BioPAX pathway converted from "PIP3 activates AKT signaling" in the Reactome database. PI3K/AKT Signaling PIP3 activates AKT signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT RAC1,RAC2,RHOG activate PI3K This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI3K alpha Reactome DB_ID: 10479817 cytosol GENE ONTOLOGY GO:0005829 Converted from EntitySet in Reactome PI3K-regulatory subunits Reactome DB_ID: 10479815 pik3r1 PIK3R1 F6Z0J4 Reactome DB_ID: 10477039 UniProt:F6Z0J4 pik3r1 Xenopus tropicalis NCBI Taxonomy 8364 UniProt F6Z0J4 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10477039 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477039 Reactome R-XTR-74789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74789.1 Reactome http://www.reactome.org pik3r2 PIK3R2 A0A6I8Q186 Reactome DB_ID: 10477043 UniProt:A0A6I8Q186 pik3r2 UniProt A0A6I8Q186 1 EQUAL 728 EQUAL Reactome Database ID Release 82 10477043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477043 Reactome R-XTR-74791 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74791.1 PIK3R3 tas2r39 Q28IS1 Reactome DB_ID: 10479813 UniProt:Q28IS1 tas2r39 UniProt Q28IS1 1 EQUAL 461 EQUAL Reactome Database ID Release 82 10479813 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479813 Reactome R-XTR-205223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205223.1 Reactome Database ID Release 82 10479815 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479815 Reactome R-XTR-391342 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-391342.1 1 pik3ca PIK3CA F6VXG1 Reactome DB_ID: 10477049 UniProt:F6VXG1 pik3ca UniProt F6VXG1 1 EQUAL 1068 EQUAL Reactome Database ID Release 82 10477049 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477049 Reactome R-XTR-74787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74787.1 1 Reactome Database ID Release 82 10479817 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479817 Reactome R-XTR-198379 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198379.1 Converted from EntitySet in Reactome RAC1:GTP,RAC2:GTP,RHOG:GTP Reactome DB_ID: 10479809 RAC1:GTP Reactome DB_ID: 10479795 plasma membrane GENE ONTOLOGY GO:0005886 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 82 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 COMPOUND C00044 additional information MI MI:0361 1 rac1 RAC1 A0A803JBP3 Reactome DB_ID: 10479793 UniProt:A0A803JBP3 rac1 UniProt A0A803JBP3 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10479793 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479793 Reactome R-XTR-351141 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-351141.1 1 Reactome Database ID Release 82 10479795 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479795 Reactome R-XTR-442641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-442641.1 RAC2:GTP Reactome DB_ID: 10479801 1 rac2 RAC2 Q5M8J2 Reactome DB_ID: 10479799 UniProt:Q5M8J2 rac2 UniProt Q5M8J2 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10479799 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479799 Reactome R-XTR-195339 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-195339.1 1 Reactome Database ID Release 82 10479801 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479801 Reactome R-XTR-9014399 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9014399.1 RHOG:GTP Reactome DB_ID: 10479807 1 rhog RHOG A0A7D9NJV5 Reactome DB_ID: 10479805 UniProt:A0A7D9NJV5 rhog UniProt A0A7D9NJV5 1 EQUAL 188 EQUAL Reactome Database ID Release 82 10479805 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479805 Reactome R-XTR-194880 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-194880.1 1 Reactome Database ID Release 82 10479807 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479807 Reactome R-XTR-9014437 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9014437.1 Reactome Database ID Release 82 10479809 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479809 Reactome R-XTR-9615275 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9615275.1 RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha Reactome DB_ID: 10479819 1 1 Reactome Database ID Release 82 10479819 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479819 Reactome R-XTR-114540 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-114540.1 Reactome Database ID Release 82 10479821 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479821 Reactome R-XTR-114542 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-114542.1 PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation. 8645157 Pubmed 1996 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase Bokoch, GM Vlahos, CJ Wang, Y Knaus, UG Traynor-Kaplan, AE Biochem J 315:775-9 7744773 Pubmed 1995 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation Kovacsovics, TJ Bachelot, C Toker, A Vlahos, CJ Duckworth, B Cantley, Lewis C Hartwig, JH J Biol Chem 270:11358-66 11803464 Pubmed 2002 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB Murga, C Zohar, M Teramoto, H Gutkind, JS Oncogene 21:207-16 7627555 Pubmed 1995 PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase Hawkins, PT Eguinoa, A Qiu, RG Stokoe, D Cooke, FT Walters, R Wennström, S Claesson-Welsh, Lena Evans, T Symons, M Curr Biol 5:393-403 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 2.7.1.153 PI3K phosphorylates PIP2 to PIP3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 PIP2 PI(4,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Phosphatidylinositol-4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate Reactome DB_ID: 179856 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonatooxy)cyclohexyl phosphate ChEBI CHEBI:58456 Reactome Database ID Release 82 179856 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179856 Reactome R-ALL-179856 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179856.4 COMPOUND C04637 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 PIP3 PI(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Phosphatidylinositol-3,4,5-trisphosphate Reactome DB_ID: 179838 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ChEBI CHEBI:57836 Reactome Database ID Release 82 179838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179838 Reactome R-ALL-179838 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179838.4 COMPOUND C05981 ACTIVATION Converted from EntitySet in Reactome Activator:PI3K Reactome DB_ID: 10524217 PI3K:p-KIT:sSCF dimer:p-KIT Reactome DB_ID: 10489996 1 p-7Y-KIT:sSCF dimer:p-7Y-KIT Reactome DB_ID: 10489970 sSCF dimer Reactome DB_ID: 10489947 extracellular region GENE ONTOLOGY GO:0005576 kitlg KITLG-1(26-190) A0A6I8RID7 Reactome DB_ID: 10489945 UniProt:A0A6I8RID7 kitlg UniProt A0A6I8RID7 26 EQUAL 190 EQUAL Reactome Database ID Release 82 10489945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489945 Reactome R-XTR-708330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-708330.1 2 Reactome Database ID Release 82 10489947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489947 Reactome R-XTR-1433307 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1433307.1 1 A0A6I8RIL9 phospho-p-7Y-KIT Reactome DB_ID: 10489968 UniProt:A0A6I8RIL9 UniProt A0A6I8RIL9 568 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 570 EQUAL 703 EQUAL 721 EQUAL 730 EQUAL 823 EQUAL 936 EQUAL 26 EQUAL 976 EQUAL Reactome Database ID Release 82 10489968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489968 Reactome R-XTR-205207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205207.1 2 Reactome Database ID Release 82 10489970 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489970 Reactome R-XTR-205310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205310.1 1 Reactome Database ID Release 82 10489996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489996 Reactome R-XTR-205177 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205177.1 CD28:PI3K Reactome DB_ID: 10496976 1 phospho CD28:B7-1/B7-2 Reactome DB_ID: 10496906 Converted from EntitySet in Reactome B7-1 homodimer/ B7-2 Reactome DB_ID: 10496878 CD80 dimer Reactome DB_ID: 10496876 cd86 CD80 A0A803K1Y5 Reactome DB_ID: 10496874 UniProt:A0A803K1Y5 cd86 UniProt A0A803K1Y5 35 EQUAL 288 EQUAL Reactome Database ID Release 82 10496874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496874 Reactome R-XTR-179789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179789.1 2 Reactome Database ID Release 82 10496876 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496876 Reactome R-XTR-179787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179787.1 cd86 CD86 A0A803K1Y5 Reactome DB_ID: 10496868 24 EQUAL 329 EQUAL Reactome Database ID Release 82 10496868 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496868 Reactome R-XTR-179784 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179784.1 Reactome Database ID Release 82 10496878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496878 Reactome R-XTR-388762 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388762.1 1 Phospho CD28 homodimer Reactome DB_ID: 10496902 Converted from EntitySet in Reactome Homologues of p-Y191-CD28 Reactome DB_ID: 10496900 A0A6I8PU10 phospho-p-Y191-CD28 Reactome DB_ID: 10496895 UniProt:A0A6I8PU10 UniProt A0A6I8PU10 191 EQUAL 19 EQUAL 220 EQUAL Reactome Database ID Release 82 10496895 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496895 Reactome R-XTR-388756 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388756.1 A0A6I8RD47 phospho-ctla4 p-Y191-CD28 Reactome DB_ID: 10496898 UniProt:A0A6I8RD47 ctla4 UniProt A0A6I8RD47 191 EQUAL 19 EQUAL 220 EQUAL Reactome Database ID Release 82 10496898 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496898 Reactome R-XTR-388756-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388756-2.1 Reactome Database ID Release 82 10496900 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496900 Reactome R-XTR-388756-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388756-3.1 2 Reactome Database ID Release 82 10496902 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496902 Reactome R-XTR-388778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388778.1 1 Converted from EntitySet in Reactome FYN,LCK Reactome DB_ID: 10496904 FYN A0A6I8RIV6 Reactome DB_ID: 10479979 UniProt:A0A6I8RIV6 UniProt A0A6I8RIV6 2 EQUAL 537 EQUAL Reactome Database ID Release 82 10479979 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479979 Reactome R-XTR-200917 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-200917.1 LCK A0A7D9NMC7 Reactome DB_ID: 10488837 UniProt:A0A7D9NMC7 UniProt A0A7D9NMC7 1 EQUAL 509 EQUAL Reactome Database ID Release 82 10488837 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10488837 Reactome R-XTR-167609 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-167609.1 Reactome Database ID Release 82 10496904 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496904 Reactome R-XTR-2395419 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2395419.1 2 Reactome Database ID Release 82 10496906 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496906 Reactome R-XTR-388777 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388777.1 1 Reactome Database ID Release 82 10496976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496976 Reactome R-XTR-388783 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388783.1 PDGF:Phospho-PDGF receptor dimer:PI3K Reactome DB_ID: 10485162 PI3K Reactome DB_ID: 10477057 Converted from EntitySet in Reactome PI3K-regulatory subunit Reactome DB_ID: 10477045 Reactome Database ID Release 82 10477045 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477045 Reactome R-XTR-74688 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74688.1 1 Converted from EntitySet in Reactome PI3K-catalytic subunit Reactome DB_ID: 10477055 pik3cb PIK3CB A0A6I8RCH0 Reactome DB_ID: 10477053 UniProt:A0A6I8RCH0 pik3cb UniProt A0A6I8RCH0 1 EQUAL 1070 EQUAL Reactome Database ID Release 82 10477053 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477053 Reactome R-XTR-74788 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74788.1 Reactome Database ID Release 82 10477055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477055 Reactome R-XTR-74689 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74689.1 1 Reactome Database ID Release 82 10477057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477057 Reactome R-XTR-74693 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74693.1 1 PDGF:Phospho-PDGF receptor dimer Reactome DB_ID: 10485124 Converted from EntitySet in Reactome Phospho- PDGF receptor dimer Reactome DB_ID: 10485102 Phospho-alpha receptor homodimer Reactome DB_ID: 10485080 A4IHL2 phospho-p-11Y-PDGFRA Reactome DB_ID: 10485078 UniProt:A4IHL2 UniProt A4IHL2 1018 EQUAL 