1 Reactome Database ID Release 83 10470715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470715 Reactome R-DRE-9641092 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9641092.1 Reactome Database ID Release 83 10470717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470717 Reactome R-DRE-9641089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9641089.1 Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. Consequently, the E3 ligase PRKN (Parkin) binds this complex and facilitates the addition of more ubiquitin molecules. (Olzmann JA et al. 2007). 17846173 Pubmed 2007 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 Olzmann, James A Li, Lian Chudaev, Maksim V Chen, Jue Perez, Francisco A Palmiter, Richard D Chin, Lih-Shen J. Cell Biol. 178:1025-38 inferred from electronic annotation EVIDENCE CODE ECO:0000203