BioPAX pathway converted from "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" in the Reactome database.LEFT-TO-RIGHT6.3.2.19Ubiquitination of Securin by phospho-APC/C:Cdc20 complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>CDC20:p-APC/C:PTTG1Reactome DB_ID: 10502894cytosolGENE ONTOLOGYGO:0005829CDC20:p-APC/CReactome DB_ID: 10502856fzyCDC20Q24044Reactome DB_ID: 10500028UniProt:Q24044fzyDrosophila melanogasterNCBI Taxonomy7227UniProtQ240441EQUAL499EQUALReactome Database ID Release 7510500028Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10500028ReactomeR-DME-1414121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-141412.1Reactomehttp://www.reactome.org1phosphorylated anaphase promoting complex (APC/C)Reactome DB_ID: 10491983mrANAPC2Q9W1E5Reactome DB_ID: 10491920UniProt:Q9W1E5mrUniProtQ9W1E51EQUAL822EQUALReactome Database ID Release 7510491920Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491920ReactomeR-DME-1742291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174229.11Ghost homologue of CDC26Reactome DB_ID: 10491952Reactome Database ID Release 7510491952Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491952ReactomeR-DME-1740521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174052.11APC4ANAPC4Q9W395Reactome DB_ID: 10491930UniProt:Q9W395APC4UniProtQ9W3951EQUAL808EQUALReactome Database ID Release 7510491930Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491930ReactomeR-DME-1741681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174168.11Cdc27CDC27Q9VS37Reactome DB_ID: 10491925UniProt:Q9VS37Cdc27UniProtQ9VS371EQUAL824EQUALReactome Database ID Release 7510491925Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491925ReactomeR-DME-1740731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174073.11Cdc16CDC16Q9VCN6Reactome DB_ID: 10491940UniProt:Q9VCN6Cdc16UniProtQ9VCN61EQUAL620EQUALReactome Database ID Release 7510491940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491940ReactomeR-DME-1741561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174156.11idaANAPC5Q9VZL2Reactome DB_ID: 10491935UniProt:Q9VZL2idaUniProtQ9VZL21EQUAL755EQUALReactome Database ID Release 7510491935Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491935ReactomeR-DME-1742111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174211.11Cdc23CDC23Q9I7L8Reactome DB_ID: 10491950UniProt:Q9I7L8Cdc23UniProtQ9I7L81EQUAL597EQUALReactome Database ID Release 7510491950Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491950ReactomeR-DME-1741371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174137.11vihUBE2CQ9VTY6Reactome DB_ID: 10491962UniProt:Q9VTY6vihUniProtQ9VTY62EQUAL179EQUALReactome Database ID Release 7510491962Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491962ReactomeR-DME-1742441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174244.11shtdANAPC1Q9VXV3Reactome DB_ID: 10491910UniProt:Q9VXV3shtdUniProtQ9VXV31EQUAL1944EQUALReactome Database ID Release 7510491910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491910ReactomeR-DME-1741891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174189.11lmgAANAPC11Q7KA43Reactome DB_ID: 10491972UniProt:Q7KA43lmgAUniProtQ7KA431EQUAL84EQUALReactome Database ID Release 7510491972Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491972ReactomeR-DME-1741261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174126.11APC7ANAPC7Q9W3Y6Reactome DB_ID: 10491945UniProt:Q9W3Y6APC7UniProtQ9W3Y61EQUAL599EQUALReactome Database ID Release 7510491945Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491945ReactomeR-DME-1742421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174242.11UBE2SQ9VX25Reactome DB_ID: 10491981UniProt:Q9VX25UniProtQ9VX251EQUAL222EQUALReactome Database ID Release 7510491981Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491981ReactomeR-DME-9476221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-947622.11Ubc2UBE2E1P52485Reactome DB_ID: 10491957UniProt:P52485Ubc2UniProtP524852EQUAL193EQUALReactome Database ID Release 7510491957Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491957ReactomeR-DME-1741001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174100.11Ghost homologue of ANAPC15Reactome DB_ID: 10491974Reactome Database ID Release 7510491974Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491974ReactomeR-DME-68051401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6805140.11APC10ANAPC10Q9V831Reactome DB_ID: 10491915UniProt:Q9V831APC10UniProtQ9V8311EQUAL185EQUALReactome Database ID Release 