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10485078 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485078 Reactome R-XTR-186806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186806.1 2 Reactome Database ID Release 82 10485080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485080 Reactome R-XTR-186816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186816.1 Phospho-alpha-Phospho-beta receptor heterodimer Reactome DB_ID: 10485098 1 A0A6I8SLH0 phospho-p-12Y-PDGFRB Reactome DB_ID: 10485096 UniProt:A0A6I8SLH0 UniProt A0A6I8SLH0 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10485096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485096 Reactome R-XTR-186803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186803.1 1 Reactome Database ID Release 82 10485098 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485098 Reactome R-XTR-186769 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186769.1 Phospho-beta receptor homodimer Reactome DB_ID: 10485100 2 Reactome Database ID Release 82 10485100 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485100 Reactome R-XTR-186805 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186805.1 Reactome Database ID Release 82 10485102 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485102 Reactome R-XTR-186821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186821.1 1 Converted from EntitySet in Reactome Active PDGF dimers (AA, AB, BB) Reactome DB_ID: 10485122 active PDGF-AA dimer Reactome DB_ID: 10485110 pdgfa PDGFA-1 A0A6I8Q0E4 Reactome DB_ID: 10485106 UniProt:A0A6I8Q0E4 pdgfa UniProt A0A6I8Q0E4 87 EQUAL 211 EQUAL Reactome Database ID Release 82 10485106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485106 Reactome R-XTR-184199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-184199.1 2 Reactome Database ID Release 82 10485110 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485110 Reactome R-XTR-380761 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-380761.1 active PDGF-BB dimer Reactome DB_ID: 10485118 pdgfb PDGFB (82-190) B1H1E3 Reactome DB_ID: 10485114 UniProt:B1H1E3 pdgfb UniProt B1H1E3 82 EQUAL 190 EQUAL Reactome Database ID Release 82 10485114 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485114 Reactome R-XTR-184201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-184201.1 2 Reactome Database ID Release 82 10485118 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485118 Reactome R-XTR-184206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-184206.1 PDGF A/B heterodimer Reactome DB_ID: 10485120 pdgfa PDGFA-2 A0A6I8Q0E4 Reactome DB_ID: 10485108 87 EQUAL 196 EQUAL Reactome Database ID Release 82 10485108 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485108 Reactome R-XTR-380739 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-380739.1 1 1 Reactome Database ID Release 82 10485120 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485120 Reactome R-XTR-380759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-380759.1 Reactome Database ID Release 82 10485122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485122 Reactome R-XTR-380760 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-380760.1 1 Reactome Database ID Release 82 10485124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485124 Reactome R-XTR-186811 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186811.1 1 Reactome Database ID Release 82 10485162 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10485162 Reactome R-XTR-186789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-186789.1 PI3K bound to TRAT Reactome DB_ID: 10488826 A0A803JAJ6 phospho-p-Y63,Y79,Y110-TRAT1 Reactome DB_ID: 10488824 UniProt:A0A803JAJ6 UniProt A0A803JAJ6 63 EQUAL 79 EQUAL 110 EQUAL 1 EQUAL 186 EQUAL Reactome Database ID Release 82 10488824 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10488824 Reactome R-XTR-202201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-202201.1 1 1 Reactome Database ID Release 82 10488826 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10488826 Reactome R-XTR-202283 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-202283.1 Phospho-IRS1/2:PI3K(p85:p110) Reactome DB_ID: 10487031 1 Converted from EntitySet in Reactome Phospho-IRS1/2 (by TRKA) Reactome DB_ID: 10487029 p-Y-IRS1 phospho-irs1 A0A6I8RNK3 Reactome DB_ID: 10487025 UniProt:A0A6I8RNK3 irs1 UniProt A0A6I8RNK3 1 EQUAL 1242 EQUAL Reactome Database ID Release 82 10487025 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10487025 Reactome R-XTR-198366 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198366.1 p-Y-IRS2 phospho-LOC100498409 A0A803JX40 Reactome DB_ID: 10487027 UniProt:A0A803JX40 LOC100498409 UniProt A0A803JX40 1 EQUAL 1338 EQUAL Reactome Database ID Release 82 10487027 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10487027 Reactome R-XTR-198334 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198334.1 Reactome Database ID Release 82 10487029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10487029 Reactome R-XTR-198369 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198369.1 1 Reactome Database ID Release 82 10487031 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10487031 Reactome R-XTR-198344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198344.1 EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K Reactome DB_ID: 10513719 EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10513717 EGF:p-EGFR:p-ERBB2:GRB2:GAB1 Reactome DB_ID: 10513715 Converted from EntitySet in Reactome Phosphorylated ERBB2:EGFR heterodimers Reactome DB_ID: 10513713 EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 Reactome DB_ID: 10512958 EGF:p-6Y-EGFR Reactome DB_ID: 10512947 egf EGF F7BYK2 Reactome DB_ID: 10484690 UniProt:F7BYK2 egf UniProt F7BYK2 971 EQUAL 1023 EQUAL Reactome Database ID Release 82 10484690 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484690 Reactome R-XTR-179863 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179863.1 1 A0A6I8T106 phospho-p-6Y-EGFR Reactome DB_ID: 10484743 UniProt:A0A6I8T106 UniProt A0A6I8T106 992 EQUAL 1045 EQUAL 1068 EQUAL 1086 EQUAL 1148 EQUAL 1173 EQUAL 25 EQUAL 1210 EQUAL Reactome Database ID Release 82 10484743 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484743 Reactome R-XTR-179803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179803.1 1 Reactome Database ID Release 82 10512947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512947 Reactome R-XTR-1248702 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248702.1 1 A0A6I8S7Y3 phospho-p-6Y,Y1112-ERBB2 Reactome DB_ID: 10512956 UniProt:A0A6I8S7Y3 UniProt A0A6I8S7Y3 1023 EQUAL 1112 EQUAL 1139 EQUAL 1196 EQUAL 1221 EQUAL 1222 EQUAL 1248 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512956 Reactome R-XTR-8864081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8864081.1 1 Reactome Database ID Release 82 10512958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512958 Reactome R-XTR-1963593 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963593.1 EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 Reactome DB_ID: 10512992 1 A0A6I8S7Y3 phospho-p-7Y,Y1112-ERBB2 Reactome DB_ID: 10512990 877 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512990 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512990 Reactome R-XTR-8864079 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8864079.1 1 Reactome Database ID Release 82 10512992 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512992 Reactome R-XTR-1248703 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248703.1 Reactome Database ID Release 82 10513713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513713 Reactome R-XTR-1963587 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963587.1 1 GRB2:GAB1 Reactome DB_ID: 10513711 grb2 GRB2-1 Q66II3 Reactome DB_ID: 10477025 UniProt:Q66II3 grb2 UniProt Q66II3 1 EQUAL 217 EQUAL Reactome Database ID Release 82 10477025 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10477025 Reactome R-XTR-74686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74686.1 1 Ghost homologue of GAB1 Reactome DB_ID: 10478401 Reactome Database ID Release 82 10478401 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478401 Reactome R-XTR-179795 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179795.1 1 Reactome Database ID Release 82 10513711 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513711 Reactome R-XTR-179849 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179849.1 1 Reactome Database ID Release 82 10513715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513715 Reactome R-XTR-1306958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1306958.1 1 pik3r1 PIK3R1 F6Z0J4 Reactome DB_ID: 10512939 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10512939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512939 Reactome R-XTR-198365 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-198365.1 1 Reactome Database ID Release 82 10513717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513717 Reactome R-XTR-1306962 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1306962.1 1 1 Reactome Database ID Release 82 10513719 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513719 Reactome R-XTR-1306961 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1306961.1 NRG1/2:p-ERBB3:p-ERBB2:PI3K Reactome DB_ID: 10512943 NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 Reactome DB_ID: 10512941 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB3 heterodimers Reactome DB_ID: 10512937 NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 Reactome DB_ID: 10512930 NRG1/2:p-10Y-ERBB3 Reactome DB_ID: 10512925 A0A6I8QFE8 phospho-p-10Y-ERBB3-1 Reactome DB_ID: 10512923 UniProt:A0A6I8QFE8 UniProt A0A6I8QFE8 1328 EQUAL 1054 EQUAL 1197 EQUAL 1199 EQUAL 1222 EQUAL 1224 EQUAL 1260 EQUAL 1262 EQUAL 1276 EQUAL 1289 EQUAL 20 EQUAL 1342 EQUAL Reactome Database ID Release 82 10512923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512923 Reactome R-XTR-1248742 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248742.1 1 nrg1 NRG1 A0A803JV31 Reactome DB_ID: 10512377 UniProt:A0A803JV31 nrg1 UniProt A0A803JV31 20 EQUAL 241 EQUAL Reactome Database ID Release 82 10512377 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512377 Reactome R-XTR-1227951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1227951.1 1 Reactome Database ID Release 82 10512925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512925 Reactome R-XTR-1248743 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248743.1 1 A0A6I8S7Y3 phospho-p-Y-ERBB2 Reactome DB_ID: 10512928 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512928 Reactome R-XTR-1678589 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1678589.1 1 Reactome Database ID Release 82 10512930 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512930 Reactome R-XTR-1963583 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963583.1 NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 Reactome DB_ID: 10512935 1 A0A6I8S7Y3 phospho-p-Y,Y877-ERBB2 Reactome DB_ID: 10512933 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512933 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512933 Reactome R-XTR-1810446 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1810446.1 1 Reactome Database ID Release 82 10512935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512935 Reactome R-XTR-1248749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248749.1 Reactome Database ID Release 82 10512937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512937 Reactome R-XTR-1963572 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963572.1 1 Reactome Database ID Release 82 10512941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512941 Reactome R-XTR-1250191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250191.1 1 1 Reactome Database ID Release 82 10512943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512943 Reactome R-XTR-1250508 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250508.1 NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K Reactome DB_ID: 10513044 PIK3CA:PIK3R1 Reactome DB_ID: 10484769 1 1 Reactome Database ID Release 82 10484769 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484769 Reactome R-XTR-1806218 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806218.1 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB4cyt1 heterodimers Reactome DB_ID: 10513042 NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 Reactome DB_ID: 10512984 A0A6I8S7Y3 phospho-p-6Y-ERBB2 Reactome DB_ID: 10512966 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512966 Reactome R-XTR-1963569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963569.1 