BioPAX pathway converted from "Vasopressin-like receptors" in the Reactome database. Vasopressin-like receptors This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT AVP(20-28) binds AVPR1A,B This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> pcdh1 AVPR1B F7EHY9 Reactome DB_ID: 10450006 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:F7EHY9 pcdh1 Xenopus tropicalis NCBI Taxonomy 8364 UniProt F7EHY9 1 EQUAL 424 EQUAL Reactome Database ID Release 81 10450006 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10450006 Reactome R-XTR-388471 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388471.1 Reactome http://www.reactome.org oxt AVP(20-28) F6X0Y1 Reactome DB_ID: 10449618 extracellular region GENE ONTOLOGY GO:0005576 UniProt:F6X0Y1 oxt UniProt F6X0Y1 20 EQUAL 28 EQUAL Reactome Database ID Release 81 10449618 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449618 Reactome R-XTR-388474 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388474.1 AVPR1A,B:AVP(20-28) Reactome DB_ID: 10450008 1 1 Reactome Database ID Release 81 10450008 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10450008 Reactome R-XTR-388502 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388502.1 Reactome Database ID Release 81 10452964 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10452964 Reactome R-XTR-388468 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388468.1 In humans there are three main arginine vasopressin receptors; AVPR1A, 1B and 2. AVPR1A (Thibonnier et al. 1994) and AVPR1B (Sugimoto et al. 1994) act as receptors for the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985) and are expressed mainly in the brain. The 1A and 1B forms use G protein alpha q/11 subunits as their second messenger system. 2991279 Pubmed 1985 The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line Sausville, E Carney, D Battey, J J Biol Chem 260:10236-41 8106369 Pubmed 1994 Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor Thibonnier, M Auzan, C Madhun, Z Wilkins, P Berti-Mattera, L Clauser, E J Biol Chem 269:3304-10 4065330 Pubmed 1985 Expression of the vasopressin and oxytocin genes in human hypothalami Mohr, E Hillers, M Ivell, R Haulica, ID Richter, D FEBS Lett 193:12-6 7929452 Pubmed 1994 Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor Sugimoto, T Saito, M Mochizuki, S Watanabe, Y Hashimoto, S Kawashima, H J Biol Chem 269:27088-92 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT AVP(20-28) binds AVPR2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> avpr2 AVPR2 F6XF22 Reactome DB_ID: 10449622 UniProt:F6XF22 avpr2 UniProt F6XF22 1 EQUAL 371 EQUAL Reactome Database ID Release 81 10449622 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449622 Reactome R-XTR-388431 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388431.1 AVPR2:AVP(20-28) Reactome DB_ID: 10449624 1 1 Reactome Database ID Release 81 10449624 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449624 Reactome R-XTR-392261 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-392261.1 Reactome Database ID Release 81 10453759 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10453759 Reactome R-XTR-392263 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-392263.1 Arginine vasopressin receptor 2 (AVPR2) (Birnbaumer et al. 1992) is expressed in the kidneys and can bind the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985). This receptor uses the G protein alpha s subunit as its second messenger system. 1534149 Pubmed 1992 Molecular cloning of the receptor for human antidiuretic hormone Birnbaumer, M Seibold, A Gilbert, S Ishido, M Barberis, C Antaramian, A Brabet, P Rosenthal, W Nature 357:333-5 LEFT-TO-RIGHT Oxytocin receptor bind oxytocin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> oxtr OXTR F7C7K9 Reactome DB_ID: 10450180 UniProt:F7C7K9 oxtr UniProt F7C7K9 1 EQUAL 389 EQUAL Reactome Database ID Release 81 10450180 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10450180 Reactome R-XTR-388428 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388428.1 OXTR:OXT(20-28) Reactome DB_ID: 10450182 1 1 Reactome Database ID Release 81 10450182 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10450182 Reactome R-XTR-388495 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388495.1 Reactome Database ID Release 81 10452966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10452966 Reactome R-XTR-388503 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388503.1 Oxytocin is a nonapetide closely related to vasopressin (Mohr E et al, 1985; Sausville E et al, 1985). It is best known for its roles in female reproduction: it is released in large amounts during labour facilitating birth and afterwards, breastfeeding. It also acts as a neurotransmitter in the brain. The actions of oxytocin via the oxytocin receptor (Kimura T et al, 1992) are mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. 