BioPAX pathway converted from "JAK1 binds IL20RA" in the Reactome database.LEFT-TO-RIGHTJAK1 binds IL20RAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>JAK1F1NMJ9Reactome DB_ID: 10437733cytosolGENE ONTOLOGYGO:0005829UniProt:F1NMJ9Gallus gallusNCBI Taxonomy9031UniProtF1NMJ91EQUAL1154EQUALReactome Database ID Release 7510437733Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10437733ReactomeR-GGA-4518981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451898.1Reactomehttp://www.reactome.orgIL20RAIL20RAF1NYV0Reactome DB_ID: 10437799plasma membraneGENE ONTOLOGYGO:0005886UniProt:F1NYV0IL20RAUniProtF1NYV030EQUAL553EQUALReactome Database ID Release 7510437799Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10437799ReactomeR-GGA-4487131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448713.1IL20RA:JAK1Reactome DB_ID: 1043780111Reactome Database ID Release 7510437801Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10437801ReactomeR-GGA-89870711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8987071.1Reactome Database ID Release 7510485051Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485051ReactomeR-GGA-89870391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8987039.1Tyrosine protein kinase JAK1 (JAK1) binds Interleukin-20 receptor subunit alpha (IL20RA). JAK1 coimmunoprecipitates with several class II receptor complexes including Interferon gamma receptor 1 (IFNGR1), Interferon alpha/beta receptor 2 (IFNAR2), Interferon lambda receptor 1 (IFNLR1), Interleukin-10 receptor subunit alpha (IL10RA), Interleukin-22 receptor subunit alpha 1 (IL22RA1) and Interleukin-20 receptor subunit alpha (IL20RA), leading to the suggestion that Class II receptors may have a common sequence motif for JAK recognition (Ferrao et al. 2016). This is a black box event because JAK1 binding to IL20RA is inferred from binding to related receptors and subsequent JAK/STAT signaling events (Ferrao et al 2016, Hann et al. 2006, Murakami et al. 1991). 16750817Pubmed2006Jaks and cytokine receptors--an intimate relationshipHaan, ClaudeKreis, StephanieMargue, ChristianeBehrmann, IrisBiochem. Pharmacol. 72:1538-461662392Pubmed1991Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor familyMurakami, MNarazaki, MHibi, MYawata, HYasukawa, KHamaguchi, MTaga, TKishimoto, TProc Natl Acad Sci U S A 88:11349-5327133025Pubmed2016The Structural Basis for Class II Cytokine Receptor Recognition by JAK1Ferrao, RyanWallweber, Heidi J AHo, HoangdungTam, ChristineFranke, YvonneQuinn, JohnLupardus, Patrick JStructure 24:897-905inferred from electronic annotationEVIDENCE CODEECO:0000203