1 NRGs/EGF-like ligands:p-ERBB4cyt1 Reactome DB_ID: 10512982 Converted from EntitySet in Reactome NRGs/EGF-like ligands Neuregulins/EGF-like ligands Reactome DB_ID: 10512385 hbegf HBEGF(63-148) A0A803JN16 Reactome DB_ID: 10484702 UniProt:A0A803JN16 hbegf UniProt A0A803JN16 63 EQUAL 148 EQUAL Reactome Database ID Release 82 10484702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484702 Reactome R-XTR-1233234 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1233234.1 Converted from EntitySet in Reactome NRG1/2/3/4 Neuregulins Reactome DB_ID: 10512383 nrg3 NRG3 A8E4T7 Reactome DB_ID: 10512381 UniProt:A8E4T7 nrg3 UniProt A8E4T7 1 EQUAL 359 EQUAL Reactome Database ID Release 82 10512381 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512381 Reactome R-XTR-1227943 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1227943.1 Reactome Database ID Release 82 10512383 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512383 Reactome R-XTR-1227957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1227957.1 Reactome Database ID Release 82 10512385 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512385 Reactome R-XTR-1233236 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1233236.1 1 Converted from EntitySet in Reactome p-ERBB4cyt1 Reactome DB_ID: 10512980 A0A6I8SHJ1 phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform Reactome DB_ID: 10512973 UniProt:A0A6I8SHJ1 UniProt A0A6I8SHJ1 1056 EQUAL 1188 EQUAL 1242 EQUAL 26 EQUAL 1308 EQUAL Reactome Database ID Release 82 10512973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512973 Reactome R-XTR-1250319 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250319.1 A0A6I8SHJ1 phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform Reactome DB_ID: 10512978 1046 EQUAL 1178 EQUAL 1232 EQUAL 26 EQUAL 1298 EQUAL Reactome Database ID Release 82 10512978 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512978 Reactome R-XTR-1250313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250313.1 Reactome Database ID Release 82 10512980 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512980 Reactome R-XTR-1250325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250325.1 1 Reactome Database ID Release 82 10512982 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512982 Reactome R-XTR-1250305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250305.1 1 Reactome Database ID Release 82 10512984 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512984 Reactome R-XTR-1250316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250316.1 NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 Reactome DB_ID: 10512996 A0A6I8S7Y3 phospho-p-7Y-ERBB2 Reactome DB_ID: 10512994 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10512994 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512994 Reactome R-XTR-1248698 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1248698.1 1 1 Reactome Database ID Release 82 10512996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10512996 Reactome R-XTR-1963579 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963579.1 Reactome Database ID Release 82 10513042 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513042 Reactome R-XTR-1963568 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1963568.1 1 Reactome Database ID Release 82 10513044 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513044 Reactome R-XTR-1306974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1306974.1 PI3K:p-ERBB4cyt1 Reactome DB_ID: 10513048 1 Converted from EntitySet in Reactome p-ERBB4cyt1 homodimers Phosphorylated ERBB4cyt1 homodimers Reactome DB_ID: 10513035 p-ERBB4jmAcyt1 Reactome DB_ID: 10513029 NRGs/EGF-like ligands:P-ERBB4jmAcyt1 Reactome DB_ID: 10513027 1 1 Reactome Database ID Release 82 10513027 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513027 Reactome R-XTR-1251957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1251957.1 2 Reactome Database ID Release 82 10513029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513029 Reactome R-XTR-1251953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1251953.1 p-ERBB4jmBcyt1 Reactome DB_ID: 10513033 NRGs/EGF-like ligands:P-ERBB4jmBcyt1 Reactome DB_ID: 10513031 1 1 Reactome Database ID Release 82 10513031 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513031 Reactome R-XTR-1251958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1251958.1 2 Reactome Database ID Release 82 10513033 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513033 Reactome R-XTR-1251954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1251954.1 Reactome Database ID Release 82 10513035 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513035 Reactome R-XTR-1250351 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250351.1 1 Reactome Database ID Release 82 10513048 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10513048 Reactome R-XTR-1250373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1250373.1 EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K Reactome DB_ID: 10484771 1 EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 Reactome DB_ID: 10484747 Ghost homologue of GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 Reactome DB_ID: 10484735 Reactome Database ID Release 82 10484735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484735 Reactome R-XTR-9038398 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9038398.1 1 EGF-like ligands:p-6Y EGFR dimer Reactome DB_ID: 10484745 Converted from EntitySet in Reactome EGF-like ligands Reactome DB_ID: 10484704 tgfa TGFA(24-98) F7AZ90 Reactome DB_ID: 10484694 UniProt:F7AZ90 tgfa UniProt F7AZ90 24 EQUAL 98 EQUAL Reactome Database ID Release 82 10484694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484694 Reactome R-XTR-9624183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9624183.1 areg AREG(101-187) F6VBJ9 Reactome DB_ID: 10484698 UniProt:F6VBJ9 areg UniProt F6VBJ9 101 EQUAL 187 EQUAL Reactome Database ID Release 82 10484698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484698 Reactome R-XTR-9624190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9624190.1 Reactome Database ID Release 82 10484704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484704 Reactome R-XTR-9624194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9624194.1 2 2 Reactome Database ID Release 82 10484745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484745 Reactome R-XTR-9624425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9624425.1 1 Reactome Database ID Release 82 10484747 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484747 Reactome R-XTR-180286 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-180286.1 1 Reactome Database ID Release 82 10484771 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10484771 Reactome R-XTR-179791 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179791.1 ICOS:PI3K Reactome DB_ID: 10496967 1 A0A6I8RF66 phospho-LOC100493997 p-Y180-ICOS Reactome DB_ID: 10496965 UniProt:A0A6I8RF66 LOC100493997 UniProt A0A6I8RF66 180 EQUAL 21 EQUAL 199 EQUAL Reactome Database ID Release 82 10496965 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496965 Reactome R-XTR-389927 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389927.1 1 Reactome Database ID Release 82 10496967 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496967 Reactome R-XTR-388785 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-388785.1 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10524145 Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524143 Activated FGFR1:p-FRS2 Reactome DB_ID: 10524141 Converted from EntitySet in Reactome Activated FGFR1 Reactome DB_ID: 10524139 Activated FGFR1b homodimer Reactome DB_ID: 10478435 p-8Y-FGFR1b dimer Reactome DB_ID: 10478433 A0A6I8SQF5 phospho-p-8Y-FGFR1b Reactome DB_ID: 10478431 UniProt:A0A6I8SQF5 UniProt A0A6I8SQF5 463 EQUAL 583 EQUAL 585 EQUAL 653 EQUAL 654 EQUAL 730 EQUAL 766 EQUAL 776 EQUAL 2 EQUAL 822 EQUAL Reactome Database ID Release 82 10478431 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478431 Reactome R-XTR-5656338 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5656338.1 2 Reactome Database ID Release 82 10478433 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478433 Reactome R-XTR-5656340 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5656340.1 1 Converted from EntitySet in Reactome FGFR1b-binding FGFs Reactome DB_ID: 10478419 FGF1 foxb1 F6XYE3 Reactome DB_ID: 10478405 UniProt:F6XYE3 foxb1 UniProt F6XYE3 16 EQUAL 155 EQUAL Reactome Database ID Release 82 10478405 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478405 Reactome R-XTR-189856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189856.1 fgf2 FGF2(10-155) Q28DZ3 Reactome DB_ID: 10478409 UniProt:Q28DZ3 fgf2 UniProt Q28DZ3 10 EQUAL 155 EQUAL Reactome Database ID Release 82 10478409 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478409 Reactome R-XTR-189898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189898.1 FGF3 A0A803JX46 Reactome DB_ID: 10478413 UniProt:A0A803JX46 UniProt A0A803JX46 18 EQUAL 239 EQUAL Reactome Database ID Release 82 10478413 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478413 Reactome R-XTR-189886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189886.1 fgf22 FGF22 B7UC02 Reactome DB_ID: 10478417 UniProt:B7UC02 fgf22 UniProt B7UC02 23 EQUAL 170 EQUAL Reactome Database ID Release 82 10478417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478417 Reactome R-XTR-189877 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189877.1 Reactome Database ID Release 82 10478419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478419 Reactome R-XTR-189963 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189963.1 2 HS Heparan Sulphate heparan sulfate Reactome DB_ID: 190915 heparan sulfate [ChEBI:28815] heparan sulfate N-Acetylheparan sulfate Heparin monosulfate Heparatan sulfate Heparitin monosulfate Heparan sulphate Heparan N-sulfate Heparitin sulfate Heparin sulfate ChEBI CHEBI:28815 Reactome Database ID Release 82 190915 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190915 Reactome R-ALL-190915 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-190915.3 1 Reactome Database ID Release 82 10478435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478435 Reactome R-XTR-190430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190430.1 Activated FGFR1c homodimer Reactome DB_ID: 10478468 A0A6I8SQF5 phospho-p-8Y-FGFR1c Reactome DB_ID: 10478466 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10478466 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478466 Reactome R-XTR-190434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190434.1 2 1 Converted from EntitySet in Reactome FGFR1c-binding FGFs Reactome DB_ID: 10478464 fgf4 FGF4 B7U3X7 Reactome DB_ID: 10478439 UniProt:B7U3X7 fgf4 UniProt B7U3X7 31 EQUAL 206 EQUAL Reactome Database ID Release 82 10478439 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478439 Reactome R-XTR-189907 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189907.1 fgf5 FGF5-1 A0A803J293 Reactome DB_ID: 10478443 UniProt:A0A803J293 fgf5 UniProt A0A803J293 18 EQUAL 268 EQUAL Reactome Database ID Release 82 10478443 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478443 Reactome R-XTR-189903 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189903.1 fgf8 FGF8-1 F6V070 Reactome DB_ID: 10478449 UniProt:F6V070 fgf8 UniProt F6V070 23 EQUAL 233 EQUAL Reactome Database ID Release 82 10478449 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478449 Reactome R-XTR-189892 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189892.1 fgf9 FGF9 F6ZB49 Reactome DB_ID: 10478453 UniProt:F6ZB49 fgf9 UniProt F6ZB49 4 EQUAL 208 EQUAL Reactome Database ID Release 82 10478453 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478453 Reactome R-XTR-189870 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189870.1 fgf20 FGF20 F7BZ47 Reactome DB_ID: 10478457 UniProt:F7BZ47 fgf20 UniProt F7BZ47 1 EQUAL 211 EQUAL Reactome Database ID Release 82 10478457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478457 Reactome R-XTR-189862 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189862.1 fgf23.2 GalNAc-T178-FGF23(25-251) A0A6I8PM12 Reactome DB_ID: 10478462 UniProt:A0A6I8PM12 fgf23.2 UniProt A0A6I8PM12 178 EQUAL O-(N-acetylamino)galactosyl-L-threonine MOD MOD:00164 25 EQUAL 251 EQUAL Reactome Database ID Release 82 10478462 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478462 Reactome R-XTR-8851633 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8851633.1 Reactome Database ID Release 82 10478464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478464 Reactome