7510491915Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491915ReactomeR-DME-1741421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174142.11UBE2D1Dmel\CG10862Q9I7T6Reactome DB_ID: 10491967UniProt:Q9I7T6Dmel\CG10862UniProtQ9I7T61EQUAL147EQUALReactome Database ID Release 7510491967Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491967ReactomeR-DME-1742361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174236.11Ghost homologue of ANAPC16Reactome DB_ID: 10491976Reactome Database ID Release 7510491976Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491976ReactomeR-DME-68051381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6805138.11Reactome Database ID Release 7510491983Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491983ReactomeR-DME-1741911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174191.11Reactome Database ID Release 7510502856Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502856ReactomeR-DME-1740811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174081.11Ghost homologue of PTTG1Reactome DB_ID: 10502892Reactome Database ID Release 7510502892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502892ReactomeR-DME-1741901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174190.11Reactome Database ID Release 7510502894Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502894ReactomeR-DME-1742121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174212.1Converted from EntitySet in ReactomeUbubiquitinReactome DB_ID: 10491404UBI-P63E 12ubiquitin 12Reactome DB_ID: 1221561UniProt:P18101 RpL40RpL40Ubi-fUBI-F52CG2960SUBUNIT 60S ribosomal protein is part of the 60S ribosomal subunit.MISCELLANEOUS In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.UniProtP181011EQUAL76EQUALReactome Database ID Release 751221561Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221561ReactomeR-DME-12215611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221561.1UBI-P63E 1ubiquitin 1Reactome DB_ID: 1221567UniProt:P0CG69 Ubi-p63EUbi-p63EUbi-mCG11624FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).MISCELLANEOUS In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG691EQUAL76EQUALReactome Database ID Release 751221567Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221567ReactomeR-DME-12215671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221567.1UBI-P63E 2ubiquitin 2Reactome DB_ID: 122155777EQUAL152EQUALReactome Database ID Release 751221557Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221557ReactomeR-DME-12215571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221557.1UBI-P63E 3ubiquitin 3Reactome DB_ID: 1221559153EQUAL228EQUALReactome Database ID Release 751221559Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221559ReactomeR-DME-12215591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221559.1Q9W418Ubi-p5EUBC(1-76)Reactome DB_ID: 10491386UniProt:Q9W418Ubi-p5EUniProtQ9W4181EQUAL76EQUALReactome Database ID Release 7510491386Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491386ReactomeR-DME-9391881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-939188.1Reactome Database ID Release 7510491404Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491404ReactomeR-DME-1135951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113595.13CDC20:pAPC/C:K11polyUb-PTTG1Reactome DB_ID: 105028981Ghost homologue of K11polyUb-PTTG1Reactome DB_ID: 10502896Reactome Database ID Release 7510502896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502896ReactomeR-DME-30959431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3095943.11Reactome Database ID Release 7510502898Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502898ReactomeR-DME-30959441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3095944.1ACTIVATIONGENE ONTOLOGYGO:0004842gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510502899Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502899Reactome Database ID Release 7510502901Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502901ReactomeR-DME-1741441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-174144.1GENE ONTOLOGYGO:0006511gene ontology term for cellular processMIMI:0359Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).18485873Pubmed2008Mechanism of ubiquitin-chain formation by the human anaphase-promoting complexJin, LWilliamson, ABanerjee, SPhilipp, IRape, MCell 133:653-6512070128Pubmed2002Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1Hagting, ADen Elzen, NVodermaier, HCWaizenegger, ICPeters, JMPines, JJ Cell Biol 157:1125-37inferred from electronic annotationEVIDENCE CODEECO:0000203