BioPAX pathway converted from "Metabolism of ingested SeMet, Sec, MeSec into H2Se" in the Reactome database.Metabolism of ingested SeMet, Sec, MeSec into H2SeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTSeMet is converted to AdoSeMet by MATThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7029356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293564Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.4Reactomehttp://www.reactome.orgSeMetL-selenomethionineReactome DB_ID: 5357707L-selenomethionine [ChEBI:30021]L-selenomethionineChEBICHEBI:30021Reactome Database ID Release 705357707Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357707ReactomeR-ALL-53577073Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357707.3ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113592ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 70113592Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592ReactomeR-ALL-1135924Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.4AdoSeMetL-adenosylselenomethionineReactome DB_ID: 5357652L-adenosylselenomethionine [ChEBI:9066]L-adenosylselenomethionineSe-AdenosylselenomethionineSe-adenosyl-L-selenomethionineChEBICHEBI:9066Reactome Database ID Release 705357652Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357652ReactomeR-ALL-53576523Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357652.3PiOrthophosphatephosphate(3-)PhosphateInorganic PhosphateReactome DB_ID: 29372phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBICHEBI:18367Reactome Database ID Release 7029372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293723Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.3PPipyrophosphatediphosphoric acidpyrophosphoric aciddiphosphateReactome DB_ID: 111294diphosphoric acid [ChEBI:29888]diphosphoric acidChEBICHEBI:29888Reactome Database ID Release 70111294Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294ReactomeR-ALL-1112943Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111294.3ACTIVATIONConverted from EntitySet in ReactomeMAT1A multimersReactome DB_ID: 10411858MAT1A:K+:2Mg2+ tetramerReactome DB_ID: 10411854MAT1A:K+:2Mg2+Reactome DB_ID: 10411852K+Potassiumpotassium(1+)Reactome DB_ID: 29804potassium(1+) [ChEBI:29103]potassium(1+)PotassiumK+ChEBICHEBI:29103Reactome Database ID Release 7029804Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29804ReactomeR-ALL-298043Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29804.31Mg2+Magnesiummagnesium(2+)Mg++Reactome DB_ID: 29926magnesium(2+) [ChEBI:18420]magnesium(2+)ChEBICHEBI:18420Reactome Database ID Release 7029926Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926ReactomeR-ALL-299265Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29926.52MAT1AE1C735Reactome DB_ID: 10411850UniProt:E1C735Gallus gallusNCBI Taxonomy9031UniProtE1C7351EQUAL395EQUALReactome Database ID Release 7010411850Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10411850ReactomeR-GGA-1743791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-174379.11Reactome Database ID Release 7010411852Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10411852ReactomeR-GGA-1744021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-174402.14Reactome Database ID Release 7010411854Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10411854ReactomeR-GGA-1744051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-174405.1MAT1A:K+:2Mg2+ dimerReactome DB_ID: 104118562Reactome Database ID Release 7010411856Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10411856ReactomeR-GGA-1743951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-174395.1Reactome Database ID Release 7010411858Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10411858ReactomeR-GGA-1743831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-174383.1GENE ONTOLOGYGO:0098601gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7010458087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458087Reactome Database ID Release 7010458089Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458089ReactomeR-GGA-24085511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408551.1Methionine adenosyltransferases (MAT multimers) consisting of a S-adenosylmethionine synthase isoform type-1 (MAT1A) homodimer and a MAT1A: S-adenosylmethionine synthase isoform type-2 (MAT2A) heterodimer are responsible for the conversion of selenomethionine (SeMet) and ATP into Se-adenosylselenomethionine (AdoSeMet), orthophosphate (Pi), and diphosphate (PPi) (Kajander et al. 1990).2339986Pubmed1990Effects of selenomethionine on cell growth and on S-adenosylmethionine metabolism in cultured malignant cellsKajander, E OHarvima, R JKauppinen, LAkerman, K KMartikainen, HPajula, R LKärenlampi, S OBiochem. J. 267:767-74inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHT4.4.1.16Sec is reduced to H2Se by PXLP-K259-SCLY dimerThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>XH2reduced acceptorReactome DB_ID: 5359016Reactome Database ID Release 705359016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359016ReactomeR-ALL-53590161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5359016.1SecL-selenocysteineReactome DB_ID: 5357697L-selenocysteine [ChEBI:16633]L-selenocysteineChEBICHEBI:16633Reactome Database ID Release 705357697Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357697ReactomeR-ALL-53576973Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357697.3L-AlaL-2-Aminopropionic acidL-alanine zwitterionL-alanineL-alpha-AlanineReactome DB_ID: 29432L-alanine zwitterion [ChEBI:57972]L-alanine zwitterionInChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1QNAYBMKLOCPYGJ-REOHCLBHSA-N(2S)-2-ammoniopropanoate89.09320C3H7NO2(2S)-2-azaniumylpropanoateL-alanineC[C@H]([NH3+])C([O-])=OChEBICHEBI:57972Reactome Database ID Release 7029432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29432ReactomeR-ALL-294324Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29432.4XacceptorReactome DB_ID: 5359011Reactome Database ID Release 705359011Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359011ReactomeR-ALL-53590111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5359011.1H2Sehydrogen selenideselaneReactome DB_ID: 5357660selane [ChEBI:16503]selaneChEBICHEBI:16503Reactome Database ID Release 705357660Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357660ReactomeR-ALL-53576603Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357660.3ACTIVATIONPXLP-K259-SCLY dimerReactome DB_ID: 10458083E1BZJ9PXLP-K259-SCLYReactome DB_ID: 10458081UniProt:E1BZJ9UniProtE1BZJ9259EQUALN6-pyridoxal phosphate-L-lysineMODMOD:001281EQUAL445EQUALReactome Database ID Release 7010458081Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458081ReactomeR-GGA-53577231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5357723.12Reactome Database ID Release 7010458083Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458083ReactomeR-GGA-53590181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5359018.1GENE ONTOLOGYGO:0009000Reactome Database ID Release 7010458084Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458084Reactome Database ID Release 7010458086Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458086ReactomeR-GGA-24085241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408524.1Selenocysteine lyase (SCLY) homodimer is involved in the reduction of selenocysteine (Sec) to hydrogen selenide (H2Se) and alanine (Ala) (Daher and Van Lente 1992).1483038Pubmed1992Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrationsDaher, RVan Lente, FJ Trace Elem Electrolytes Health Dis 6:189-9420164179Pubmed2010Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyaseOmi, RieKurokawa, SuguruMihara, HisaakiHayashi, HideyukiGoto, MMiyahara, IKurihara, TatsuoHirotsu, KEsaki, NobuyoshiJ. Biol. Chem. 285:12133-9Reactome Database ID Release 7010505082Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10505082ReactomeR-GGA-24085081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408508.1GENE ONTOLOGYGO:0001887gene ontology term for cellular processMIMI:0359Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).20383543Pubmed2011Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compoundsPinto, John TLee, Jeong-InSinha, RaghuMacEwan, Melanie ECooper, Arthur J LAmino Acids 41:29-416456763Pubmed1981Enzymatic synthesis of selenocysteine in rat liverEsaki, NNakamura, TTanaka, HSuzuki, TMorino, YSoda, KBiochemistry 20:4492-6