R-XTR-189953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189953.1 2 Reactome Database ID Release 82 10478468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478468 Reactome R-XTR-190425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190425.1 Activated FGFR1c bound to FGF23:Klotho Reactome DB_ID: 10478488 2 1 Klotho bound to FGF23 Reactome DB_ID: 10478486 Klotho homodimer Reactome DB_ID: 10478484 Converted from EntitySet in Reactome Klotho Reactome DB_ID: 10478482 Membrane-bound Klotho homodimer Reactome DB_ID: 10478476 kl KL-1 A0A6I8SJT2 Reactome DB_ID: 10478474 UniProt:A0A6I8SJT2 kl UniProt A0A6I8SJT2 34 EQUAL 1012 EQUAL Reactome Database ID Release 82 10478474 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478474 Reactome R-XTR-190198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190198.1 2 Reactome Database ID Release 82 10478476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478476 Reactome R-XTR-190204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190204.1 Secreted Klotho homodimer Reactome DB_ID: 10478480 kl KL-2 A0A6I8SJT2 Reactome DB_ID: 10478478 34 EQUAL 549 EQUAL Reactome Database ID Release 82 10478478 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478478 Reactome R-XTR-190201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190201.1 2 Reactome Database ID Release 82 10478480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478480 Reactome R-XTR-190203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190203.1 Reactome Database ID Release 82 10478482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478482 Reactome R-XTR-190207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190207.1 2 Reactome Database ID Release 82 10478484 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478484 Reactome R-XTR-190309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190309.1 1 fgf23.2 FGF23(25-251) A0A6I8PM12 Reactome DB_ID: 10478470 25 EQUAL 251 EQUAL Reactome Database ID Release 82 10478470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478470 Reactome R-XTR-189891 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189891.1 1 Reactome Database ID Release 82 10478486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478486 Reactome R-XTR-190208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190208.1 2 Reactome Database ID Release 82 10478488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478488 Reactome R-XTR-500333 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-500333.1 Reactome Database ID Release 82 10524139 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524139 Reactome R-XTR-5654170 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654170.1 1 B5DE89 phospho-frs2 p-6Y-FRS2 Reactome DB_ID: 10478607 UniProt:B5DE89 frs2 UniProt B5DE89 436 EQUAL 196 EQUAL 306 EQUAL 349 EQUAL 392 EQUAL 471 EQUAL 1 EQUAL 508 EQUAL Reactome Database ID Release 82 10478607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478607 Reactome R-XTR-170959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-170959.1 1 Reactome Database ID Release 82 10524141 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524141 Reactome R-XTR-5654200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654200.1 1 GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524137 1 1 Reactome Database ID Release 82 10524137 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524137 Reactome R-XTR-179864 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179864.1 1 Reactome Database ID Release 82 10524143 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524143 Reactome R-XTR-5654186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654186.1 1 1 Reactome Database ID Release 82 10524145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524145 Reactome R-XTR-5654205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654205.1 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10524153 Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524151 Activated FGFR2:p-FRS2 Reactome DB_ID: 10524149 Converted from EntitySet in Reactome Activated FGFR2 Reactome DB_ID: 10524147 Converted from EntitySet in Reactome Activated FGFR2b homodimer bound to FGF Reactome DB_ID: 10478521 Activated FGFR2b long homodimer Reactome DB_ID: 10478508 Converted from EntitySet in Reactome FGFR2b-binding FGFs Reactome DB_ID: 10478494 fgf7 FGF7 Q5M7N7 Reactome DB_ID: 10478492 UniProt:Q5M7N7 fgf7 UniProt Q5M7N7 32 EQUAL 194 EQUAL Reactome Database ID Release 82 10478492 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478492 Reactome R-XTR-189884 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189884.1 Reactome Database ID Release 82 10478494 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478494 Reactome R-XTR-189967 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189967.1 2 A0A6I8QAJ2 phospho-p-8Y-FGFR2-3 Reactome DB_ID: 10478506 UniProt:A0A6I8QAJ2 UniProt A0A6I8QAJ2 467 EQUAL 587 EQUAL 589 EQUAL 657 EQUAL 658 EQUAL 734 EQUAL 770 EQUAL 780 EQUAL 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10478506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478506 Reactome R-XTR-190412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190412.1 2 1 Reactome Database ID Release 82 10478508 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478508 Reactome R-XTR-190411 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190411.1 Activated FGFR2b short homodimer bound to FGF Reactome DB_ID: 10478519 2 1 A0A6I8QAJ2 phospho-Phosphorylated Fibroblast growth factor receptor 2b short Reactome DB_ID: 10478517 465 EQUAL 585 EQUAL 655 EQUAL 656 EQUAL 732 EQUAL 768 EQUAL 778 EQUAL 22 EQUAL 820 EQUAL Reactome Database ID Release 82 10478517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478517 Reactome R-XTR-192603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192603.1 2 Reactome Database ID Release 82 10478519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478519 Reactome R-XTR-192597 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192597.1 Reactome Database ID Release 82 10478521 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478521 Reactome R-XTR-192606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192606.1 Converted from EntitySet in Reactome Activated FGFR2c homodimer bound to FGF Reactome DB_ID: 10478548 Activated FGFR2c long homodimer Reactome DB_ID: 10478537 A0A6I8QAJ2 phospho-p-8Y-FGFR2c long Reactome DB_ID: 10478535 466 EQUAL 586 EQUAL 588 EQUAL 733 EQUAL 769 EQUAL 779 EQUAL 22 EQUAL 821 EQUAL Reactome Database ID Release 82 10478535 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478535 Reactome R-XTR-190416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190416.1 2 1 Converted from EntitySet in Reactome FGFR2c-binding FGFs Reactome DB_ID: 10478527 fgf16 FGF16 A0A6I8QXV8 Reactome DB_ID: 10478525 UniProt:A0A6I8QXV8 fgf16 UniProt A0A6I8QXV8 1 EQUAL 207 EQUAL Reactome Database ID Release 82 10478525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478525 Reactome R-XTR-189918 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189918.1 Reactome Database ID Release 82 10478527 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478527 Reactome R-XTR-189957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189957.1 2 Reactome Database ID Release 82 10478537 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478537 Reactome R-XTR-190418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190418.1 Activated FGFR2c short homodimer bound to FGF Reactome DB_ID: 10478546 A0A6I8QAJ2 phospho-p-8Y-FGFR2-5 Reactome DB_ID: 10478544 464 EQUAL 584 EQUAL 654 EQUAL 731 EQUAL 767 EQUAL 22 EQUAL 819 EQUAL Reactome Database ID Release 82 10478544 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478544 Reactome R-XTR-192600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192600.1 2 1 2 Reactome Database ID Release 82 10478546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478546 Reactome R-XTR-192592 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192592.1 Reactome Database ID Release 82 10478548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478548 Reactome R-XTR-192616 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-192616.1 Reactome Database ID Release 82 10524147 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524147 Reactome R-XTR-5654152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654152.1 1 1 Reactome Database ID Release 82 10524149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524149 Reactome R-XTR-5654201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654201.1 1 1 Reactome Database ID Release 82 10524151 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524151 Reactome R-XTR-5654189 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654189.1 1 1 Reactome Database ID Release 82 10524153 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524153 Reactome R-XTR-5654190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654190.1 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10524161 Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524159 1 Activated FGFR3:p-FRS2 Reactome DB_ID: 10524157 Converted from EntitySet in Reactome Activated FGFR3 Reactome DB_ID: 10524155 Activated FGFR3b homodimer Reactome DB_ID: 10478562 Converted from EntitySet in Reactome FGFR3b-binding FGFs Reactome DB_ID: 10478550 Reactome Database ID Release 82 10478550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478550 Reactome R-XTR-189964 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189964.1 2 1 A0A6I8RGZ1 phospho-p-6Y-FGFR3b Reactome DB_ID: 10478560 UniProt:A0A6I8RGZ1 UniProt A0A6I8RGZ1 579 EQUAL 649 EQUAL 650 EQUAL 726 EQUAL 762 EQUAL 772 EQUAL 23 EQUAL 806 EQUAL Reactome Database ID Release 82 10478560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478560 Reactome R-XTR-190384 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190384.1 2 Reactome Database ID Release 82 10478562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478562 Reactome R-XTR-190380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190380.1 Activated FGFR3c homodimer Reactome DB_ID: 10478572 1 2 A0A6I8RGZ1 phospho-p-6Y-FGFR3c Reactome DB_ID: 10478570 577 EQUAL 647 EQUAL 648 EQUAL 724 EQUAL 760 EQUAL 770 EQUAL 23 EQUAL 808 EQUAL Reactome Database ID Release 82 10478570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478570 Reactome R-XTR-190382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190382.1 2 Reactome Database ID Release 82 10478572 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478572 Reactome R-XTR-190389 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190389.1 Reactome Database ID Release 82 10524155 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524155 Reactome R-XTR-5654146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654146.1 1 1 Reactome Database ID Release 82 10524157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524157 Reactome R-XTR-5654196 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654196.1 1 Reactome Database ID Release 82 10524159 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524159 Reactome R-XTR-5654203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654203.1 1 1 Reactome Database ID Release 82 10524161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524161 Reactome R-XTR-5654195 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654195.1 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10524169 Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524167 1 Activated FGFR4:p-FRS2 Reactome DB_ID: 10524165 Converted from EntitySet in Reactome Activated FGFR4 Reactome DB_ID: 10524163 Activated FGFR4 homodimer Reactome DB_ID: 10478589 1 Converted from EntitySet in Reactome FGFR4-binding FGFs Reactome DB_ID: 10478587 fgf19 FGF19 A0A803JCN9 Reactome DB_ID: 10478585 UniProt:A0A803JCN9 fgf19 UniProt A0A803JCN9 25 EQUAL 216 EQUAL Reactome Database ID Release 82 10478585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478585 Reactome R-XTR-189888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189888.1 Reactome Database ID Release 82 10478587 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478587 Reactome R-XTR-189959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-189959.1 2 F6VYS9 phospho-p-5Y-FGFR4 Reactome DB_ID: 10478581 UniProt:F6VYS9 UniProt F6VYS9 643 EQUAL 642 EQUAL 719 EQUAL 754 EQUAL 764 EQUAL 22 EQUAL 802 EQUAL Reactome Database ID Release 82 10478581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478581 Reactome R-XTR-190330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190330.1 2 Reactome Database ID Release 82 10478589 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478589 Reactome R-XTR-190328 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-190328.1 Activated FGFR4 bound to