1313946 Pubmed 1992 Structure and expression of a human oxytocin receptor Kimura, T Tanizawa, O Mori, K Brownstein, MJ Okayama, H Nature 356:526-9 LEFT-TO-RIGHT AVPR1A,B bind desmopressin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> dDAVP desmopressin 1-deamino,<small>D</small>-AVP [deamino-Cys<sup>1</sup>,<small>D</small>-Arg<sup>8</sup>]vasopressin Noctiva&reg; Reactome DB_ID: 9667393 desmopressin [Guide to Pharmacology:2182] desmopressin 1-deamino,<small>D</small>-AVP [deamino-Cys<sup>1</sup>,<small>D</small>-Arg<sup>8</sup>]vasopressin dDAVP Noctiva&reg; Guide to Pharmacology 2182 Reactome Database ID Release 81 9667393 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667393 Reactome R-ALL-9667393 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667393.1 AVPR1A,1B:desmopressin Reactome DB_ID: 10519951 1 1 Reactome Database ID Release 81 10519951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519951 Reactome R-XTR-9667471 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667471.1 Reactome Database ID Release 81 10519953 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519953 Reactome R-XTR-9667456 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667456.1 Desmopressin (trade name DDAVP) is a vasopressin receptor agonist drug used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. Desmopressin works by binding to arginine vasopressin receptors 1A and 1B (AVP1A,B) in the renal collecting duct (Saito et al. 1997, Derick et al. 2002). As a consequence, downstream signalling stimulates aquaporin channel translocation to the apical membrane of the collecting duct where they increase water reabsorption from urine (antidiuretic). 9264324 Pubmed 1997 1-desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor Saito, M Tahara, A Sugimoto, T Biochem. Pharmacol. 53:1711-7 12446593 Pubmed 2002 [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors Derick, S Cheng, L L Voirol, M J Stoev, S Giacomini, M Wo, N C Szeto, H H Ben Mimoun, M Andres, M Gaillard, R C Guillon, G Manning, M Endocrinology 143:4655-64 LEFT-TO-RIGHT AVPR2 bind desmopressin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> AVPR2:desmopressin Reactome DB_ID: 10519955 1 1 Reactome Database ID Release 81 10519955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519955 Reactome R-XTR-9667561 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667561.1 Reactome Database ID Release 81 10519957 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519957 Reactome R-XTR-9667563 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667563.1 Desmopressin (trade name DDAVP) is a vasopressin receptor agonist drug used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. Desmopressin stimulates the release of von Willebrand factor from endothelial cells (Warrier & Lusher 1983, Santiago-Borrero & Casanova 1990) via arginine vasopressin receptor 2 (AVPR2) (Slusarz et al. 2006). Unlike vasopressin, desmopressin has little effect on blood pressure. 2115785 Pubmed 1990 Response of patients with hemophilia A and von Willebrand disease to desmopressin (DDAVP) Santiago-Borrero, P J Casanova, R Bol Asoc Med P R 82:207-10 16333859 Pubmed 2006 Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system Slusarz, Magdalena J Slusarz, Rafał Ciarkowski, Jerzy Biopolymers 81:321-38 6401806 Pubmed 1983 DDAVP: a useful alternative to blood components in moderate hemophilia A and von Willebrand disease Warrier, A I Lusher, J M J. Pediatr. 102:228-33 LEFT-TO-RIGHT AVPR1A,2 bind AVPR antagonists This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome AVPR antagonists Reactome DB_ID: 9667595 YM087 conivaptan Vaprisol&reg; YM-087 Reactome DB_ID: 9667603 conivaptan [Guide to Pharmacology:2203] conivaptan Vaprisol&reg; YM-087 YM087 Guide to Pharmacology 2203 Reactome Database ID Release 81 9667603 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667603 Reactome R-ALL-9667603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667603.1 tolvaptan OPC-41061 Samsca&reg; Reactome DB_ID: 9667573 tolvaptan [Guide to Pharmacology:2226] tolvaptan OPC-41061 Samsca&reg; Guide to Pharmacology 2226 Reactome Database ID Release 81 9667573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667573 Reactome R-ALL-9667573 