BioPAX pathway converted from "Sodium/Proton exchangers" in the Reactome database.Sodium/Proton exchangersThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTNa+/H+ exchanger transport (at cell membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Na+sodium ionsodium(1+)SodiumReactome DB_ID: 74113extracellular regionGENE ONTOLOGYGO:0005576sodium(1+) [ChEBI:29101]sodium(1+)ChEBICHEBI:29101Reactome Database ID Release 7574113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113ReactomeR-ALL-741133Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74113.3Reactomehttp://www.reactome.orgCOMPOUNDC01330additional informationMIMI:0361H+protonhydronReactome DB_ID: 70106cytosolGENE ONTOLOGYGO:0005829hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 7570106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106ReactomeR-ALL-701064Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4COMPOUNDC00080Na+sodium ionsodium(1+)SodiumReactome DB_ID: 83910Reactome Database ID Release 7583910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910ReactomeR-ALL-839103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83910.3COMPOUNDC01330H+hydronReactome DB_ID: 351626Reactome Database ID Release 75351626Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626ReactomeR-ALL-3516264Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-351626.4COMPOUNDC00080ACTIVATIONConverted from EntitySet in ReactomeSLC9A1-5Na+/H+ exchanger proteinsReactome DB_ID: 10435546SLC9A1SLC9A1A0A3Q3AS64Reactome DB_ID: 10435532plasma membraneGENE ONTOLOGYGO:0005886UniProt:A0A3Q3AS64SLC9A1Gallus gallusNCBI Taxonomy9031UniProtA0A3Q3AS641EQUAL815EQUALReactome Database ID Release 7510435532Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435532ReactomeR-GGA-4260061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426006.1SLC9A2SLC9A2E1BV56Reactome DB_ID: 10435536UniProt:E1BV56SLC9A2UniProtE1BV561EQUAL812EQUALReactome Database ID Release 7510435536Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435536ReactomeR-GGA-4259751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425975.1SLC9A3A0A1D5NYQ5Reactome DB_ID: 10435540UniProt:A0A1D5NYQ5UniProtA0A1D5NYQ51EQUAL834EQUALReactome Database ID Release 7510435540Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435540ReactomeR-GGA-4259921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425992.1SLC9A5F1NL74Reactome DB_ID: 10435544UniProt:F1NL74UniProtF1NL741EQUAL896EQUALReactome Database ID Release 7510435544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435544ReactomeR-GGA-4259891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425989.1Reactome Database ID Release 7510435546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435546ReactomeR-GGA-4259631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425963.1GENE ONTOLOGYGO:0015385gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510435547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435547Reactome Database ID Release 7510435549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435549ReactomeR-GGA-4259941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425994.1NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS. 10444453Pubmed1999Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Malakooti, JDahdal, RYSchmidt, LLayden, TJDudeja, PKRamaswamy, KAm J Physiol 277:G383-909933641Pubmed1999Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainBaird, NROrlowski, JSzabó, EZZaun, HCSchultheis, PJMenon, AGShull, GEJ Biol Chem 274:4377-822536298Pubmed1989Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterSardet, CFranchi, APouysségur, JacquesCell 56:271-807631746Pubmed1995Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Brant, SRYun, CHDonowitz, MTse, CMAm J Physiol 269:C198-206inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTNa+/H+ exchanger transport (at early endosome membrane)SLC9A6,7 exchange Na+ for H+ across the early endosome membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H+hydronReactome DB_ID: 425978early endosome lumenGENE ONTOLOGYGO:0031905Reactome Database ID Release 75425978Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425978ReactomeR-ALL-4259783Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425978.3COMPOUNDC00080Na+Sodium ionsodium(1+)Reactome DB_ID: 425971Reactome Database ID Release 75425971Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425971ReactomeR-ALL-4259713Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425971.3ACTIVATIONConverted from EntitySet in ReactomeSLC9A6,7Reactome DB_ID: 10435525SLC9A6SLC9A6F1NCB2Reactome DB_ID: 10435519early endosome membraneGENE ONTOLOGYGO:0031901UniProt:F1NCB2SLC9A6UniProtF1NCB21EQUAL669EQUALReactome Database ID Release 7510435519Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435519ReactomeR-GGA-4259841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425984.1SLC9A7SLC9A7A0A1D5NY95Reactome