FGF19:BetaKlotho Reactome DB_ID: 10478595 klb KLB A0A6I8R8T1 Reactome DB_ID: 10478593 UniProt:A0A6I8R8T1 klb UniProt A0A6I8R8T1 1 EQUAL 1044 EQUAL Reactome Database ID Release 82 10478593 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478593 Reactome R-XTR-1307932 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1307932.1 2 2 2 Reactome Database ID Release 82 10478595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478595 Reactome R-XTR-1307958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1307958.1 Reactome Database ID Release 82 10524163 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524163 Reactome R-XTR-5654158 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654158.1 1 1 Reactome Database ID Release 82 10524165 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524165 Reactome R-XTR-5654193 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654193.1 1 Reactome Database ID Release 82 10524167 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524167 Reactome R-XTR-5654191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654191.1 1 1 Reactome Database ID Release 82 10524169 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524169 Reactome R-XTR-5654187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654187.1 Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10524175 1 Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524173 Activated FGFR1:p-FRS2:p-PTPN11 Reactome DB_ID: 10524171 A0A6I8Q7T1 phospho-p-Y546,Y584-PTPN11 Reactome DB_ID: 10478615 UniProt:A0A6I8Q7T1 UniProt A0A6I8Q7T1 546 EQUAL 584 EQUAL 1 EQUAL 597 EQUAL Reactome Database ID Release 82 10478615 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478615 Reactome R-XTR-162573 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-162573.1 1 1 Reactome Database ID Release 82 10524171 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524171 Reactome R-XTR-5654204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654204.1 1 1 Reactome Database ID Release 82 10524173 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524173 Reactome R-XTR-5654185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654185.1 1 Reactome Database ID Release 82 10524175 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524175 Reactome R-XTR-5654188 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654188.1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10524181 1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524179 Activated FGFR2:p-FRS2:p-PTPN11 Reactome DB_ID: 10524177 1 1 Reactome Database ID Release 82 10524177 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524177 Reactome R-XTR-5654184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654184.1 1 1 Reactome Database ID Release 82 10524179 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524179 Reactome R-XTR-5654194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654194.1 1 Reactome Database ID Release 82 10524181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524181 Reactome R-XTR-5654192 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654192.1 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10524187 1 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10524185 Activated FGFR3:p-FRS2:p-PTPN11 Reactome DB_ID: 10524183 1 1 Reactome Database ID Release 82 10524183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524183 Reactome R-XTR-5654198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654198.1 1 1 Reactome Database ID Release 82 10524185 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524185 Reactome R-XTR-5654199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654199.1 1 Reactome Database ID Release 82 10524187 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524187 Reactome R-XTR-5654197 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5654197.1 HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K Reactome DB_ID: 10524203 HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 Reactome DB_ID: 10524201 HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer Reactome DB_ID: 10524197 HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET Reactome DB_ID: 10524195 HGF dimer Reactome DB_ID: 10502439 hgf HGF(32-494) A0A6I8R680 Reactome DB_ID: 10502437 UniProt:A0A6I8R680 hgf UniProt A0A6I8R680 32 EQUAL 494 EQUAL Reactome Database ID Release 82 10502437 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502437 Reactome R-XTR-56497 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-56497.1 1 hgf HGF(495-728) A0A6I8R680 Reactome DB_ID: 10502435 495 EQUAL 728 EQUAL Reactome Database ID Release 82 10502435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502435 Reactome R-XTR-141767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-141767.1 1 Reactome Database ID Release 82 10502439 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10502439 Reactome R-XTR-141763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-141763.1 1 A0A6I8Q702 phospho-p-Y1234,Y1235,Y1349,Y1356-MET Reactome DB_ID: 10524193 UniProt:A0A6I8Q702 UniProt A0A6I8Q702 1234 EQUAL 1235 EQUAL 1349 EQUAL 1356 EQUAL 25 EQUAL 1390 EQUAL Reactome Database ID Release 82 10524193 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524193 Reactome R-XTR-6806973 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6806973.1 1 Reactome Database ID Release 82 10524195 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524195 Reactome R-XTR-6806975 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6806975.1 2 Reactome Database ID Release 82 10524197 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524197 Reactome R-XTR-6806977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6806977.1 1 Ghost homologue of p-5Y-GAB1 Reactome DB_ID: 10524199 Reactome Database ID Release 82 10524199 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524199 Reactome R-XTR-180344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-180344.1 1 1 Reactome Database ID Release 82 10524201 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524201 Reactome R-XTR-8851942 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8851942.1 1 1 Reactome Database ID Release 82 10524203 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524203 Reactome R-XTR-8851953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8851953.1 ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha Reactome DB_ID: 10524215 1 ESRs:STRN:ESTG:MyrG-pY419-SRC Reactome DB_ID: 10524213 ESRs:STRN:ESTG Reactome DB_ID: 10524211 Ghost homologue of ESRs Reactome DB_ID: 10524205 Reactome Database ID Release 82 10524205 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524205 Reactome R-XTR-9021045 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9021045.1 2 ESTG estrogen Reactome DB_ID: 9027649 estrogen [ChEBI:50114] estrogen ChEBI CHEBI:50114 Reactome Database ID Release 82 9027649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9027649 Reactome R-ALL-9027649 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9027649.3 2 strn STRN A0A6I8SGM2 Reactome DB_ID: 10524209 UniProt:A0A6I8SGM2 strn UniProt A0A6I8SGM2 1 EQUAL 780 EQUAL Reactome Database ID Release 82 10524209 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524209 Reactome R-XTR-9037081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9037081.1 2 Reactome Database ID Release 82 10524211 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524211 Reactome R-XTR-9027648 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9027648.1 1 F7DXH6 phospho-MyrG-p-Y419-SRC Reactome DB_ID: 10496370 UniProt:F7DXH6 UniProt F7DXH6 2 EQUAL N-myristoylglycine MOD MOD:00068 419 EQUAL 2 EQUAL 536 EQUAL Reactome Database ID Release 82 10496370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10496370 Reactome R-XTR-1810408 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1810408.1 1 Reactome Database ID Release 82 10524213 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524213 Reactome R-XTR-9021593 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9021593.1 1 Reactome Database ID Release 82 10524215 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524215 Reactome R-XTR-9021654 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9021654.1 Reactome Database ID Release 82 10524217 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524217 Reactome R-XTR-2316432 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2316432.1 GENE ONTOLOGY GO:0046934 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10524218 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524218 Reactome Database ID Release 82 10524220 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524220 Reactome R-XTR-2316434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2316434.1 GENE ONTOLOGY GO:0051897 gene ontology term for cellular process MI MI:0359 A number of different extracellular signals converge on PI3K activation. PI3K can be activated downstream of receptor tyrosine kinases (RTKs) such as FGFR (Ong et al. 2001, Eswarakumar et al. 2005), KIT (Chian et al. 2001, Ronnstrand 2004, Reber et al. 2006), PDGF (Coughlin et al. 1989, Fantl et al. 1992, Heldin et al. 1998), insulin receptor IGF1R (Hadari et al. 1992, Kooijman et al. 1995), and EGFR and its family members (Rodrigues et al. 2000, Jackson et al. 2004, Kainulainen et al. 2000, Junttila et al. 2009). Other proteins, such as CD28 (Pages et al. 1996, Koyasu 2003, Kane and Weiss, 2003) and TRAT1 (Bruyns et al. 1998, Koyasu 2003, Kolsch et al. 2006), can also trigger PI3K activity.<br><br>In unstimulated cells, PI3K class IA exists as an inactive heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). Binding of the iSH2 domain of the p85 regulatory subunit to the ABD and C2 domains of the p110 catalytic subunit both stabilizes p110 and inhibits its catalytic activity. This inhibition is relieved when the SH2 domains of p85 bind phosphorylated tyrosines on activated RTKs or their adaptor proteins. Binding to membrane-associated receptors brings activated PI3K in proximity to its membrane-localized substrate, PIP2 (Mandelker et al. 2009, Burke et al. 2011). 16612002 Pubmed 2006 Normal T-cell development and immune functions in TRIM-deficient mice Kolsch, U Arndt, B Reinhold, D Lindquist, JA Juling, N Kliche, S Pfeffer, K Bruyns, E Schraven, B Simeoni, L Mol Cell Biol 26:3639-48 10722704 Pubmed 2000 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis Kainulainen, V Sundvall, M Määttä, JA Santiestevan, E Klagsbrun, Michael Elenius, K J Biol Chem 275:8641-9 21827948 Pubmed 2011 Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110? Burke, John E Vadas, Oscar Berndt, Alex Finegan, Tara Perisic, O Williams, RL Structure 19:1127-37 11353842 Pubmed 2001 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH Hadari, YR Gotoh, N Guy, GR Schlessinger, J Lax, I Proc Natl Acad Sci U S A 98:6074-9 2466336 Pubmed 1989 Role of phosphatidylinositol kinase in PDGF receptor signal transduction Coughlin, SR Escobedo, JA Williams, LT Science 243:1191-4 16483568 Pubmed 2006 Stem cell factor and its receptor c-Kit as targets for inflammatory diseases Reber, L Da Silva, CA Frossard, N Eur J Pharmacol 533:327-40 10648629 Pubmed 2000 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA Falasca, M Zhang, Z Ong, SH Schlessinger, J Mol Cell Biol 20:1448-59 15526160 Pubmed 2004 Signal transduction via the stem cell factor receptor/c-Kit Rönnstrand, Lars Cell Mol Life Sci 61:2535-48 15059917 Pubmed 2004 Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects Jackson, JG St Clair, P Sliwkowski, MX Brattain, Michael G Cancer Res 64:2601-9 12660731 Pubmed 2003 The role of PI3K in immune cells Koyasu, S Nat Immunol 4:313-9 15863030 Pubmed 2005 Cellular signaling by fibroblast growth factor receptors Eswarakumar, VP Lax, I Schlessinger, J Cytokine Growth Factor Rev 16:139-49 8621607 Pubmed 1996 Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association Pagès, F Ragueneau, M Klasen, S Battifora, M Couez, D Sweet, R Truneh, A Ward, SG Olive, D J Biol Chem 271:9403-9 19411071 Pubmed 2009 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 Junttila, TT Akita, Robert W Parsons, K Fields, C Lewis Phillips, GD Friedman, LS Sampath, D Sliwkowski, MX Cancer Cell 15:429-40 1381348 Pubmed 1992 Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers Hadari, Yaron Tzahar, E Nadiv, Orna Rothenberg, Paul Roberts, Charles LeRoith, Derek Yarden, Y Zick, Yehiel J. Biol. Chem. 267:17483-6 11520784 Pubmed 2001 Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant Chian, R Young, S Danilkovitch-Miagkova, A Rönnstrand, Lars Leonard, E Ferrao, P Ashman, L Linnekin, D Blood 98:1365-73 9687533 Pubmed 1998 T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane Bruyns, E Marie-Cardine, A Kirchgessner, H