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667573.1 mozavaptan Reactome DB_ID: 9703962 mozavaptan [Guide to Pharmacology:2197] mozavaptan OPC31260 OPC 31260 OPC-31260 Guide to Pharmacology 2197 Reactome Database ID Release 81 9703962 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9703962 Reactome R-ALL-9703962 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9703962.1 satavaptan Reactome DB_ID: 9703946 satavaptan [Guide to Pharmacology:2199] satavaptan SR121463A SR 121463A SR-121463B SR-121463F Guide to Pharmacology 2199 Reactome Database ID Release 81 9703946 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9703946 Reactome R-ALL-9703946 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9703946.1 lixivaptan Reactome DB_ID: 9703935 lixivaptan [Guide to Pharmacology:2238] lixivaptan VPA985 VPA-985 WAY-VPA-985 Guide to Pharmacology 2238 Reactome Database ID Release 81 9703935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9703935 Reactome R-ALL-9703935 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9703935.1 Reactome Database ID Release 81 9667595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667595 Reactome R-ALL-9667595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667595.1 AVPR1A,2:AVPR antagonists Reactome DB_ID: 10519959 1 1 Reactome Database ID Release 81 10519959 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519959 Reactome R-XTR-9667602 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667602.1 Reactome Database ID Release 81 10519961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519961 Reactome R-XTR-9667569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667569.1 Conivaptan (YM087, brand name Vaprisol) (Tahara et al. 1998, 1998b) and tolvaptan (trade names Samsca, Jinarc) (Schrier et al. 2006) are non-peptide inhibitors of the vasopressin receptors AVPR1A and AVPR2. They are used to treat hyponatremia (low blood sodium levels) (Greenberg & Verbalis 2006). They function by antagonizing AVPR2 receptors in the renal collecting ducts thus causing aquaresis (water secretion) but without electrolyte loss. AVPV2 receptor antagonists may also be useful in the treatment of polycystic kidney disease (PKD) (Belibi et al. 2004, Poch et al. 2018). Satavaptan was under investigation in clinical trials for the prevention of ascites (Soupart et al. 2006) and hyponatremia (Gines et al. 2008) but development has been discontinued. Lixivaptan is a potent, non-peptide, selective AVPR2 antagonist (Albright et al. 1998) that shows promise in treating heart failure in patients with hyponatremia (Abraham et al. 2008, Liamis et al. 2014). 24766294 Pubmed 2014 Treatment of hyponatremia: the role of lixivaptan Liamis, George Filippatos, Theodosios D Elisaf, Moses S 7:431-41 9651149 Pubmed 1998 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors Albright, J D Reich, M F Delos Santos, E G Dusza, J P Sum, F W Venkatesan, A M Coupet, J Chan, P S Ru, X Mazandarani, H Bailey, T 41:2442-4 18508290 Pubmed 2008 Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial Ginès, Pere Wong, Florence Watson, Hugh Milutinovic, Slobodan del Arbol, Luis Ruiz Olteanu, Dan HypoCAT Study Investigators, - 48:204-13 17699341 Pubmed 2006 Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist Soupart, Alain Gross, Peter Legros, Jean-Jacques Alföldi, Sándor Annane, Djillali Heshmati, Hassan M Decaux, Guy 1:1154-60 30303493 Pubmed 2018 An update on tolvaptan for autosomal dominant polycystic kidney disease Poch, E Rodas, L Blasco, M Molina, A Quintana, L Drugs Today 54:519-533 16672911 Pubmed 2006 Vasopressin receptor antagonists Greenberg, A Verbalis, J G Kidney Int. 69:2124-30 9884074 Pubmed 1998 Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells Tahara, A Saito, M Sugimoto, T Tomura, Y Wada, K Kusayama, T Tsukada, J Ishii, N Yatsu, T Uchida, W Tanaka, A Br. J. Pharmacol. 125:1463-70 20973922 Pubmed 2010 Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study Abraham, William T Aranda, Juan M Boehmer, John P Elkayam, Uri Gilbert, Edward M Gottlieb, Stephen S Hasenfuss, Gerd Kukin, Marrick Lowes, Brian D O'Connell, John B Tavazzi, Luigi Feldman, Arthur M Ticho, Barry Orlandi, Cesare 3:249-53 9459574 Pubmed 1998 Pharmacological characterization of YM087, a potent, nonpeptide human vasopressin V1A and V2 receptor antagonist Tahara, A Saito, M Sugimoto, T Tomura, Y Wada, K Kusayama, T Tsukada, J Ishii, N Yatsu, T Uchida, W Tanaka, A Naunyn Schmiedebergs Arch. Pharmacol. 