DB_ID: 10435523UniProt:A0A1D5NY95SLC9A7UniProtA0A1D5NY951EQUAL725EQUALReactome Database ID Release 7510435523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435523ReactomeR-GGA-40846751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4084675.1Reactome Database ID Release 7510435525Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435525ReactomeR-GGA-40846781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-4084678.1Reactome Database ID Release 7510435526Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435526Reactome Database ID Release 7510435528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435528ReactomeR-GGA-4259831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425983.1NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.11940519Pubmed2002Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondriaBrett, CLWei, YDonowitz, MRao, RAm J Physiol Cell Physiol 282:C1031-4115522866Pubmed2005Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationNakamura, NTanaka, STeko, YMitsui, KKanazawa, HJ Biol Chem 280:1561-72LEFT-TO-RIGHTNa+/H+ exchanger transport (at trans-golgi membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H+hydronReactome DB_ID: 425969Golgi lumenGENE ONTOLOGYGO:0005796Reactome Database ID Release 75425969Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425969ReactomeR-ALL-4259693Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425969.3COMPOUNDC00080Na+sodium ionsodium(1+)SodiumReactome DB_ID: 425958Reactome Database ID Release 75425958Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425958ReactomeR-ALL-4259583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425958.3COMPOUNDC01330ACTIVATIONConverted from EntitySet in ReactomeSLC9A7/8Na+/H+ exchanger proteins 7/8Reactome DB_ID: 10435557SLC9A7SLC9A7A0A1D5NY95Reactome DB_ID: 10435551Golgi membraneGENE ONTOLOGYGO:00001391EQUAL725EQUALReactome Database ID Release 7510435551Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435551ReactomeR-GGA-4259601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425960.1SLC9A8SLC9A8F1N9A5Reactome DB_ID: 10435555UniProt:F1N9A5SLC9A8UniProtF1N9A51EQUAL581EQUALReactome Database ID Release 7510435555Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435555ReactomeR-GGA-4260031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426003.1Reactome Database ID Release 7510435557Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435557ReactomeR-GGA-4260051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426005.1Reactome Database ID Release 7510435558Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435558Reactome Database ID Release 7510435560Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435560ReactomeR-GGA-4260151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426015.1NHE7 and 8 (SLC9A7,8) (Nakamura N et al, 2005) are expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the trans-golgi network.11279194Pubmed2001Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi networkNumata, MOrlowski, JJ Biol Chem 276:17387-94LEFT-TO-RIGHTNa+/H+ exchanger transport (at late endosome membrane)SLC9A9 exchanges Na+ for H+ across the late endosome membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H+hydronReactome DB_ID: 425999late endosome lumenGENE ONTOLOGYGO:0031906Reactome Database ID Release 75425999Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425999ReactomeR-ALL-4259993Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425999.3COMPOUNDC00080Na+Sodium ionsodium(1+)Reactome DB_ID: 425977Reactome Database ID Release 75425977Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425977ReactomeR-ALL-4259773Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-425977.3ACTIVATIONSLC9A9SLC9A9F1NYM1Reactome DB_ID: 10435512late endosome membraneGENE ONTOLOGYGO:0031902UniProt:F1NYM1SLC9A9UniProtF1NYM11EQUAL645EQUALReactome Database ID Release 7510435512Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435512ReactomeR-GGA-4259721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425972.1Reactome Database ID Release 7510435513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435513Reactome Database ID Release 7510435515Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435515ReactomeR-GGA-4259651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425965.1NHE9 (SLC9A9) (Nakamura al. 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the late endosome membrane.Reactome Database ID Release 7510489360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489360ReactomeR-GGA-4259861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425986.1The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.12845533Pubmed2004Diversity of the mammalian sodium/proton exchanger SLC9 gene familyOrlowski, JGrinstein, SPflugers Arch 447:549-65