Sagolla, K Shevchenko, A Mann, M Autschbach, F Bensussan, A Meuer, S Schraven, B J Exp Med 188:561-75 9739761 Pubmed 1998 Signal transduction via platelet-derived growth factor receptors Heldin, Carl-Henrik Ostman, A Rönnstrand, Lars Biochim Biophys Acta 1378:F79-113 19805105 Pubmed 2009 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane Mandelker, Diana Gabelli, Sandra B Schmidt-Kittler, Oleg Zhu, Jiuxiang Cheong, Ian Huang, Chuan-Hsiang Kinzler, KW Vogelstein, B Amzel, L Mario Proc. Natl. Acad. Sci. U.S.A. 106:16996-7001 7543144 Pubmed 1995 Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes Kooijman, Ron Lauf, Jeroen Kappers, Astrid Rijkers, Ger J. Exp. Med. 182:593-7 1374684 Pubmed 1992 Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Fantl, WJ Escobedo, JA Martin, GA Turck, CW del Rosario, M McCormick, F Williams, LT Cell 69:413-23 12670391 Pubmed 2003 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 Kane, LP Weiss, A Immunol Rev 192:7-20 LEFT-TO-RIGHT PIP3 recruits PDPK1 to the membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PDPK1 F6ZJI9 Reactome DB_ID: 10488724 UniProt:F6ZJI9 UniProt F6ZJI9 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10488724 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10488724 Reactome R-XTR-202210 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-202210.1 PDPK1:PIP3 Reactome DB_ID: 10478632 PDPK1 F6ZJI9 Reactome DB_ID: 10478630 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10478630 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478630 Reactome R-XTR-61459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-61459.1 1 1 Reactome Database ID Release 82 10478632 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10478632 Reactome R-XTR-109697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109697.1 Reactome Database ID Release 82 10524135 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10524135 Reactome R-XTR-2316429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2316429.1 PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999). 9895304 Pubmed 1999 Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Currie, RA Walker, KS Gray, A Deak, M Casamayor, A Downes, CP Cohen, P Alessi, DR Lucocq, J Biochem J 337:575-83 Negative regulation of the PI3K/AKT network This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.1.68 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI4P Phosphatidylinositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphates Reactome DB_ID: 392417 1-phosphatidyl-1D-myo-inositol 4-phosphate [ChEBI:17526] 1-phosphatidyl-1D-myo-inositol 4-phosphate ChEBI CHEBI:17526 Reactome Database ID Release 82 392417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392417 Reactome R-ALL-392417 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-392417.3 COMPOUND C01277 PubChem Substance 4496 ACTIVATION Converted from EntitySet in Reactome PIP5K1A-C Reactome DB_ID: 10516945 pip5k1b PIP5K1B A0A6I8Q3Y8 Reactome DB_ID: 10516939 UniProt:A0A6I8Q3Y8 pip5k1b UniProt A0A6I8Q3Y8 1 EQUAL 540 EQUAL Reactome Database ID Release 82 10516939 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516939 Reactome R-XTR-1806216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806216.1 pip5k1c PIP5K1C A0A6I8R1B8 Reactome DB_ID: 10516943 UniProt:A0A6I8R1B8 pip5k1c UniProt A0A6I8R1B8 1 EQUAL 668 EQUAL Reactome Database ID Release 82 10516943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516943 Reactome R-XTR-392427 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-392427.1 Reactome Database ID Release 82 10516945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516945 Reactome R-XTR-1806157 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806157.1 GENE ONTOLOGY GO:0016308 Reactome Database ID Release 82 10517185 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10517185 Reactome Database ID Release 82 10517187 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10517187 Reactome R-XTR-1676082 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1676082.1 At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).<br><br>This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007). 17245604 Pubmed 2007 Phospholipase D signaling: orchestration by PIP2 and small GTPases Oude Weernink, PA López de Jesús, M Schmidt, M Naunyn Schmiedebergs Arch Pharmacol 374:399-411 9211928 Pubmed 1997 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Zhang, Xiaoxuan Loijens, JC Boronenkov, IV Parker, GJ Norris, FA Chen, J Thum, O Prestwich, GD Majerus, PW Anderson, RA J Biol Chem 272:17756-61 16979564 Pubmed 2006 A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis Halstead, JR van Rheenen, J Snel, MH Meeuws, S Mohammed, S D'Santos, CS Heck, AJ Jalink, K Divecha, Nullin Curr Biol 16:1850-6 12422219 Pubmed 2002 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Di Paolo, G Pellegrini, L Letinic, K Cestra, G Zoncu, R Voronov, S Chang, S Guo, J Wenk, MR De Camilli, Pietro Nature 420:85-9 15464023 Pubmed 2004 Regulation and cellular roles of phosphoinositide 5-kinases Oude Weernink, PA Schmidt, M Jakobs, KH Eur J Pharmacol 500:87-99 LEFT-TO-RIGHT 2.7.1.149 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI5P 1-phosphatidyl-1D-myo-inositol 5-phosphate Reactome DB_ID: 1806240 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [ChEBI:57795] 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) 1-phosphatidyl-1D-myo-inositol 5-phosphate trianions a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3R,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonatooxy)cyclohexyl phosphate 1-phosphatidyl-1D-myo-inositol 5-phosphate trianion ChEBI CHEBI:57795 Reactome Database ID Release 82 1806240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240 Reactome R-ALL-1806240 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806240.4 ACTIVATION Converted from EntitySet in Reactome PIP4K2 dimers Reactome DB_ID: 10516974 PIP4K2A:PIP4K2A Reactome DB_ID: 10516954 B3DL88 pip4k2a PIP4K2A Reactome DB_ID: 10516952 UniProt:B3DL88 pip4k2a UniProt B3DL88 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10516952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516952 Reactome R-XTR-1604641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1604641.1 2 Reactome Database ID Release 82 10516954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516954 Reactome R-XTR-1806252 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806252.1 PIP4K2A:PIP4K2B Reactome DB_ID: 10516960 F7E1Q8 pip4k2b PIP4K2B Reactome DB_ID: 10516958 UniProt:F7E1Q8 pip4k2b UniProt F7E1Q8 1 EQUAL 416 EQUAL Reactome Database ID Release 82 10516958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516958 Reactome R-XTR-1806208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806208.1 1 1 Reactome Database ID Release 82 10516960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516960 Reactome R-XTR-1806183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806183.1 PIP4K2B:PIP4K2B Reactome DB_ID: 10516962 2 Reactome Database ID Release 82 10516962 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516962 Reactome R-XTR-1806168 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806168.1 PIP4K2A:PIP4K2C Reactome DB_ID: 10516968 pip4k2c PIP4K2C A0A6I8RJB1 Reactome DB_ID: 10516966 UniProt:A0A6I8RJB1 pip4k2c UniProt A0A6I8RJB1 2 EQUAL 421 EQUAL Reactome Database ID Release 82 10516966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516966 Reactome R-XTR-1604638 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1604638.1 1 1 Reactome Database ID Release 82 10516968 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516968 Reactome R-XTR-6808605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6808605.1 PIP4K2C:PIP4K2C Reactome DB_ID: 10516970 2 Reactome Database ID Release 82 10516970 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516970 Reactome R-XTR-6808604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6808604.1 PIP4K2B:PIP4K2C Reactome DB_ID: 10516972 1 1 Reactome Database ID Release 82 10516972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516972 Reactome R-XTR-6808599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6808599.1 Reactome Database ID Release 82 10516974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516974 Reactome R-XTR-1806229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1806229.1 GENE ONTOLOGY GO:0016309 Reactome Database ID Release 82 10516975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516975 Reactome Database ID Release 82 10516977 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10516977 Reactome R-XTR-1675776 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1675776.1 At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015). 18753295 Pubmed 2008 Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Clarke, JH Emson, PC Irvine, RF Am J Physiol Renal Physiol 295:F1422-30 19896968 Pubmed 2010 Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Clarke, JH Wang, M Irvine, RF Adv Enzyme Regul 50:12-8 23758345 Pubmed 2013 Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Clarke, Jonathan H Irvine, Robin F Biochem. J. 454:49-57 9367159 Pubmed 1997 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Rameh, Lucia Tolias, KF Duckworth, BC Cantley, Lewis C Nature 390:192-6 25495341 Pubmed 2015 The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site Clarke, Jonathan H Giudici, Maria-Luisa Burke, John E Williams, RL Maloney, David J Marugan, Juan Irvine, Robin F Biochem. J. 466:359-67 LEFT-TO-RIGHT 2.7.10.2 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PP2A Reactome DB_ID: 10480587 Converted from EntitySet in Reactome PP2A-subunit A Reactome DB_ID: 10480579 ppp2r1a PPP2R1A A0A803KKN3 Reactome DB_ID: 10480575 UniProt:A0A803KKN3 ppp2r1a UniProt A0A803KKN3 2 EQUAL 589 EQUAL Reactome Database ID Release 82 10480575 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480575 Reactome R-XTR-165982 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165982.1 F7AAX3 ppp2r1b PPP2R1B Reactome DB_ID: 10480577 UniProt:F7AAX3 ppp2r1b UniProt F7AAX3 1 EQUAL 601 EQUAL Reactome Database ID Release 82 10480577 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480577 Reactome R-XTR-165980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165980.1 Reactome Database ID Release 82 10480579 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480579 Reactome R-XTR-165990 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165990.1 1 Converted from EntitySet in Reactome PP2A-catalytic subunit C Reactome DB_ID: 10480585 csf1 PPP2CA Q6P365 Reactome DB_ID: 10480581 UniProt:Q6P365 csf1 UniProt Q6P365 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10480581 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480581 Reactome R-XTR-165971 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165971.1 ppp2cb PPP2CB Q6GLE6 Reactome DB_ID: 10480583 UniProt:Q6GLE6 ppp2cb UniProt Q6GLE6 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10480583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480583 Reactome R-XTR-165987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165987.1 Reactome Database ID Release 82 10480585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480585 Reactome R-XTR-165977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-165977.1 1 Converted from EntitySet in Reactome PP2A regulatory subunit B56 Reactome DB_ID: 10480573 ppp2r5a PPP2R5A A0A6I8RZ67 Reactome DB_ID: 10480559 UniProt:A0A6I8RZ67 ppp2r5a UniProt A0A6I8RZ67 1 EQUAL 486 EQUAL Reactome Database ID Release 82 10480559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480559 Reactome R-XTR-196235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-196235.1 ppp2r5b PPP2R5B A0A6I8RK11 Reactome DB_ID: 10480563 UniProt:A0A6I8RK11 ppp2r5b UniProt A0A6I8RK11 1 EQUAL 497 EQUAL Reactome Database ID Release 82 10480563 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480563 Reactome R-XTR-535469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-535469.1 Q6P3P7 ppp2r5c PPP2R5C Reactome DB_ID: 10480567 UniProt:Q6P3P7 ppp2r5c UniProt Q6P3P7 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10480567 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480567 Reactome R-XTR-3008954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3008954.1 K9J7P6 ppp2r5e PPP2R5E Reactome DB_ID: 10480571 UniProt:K9J7P6 ppp2r5e UniProt K9J7P6 1 EQUAL 467 EQUAL Reactome Database ID Release 82 10480571 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480571 Reactome R-XTR-1638770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1638770.1 Reactome Database ID Release 82 10480573 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480573 Reactome R-XTR-196216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-196216.1 