BioPAX pathway converted from "Dimerization of phosphorylated IRF3/IRF7" in the Reactome database. LEFT-TO-RIGHT Dimerization of phosphorylated IRF3/IRF7 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome phosphorylated IRF3/IRF7 p-4S,T404-IRF3,p-S477,S479-IRF7 Reactome DB_ID: 10482403 A0A6I8SVQ2 phospho-p-4S,T404-IRF3 Reactome DB_ID: 10482397 cytosol GENE ONTOLOGY GO:0005829 UniProt:A0A6I8SVQ2 Xenopus tropicalis NCBI Taxonomy 8364 UniProt A0A6I8SVQ2 396 EQUAL O-phospho-L-serine MOD MOD:00046 398 EQUAL 402 EQUAL 405 EQUAL 404 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 427 EQUAL Reactome Database ID Release 82 10482397 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10482397 Reactome R-XTR-166258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-166258.1 Reactome http://www.reactome.org A0A803JAL6 phospho-irf7 p-S477,S479-IRF7 Reactome DB_ID: 10482401 UniProt:A0A803JAL6 irf7 UniProt A0A803JAL6 477 EQUAL 479 EQUAL 1 EQUAL 503 EQUAL Reactome Database ID Release 82 10482401 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10482401 Reactome R-XTR-450318 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-450318.1 Reactome Database ID Release 82 10482403 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10482403 Reactome R-XTR-450240 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-450240.1 2 Converted from EntitySet in Reactome phosphorylated IRF3 and/or IRF7 dimer Reactome DB_ID: 10483278 p-2S-IRF7:p-2S-IRF7 Reactome DB_ID: 10483274 2 Reactome Database ID Release 82 10483274 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10483274 Reactome R-XTR-450344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-450344.1 p-T,4S-IRF3:p-T,4S-IRF3 Reactome DB_ID: 10483276 2 Reactome Database ID Release 82 10483276 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10483276 Reactome R-XTR-166272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-166272.1 Reactome Database ID Release 82 10483278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10483278 Reactome R-XTR-450256 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-450256.1 Reactome Database ID Release 82 10483280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10483280 Reactome R-XTR-168933 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-168933.1 Phosphorylation results in IRF-3 dimerization and removal of an autoinhibitory structure to allow interaction with the coactivators CBP/p300. 14555995 Pubmed 2003 X-ray crystal structure of IRF-3 and its functional implications Takahasi, K Suzuki, NN Horiuchi, M Mori, M Suhara, W Okabe, Y Fukuhara, Y Terasawa, H Akira, Shizuo Fujita, T Inagaki, F Nat Struct Biol 10:922-7 12692549 Pubmed 2003 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Fitzgerald, Katherine A McWhirter, SM Faia, KL Rowe, DC Latz, E Golenbock, DT Coyle, AJ Liao, SM Maniatis, T Nat Immunol 4:491-6 inferred from electronic annotation EVIDENCE CODE ECO:0000203