357:63-9 17105757 Pubmed 2006 Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia Schrier, Robert W Gross, Peter Gheorghiade, Mihai Berl, Tomas Verbalis, Joseph G Czerwiec, Frank S Orlandi, Cesare SALT Investigators, - N. Engl. J. Med. 355:2099-112 15327388 Pubmed 2004 Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells Belibi, Franck A Reif, Gail Wallace, Darren P Yamaguchi, Tamio Olsen, Lincoln Li, Hong Helmkamp, George M Grantham, Jared J Kidney Int. 66:964-73 LEFT-TO-RIGHT AVPR1A,B,2 bind atosiban This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome AVPR1A,B, 2 Arg-vasopressin receptor types 1A, 1B and 2 Reactome DB_ID: 10519963 Reactome Database ID Release 81 10519963 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519963 Reactome R-XTR-5621452 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5621452.1 atosiban Antocin&reg; d[<small>D</small>-Tyr(Et)<sup>2</sup>,Thr<sup>4</sup>,Orn<sup>8</sup>]vasotocin d[<small>D</small>-Tyr(Et)<sup>2</sup>,Thr<sup>4</sup>]OVT ORF22164 RWJ 22164 Tractocile&reg; Reactome DB_ID: 9667607 atosiban [Guide to Pharmacology:2213] atosiban Antocin&reg; d[<small>D</small>-Tyr(Et)<sup>2</sup>,Thr<sup>4</sup>,Orn<sup>8</sup>]vasotocin d[<small>D</small>-Tyr(Et)<sup>2</sup>,Thr<sup>4</sup>]OVT ORF22164 RWJ 22164 Tractocile&reg; Guide to Pharmacology 2213 Reactome Database ID Release 81 9667607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667607 Reactome R-ALL-9667607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667607.1 AVPR1A,B,2:atosiban Reactome DB_ID: 10519965 1 1 Reactome Database ID Release 81 10519965 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519965 Reactome R-XTR-9667621 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667621.1 Reactome Database ID Release 81 10519967 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519967 Reactome R-XTR-9667619 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9667619.1 Atosiban (trade names Tractocile, Antocin, Atosiban SUN) is a nonapeptide, desamino-oxytocin analogue, competitive vasopressin/oxytocin receptor antagonist used as a labour repressant (tocolytic) to halt premature labour. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane resulting in reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells as well as reduced influx of Ca2+ from the extracellular space through voltage-gated channels. In addition, atosiban suppresses oxytocin-mediated release of prostaglandins PGE and PGF from the decidua (Sanu & Lamont 2010, Kim et al. 2019). Atosiban antagonises uterine contractions and induces uterine quiescence. (Akerlund et al. 1985, Bossmar et al. 1994). 7802081 Pubmed 1994 Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban Bossmar, T Akerlund, M Fantoni, G Szamatowicz, J Melin, P Maggi, M Am. J. Obstet. Gynecol. 171:1634-42 4061066 Pubmed 1985 The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin Akerlund, M Carlsson, A M Melin, P Trojnar, J Acta Obstet Gynecol Scand 64:499-504 20463780 Pubmed 2010 Critical appraisal and clinical utility of atosiban in the management of preterm labor Sanu, Olaleye Lamont, Ronald F Ther Clin Risk Manag 6:191-9 30962532 Pubmed 2019 Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F<sub>2α</sub>-induced Contractions and Inflammatory Responses in Human Myometrium Kim, Sung Hye Riaposova, Lucia Ahmed, Hauwa Pohl, Oliver Chollet, Andre Gotteland, Jean-Pierre Hanyaloglu, Aylin Bennett, Phillip R Terzidou, Vasso Sci Rep 9:5792 Reactome Database ID Release 81 10523804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10523804 Reactome R-XTR-388479 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388479.1 The vasopressins are peptide hormones consisting of nine amino acids (nonapeptides). They include arginine vasopressin (AVP; anti-diuretic hormone, ADH) and oxytocin. They are synthesized in the hypothalamus from a precursor and released from stores in the posterior pituitary into the blood stream. One of the most important roles of vasopressins is the regulation of water retention in the body. Oxytocin is important in uterine contraction during birth. The vasopressins act via AVP and oxytocin receptors. These are connected to G proteins which act as second messengers and convey the signal inside the cell. 11274341 Pubmed 2001 The oxytocin receptor system: structure, function, and regulation Gimpl, G Fahrenholz, F Physiol Rev 81:629-83 8734452 Pubmed 1996 Vasopressin and oxytocin receptors Zingg, HH Baillieres Clin Endocrinol Metab 10:75-96 8719042 Pubmed 1995 Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family Peter, J Burbach, H Adan, RA Lolait, SJ van Leeuwen, FW Mezey, E Palkovits, M Barberis, C Cell Mol Neurobiol 15:573-95