BioPAX pathway converted from "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA" in the Reactome database.LEFT-TO-RIGHT1.11.1.12GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GSHReduced glutathioneglutathione5-L-Glutamyl-L-cysteinylglycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinegamma-L-Glutamyl-L-cysteinyl-glycineReactome DB_ID: 29450cytosolGENE ONTOLOGYGO:0005829glutathione [ChEBI:16856]glutathioneChEBICHEBI:16856Reactome Database ID Release 7529450Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450ReactomeR-ALL-294503Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29450.3Reactomehttp://www.reactome.orgCOMPOUNDC00051additional informationMIMI:0361217(S)-Hp-DHA(17S)-HPDoHE(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid17(S)-hydroperoxy-docosahexaenoic acidReactome DB_ID: 9024012(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid [ChEBI:136113](4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acidChEBICHEBI:136113Reactome Database ID Release 759024012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9024012ReactomeR-ALL-90240123Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9024012.3GSSGoxidized glutathioneglutathione disulfideReactome DB_ID: 111745glutathione disulfide [ChEBI:17858]glutathione disulfideChEBICHEBI:17858Reactome Database ID Release 75111745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745ReactomeR-ALL-1117453Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111745.3COMPOUNDC0012717(S)-HDHA17(S)-hydroxydocosahexaenoic acid17(S)-HDoHEReactome DB_ID: 902481517(S)-HDoHE [ChEBI:138640]17(S)-HDoHEChEBICHEBI:138640Reactome Database ID Release 759024815Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9024815ReactomeR-ALL-90248154Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9024815.4H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001ACTIVATIONGPX4-2A0A3Q3AIE0Reactome DB_ID: 10485637UniProt:A0A3Q3AIE0Gallus gallusNCBI Taxonomy9031UniProtA0A3Q3AIE028EQUAL197EQUALReactome Database ID Release 7510485637Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485637ReactomeR-GGA-90205721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9020572.1GENE ONTOLOGYGO:0047066gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510485638Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485638Reactome Database ID Release 7510485670Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485670ReactomeR-GGA-90202731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9020273.1Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) to 17(S)-hydroxydocosahexaenoic acid (17(S)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).24170573Pubmed2013Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidaseHan, XiaoFan, ZhenlinYu, YangLiu, ShaoliHao, YazhouHuo, RuiWei, JingyanIUBMB Life 65:951-68605014Pubmed1996Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injuryYagi, KKomura, SKojima, HSun, QNagata, NOhishi, NNishikimi, MBiochem. Biophys. Res. Commun. 219:486-9123201771Pubmed2013Glutathione peroxidasesBrigelius-Flohé, ReginaMaiorino, MatildeBiochim. Biophys. Acta 1830:3289-303inferred from electronic annotationEVIDENCE CODEECO:0000203