1 Reactome Database ID Release 82 10480587 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10480587 Reactome R-XTR-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-196206.1 p-Y307-PP2A Reactome DB_ID: 10553513 Converted from EntitySet in Reactome p-Y307-PP2A-catalytic subunit C Reactome DB_ID: 10553511 Q6P365 phospho-csf1 p-Y307-PPP2CA Reactome DB_ID: 10553506 307 EQUAL 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10553506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553506 Reactome R-XTR-8857939 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857939.1 Q6GLE6 phospho-ppp2cb p-Y307-PPP2CB Reactome DB_ID: 10553509 307 EQUAL 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10553509 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553509 Reactome R-XTR-8857935 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857935.1 Reactome Database ID Release 82 10553511 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553511 Reactome R-XTR-8857933 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857933.1 1 1 1 Reactome Database ID Release 82 10553513 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553513 Reactome R-XTR-8857938 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857938.1 ACTIVATION Converted from EntitySet in Reactome Activated SRC,LCK,EGFR,INSR Reactome DB_ID: 10553521 F7DXH6 phospho-p-Y419-SRC-1 Reactome DB_ID: 10553515 2 EQUAL 536 EQUAL Reactome Database ID Release 82 10553515 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553515 Reactome R-XTR-112331 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-112331.1 EGF:p-6Y-EGFR dimer Reactome DB_ID: 10553517 2 Reactome Database ID Release 82 10553517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553517 Reactome R-XTR-179882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-179882.1 Insulin:p-6Y-Insulin receptor Reactome DB_ID: 10476820 p-6Y-insulin receptor Reactome DB_ID: 10476805 A0A6I8RXV0 phospho-p-6Y-INSR(763-1382) Reactome DB_ID: 10476803 UniProt:A0A6I8RXV0 UniProt A0A6I8RXV0 999 EQUAL 1185 EQUAL 1189 EQUAL 1190 EQUAL 1355 EQUAL 1361 EQUAL 763 EQUAL 1382 EQUAL Reactome Database ID Release 82 10476803 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476803 Reactome R-XTR-74670 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74670.1 2 A0A6I8RXV0 INSR(28-758) Reactome DB_ID: 10476795 28 EQUAL 758 EQUAL Reactome Database ID Release 82 10476795 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476795 Reactome R-XTR-74668 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74668.1 2 Reactome Database ID Release 82 10476805 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476805 Reactome R-XTR-74671 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74671.1 1 Insulin Reactome DB_ID: 10476818 fbxw8 2xHC-INS(25-54) F6QRS1 Reactome DB_ID: 10476816 UniProt:F6QRS1 fbxw8 UniProt F6QRS1 31 EQUAL L-cystine (cross-link) MOD MOD:00034 43 EQUAL 25 EQUAL 54 EQUAL Reactome Database ID Release 82 10476816 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476816 Reactome R-XTR-74673 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74673.1 1 fbxw8 4xHC-INS(90-110) F6QRS1 Reactome DB_ID: 10476812 95 EQUAL 109 EQUAL 96 EQUAL 90 EQUAL 110 EQUAL Reactome Database ID Release 82 10476812 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476812 Reactome R-XTR-74672 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74672.1 1 Reactome Database ID Release 82 10476818 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476818 Reactome R-XTR-74674 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74674.1 1 Reactome Database ID Release 82 10476820 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476820 Reactome R-XTR-74678 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74678.1 A0A7D9NMC7 phospho-p-Y394-LCK Reactome DB_ID: 10553519 394 EQUAL 1 EQUAL 509 EQUAL Reactome Database ID Release 82 10553519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553519 Reactome R-XTR-8857940 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857940.1 Reactome Database ID Release 82 10553521 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553521 Reactome R-XTR-8857936 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857936.1 GENE ONTOLOGY GO:0004713 Reactome Database ID Release 82 10553522 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553522 Reactome Database ID Release 82 10553524 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10553524 Reactome R-XTR-8857925 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8857925.1 SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307. 19576174 Pubmed 2009 PtdIns5P protects Akt from dephosphorylation through PP2A inhibition Ramel, Damien Lagarrigue, Frédéric Dupuis-Coronas, Sophie Chicanne, Gaëtan Leslie, Nicholas Gaits-Iacovoni, Frédérique Payrastre, Bernard Tronchère, Hélène Biochem. Biophys. Res. Commun. 387:127-31 1325671 Pubmed 1992 Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Chen, J Martin, B L Brautigan, D L Science 257:1261-4 ACTIVATION Reactome Database ID Release 82 9909778 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9909778 LEFT-TO-RIGHT IEX1 recruits ERKs to PP2A IER3 recruits MAPKs to PP2A-B56-beta,gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-T185,Y187 MAPK1 dimer Reactome DB_ID: 10483775 Q28H11 phospho-p-T185,Y187-MAPK1 Reactome DB_ID: 10479132 UniProt:Q28H11 UniProt Q28H11 185 EQUAL O-phospho-L-threonine MOD MOD:00047 187 EQUAL 2 EQUAL 360 EQUAL Reactome Database ID Release 82 10479132 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10479132 Reactome R-XTR-109853 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109853.1 2 Reactome Database ID Release 82 10483775 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10483775 Reactome R-XTR-109855 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109855.1 PP2A-B56-beta,gamma Reactome DB_ID: 10550653 1 1 Converted from EntitySet in Reactome PPP2R5B,PPP2R5C B56beta,B56gamma Reactome DB_ID: 10550651 Reactome Database ID Release 82 10550651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550651 Reactome R-XTR-6811516 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811516.1 1 Reactome Database ID Release 82 10550653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550653 Reactome R-XTR-6811526 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811526.1 IER3 A0A6I8RRT0 Reactome DB_ID: 10550649 UniProt:A0A6I8RRT0 UniProt A0A6I8RRT0 1 EQUAL 156 EQUAL Reactome Database ID Release 82 10550649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550649 Reactome R-XTR-6811515 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811515.1 PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers Reactome DB_ID: 10550655 1 1 1 Reactome Database ID Release 82 10550655 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550655 Reactome R-XTR-6811477 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811477.1 Reactome Database ID Release 82 10550670 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550670 Reactome R-XTR-6811472 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811472.1 IER3 (IEX-1) recruits both an activated MAPK (MAPK1 (ERK2) or MAPK3 (ERK1)) and the protein phosphatase 2A (PP2A) complex containing regulatory subunits B56-beta (PPP2R5B) or B56-gamma (PPP2R5C), through an interaction with the B56 subunit, forming a tripartite complex (Letourneux et al. 2006, Rocher et al. 2007). 16456541 Pubmed 2006 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK Letourneux, C Rocher, G Porteu, F EMBO J 25:727-38 17200115 Pubmed 2007 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, Géraldine Letourneux, Claire Lenormand, Philippe Porteu, Françoise J. Biol. Chem. 282:5468-77 LEFT-TO-RIGHT 2.7.11.1 MAPKs phosphorylate PP2A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PP2A-A:PP2A-C Reactome DB_ID: 10550665 1 1 Reactome Database ID Release 82 10550665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550665 Reactome R-XTR-6811485 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811485.1 Converted from EntitySet in Reactome p-S-B56-beta,gamma p-S368-PPP2R5B,p-S337-PPP2R5C Reactome DB_ID: 10550663 Q6P3P7 phospho-ppp2r5c p-S337-PPP2R5C Reactome DB_ID: 10550658 337 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10550658 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550658 Reactome R-XTR-6811447 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811447.1 A0A6I8RK11 phospho-ppp2r5b p-S368-PPP2R5B Reactome DB_ID: 10550661 368 EQUAL 1 EQUAL 497 EQUAL Reactome Database ID Release 82 10550661 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550661 Reactome R-XTR-6811453 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811453.1 Reactome Database ID Release 82 10550663 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550663 Reactome R-XTR-6811475 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811475.1 ACTIVATION activeUnit: #Complex124 GENE ONTOLOGY GO:0004674 Reactome Database ID Release 82 10550666 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550666 Reactome Database ID Release 82 10550668 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10550668 Reactome R-XTR-6811454 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811454.1 Activated MAPK1 (ERK2) or MAPK3 (ERK1), recruited to the PP2A complex through IER3 (IEX-1), phosphorylate the regulatory subunit PPP2R5B (B56-beta) or PPP2R5C (B56-gamma) of the PP2A complex on serine residue S368 or S337, respectively. ERK-mediated phosphorylation of the PP2A regulatory subunits causes dissociation of the PP2A complex and prevents PP2A-mediated dephosphorylation of AKT1 (Letourneux et al. 2006, Rocher et al. 2007). Reactome Database ID Release 82 10568406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568406 Reactome R-XTR-6811558 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6811558.1 GENE ONTOLOGY GO:0014066 Phosphatidylinositol-5-phosphate (PI5P) may modulate PI3K/AKT signaling in several ways. PI5P is used as a substrate for production of phosphatidylinositol-4,5-bisphosphate, PI(4,5)P2 (Rameh et al. 1997, Clarke et al. 2008, Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015), which serves as a substrate for activated PI3K, resulting in the production of PIP3 (Mandelker et al. 2009, Burke et al. 2011). The majority of PI(4,5)P2 in the cell, however, is produced from the phosphatidylinositol-4-phosphate (PI4P) substrate (Zhang et al. 1997, Di Paolo et al. 2002, Oude Weernink et al. 2004, Halstead et al. 2006, Oude Weernink et al. 2007). PIP3 is necessary for the activating phosphorylation of AKT. AKT1 can be deactivated by the protein phosphatase 2A (PP2A) complex that contains a regulatory subunit B56-beta (PPP2R5B) or B56-gamma (PPP2R5C). PI5P inhibits AKT1 dephosphorylation by PP2A through an unknown mechanism (Ramel et al. 2009). Increased PI5P levels correlate with inhibitory phosphorylation(s) of the PP2A complex. MAPK1 (ERK2) and MAPK3 (ERK1) are involved in inhibitory phosphorylation of PP2A, in a process that involves IER3 (IEX-1) (Letourneux et al. 2006, Rocher et al. 2007). It is uncertain, however, whether PI5P is in any way involved in ERK-mediated phosphorylation of PP2A or if it regulates another PP2A kinase. Reactome Database ID Release 82 10568408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568408 Reactome R-XTR-199418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-199418.1 The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation. LEFT-TO-RIGHT PDPK1 binds PIP2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PDPK1:PIP2 Reactome DB_ID: 10523799 1 1 Reactome Database ID Release 82 10523799 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10523799 Reactome R-XTR-2219520 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2219520.1 Reactome Database ID Release 82 10523801 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10523801 Reactome R-XTR-2219524 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2219524.1 PDPK1 (PDK1) possesses low affinity for PIP2, so small amounts of PDPK1 are always present at the membrane, in the absence of PI3K activity (Currie et al. 1999). PTEN Regulation This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Regulation of PTEN gene transcription This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT SALL4 recruits NuRD to PTEN gene This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> SALL4:PTEN gene Reactome DB_ID: 10558004 nucleoplasm GENE ONTOLOGY GO:0005654 Ghost homologue of PTEN gene Reactome DB_ID: 10558002 Reactome Database ID Release 82 10558002 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558002 Reactome R-XTR-5632949 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5632949.1 1 sall4 SALL4 A0A6I8QN79 Reactome DB_ID: 10526138 UniProt:A0A6I8QN79 sall4 UniProt A0A6I8QN79 1 EQUAL 1053 EQUAL Reactome Database ID Release 82 10526138 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526138 Reactome R-XTR-452644 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-452644.1 1 Reactome Database ID Release 82 10558004 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558004 Reactome R-XTR-8943729 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943729.1 NuRD complex Reactome DB_ID: 10476254 Converted from EntitySet in Reactome MTA1, MTA2, MTA3 Reactome DB_ID: 10476242 mta1 MTA1 A0A6I8S661 Reactome DB_ID: 10476236 UniProt:A0A6I8S661 mta1 UniProt A0A6I8S661 1 EQUAL 715 EQUAL Reactome Database ID Release 82 10476236 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476236 Reactome R-XTR-3465550 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3465550.1 mta2 MTA2 A0A6I8RQK7 Reactome DB_ID: 10476240 UniProt:A0A6I8RQK7 mta2 UniProt A0A6I8RQK7 1 EQUAL 668 EQUAL Reactome Database ID Release 82 10476240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476240 Reactome R-XTR-4657009 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657009.1 Reactome Database ID Release 82 10476242 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476242 Reactome R-XTR-4657019 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657019.1 1 rbbp4 RBBP4 A0A6I8QVR5 Reactome DB_ID: 10476214 UniProt:A0A6I8QVR5 rbbp4 UniProt A0A6I8QVR5 2 EQUAL 425 EQUAL Reactome Database ID Release 82 10476214 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476214 Reactome R-XTR-212223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212223.1 1 rbbp7 RBBP7 Q6P315 Reactome DB_ID: 10476218 UniProt:Q6P315 rbbp7 UniProt Q6P315 2 EQUAL 425 EQUAL Reactome Database ID Release 82 10476218 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476218 Reactome R-XTR-212227 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212227.1 1 Converted from EntitySet in Reactome (GATAD2A, GATAD2B) Reactome DB_ID: 10476252 gatad2a GATAD2A A0A6I8PQR1 Reactome DB_ID: 10476246 UniProt:A0A6I8PQR1 gatad2a UniProt A0A6I8PQR1 1 EQUAL 633 EQUAL Reactome Database ID Release 82 10476246 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476246 Reactome R-XTR-3702077 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3702077.1 gatad2b GATAD2B A0A803KAN5 Reactome DB_ID: 10476250 UniProt:A0A803KAN5 gatad2b UniProt A0A803KAN5 1 EQUAL 593 EQUAL Reactome Database ID Release 82 10476250 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476250 Reactome R-XTR-3702079 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3702079.1 Reactome Database ID Release 82 10476252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476252 Reactome R-XTR-4657014 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657014.1 1 Converted from EntitySet in Reactome Mi-2 Reactome DB_ID: 10476228 chd4 CHD4 A0A6I8RFD2 Reactome DB_ID: 10476222 UniProt:A0A6I8RFD2 chd4 UniProt A0A6I8RFD2 1 EQUAL 1912 EQUAL Reactome Database ID Release 82 10476222 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476222 Reactome R-XTR-3702078 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3702078.1 chd3 CHD3 F6PUX9 Reactome DB_ID: 10476226 UniProt:F6PUX9 chd3 UniProt F6PUX9 1 EQUAL 2000 EQUAL Reactome Database ID Release 82 10476226 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476226 Reactome R-XTR-4657012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657012.1 Reactome Database ID Release 82 10476228 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476228 Reactome R-XTR-4657021 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657021.1 1 HDAC1:HDAC2 Reactome DB_ID: 10476210 HDAC1 F6ULG8 Reactome DB_ID: 10476204 UniProt:F6ULG8 UniProt F6ULG8 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10476204 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476204 Reactome R-XTR-205021 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205021.1 1 HDAC2 Q28CG8 Reactome DB_ID: 10476208 UniProt:Q28CG8 UniProt Q28CG8 1 EQUAL 488 EQUAL Reactome Database ID Release 82 10476208 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476208 Reactome R-XTR-205135 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-205135.1 1 Reactome Database ID Release 82 10476210 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476210 Reactome R-XTR-4657004 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657004.1 1 mbd3 MBD3 A0A803KBL6 Reactome DB_ID: 10476232 UniProt:A0A803KBL6 mbd3 UniProt A0A803KBL6 1 EQUAL 291 EQUAL Reactome Database ID Release 82 10476232 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476232 Reactome R-XTR-4657010 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657010.1 1 Reactome Database ID Release 82 10476254 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10476254 Reactome R-XTR-4657018 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4657018.1 SALL4:NuRD:PTEN gene Reactome DB_ID: 10558008 1 SALL4:NuRD Reactome DB_ID: 10558006 1 1 Reactome Database ID Release 82 10558006 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558006 Reactome R-XTR-8943778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943778.1 1 Reactome Database ID Release 82 10558008 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558008 Reactome R-XTR-8943781 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943781.1 Reactome Database ID Release 82 10558010 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558010 Reactome R-XTR-8943780 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943780.1 SALL4 recruits the transcriptional repressor complex NuRD, containing histone deacetylases HDAC1 and HDAC2, to the PTEN gene promoter (Lu et al 2009, Gao et al. 2013). SALL4 may also recruit DNA methyltransferases (DNMTs) to the PTEN promoter (Yang et al. 2012). 22128185 Pubmed 2012 Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases Yang, Jianchang Corsello, Tyler R Ma, Yupo J. Biol. Chem. 287:1996-2005 19440552 Pubmed 2009 Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex Lu, J Jeong, HW Kong, N Yang, Y Carroll, J Luo, HR Silberstein, LE Yupoma, LE Chai, L PLoS One 4:e5577 23287862 Pubmed 2013 Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex Gao, Chong Dimitrov, Todor Yong, Kol Jia Tatetsu, Hiro Jeong, Ha-Won Luo, Hongbo R Bradner, James E Tenen, Daniel G Chai, Li Blood 121:1413-21 LEFT-TO-RIGHT MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome PRC1.4,PRC2 (EZH2) core Reactome DB_ID: 10558014 PRC2 (EZH2) Core Reactome DB_ID: 10490819 eed EED Q28DT7 Reactome DB_ID: 10490807 UniProt:Q28DT7 eed UniProt Q28DT7 1 EQUAL 441 EQUAL Reactome Database ID Release 82 10490807 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10490807 Reactome R-XTR-212278 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212278.1 1 suz12 SUZ12 F6Y738 Reactome DB_ID: 10490815 UniProt:F6Y738 suz12 UniProt F6Y738 1 EQUAL 739 EQUAL Reactome Database ID Release 82 10490815 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10490815 Reactome R-XTR-212217 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212217.1 1 Converted from EntitySet in Reactome RBBP4,7 Reactome DB_ID: 10490817 Reactome Database ID Release 82 10490817 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10490817 Reactome R-XTR-4839773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-4839773.1 1 ezh2 EZH2 Q28D84 Reactome DB_ID: 10490811 UniProt:Q28D84 ezh2 UniProt Q28D84 1 EQUAL 746 EQUAL Reactome Database ID Release 82 10490811 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10490811 Reactome R-XTR-212298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212298.1 1 Reactome Database ID Release 82 10490819 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10490819 Reactome R-XTR-212285 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-212285.1 PRC1.4 Reactome DB_ID: 10527045 Converted from EntitySet in Reactome CBX2,CBX4,CBX6,CBX8 Reactome DB_ID: 10527043 CBX2 syngr2 F7EJK9 Reactome DB_ID: 10526634 UniProt:F7EJK9 syngr2 UniProt F7EJK9 1 EQUAL 532 EQUAL Reactome Database ID Release 82 10526634 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526634 Reactome R-XTR-389110 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389110.1 CBX4 A0A6I8SPI5 Reactome DB_ID: 10526638 UniProt:A0A6I8SPI5 UniProt A0A6I8SPI5 1 EQUAL 560 EQUAL Reactome Database ID Release 82 10526638 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526638 Reactome R-XTR-389118 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389118.1 cbx6 CBX6 Q28IA4 Reactome DB_ID: 10527041 UniProt:Q28IA4 cbx6 UniProt Q28IA4 1 EQUAL 412 EQUAL Reactome Database ID Release 82 10527041 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10527041 Reactome R-XTR-3229071 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3229071.1 Reactome Database ID Release 82 10527043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10527043 Reactome R-XTR-9007203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9007203.1 1 Converted from EntitySet in Reactome RING1,RNF2 RING1A,RING1B Reactome DB_ID: 10526630 ring1 RING1 A4IGP4 Reactome DB_ID: 10526624 UniProt:A4IGP4 ring1 UniProt A4IGP4 1 EQUAL 406 EQUAL Reactome Database ID Release 82 10526624 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526624 Reactome R-XTR-389113 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389113.1 rnf2 RNF2 A0A803K5S7 Reactome DB_ID: 10526628 UniProt:A0A803K5S7 rnf2 UniProt A0A803K5S7 1 EQUAL 336 EQUAL Reactome Database ID Release 82 10526628 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526628 Reactome R-XTR-389119 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389119.1 Reactome Database ID Release 82 10526630 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526630 Reactome R-XTR-9007201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9007201.1 1 scmh1 SCMH1-2 Q6DJ53 Reactome DB_ID: 10526596 UniProt:Q6DJ53 scmh1 UniProt Q6DJ53 1 EQUAL 660 EQUAL Reactome Database ID Release 82 10526596 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526596 Reactome R-XTR-389122 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389122.1 1 bmi1 BMI1 A0A803KF08 Reactome DB_ID: 10526600 UniProt:A0A803KF08 bmi1 UniProt A0A803KF08 1 EQUAL 326 EQUAL Reactome Database ID Release 82 10526600 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526600 Reactome R-XTR-389121 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389121.1 1 Converted from EntitySet in Reactome PHC1,PHC2,PHC3 Reactome DB_ID: 10526620 phc1 PHC1 F6TCW7 Reactome DB_ID: 10526610 UniProt:F6TCW7 phc1 UniProt F6TCW7 1 EQUAL 1004 EQUAL Reactome Database ID Release 82 10526610 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526610 Reactome R-XTR-389111 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389111.1 phc2 PHC2 A0A803J520 Reactome DB_ID: 10526614 UniProt:A0A803J520 phc2 UniProt A0A803J520 1 EQUAL 858 EQUAL Reactome Database ID Release 82 10526614 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526614 Reactome R-XTR-389112 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389112.1 phc3 PHC3 F7DVI8 Reactome DB_ID: 10526618 UniProt:F7DVI8 phc3 UniProt F7DVI8 1 EQUAL 983 EQUAL Reactome Database ID Release 82 10526618 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526618 Reactome R-XTR-389116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-389116.1 Reactome Database ID Release 82 10526620 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10526620 Reactome R-XTR-9007200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9007200.1 1 Reactome Database ID Release 82 10527045 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10527045 Reactome R-XTR-3229073 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3229073.1 Reactome Database ID Release 82 10558014 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558014 Reactome R-XTR-8943822 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943822.1 MECOM:PTEN gene Reactome DB_ID: 10558016 MECOM znf524 A0A6I8RJH7 Reactome DB_ID: 10558012 UniProt:A0A6I8RJH7 znf524 UniProt A0A6I8RJH7 1 EQUAL 1051 EQUAL Reactome Database ID Release 82 10558012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558012 Reactome R-XTR-8943897 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943897.1 1 1 Reactome Database ID Release 82 10558016 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558016 Reactome R-XTR-8943810 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8943810.1 MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene Reactome DB_ID: 10558020 MECOM:(PRC1.4,PRC2 (EZH2) core) Reactome DB_ID: 10558018 1 1 Reactome Database ID Release 82 10558018 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10558018 Reactome R-XTR-8943820 1